BRPI0512526A - composto, composição farmacêutica, método para tratar um paciente com cáncer e método para preparar um di-sal de bis(tio-hidrazida amida) - Google Patents

composto, composição farmacêutica, método para tratar um paciente com cáncer e método para preparar um di-sal de bis(tio-hidrazida amida)

Info

Publication number
BRPI0512526A
BRPI0512526A BRPI0512526-0A BRPI0512526A BRPI0512526A BR PI0512526 A BRPI0512526 A BR PI0512526A BR PI0512526 A BRPI0512526 A BR PI0512526A BR PI0512526 A BRPI0512526 A BR PI0512526A
Authority
BR
Brazil
Prior art keywords
bis
salt
treating
cancer patient
thiohydrazide amide
Prior art date
Application number
BRPI0512526-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Elena Kostik
Farid Vaghefi
Keizo Koya
Noriaki Tatsuta
Takayo Inoue
Guiqing Liang
Lijun Sun
Shoujun Chen
Zhi-Qiang Xia
Original Assignee
Synta Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of BRPI0512526A publication Critical patent/BRPI0512526A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
BRPI0512526-0A 2004-06-23 2005-06-20 composto, composição farmacêutica, método para tratar um paciente com cáncer e método para preparar um di-sal de bis(tio-hidrazida amida) BRPI0512526A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58259604P 2004-06-23 2004-06-23
US68136805P 2005-05-16 2005-05-16
PCT/US2005/021642 WO2006009940A1 (en) 2004-06-23 2005-06-20 Bis(thio-hydrazide amide) salts for treatment of cancers

Publications (1)

Publication Number Publication Date
BRPI0512526A true BRPI0512526A (pt) 2008-03-11

Family

ID=34993190

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512526-0A BRPI0512526A (pt) 2004-06-23 2005-06-20 composto, composição farmacêutica, método para tratar um paciente com cáncer e método para preparar um di-sal de bis(tio-hidrazida amida)

Country Status (21)

Country Link
US (5) US7385084B2 (enExample)
EP (2) EP1781604B1 (enExample)
JP (1) JP5362986B2 (enExample)
KR (1) KR101313027B1 (enExample)
CN (1) CN1993318B (enExample)
AU (1) AU2005265202B2 (enExample)
BR (1) BRPI0512526A (enExample)
CA (1) CA2570698C (enExample)
DK (1) DK1781604T3 (enExample)
ES (1) ES2430373T3 (enExample)
HR (1) HRP20131023T1 (enExample)
IL (1) IL179632A (enExample)
ME (1) ME01644B (enExample)
NO (1) NO20070378L (enExample)
NZ (1) NZ552159A (enExample)
PL (1) PL1781604T3 (enExample)
PT (1) PT1781604E (enExample)
RS (1) RS52999B (enExample)
RU (2) RU2406722C2 (enExample)
TW (1) TWI389684B (enExample)
WO (1) WO2006009940A1 (enExample)

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RU2400471C1 (ru) * 2009-04-30 2010-09-27 Учреждение Российской академии наук Институт органической химии им. Н.Д. Зелинского РАН (ИОХ РАН) N-замещенные производные тиогидразидов оксаминовых кислот, способ их получения и их использование
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US8815945B2 (en) * 2010-04-20 2014-08-26 Masazumi Nagai Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers
JP2013545759A (ja) 2010-11-18 2013-12-26 シンタ ファーマスーティカルズ コーポレーション 低酸素状態に基づくエレスクロモールによる治療に適した被験体の事前選択
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Also Published As

Publication number Publication date
US20080269340A1 (en) 2008-10-30
WO2006009940A1 (en) 2006-01-26
CN1993318B (zh) 2012-10-03
NO20070378L (no) 2007-03-16
CA2570698C (en) 2013-11-19
ES2430373T3 (es) 2013-11-20
US7795313B2 (en) 2010-09-14
US20060135595A1 (en) 2006-06-22
RU2406722C2 (ru) 2010-12-20
KR20070029259A (ko) 2007-03-13
EP2305642A3 (en) 2011-12-14
US7579503B2 (en) 2009-08-25
HK1104526A1 (en) 2008-01-18
RU2010145056A (ru) 2012-05-20
JP2008504264A (ja) 2008-02-14
CN1993318A (zh) 2007-07-04
US20120035266A1 (en) 2012-02-09
KR101313027B1 (ko) 2013-10-02
US20090281172A1 (en) 2009-11-12
AU2005265202B2 (en) 2009-07-23
ME01644B (me) 2014-09-20
DK1781604T3 (da) 2013-09-16
US20100324143A1 (en) 2010-12-23
AU2005265202A1 (en) 2006-01-26
NZ552159A (en) 2009-12-24
RS52999B (sr) 2014-02-28
PT1781604E (pt) 2013-10-15
HRP20131023T1 (hr) 2013-12-06
TWI389684B (zh) 2013-03-21
EP2305642A2 (en) 2011-04-06
RU2007101898A (ru) 2008-07-27
JP5362986B2 (ja) 2013-12-11
PL1781604T3 (pl) 2014-01-31
IL179632A (en) 2012-08-30
CA2570698A1 (en) 2006-01-26
IL179632A0 (en) 2007-05-15
US8048925B2 (en) 2011-11-01
EP1781604A1 (en) 2007-05-09
TW200612895A (en) 2006-05-01
EP1781604B1 (en) 2013-08-07
US7385084B2 (en) 2008-06-10
US8461208B2 (en) 2013-06-11

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