BRPI0415147A - método para a produção de uma proteìna, método para a purificação de um hormÈnio de crescimento recombinante do leite de um mamìfero transgênico não humano que produz um hormÈnio de crescimento recombinante e método para a purificação de um hormÈnio de crescimento recombinante do leite de um mamìfero não transgênico que produz um hormÈnio de crescimento recombinante - Google Patents
método para a produção de uma proteìna, método para a purificação de um hormÈnio de crescimento recombinante do leite de um mamìfero transgênico não humano que produz um hormÈnio de crescimento recombinante e método para a purificação de um hormÈnio de crescimento recombinante do leite de um mamìfero não transgênico que produz um hormÈnio de crescimento recombinanteInfo
- Publication number
- BRPI0415147A BRPI0415147A BRPI0415147-0A BRPI0415147A BRPI0415147A BR PI0415147 A BRPI0415147 A BR PI0415147A BR PI0415147 A BRPI0415147 A BR PI0415147A BR PI0415147 A BRPI0415147 A BR PI0415147A
- Authority
- BR
- Brazil
- Prior art keywords
- transgenic
- growth hormone
- producing
- milk
- protein
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 17
- 238000000034 method Methods 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 102000018997 Growth Hormone Human genes 0.000 title abstract 6
- 108010051696 Growth Hormone Proteins 0.000 title abstract 6
- 235000013336 milk Nutrition 0.000 title abstract 6
- 239000008267 milk Substances 0.000 title abstract 6
- 210000004080 milk Anatomy 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 241000124008 Mammalia Species 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 241000283690 Bos taurus Species 0.000 abstract 9
- 235000018102 proteins Nutrition 0.000 abstract 4
- 210000002257 embryonic structure Anatomy 0.000 abstract 3
- 102000002265 Human Growth Hormone Human genes 0.000 abstract 2
- 108010000521 Human Growth Hormone Proteins 0.000 abstract 2
- 239000000854 Human Growth Hormone Substances 0.000 abstract 2
- 206010042573 Superovulation Diseases 0.000 abstract 2
- 230000009027 insemination Effects 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 210000000582 semen Anatomy 0.000 abstract 2
- 102000011632 Caseins Human genes 0.000 abstract 1
- 108010076119 Caseins Proteins 0.000 abstract 1
- 229960000074 biopharmaceutical Drugs 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 210000003754 fetus Anatomy 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 244000144980 herd Species 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 210000005075 mammary gland Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
- 210000001082 somatic cell Anatomy 0.000 abstract 1
- 238000001890 transfection Methods 0.000 abstract 1
- 235000021247 β-casein Nutrition 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
"MéTODO PARA A PRODUçãO DE UMA PROTEìNA, MéTODO PARA A PURIFICAçãO DE UM HORMÈNIO DE CRESCIMENTO RECOMBINANTE DO LEITE DE UM MAMìFERO TRANSGêNICO NãO HUMANO QUE PRODUZ UM HORMÈNIO DE CRESCIMENTO RECOMBINANTE E MéTODO PARA A PURIFICAçãO DE UM HORMÈNIO DE CRESCIMENTO RECOMBINANTE DO LEITE DE UM MAMìFERO NãO TRANSGêNICO QUE PRODUZ UM HORMÈNIO DE CRESCIMENTO RECOMBINANTE". A invenção refere-se a um método para a produção de uma proteína de interesse, o qual compreende a produção de um mamífero transgênico não humano que produz a dita proteína em seu leite, a obtenção do dito leite do mamífero transgênico não humano, e a purificação da dita proteína de interesse do leite. Foram gerados animais bovinos transgênicos, os quais têm capacidade de produzir o hormónio de crescimento humano nas glândulas mamárias. O método envolve a