BRPI0406614A - Composto, uso do mesmo, composição farmacêutica, métodos para a terapia de dor em um animal de sangue quente e para a terapia de distúrbios gastrointestinais funcionais em um animal de sangue quente, e, processo para preparar um composto - Google Patents
Composto, uso do mesmo, composição farmacêutica, métodos para a terapia de dor em um animal de sangue quente e para a terapia de distúrbios gastrointestinais funcionais em um animal de sangue quente, e, processo para preparar um compostoInfo
- Publication number
- BRPI0406614A BRPI0406614A BR0406614-6A BRPI0406614A BRPI0406614A BR PI0406614 A BRPI0406614 A BR PI0406614A BR PI0406614 A BRPI0406614 A BR PI0406614A BR PI0406614 A BRPI0406614 A BR PI0406614A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- therapy
- warm
- blooded animal
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000002560 therapeutic procedure Methods 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 208000018522 Gastrointestinal disease Diseases 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 208000014540 Functional gastrointestinal disease Diseases 0.000 abstract 1
- -1 USE OF THE SAME Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
"COMPOSTO, USO DO MESMO, COMPOSIçãO FARMACêUTICA, MéTODOS PARA A TERAPIA DE DOR EM UM ANIMAL DE SANGUE QUENTE E PARA A TERAPIA DE DISTúRBIOS GASTROINTESTINAIS FUNCIONAIS EM UM ANIMAL DE SANGUE QUENTE, E, PROCESSO PARA PREPARAR UM COMPOSTO". Os compostos da fórmula geral: em que R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬ e R¬ 5¬ são como definidos no relatório descritivo, assim como sais, seus enanciómeros e composições farmacêuticas que incluem os compostos são preparados. Eles são úteis em terapia, em particular no controle da dor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0300105A SE0300105D0 (sv) | 2003-01-16 | 2003-01-16 | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
PCT/GB2004/000099 WO2004062562A2 (en) | 2003-01-16 | 2004-01-13 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0406614A true BRPI0406614A (pt) | 2005-12-06 |
Family
ID=20290140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0406614-6A BRPI0406614A (pt) | 2003-01-16 | 2004-01-13 | Composto, uso do mesmo, composição farmacêutica, métodos para a terapia de dor em um animal de sangue quente e para a terapia de distúrbios gastrointestinais funcionais em um animal de sangue quente, e, processo para preparar um composto |
Country Status (21)
Country | Link |
---|---|
US (1) | US20060154964A1 (pt) |
EP (1) | EP1587790A2 (pt) |
JP (1) | JP2006516559A (pt) |
KR (1) | KR20050096137A (pt) |
CN (1) | CN100422151C (pt) |
AR (1) | AR042887A1 (pt) |
AU (1) | AU2004204390B2 (pt) |
BR (1) | BRPI0406614A (pt) |
CA (1) | CA2510382A1 (pt) |
IL (1) | IL169366A0 (pt) |
IS (1) | IS7980A (pt) |
MX (1) | MXPA05007484A (pt) |
NO (1) | NO20053809L (pt) |
NZ (1) | NZ540758A (pt) |
PL (1) | PL378336A1 (pt) |
RU (1) | RU2324680C2 (pt) |
SE (1) | SE0300105D0 (pt) |
TW (1) | TW200504059A (pt) |
UA (1) | UA80012C2 (pt) |
WO (1) | WO2004062562A2 (pt) |
ZA (1) | ZA200505186B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY140070A (en) | 2001-05-18 | 2009-11-30 | Astrazeneca Ab | 4-(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203301D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
US20070099957A1 (en) * | 2003-05-16 | 2007-05-03 | Astra Zeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
NZ546834A (en) | 2003-10-01 | 2010-03-26 | Adolor Corp | Spirocyclic heterocyclic derivatives and methods of their use |
DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
JP2008531683A (ja) * | 2005-02-28 | 2008-08-14 | アストラゼネカ・アクチエボラーグ | ジアリールメチルピペラジン誘導体、その製造及びその使用 |
US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
MY148880A (en) * | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
CN111825654A (zh) * | 2019-04-19 | 2020-10-27 | 北京酷瓴生物技术有限公司 | 苯甲烯哌啶衍生物及其制备方法、中间体和用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
US5140029A (en) * | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
US4939137A (en) * | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
US5683998A (en) * | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
AU2001241676A1 (en) * | 2000-03-03 | 2001-09-17 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives |
US6556387B1 (en) * | 2000-03-31 | 2003-04-29 | Seagate Technology Llc | Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly |
SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
SE0101766D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
BRPI0411998A (pt) * | 2003-06-27 | 2006-09-05 | Janssen Pharmaceutica Nv | moduladores delta-opióides tricìclicos |
-
2003
- 2003-01-16 SE SE0300105A patent/SE0300105D0/xx unknown
-
2004
- 2004-01-13 KR KR1020057013174A patent/KR20050096137A/ko not_active Application Discontinuation
- 2004-01-13 JP JP2006500202A patent/JP2006516559A/ja not_active Abandoned
- 2004-01-13 PL PL378336A patent/PL378336A1/pl not_active Application Discontinuation
- 2004-01-13 RU RU2005121491/04A patent/RU2324680C2/ru not_active IP Right Cessation
- 2004-01-13 NZ NZ540758A patent/NZ540758A/en unknown
- 2004-01-13 CA CA002510382A patent/CA2510382A1/en not_active Abandoned
- 2004-01-13 WO PCT/GB2004/000099 patent/WO2004062562A2/en active Application Filing
- 2004-01-13 AU AU2004204390A patent/AU2004204390B2/en not_active Ceased
- 2004-01-13 UA UAA200506380A patent/UA80012C2/uk unknown
- 2004-01-13 BR BR0406614-6A patent/BRPI0406614A/pt not_active IP Right Cessation
- 2004-01-13 MX MXPA05007484A patent/MXPA05007484A/es not_active Application Discontinuation
- 2004-01-13 US US10/541,522 patent/US20060154964A1/en not_active Abandoned
- 2004-01-13 CN CNB2004800022753A patent/CN100422151C/zh not_active Expired - Fee Related
- 2004-01-13 EP EP04701624A patent/EP1587790A2/en not_active Withdrawn
- 2004-01-14 TW TW093100912A patent/TW200504059A/zh unknown
- 2004-01-15 AR ARP040100105A patent/AR042887A1/es not_active Application Discontinuation
-
2005
- 2005-06-23 IL IL169366A patent/IL169366A0/en unknown
- 2005-06-27 ZA ZA200505186A patent/ZA200505186B/en unknown
- 2005-08-12 NO NO20053809A patent/NO20053809L/no not_active Application Discontinuation
- 2005-08-12 IS IS7980A patent/IS7980A/is unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004204390B2 (en) | 2007-09-06 |
WO2004062562A3 (en) | 2004-09-16 |
RU2324680C2 (ru) | 2008-05-20 |
AU2004204390A1 (en) | 2004-07-29 |
NO20053809D0 (no) | 2005-08-12 |
ZA200505186B (en) | 2006-04-26 |
CA2510382A1 (en) | 2004-07-29 |
AR042887A1 (es) | 2005-07-06 |
TW200504059A (en) | 2005-02-01 |
IL169366A0 (en) | 2007-07-04 |
KR20050096137A (ko) | 2005-10-05 |
CN100422151C (zh) | 2008-10-01 |
NZ540758A (en) | 2008-03-28 |
UA80012C2 (en) | 2007-08-10 |
CN1738801A (zh) | 2006-02-22 |
NO20053809L (no) | 2005-10-17 |
SE0300105D0 (sv) | 2003-01-16 |
RU2005121491A (ru) | 2006-02-10 |
WO2004062562A2 (en) | 2004-07-29 |
JP2006516559A (ja) | 2006-07-06 |
MXPA05007484A (es) | 2005-09-21 |
EP1587790A2 (en) | 2005-10-26 |
IS7980A (is) | 2005-08-12 |
PL378336A1 (pl) | 2006-03-20 |
US20060154964A1 (en) | 2006-07-13 |
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