BRPI0408639B8 - molécula de ácido nucleico, vetor, célula hospedeira de levedura e método para produzir partículas semelhantes a vírus de hpv31 - Google Patents

molécula de ácido nucleico, vetor, célula hospedeira de levedura e método para produzir partículas semelhantes a vírus de hpv31

Info

Publication number
BRPI0408639B8
BRPI0408639B8 BRPI0408639A BRPI0408639A BRPI0408639B8 BR PI0408639 B8 BRPI0408639 B8 BR PI0408639B8 BR PI0408639 A BRPI0408639 A BR PI0408639A BR PI0408639 A BRPI0408639 A BR PI0408639A BR PI0408639 B8 BRPI0408639 B8 BR PI0408639B8
Authority
BR
Brazil
Prior art keywords
hpv31
particles
vector
nucleic acid
host cell
Prior art date
Application number
BRPI0408639A
Other languages
English (en)
Inventor
Z Markus Henry
U Jansen Kathrin
D Schultz Loren
P Neeper Michael
Original Assignee
Merck Sharp & Dohme
Merck & Co Inc
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Merck & Co Inc, Schering Corp filed Critical Merck Sharp & Dohme
Publication of BRPI0408639A publication Critical patent/BRPI0408639A/pt
Publication of BRPI0408639B1 publication Critical patent/BRPI0408639B1/pt
Publication of BRPI0408639B8 publication Critical patent/BRPI0408639B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

molécula de ácido nucleico, vetor, célula hospedeira, partículas semelhantes a vírus, método para produzir partículas semelhantes a vírus, vacina, composições farmacêuticas, e, métodos para prevenir a infecção por hpv e para induzir uma resposta imune em um animal. as moléculas de dna sintéticas que codificam a proteína hpv31 l1 são fornecidas. especificamente, a presente invenção fornece polinucleotídeos que codificam a proteína hpv31 l1, em que os ditos polinucleotídeos são isentos de sinais de terminação de transcrição internos que são reconhecidos pela levedura. também são fornecidos polinucleotídeos sintéticos que codifica hpv31 l1 em que os polinucleotídeos foram otimizados por códon para a expressão de alto nível em uma célula de levedura. as moléculas sintéticas podem ser usadas para produzir partículas semelhantes ao vírus hpv31 (vlps) e para produzir vacinas e composições farmacêuticas que compreendem os hpv31 vlps. as vacinas da presente invenção fornecem imunoprofilaxia eficaz contra infecção por papilomavírus através do anticorpo neutralizador e imunidade mediada por célula.
BRPI0408639A 2003-03-24 2004-03-19 molécula de ácido nucleico, vetor, célula hospedeira de levedura e método para produzir partículas semelhantes a vírus de hpv31 BRPI0408639B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45717203P 2003-03-24 2003-03-24
US60/457,172 2003-03-24
PCT/US2004/008677 WO2004084831A2 (en) 2003-03-24 2004-03-19 Optimized expression of hpv 31 l1 in yeast

Publications (3)

Publication Number Publication Date
BRPI0408639A BRPI0408639A (pt) 2006-03-28
BRPI0408639B1 BRPI0408639B1 (pt) 2020-08-18
BRPI0408639B8 true BRPI0408639B8 (pt) 2021-05-25

Family

ID=33098208

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408639A BRPI0408639B8 (pt) 2003-03-24 2004-03-19 molécula de ácido nucleico, vetor, célula hospedeira de levedura e método para produzir partículas semelhantes a vírus de hpv31

Country Status (22)

Country Link
US (2) US7276243B2 (pt)
EP (1) EP1608767B1 (pt)
JP (1) JP4505452B2 (pt)
KR (1) KR101080628B1 (pt)
CN (1) CN100506999C (pt)
AT (1) ATE546529T1 (pt)
AU (1) AU2004224335B2 (pt)
BR (1) BRPI0408639B8 (pt)
CA (1) CA2519112C (pt)
EC (1) ECSP056032A (pt)
ES (1) ES2381964T3 (pt)
FR (1) FR15C0079I2 (pt)
HK (1) HK1090953A1 (pt)
IL (1) IL171067A (pt)
IS (1) IS2859B (pt)
MX (1) MXPA05010285A (pt)
NL (1) NL300772I2 (pt)
NO (2) NO341527B1 (pt)
NZ (1) NZ542246A (pt)
RU (1) RU2356943C2 (pt)
WO (1) WO2004084831A2 (pt)
ZA (1) ZA200507178B (pt)

