BRPI0517917A - compostos, sais de adição de ácido, método para preparar os compostos, uso de compostos, composição topicamente aplicável, e, método para o tratamento de rugas de expressão e/ou relacionadas com a idade em pele humana - Google Patents

compostos, sais de adição de ácido, método para preparar os compostos, uso de compostos, composição topicamente aplicável, e, método para o tratamento de rugas de expressão e/ou relacionadas com a idade em pele humana

Info

Publication number
BRPI0517917A
BRPI0517917A BRPI0517917-3A BRPI0517917A BRPI0517917A BR PI0517917 A BRPI0517917 A BR PI0517917A BR PI0517917 A BRPI0517917 A BR PI0517917A BR PI0517917 A BRPI0517917 A BR PI0517917A
Authority
BR
Brazil
Prior art keywords
compounds
possibly substituted
age
human skin
expression
Prior art date
Application number
BRPI0517917-3A
Other languages
English (en)
Inventor
Dominik Imfeld
Hugo Ziegler
Peter Wikstroem
Original Assignee
Pentapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm Ag filed Critical Pentapharm Ag
Publication of BRPI0517917A publication Critical patent/BRPI0517917A/pt
Publication of BRPI0517917B1 publication Critical patent/BRPI0517917B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPOSTOS, SAIS DE ADIçãO DE áCIDO, MéTODO PARA PREPARAR OS COMPOSTOS, USO DE COMPOSTOS, COMPOSIçãO TOPICAMENTE APLICáVEL, E, MéTODO PARA O TRATAMENTO DE RUGAS DE EXPRESSãO E/OU RELACIONADAS COM A IDADE EM PELE HUMANA. A invenção refere-se a novos compostos de fórmula (I) em que X = uma ligação ou NH-CH (C=O) - (CH~2~) ~3~-NH-R¬5¬, n = O, 1 ou 2, R˜, R¬4¬ e R¬5¬ independentemente = H, C~6~ alquila opcionalmente substituída, amidino ou tetra C~ 1~-C ~6~ alquilamidínio, R = H ou C ~1~-C ~6~ alquila opcionalmente substituida, ou R˜ e R, juntos com o grupo a que eles estão ligados formam um anel saturado de 5 a 7 membros, R = C~ 1~-C~ 12~ alcóxi, C~ 1~- C~ 12~ alquilamino, arila opcionalmente substituida C~ 1~-C~ 6~ alquilamino, heteroarila opcionalmente substituida C~ 1~ -C~ 6~ alquilamino, arila opêionalmente substituida C~ 1~-C~ 6~ alcóxi ou heteroarila opcionalmente substituida C~ 1~-C~ 6~ alcóxi, e R¬6¬ = H ou, quando n = 1, amino, ou junto com R˜ e o grupo a que R¬6¬ e R˜ são ligados, um anel saturado de 7 membros e seus sais fisiologicamente aceitáveis. O acima pode ser produzido por métodos convencionais e processado para fornecer composições de aplicação tópica, adequadas para tratamento de rugas de expressão e/ou relacionadas com a idade na pele humana.
BRPI0517917-3A 2004-11-02 2005-11-01 compostos, sais de adição de ácido, método para preparar os compostos, uso de compostos, composição topicamente aplicável, e, método para o tratamento de rugas de expressão e/ou relacionadas com a idade em pele humana BRPI0517917B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH18092004 2004-11-02
CH1809/04 2004-11-02
PCT/CH2005/000638 WO2006047900A2 (de) 2004-11-02 2005-11-01 Neue topisch anwendbare wirkstoffe gegen mimische und alterabedingt falten

Publications (2)

Publication Number Publication Date
BRPI0517917A true BRPI0517917A (pt) 2008-10-21
BRPI0517917B1 BRPI0517917B1 (pt) 2020-11-10

Family

ID=35841896

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517917-3A BRPI0517917B1 (pt) 2004-11-02 2005-11-01 compostos, sais de adição de ácido, método para preparar os compostos, uso de compostos, composição topicamente aplicável, e, método para o tratamento de rugas de expressão e/ou relacionadas com a idade em pele humana

Country Status (12)

Country Link
US (1) US7964630B2 (pt)
EP (1) EP1809652B1 (pt)
JP (1) JP5006789B2 (pt)
KR (1) KR101227301B1 (pt)
CN (1) CN101061134B (pt)
AT (1) ATE466867T1 (pt)
BR (1) BRPI0517917B1 (pt)
CA (1) CA2584643C (pt)
DE (1) DE502005009544D1 (pt)
ES (1) ES2345667T3 (pt)
PL (1) PL1809652T3 (pt)
WO (1) WO2006047900A2 (pt)

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US9815875B2 (en) 2008-02-19 2017-11-14 Myocept Inc. Postsynaptically targeted chemodenervation agents and their methods of use
WO2010003861A1 (en) * 2008-07-08 2010-01-14 Unilever Plc Antiperspirant products
WO2010003781A1 (en) * 2008-07-08 2010-01-14 Unilever Plc Antiperspirant compositions
WO2011009626A1 (en) 2009-07-24 2011-01-27 Lipotec, S.A. Compounds which inhibit muscle contraction
JP4666537B1 (ja) * 2010-01-21 2011-04-06 株式会社資生堂 しわ改善用美容セット並びにこれを使用する美容方法
US10149812B2 (en) 2012-04-13 2018-12-11 Activen Cosmetic composition comprising a muconopeptide
WO2013153236A2 (en) 2012-04-13 2013-10-17 Activen Cosmetic composition comprising a muconopeptide
RU2524428C1 (ru) 2013-01-21 2014-07-27 Общество с ограниченной ответственностью "Синейро" Пептиды и их производные, взаимодействующие с никотиновым ацетилхолиновым рецептором и пригодные для использования в косметологии против мимических и возрастных морщин
CN103570804B (zh) * 2013-09-11 2015-04-15 深圳市维琪医药研发有限公司 一种具皮肤活性的多肽的合成方法
WO2015063613A2 (en) 2013-11-01 2015-05-07 Spherium Biomed S.L. Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
RU2551276C1 (ru) * 2014-02-03 2015-05-20 Закрытое Акционерное Общество "Фарм-Синтез" Способ получения диацетата трипептида
WO2015168564A1 (en) * 2014-05-01 2015-11-05 Anterios, Inc. Methods to treat, prevent, and improve skin conditions
CN104327155A (zh) * 2014-10-20 2015-02-04 张嘎 一种含有15n—l—脯氨酸残基的三肽型减皱化合物及其制备方法和应用
CN104478991B (zh) * 2014-12-10 2018-06-19 深圳市维琪医药研发有限公司 一种新型多肽化合物及其制备方法和其医药应用
KR101710486B1 (ko) * 2015-01-05 2017-02-28 주식회사 앤코스메슈 올리고펩타이드 유도체 및 이를 포함하는 주름개선용 조성물
CN104592348A (zh) * 2015-01-16 2015-05-06 张嘎 一种含有3,4-脱氢-l-脯氨酸残基的三肽减皱化合物及其制备方法和应用
KR20180094980A (ko) * 2015-12-16 2018-08-24 디에스엠 아이피 어셋츠 비.브이. 신규한 용도
US10561702B2 (en) 2015-12-16 2020-02-18 Dsm Ip Assets B.V. Method for the treatment of skin disorders using dipeptide diaminobutyroyl benzylamide diacetate
CN106187793A (zh) * 2016-01-26 2016-12-07 赵鸣 5‑氨基酮戊酸及其衍生物的盐化合物和应用
CN106038385A (zh) * 2016-06-08 2016-10-26 广州市创美时美容化妆品有限公司 一种刺激胶原蛋白生成抵抗皱纹的化妆品组合物
CN107936108A (zh) * 2017-12-05 2018-04-20 陕西慧康生物科技有限责任公司 一种类蛇毒三肽的液相合成方法
CN107857797A (zh) * 2017-12-07 2018-03-30 陕西慧康生物科技有限责任公司 一种类蛇毒三肽的液相片段合成方法
JP7296642B2 (ja) 2018-02-27 2023-06-23 リポトゥルー，エセ．エレ． 化粧料および医薬に使用するためのペプチドおよび組成物
JP2021524454A (ja) 2018-05-24 2021-09-13 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． プロリン誘導体の新規の使用
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Also Published As

Publication number Publication date
KR20070085372A (ko) 2007-08-27
US7964630B2 (en) 2011-06-21
WO2006047900A3 (de) 2006-07-27
CN101061134B (zh) 2011-05-11
WO2006047900A2 (de) 2006-05-11
ES2345667T3 (es) 2010-09-29
JP2008518978A (ja) 2008-06-05
US20090111731A1 (en) 2009-04-30
KR101227301B1 (ko) 2013-01-29
JP5006789B2 (ja) 2012-08-22
EP1809652B1 (de) 2010-05-05
DE502005009544D1 (de) 2010-06-17
PL1809652T3 (pl) 2010-10-29
CA2584643C (en) 2013-01-29
CN101061134A (zh) 2007-10-24
EP1809652A2 (de) 2007-07-25
BRPI0517917B1 (pt) 2020-11-10
CA2584643A1 (en) 2006-05-11
ATE466867T1 (de) 2010-05-15

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