clonagem de um construto genético que codifica um gene de hGH e um promotor de beta caseína convenientemente em um vetor de expressão. Ele também inclui procedimentos de transfecção em células somáticas de fetos de bovinos, geralmente fibroblastos, e a transferência nuclear para oócitos de bovino enucleados, dessa maneira gerando embriões transgênicos. O método também inclui outros procedimentos para a geração de embriões transgênicos para uma expansão maior do rebanho transgênico, tal como a subclonagem de fêmeas bovinas transgênicas, a superovulação de vacas transgênicas e a sua inseminação com sêmen ou de um macho bovino transgênico ou não transgênico, e a superovulação de vacas não transgênicas e a sua inseminação com sêmen de machos bovinos transgênicos. Em seguida, os embriões transgênicos resultam em gado transgênico que produz o hormónio do crescimento humano em grandes quantidades em seu leite, do qual o hormónio é completamente purificado e analisado para preencher todos os requisitos para a manufatura de um produto biofarmacêutico puro.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50673503P | 2003-09-30 | 2003-09-30 | |
| US50673603P | 2003-09-30 | 2003-09-30 | |
| US55602604P | 2004-03-25 | 2004-03-25 | |
| US55602704P | 2004-03-25 | 2004-03-25 | |
| PCT/US2004/031819 WO2005033274A2 (en) | 2003-09-30 | 2004-09-29 | A process for producing exogenous protein in the milk of trangenic mammals and a process for purifying proteins therefrom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0415147A true BRPI0415147A (pt) | 2006-11-28 |
Family
ID=34427057
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0415146-1A BRPI0415146A (pt) | 2003-09-30 | 2004-09-29 | plasmìdio, fragmento linear do plasmìdio, método para a transfecção de construtos genéticos, mamìfero transgênico não humano, mamìfero não transgênico não humano, mamìfero transgênico não humano da espécie bovina e método para a produção de um mamìfero transgênico não humano |
| BRPI0415147-0A BRPI0415147A (pt) | 2003-09-30 | 2004-09-29 | método para a produção de uma proteìna, método para a purificação de um hormÈnio de crescimento recombinante do leite de um mamìfero transgênico não humano que produz um hormÈnio de crescimento recombinante e método para a purificação de um hormÈnio de crescimento recombinante do leite de um mamìfero não transgênico que produz um hormÈnio de crescimento recombinante |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0415146-1A BRPI0415146A (pt) | 2003-09-30 | 2004-09-29 | plasmìdio, fragmento linear do plasmìdio, método para a transfecção de construtos genéticos, mamìfero transgênico não humano, mamìfero não transgênico não humano, mamìfero transgênico não humano da espécie bovina e método para a produção de um mamìfero transgênico não humano |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7718845B2 (pt) |
| EP (2) | EP1685245A4 (pt) |
| JP (2) | JP2007507510A (pt) |
| AR (2) | AR047720A1 (pt) |
| AU (2) | AU2004278747B2 (pt) |
| BR (2) | BRPI0415146A (pt) |
| CA (2) | CA2540667A1 (pt) |
| MX (1) | MXPA06003553A (pt) |
| WO (2) | WO2005033274A2 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2540667A1 (en) * | 2003-09-30 | 2005-04-14 | Sterrenbeld Biotechnologie North America, Inc. | A process for producing exogenous protein in the milk of trangenic mammals and a process for purifying proteins therefrom |
| WO2006057466A1 (en) * | 2004-11-23 | 2006-06-01 | Korea Research Institute Of Bioscience And Biotechnology | Beta-casein gene targeting vector using homologous recombination |
| GB2438760A (en) * | 2004-12-22 | 2007-12-05 | Ambrx Inc | Methods for expression and purification of recombinant human growth hormone |
| US20070067842A1 (en) * | 2005-08-08 | 2007-03-22 | Greene Michael P | Systems and methods for collecting files related to malware |
| US8383125B2 (en) | 2006-03-23 | 2013-02-26 | Agriculture Victoria Services Pty, Limited | Antimicrobial protein |
| CN1970750B (zh) * | 2006-12-11 | 2010-10-13 | 中国人民解放军军事医学科学院军事兽医研究所 | 一种利用抗菌肽培育具有抗乳房炎病奶牛重构胚的方法 |
| RU2010100911A (ru) * | 2007-06-13 | 2011-07-20 | Стэрнбэлт Байэутекнолэджай Нос Эмерикэ, Инк. (US) | Плазмида, содержащая нуклеотидную последовательность, кодирующую модифицированный предшественник инсулина, и способ ее трансфекции в клетки млекопитающего, трансгенное млекопитающее, продуцирующее указанный предшественник, и способ его получения |
| EP2242478A2 (en) * | 2008-01-02 | 2010-10-27 | Kringle Pharma Inc. | Topical compositions for delivery of proteins and peptides |
| WO2009111838A1 (en) * | 2008-03-13 | 2009-09-17 | Agriculture Victoria Services Pty Limited | Method of treatment using antimicrobial composition |
| US9238878B2 (en) | 2009-02-17 | 2016-01-19 | Redwood Bioscience, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| AU2012205301B2 (en) | 2011-01-14 | 2017-01-05 | Redwood Bioscience, Inc. | Aldehyde-tagged immunoglobulin polypeptides and method of use thereof |
| JP2012210199A (ja) * | 2011-03-31 | 2012-11-01 | National Agriculture & Food Research Organization | 体外発育卵母細胞をレシピエント卵子とするクローン動物個体の作成法 |
| CN102628045A (zh) * | 2012-04-09 | 2012-08-08 | 西北农林科技大学 | 一种干扰BVDV复制的shRNA表达载体及构建的重组细胞 |
| KR101504824B1 (ko) | 2013-05-31 | 2015-03-23 | 씨제이헬스케어 주식회사 | 고당화된 지속형 인간 성장호르몬 단백질 및 이의 제조방법 |
| WO2013183948A1 (ko) * | 2012-06-05 | 2013-12-12 | 씨제이제일제당 (주) | 고당화된 지속형 인간 성장호르몬 단백질 및 이의 제조방법 |
| FR3025515B1 (fr) | 2014-09-05 | 2016-09-09 | Lab Francais Du Fractionnement | Procede de purification d'un anticorps monoclonal |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| CN109071634A (zh) | 2016-04-26 | 2018-12-21 | R.P.谢勒技术有限责任公司 | 抗体偶联物及其制备和使用方法 |
| FR3060394B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-amhrii |
| FR3060395B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-her2 |
| FR3076294B1 (fr) | 2017-12-29 | 2022-01-28 | Lab Francais Du Fractionnement | Procede de purification d'anticorps a partir de lait brut |
| CA3223956A1 (en) | 2021-12-20 | 2023-06-29 | Vetoquinol Sa | Anti-canine interleukine-31-receptor a (il-31ra) antibodies and the uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371462A (en) * | 1982-01-21 | 1983-02-01 | Genex Corporation | Method for purification of anterior pituitary hormones |
| JPH04506751A (ja) | 1989-09-11 | 1992-11-26 | ティー エスアイ コーポレーション | 遺伝子導入動物の乳汁中での成長ホルモンの生産 |
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| US5160312A (en) * | 1990-02-09 | 1992-11-03 | W. R. Grace & Co.-Conn. | Cryopreservation process for direct transfer of embryos |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US6011197A (en) * | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
| AU702218B2 (en) * | 1997-03-31 | 1999-02-18 | Kyushu-Taiyoukasei., Ltd. | Liner film for bulk container and container liner |
| US6451527B1 (en) * | 1997-08-29 | 2002-09-17 | Selective Genetics, Inc. | Methods using genetic package display for selecting internalizing ligands for gene delivery |
| CA2259368C (en) * | 1998-01-16 | 2010-10-05 | Agrobiogen Gmbh | Efficient nucleus transfer with foetal fibroblasts |
| GB9807464D0 (en) | 1998-04-07 | 1998-06-10 | Pharming Bv | Purification of human acid µ-glucosidase |
| US20030005468A1 (en) * | 1998-06-19 | 2003-01-02 | Meade Harry M. | Methods and vectors for improving nucleic acid expression |
