CN1993318B - 用于治疗癌症的双（硫代-酰肼酰胺）盐 - Google Patents

用于治疗癌症的双（硫代-酰肼酰胺）盐 Download PDF

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Publication number
CN1993318B
CN1993318B CN2005800264456A CN200580026445A CN1993318B CN 1993318 B CN1993318 B CN 1993318B CN 2005800264456 A CN2005800264456 A CN 2005800264456A CN 200580026445 A CN200580026445 A CN 200580026445A CN 1993318 B CN1993318 B CN 1993318B
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methyl
thio
bis
substituted
group
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Expired - Fee Related
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Chinese (zh)
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CN1993318A (zh
Inventor
艾雷娜·高斯提克
法利德·梵奇菲
梁桂青
古屋圭三
孙利军
辰田宪昭
陈寿军
井上孝也
夏志强
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Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
CN2005800264456A 2004-06-23 2005-06-20 用于治疗癌症的双（硫代-酰肼酰胺）盐 Expired - Fee Related CN1993318B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58259604P 2004-06-23 2004-06-23
US60/582,596 2004-06-23
US68136805P 2005-05-16 2005-05-16
US60/681,368 2005-05-16
PCT/US2005/021642 WO2006009940A1 (en) 2004-06-23 2005-06-20 Bis(thio-hydrazide amide) salts for treatment of cancers

Publications (2)

Publication Number Publication Date
CN1993318A CN1993318A (zh) 2007-07-04
CN1993318B true CN1993318B (zh) 2012-10-03

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CN2005800264456A Expired - Fee Related CN1993318B (zh) 2004-06-23 2005-06-20 用于治疗癌症的双（硫代-酰肼酰胺）盐

Country Status (21)

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US (5) US7385084B2 (enExample)
EP (2) EP2305642A3 (enExample)
JP (1) JP5362986B2 (enExample)
KR (1) KR101313027B1 (enExample)
CN (1) CN1993318B (enExample)
AU (1) AU2005265202B2 (enExample)
BR (1) BRPI0512526A (enExample)
CA (1) CA2570698C (enExample)
DK (1) DK1781604T3 (enExample)
ES (1) ES2430373T3 (enExample)
HR (1) HRP20131023T1 (enExample)
IL (1) IL179632A (enExample)
ME (1) ME01644B (enExample)
NO (1) NO20070378L (enExample)
NZ (1) NZ552159A (enExample)
PL (1) PL1781604T3 (enExample)
PT (1) PT1781604E (enExample)
RS (1) RS52999B (enExample)
RU (2) RU2406722C2 (enExample)
TW (1) TWI389684B (enExample)
WO (1) WO2006009940A1 (enExample)

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CA2570698A1 (en) 2006-01-26
JP5362986B2 (ja) 2013-12-11
NZ552159A (en) 2009-12-24
RU2010145056A (ru) 2012-05-20
AU2005265202B2 (en) 2009-07-23
JP2008504264A (ja) 2008-02-14
US20120035266A1 (en) 2012-02-09
IL179632A (en) 2012-08-30
AU2005265202A1 (en) 2006-01-26
TW200612895A (en) 2006-05-01
US7385084B2 (en) 2008-06-10
IL179632A0 (en) 2007-05-15
WO2006009940A1 (en) 2006-01-26
CN1993318A (zh) 2007-07-04
US7579503B2 (en) 2009-08-25
KR20070029259A (ko) 2007-03-13
US20100324143A1 (en) 2010-12-23
EP1781604B1 (en) 2013-08-07
RU2007101898A (ru) 2008-07-27
HK1104526A1 (en) 2008-01-18
PT1781604E (pt) 2013-10-15
HRP20131023T1 (hr) 2013-12-06
DK1781604T3 (da) 2013-09-16
US7795313B2 (en) 2010-09-14
NO20070378L (no) 2007-03-16
RS52999B (sr) 2014-02-28
US20060135595A1 (en) 2006-06-22
EP1781604A1 (en) 2007-05-09
US20080269340A1 (en) 2008-10-30
US20090281172A1 (en) 2009-11-12
CA2570698C (en) 2013-11-19
EP2305642A2 (en) 2011-04-06
ME01644B (me) 2014-09-20
TWI389684B (zh) 2013-03-21
PL1781604T3 (pl) 2014-01-31
RU2406722C2 (ru) 2010-12-20
BRPI0512526A (pt) 2008-03-11
KR101313027B1 (ko) 2013-10-02
EP2305642A3 (en) 2011-12-14
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US8461208B2 (en) 2013-06-11
US8048925B2 (en) 2011-11-01

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