BRPI0516408B8 - derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide - Google Patents

derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide

Info

Publication number
BRPI0516408B8
BRPI0516408B8 BRPI0516408A BRPI0516408A BRPI0516408B8 BR PI0516408 B8 BRPI0516408 B8 BR PI0516408B8 BR PI0516408 A BRPI0516408 A BR PI0516408A BR PI0516408 A BRPI0516408 A BR PI0516408A BR PI0516408 B8 BRPI0516408 B8 BR PI0516408B8
Authority
BR
Brazil
Prior art keywords
imaging
binding
stilbene derivatives
amyloid plaques
amyloid
Prior art date
Application number
BRPI0516408A
Other languages
English (en)
Portuguese (pt)
Inventor
F Kung Hank
Kung Mei-Ping
Zhuang Zhi-Ping
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of BRPI0516408A publication Critical patent/BRPI0516408A/pt
Publication of BRPI0516408B1 publication Critical patent/BRPI0516408B1/pt
Publication of BRPI0516408B8 publication Critical patent/BRPI0516408B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0516408A 2004-12-17 2005-12-19 derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide BRPI0516408B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US60/636,696 2004-12-17
US68639505P 2005-06-02 2005-06-02
US60/686,395 2005-06-02
PCT/US2005/045682 WO2006066104A2 (en) 2004-12-17 2005-12-19 Stilbene derivatives and their use for binding and imaging amyloid plaques

Publications (3)

Publication Number Publication Date
BRPI0516408A BRPI0516408A (pt) 2008-09-02
BRPI0516408B1 BRPI0516408B1 (pt) 2021-03-23
BRPI0516408B8 true BRPI0516408B8 (pt) 2021-05-25

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516408A BRPI0516408B8 (pt) 2004-12-17 2005-12-19 derivados de estilbeno e seu uso para ligação e formação de imagem de placas de amilóide

Country Status (25)

Country Link
US (2) US7807135B2 (Direct)
EP (3) EP1841465A4 (Direct)
JP (1) JP5128956B2 (Direct)
KR (1) KR101321619B1 (Direct)
AU (1) AU2005316421B2 (Direct)
BE (1) BE2015C015I2 (Direct)
BR (1) BRPI0516408B8 (Direct)
CA (1) CA2591534C (Direct)
DK (1) DK2213652T3 (Direct)
EA (1) EA012334B1 (Direct)
ES (1) ES2526655T3 (Direct)
FR (1) FR15C0012I2 (Direct)
HU (1) HUS1500014I1 (Direct)
IL (2) IL183946A (Direct)
LT (1) LTC2213652I2 (Direct)
LU (1) LU92647I2 (Direct)
MX (1) MX2007007380A (Direct)
NL (1) NL300719I2 (Direct)
NO (1) NO339195B1 (Direct)
NZ (1) NZ555942A (Direct)
PL (1) PL2213652T3 (Direct)
PT (1) PT2213652E (Direct)
SG (1) SG194363A1 (Direct)
SI (1) SI2213652T1 (Direct)
WO (1) WO2006066104A2 (Direct)