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CN107916234A (zh) * 2012-03-28 2018-04-17 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv6 l1蛋白的方法
CN103361280B (zh) * 2012-03-28 2018-07-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
CN110592133A (zh) * 2013-05-17 2019-12-20 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv31 l1蛋白的方法
CN104164373B (zh) * 2013-05-17 2019-04-02 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv68l1蛋白的方法
CN112280792B (zh) * 2013-09-29 2022-06-24 上海泽润生物科技有限公司 人乳头瘤病毒基因，及载体，菌株，表达方法
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RU2546243C1 (ru) * 2014-02-13 2015-04-10 Закрытое акционерное общество научно-производственная компания "Комбиотех" Рекомбинантная вакцина для профилактики папилломавирусной инфекции человека и способ ее получения
US9951344B2 (en) * 2014-10-10 2018-04-24 Board Of Regents, The University Of Texas System Exogenous terminators for controlling fungal gene expression
EA201790944A1 (ru) * 2014-12-26 2017-11-30 Айджин, Инк. Способ получения вирусоподобных частиц папилломавируса человека
CN106148359A (zh) * 2015-03-30 2016-11-23 上海泽润生物科技有限公司 重组人乳头瘤病毒33亚型蛋白表达
CN106701797B (zh) * 2015-08-12 2021-06-15 北京康乐卫士生物技术股份有限公司 31型重组人乳头瘤病毒病毒样颗粒及其制备方法
WO2017092710A1 (zh) * 2015-12-04 2017-06-08 厦门大学 一种人乳头瘤病毒58型l1蛋白的突变体
WO2021013062A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人乳头瘤病毒31型l1蛋白
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Also Published As

Publication number Publication date
CA2519112A1 (en) 2004-10-07
RU2005132603A (ru) 2006-04-27
BRPI0408639A (pt) 2006-03-28
NO341527B1 (no) 2017-12-04
ECSP056032A (es) 2006-01-27
AU2004224335A1 (en) 2004-10-07
BRPI0408639B1 (pt) 2020-08-18
NZ542246A (en) 2007-12-21
US20060177817A1 (en) 2006-08-10
CN100506999C (zh) 2009-07-01
FR15C0079I2 (fr) 2016-11-25
IL171067A (en) 2011-11-30
WO2004084831A3 (en) 2004-11-11
NL300772I1 (pt) 2015-12-29
EP1608767A2 (en) 2005-12-28
KR101080628B1 (ko) 2011-11-08
WO2004084831A2 (en) 2004-10-07
JP2006523099A (ja) 2006-10-12
ZA200507178B (en) 2006-08-30
IS8019A (is) 2005-09-12
AU2004224335B2 (en) 2010-01-28
NO2018010I1 (no) 2018-03-27
NO20054889L (no) 2005-12-19
KR20050119141A (ko) 2005-12-20
RU2356943C2 (ru) 2009-05-27
CN1761759A (zh) 2006-04-19
EP1608767A4 (en) 2006-08-30
MXPA05010285A (es) 2005-11-17
NL300772I2 (pt) 2015-12-29
FR15C0079I1 (pt) 2016-08-01
EP1608767B1 (en) 2012-02-22
IS2859B (is) 2013-12-15
JP4505452B2 (ja) 2010-07-21
US7276243B2 (en) 2007-10-02
US7482428B2 (en) 2009-01-27
ES2381964T3 (es) 2012-06-04
HK1090953A1 (en) 2007-01-05
NO20054889D0 (no) 2005-10-21
CA2519112C (en) 2012-09-11
US20080166371A1 (en) 2008-07-10
ATE546529T1 (de) 2012-03-15

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

Free format text: NOME ALTERADO DE: MERCK AND CO., INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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