| EP1090132A1 (en) * | 1998-06-26 | 2001-04-11 | PPL Therapeutics (Scotland) Limited | Methods for production of recombinant polypeptides |
| JP2001197846A (ja) * | 2000-01-18 | 2001-07-24 | Ys New Technology Kenkyusho:Kk | 免疫寛容動物の作製方法 |
| MXPA03004313A (es) * | 2000-11-17 | 2007-02-27 | Hematech Llc | Expresion de inmunoglobulinas xenogenas (humanas) en ungulados transgenicos, clonados. |
| US7105314B2 (en) * | 2001-04-02 | 2006-09-12 | Novo Nordisk A/S | Method for making human insulin precursors |
| AUPR451401A0 (en) * | 2001-04-20 | 2001-05-24 | Monash University | A method of nuclear transfer |
| AU2002364596A1 (en) * | 2001-12-21 | 2003-07-15 | Immerge Biotherapeutics, Inc. | Knockout swine and methods for making the same |
| CA2540667A1 (en) * | 2003-09-30 | 2005-04-14 | Sterrenbeld Biotechnologie North America, Inc. | A process for producing exogenous protein in the milk of trangenic mammals and a process for purifying proteins therefrom |
-
2004
- 2004-09-29 CA CA002540667A patent/CA2540667A1/en not_active Abandoned
- 2004-09-29 WO PCT/US2004/031819 patent/WO2005033274A2/en active Application Filing
- 2004-09-29 AR ARP040103538A patent/AR047720A1/es unknown
- 2004-09-29 US US10/952,377 patent/US7718845B2/en not_active Expired - Fee Related
- 2004-09-29 EP EP04789272A patent/EP1685245A4/en not_active Withdrawn
- 2004-09-29 MX MXPA06003553A patent/MXPA06003553A/es active IP Right Grant
- 2004-09-29 BR BRPI0415146-1A patent/BRPI0415146A/pt not_active IP Right Cessation
- 2004-09-29 AR ARP040103539A patent/AR047721A1/es active IP Right Grant
- 2004-09-29 JP JP2006534022A patent/JP2007507510A/ja active Pending
- 2004-09-29 JP JP2006534064A patent/JP2007507232A/ja active Pending
- 2004-09-29 WO PCT/US2004/032019 patent/WO2005033281A2/en active Application Filing
- 2004-09-29 US US10/952,376 patent/US7807862B2/en not_active Expired - Fee Related
- 2004-09-29 BR BRPI0415147-0A patent/BRPI0415147A/pt not_active Application Discontinuation
- 2004-09-29 AU AU2004278747A patent/AU2004278747B2/en not_active Ceased
- 2004-09-29 AU AU2004278763A patent/AU2004278763A1/en not_active Abandoned
- 2004-09-29 CA CA002540854A patent/CA2540854A1/en not_active Abandoned
- 2004-09-29 EP EP04789169.2A patent/EP1687421B1/en not_active Expired - Fee Related
-
2007
- 2007-07-11 US US11/822,985 patent/US20080060089A1/en not_active Abandoned
- 2007-07-11 US US11/822,984 patent/US20080229438A1/en not_active Abandoned
-
2010
- 2010-05-17 US US12/781,500 patent/US20110072526A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1685245A2 (en) | 2006-08-02 |
| US20050177878A1 (en) | 2005-08-11 |
| AR047720A1 (es) | 2006-02-15 |
| WO2005033274A3 (en) | 2005-07-14 |
| AU2004278747A1 (en) | 2005-04-14 |
| CA2540667A1 (en) | 2005-04-14 |
| WO2005033281A2 (en) | 2005-04-14 |
| JP2007507510A (ja) | 2007-03-29 |
| US20080229438A1 (en) | 2008-09-18 |
| AU2004278763A1 (en) | 2005-04-14 |
| US20110072526A1 (en) | 2011-03-24 |
| US7807862B2 (en) | 2010-10-05 |
| US7718845B2 (en) | 2010-05-18 |
| AU2004278747B2 (en) | 2011-04-28 |
| US20050177879A1 (en) | 2005-08-11 |
| EP1687421A4 (en) | 2006-12-20 |
| BRPI0415146A (pt) | 2006-11-28 |
| EP1687421A2 (en) | 2006-08-09 |
| US20080060089A1 (en) | 2008-03-06 |
| WO2005033274A2 (en) | 2005-04-14 |
| CA2540854A1 (en) | 2005-04-14 |
| EP1685245A4 (en) | 2007-01-03 |
| MXPA06003553A (es) | 2007-02-02 |
| EP1687421B1 (en) | 2018-06-27 |
| AR047721A1 (es) | 2006-02-15 |
| JP2007507232A (ja) | 2007-03-29 |
| WO2005033281A3 (en) | 2005-05-19 |
Similar Documents
| Publication | Publication Date | Title |
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