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CN101003526B (zh) * 2001-08-27 2012-02-22 宾夕法尼亚州大学理事会 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途
PT2213652E (pt) * 2004-12-17 2015-01-02 Univ Pennsylvania Derivados do estilbeno e a sua utilização para ligação e diagnóstico por imagem de placas amiloides
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
EP1893245A4 (en) * 2005-06-24 2009-06-24 Univ Pennsylvania RADIOMARQUE PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS
CN101522624B (zh) 2006-03-30 2013-11-06 宾夕法尼亚大学理事会 苯乙烯基吡啶衍生物及其用于结合和成像淀粉样蛋白斑的用途
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
WO2009001046A2 (en) * 2007-06-22 2008-12-31 The University Court Of The University Of Aberdeen [11c]methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (tms) and its preparation and use
EP2172444A4 (en) * 2007-07-04 2010-12-22 Univ Tohoku PET PROBE WITH FLUORO-SUBSTITUTED ALKOXY GROUP AND HYDROXYGRUPPE
WO2009052116A1 (en) * 2007-10-15 2009-04-23 The Salk Institute For Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
LT2247558T (lt) * 2008-02-14 2022-04-11 Eli Lilly And Company Nauji vizualizavimo agentai neurologinės disfunkcijos aptikimui
AU2009219406A1 (en) * 2008-02-27 2009-09-03 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled A-beta binding compounds
JP5603855B2 (ja) * 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
JP2012508889A (ja) * 2008-11-13 2012-04-12 アビッド レディオファーマシューティカルズ、インク． 神経変性疾患の検出と診断のためのヒストグラムに基づいた分析方法
KR20110106895A (ko) 2008-12-22 2011-09-29 바이엘 파마 악티엔게젤샤프트 교환 수지를 사용하여 방사성핵종-표지된 화합물을 합성하는 방법
EA023014B1 (ru) * 2008-12-31 2016-04-29 Эвид Рэйдиофармасьютикалз, Инк. Синтез стирилпиридинов, меченных радиоактивным изотопомf, из предшественников тозилата и их стабильные фармацевтические композиции
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
CA2767475A1 (en) * 2009-07-10 2011-01-13 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
SG181903A1 (en) * 2009-12-23 2012-07-30 Piramal Imaging Sa Formulations suitable for pet imaging with hydrophobic pet agents
HUE033237T2 (hu) * 2010-06-04 2017-11-28 Piramal Imaging Sa Eljárás F-18 jelölt béta-amiloid ligandumok elõállítására
BR112012030944A2 (pt) 2010-06-04 2016-11-01 Piramal Imaging Sa método para a produção de ligantes para beta amiloide marcados com f-18
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
MX2012014115A (es) * 2010-06-04 2013-07-03 Piramal Imaging Sa Metodo para la produccion de ligandos beta amiloide marcados con 18f.
WO2012051170A2 (en) * 2010-10-12 2012-04-19 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phingylbenzothiazole, stilbene, or biphenylalkyne derivatives
US9272055B2 (en) 2011-04-21 2016-03-01 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
JP6081997B2 (ja) * 2011-06-21 2017-02-15 ピラマル イメージング ソシエテ アノニム Ｐｅｔイメージングに適したフッ素化スチルベンの製剤
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
JP2015501305A (ja) 2011-10-19 2015-01-15 ピラマル イメージング ソシエテ アノニム Ｆ‐１８標識Ａβリガンドの改良された製造方法
ES2725314T3 (es) 2012-04-10 2019-09-23 Lantheus Medical Imaging Inc Métodos de síntesis radiofarmacéutica
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) * 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
CN109790184B (zh) 2016-09-29 2021-06-29 韩国原子力研究院 姜黄素衍生物、其制备方法、以及用于检测β-淀粉样蛋白斑的包含该姜黄素衍生物的光声成像剂
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret

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US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
PT2213652E (pt) * 2004-12-17 2015-01-02 Univ Pennsylvania Derivados do estilbeno e a sua utilização para ligação e diagnóstico por imagem de placas amiloides
EP1893245A4 (en) * 2005-06-24 2009-06-24 Univ Pennsylvania RADIOMARQUE PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS

Also Published As

Publication number Publication date
LU92647I2 (fr) 2015-11-03
FR15C0012I1 (Direct) 2015-03-20
EP1841465A4 (en) 2009-04-01
DK2213652T3 (en) 2015-01-26
IL183946A0 (en) 2007-10-31
NO339195B1 (no) 2016-11-14
US8465726B2 (en) 2013-06-18
BE2015C015I2 (Direct) 2025-04-29
MX2007007380A (es) 2007-10-11
AU2005316421A1 (en) 2006-06-22
NL300719I1 (Direct) 2015-12-29
LTC2213652I2 (lt) 2016-12-27
BRPI0516408A (pt) 2008-09-02
JP2008524243A (ja) 2008-07-10
KR20070093427A (ko) 2007-09-18
NO20073650L (no) 2007-09-14
US20100266500A1 (en) 2010-10-21
NL300719I2 (Direct) 2015-12-29
BRPI0516408B1 (pt) 2021-03-23
WO2006066104A2 (en) 2006-06-22
FR15C0012I2 (fr) 2015-11-20
ES2526655T3 (es) 2015-01-14
NZ555942A (en) 2011-01-28
IL206091A (en) 2013-08-29
WO2006066104A3 (en) 2006-08-03
EP2213652B1 (en) 2014-10-22
SG194363A1 (en) 2013-11-29
CA2591534A1 (en) 2006-06-22
IL183946A (en) 2011-08-31
HUS1500014I1 (hu) 2016-11-28
CA2591534C (en) 2013-08-06
EA200701299A1 (ru) 2007-12-28
AU2005316421B2 (en) 2012-04-05
US7807135B2 (en) 2010-10-05
EP2213652A1 (en) 2010-08-04
PT2213652E (pt) 2015-01-02
EP1838298A4 (en) 2009-03-04
JP5128956B2 (ja) 2013-01-23
KR101321619B1 (ko) 2013-10-30
EP1838298A2 (en) 2007-10-03
SI2213652T1 (sl) 2015-03-31
EA012334B1 (ru) 2009-08-28
PL2213652T3 (pl) 2015-04-30
EP1841465A2 (en) 2007-10-10
US20060269473A1 (en) 2006-11-30

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/12/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF