ATE546529T1 - Optimierte expression von hpv 31 l1 in hefe - Google Patents
Optimierte expression von hpv 31 l1 in hefeInfo
- Publication number
- ATE546529T1 ATE546529T1 AT04757990T AT04757990T ATE546529T1 AT E546529 T1 ATE546529 T1 AT E546529T1 AT 04757990 T AT04757990 T AT 04757990T AT 04757990 T AT04757990 T AT 04757990T AT E546529 T1 ATE546529 T1 AT E546529T1
- Authority
- AT
- Austria
- Prior art keywords
- hpv31
- yeast
- polynucleotides
- synthetic
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Medical Informatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45717203P | 2003-03-24 | 2003-03-24 | |
PCT/US2004/008677 WO2004084831A2 (en) | 2003-03-24 | 2004-03-19 | Optimized expression of hpv 31 l1 in yeast |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE546529T1 true ATE546529T1 (de) | 2012-03-15 |
Family
ID=33098208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04757990T ATE546529T1 (de) | 2003-03-24 | 2004-03-19 | Optimierte expression von hpv 31 l1 in hefe |
Country Status (22)
Country | Link |
---|---|
US (2) | US7276243B2 (de) |
EP (1) | EP1608767B1 (de) |
JP (1) | JP4505452B2 (de) |
KR (1) | KR101080628B1 (de) |
CN (1) | CN100506999C (de) |
AT (1) | ATE546529T1 (de) |
AU (1) | AU2004224335B2 (de) |
BR (1) | BRPI0408639B8 (de) |
CA (1) | CA2519112C (de) |
EC (1) | ECSP056032A (de) |
ES (1) | ES2381964T3 (de) |
FR (1) | FR15C0079I2 (de) |
HK (1) | HK1090953A1 (de) |
IL (1) | IL171067A (de) |
IS (1) | IS2859B (de) |
MX (1) | MXPA05010285A (de) |
NL (1) | NL300772I1 (de) |
NO (2) | NO341527B1 (de) |
NZ (1) | NZ542246A (de) |
RU (1) | RU2356943C2 (de) |
WO (1) | WO2004084831A2 (de) |
ZA (1) | ZA200507178B (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7858098B2 (en) * | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
MY140664A (en) | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
MY139500A (en) | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
CA2560487C (en) * | 2004-03-24 | 2013-01-29 | Merck & Co., Inc. | Optimized expression of hpv 52 l1 in yeast |
WO2005123762A2 (en) * | 2004-06-18 | 2005-12-29 | Indian Immunologicals Ltd | Codon-optimized hpv16 li for salmonella vaccine strains against human papillomavirus type 16 |
JP2006262846A (ja) * | 2005-03-25 | 2006-10-05 | Niigata Bio Research Park Kk | 酵母による2−デオキシ−シロ−イノソースの合成および精製する方法並びに得られた2−デオキシ−シロ−イノソース |
US20100203496A1 (en) * | 2005-04-28 | 2010-08-12 | Taddeo Frank J | Fluorescent Multiplex HPV PCR Assays |
CN100392084C (zh) * | 2006-03-13 | 2008-06-04 | 曾毅 | 含密码子优化型hpv16l1基因的重组腺病毒 |
KR100904844B1 (ko) * | 2006-08-28 | 2009-06-25 | 성균관대학교산학협력단 | 인유두종 바이러스(hpv)유전자를 포함하는자궁경부암의 치료 또는 예방용 dna 백신 |
EP2129394B1 (de) * | 2007-03-09 | 2012-06-20 | Merck Sharp & Dohme Corp. | Impfstoffzusammensetzung gegen papillomavirus |
CN101113417B (zh) * | 2007-06-22 | 2011-04-27 | 山东大学 | Hpv基因酵母体外翻译系统的建立 |
CN101835797A (zh) | 2007-11-23 | 2010-09-15 | 上海泽润生物科技有限公司 | 人乳头状瘤病毒主要衣壳蛋白l1基因及其用途 |
US20110201086A1 (en) | 2010-02-12 | 2011-08-18 | Otsuka Pharmaceutical Co., Ltd. | Method for producing recombinant virus |
JP6153866B2 (ja) | 2010-05-25 | 2017-06-28 | キアゲン ガイサーズバーグ アイエヌシー. | 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ |
JP6050811B2 (ja) | 2011-06-24 | 2016-12-21 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | アルミニウムアジュバントを含むhpvワクチン製剤およびその産生方法 |
CN103215302B (zh) * | 2012-01-21 | 2019-01-15 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv18 l1蛋白的方法 |
CN107916234A (zh) * | 2012-03-28 | 2018-04-17 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv6 l1蛋白的方法 |
CN103361280B (zh) * | 2012-03-28 | 2018-07-24 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv11 l1蛋白的方法 |
CN104164374B (zh) * | 2013-05-17 | 2019-10-22 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv31 l1蛋白的方法 |
CN104164373B (zh) * | 2013-05-17 | 2019-04-02 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv68l1蛋白的方法 |
CN112280792B (zh) * | 2013-09-29 | 2022-06-24 | 上海泽润生物科技有限公司 | 人乳头瘤病毒基因,及载体,菌株,表达方法 |
EP3057612B1 (de) | 2013-10-16 | 2020-05-06 | Merck Sharp & Dohme Corp. | Verfahren zur herstellung von wärmestabilen getrockneten impfstoffformulierungen |
RU2546243C1 (ru) * | 2014-02-13 | 2015-04-10 | Закрытое акционерное общество научно-производственная компания "Комбиотех" | Рекомбинантная вакцина для профилактики папилломавирусной инфекции человека и способ ее получения |
WO2016057954A2 (en) * | 2014-10-10 | 2016-04-14 | Board Of Regents Of The University Of Texas System | Exogenous terminators for controlling fungal gene expression |
WO2016104923A1 (ko) * | 2014-12-26 | 2016-06-30 | 아이진 주식회사 | 인유두종 바이러스의 바이러스 유사 입자 제조방법 |
CN106148359A (zh) * | 2015-03-30 | 2016-11-23 | 上海泽润生物科技有限公司 | 重组人乳头瘤病毒33亚型蛋白表达 |
CN106701797B (zh) * | 2015-08-12 | 2021-06-15 | 北京康乐卫士生物技术股份有限公司 | 31型重组人乳头瘤病毒病毒样颗粒及其制备方法 |
EP3385273A4 (de) * | 2015-12-04 | 2019-08-07 | Xiamen University | Mutant des menschlichen papillomavirus-typ-58-l1-proteins |
WO2021013062A1 (zh) * | 2019-07-19 | 2021-01-28 | 神州细胞工程有限公司 | 嵌合的人乳头瘤病毒31型l1蛋白 |
JP2023516904A (ja) | 2020-02-14 | 2023-04-21 | メルク・シャープ・アンド・ドーム・エルエルシー | Hpvワクチン |
CN113073105B (zh) * | 2021-03-23 | 2023-06-13 | 重庆博唯佰泰生物制药有限公司 | 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用 |
TW202313658A (zh) | 2021-08-06 | 2023-04-01 | 美商默沙東有限責任公司 | Hpv疫苗 |
WO2023023152A1 (en) | 2021-08-19 | 2023-02-23 | Merck Sharp & Dohme Llc | Thermostable lipid nanoparticle and methods of use thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5821087A (en) * | 1995-03-30 | 1998-10-13 | Merck & Co., Inc. | Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA |
IL117591A0 (en) | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
EE9900343A (et) | 1997-02-07 | 2000-02-15 | Merck & Co., Inc. | Sünteetiline polünukleotiid, immuunvastuste tekitamise meetod, immunogeenne kompositsioon, anti-HIV immuunvastuste indutseerimise meetod, meetod antigeeni tekitava raku indutseerimiseks ja farmatseutiline kompositsioon |
CA2296067C (en) | 1997-07-09 | 2008-10-07 | The University Of Queensland | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
GB9717953D0 (en) * | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
FR2768748B1 (fr) * | 1997-09-24 | 2001-06-08 | Rhone Poulenc Agrochimie | Recodage de sequences d'adn permettant leur expression dans les levures et levures transformees obtenues |
US6991795B1 (en) * | 1998-08-14 | 2006-01-31 | Merck & Co., Inc. | Protein delivery system using human papillomavirus virus-like particles |
AU753391B2 (en) * | 1998-08-14 | 2002-10-17 | Merck Sharp & Dohme Corp. | Protein delivery system using human papillomavirus virus-like particles |
ATE284898T1 (de) * | 1999-08-25 | 2005-01-15 | Merck & Co Inc | Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind |
US6436402B1 (en) * | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
IL154009A0 (en) | 2000-07-21 | 2003-07-31 | Glaxo Group Ltd | Codon-optimized papilloma virus sequences |
AU2001267896A1 (en) | 2000-07-26 | 2002-02-05 | Shinko Pantec Co., Ltd. | Hydrogen/oxygen supply system |
US20040121465A1 (en) * | 2002-02-14 | 2004-06-24 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
-
2004
- 2004-03-19 CN CNB2004800077258A patent/CN100506999C/zh not_active Expired - Lifetime
- 2004-03-19 WO PCT/US2004/008677 patent/WO2004084831A2/en active Application Filing
- 2004-03-19 MX MXPA05010285A patent/MXPA05010285A/es active IP Right Grant
- 2004-03-19 CA CA2519112A patent/CA2519112C/en not_active Expired - Lifetime
- 2004-03-19 ES ES04757990T patent/ES2381964T3/es not_active Expired - Lifetime
- 2004-03-19 KR KR1020057017936A patent/KR101080628B1/ko active IP Right Grant
- 2004-03-19 US US10/551,057 patent/US7276243B2/en not_active Expired - Lifetime
- 2004-03-19 BR BRPI0408639A patent/BRPI0408639B8/pt active IP Right Grant
- 2004-03-19 NZ NZ542246A patent/NZ542246A/en not_active IP Right Cessation
- 2004-03-19 RU RU2005132603/13A patent/RU2356943C2/ru active
- 2004-03-19 JP JP2006507439A patent/JP4505452B2/ja not_active Expired - Lifetime
- 2004-03-19 AU AU2004224335A patent/AU2004224335B2/en active Active
- 2004-03-19 AT AT04757990T patent/ATE546529T1/de active
- 2004-03-19 EP EP04757990A patent/EP1608767B1/de not_active Expired - Lifetime
-
2005
- 2005-09-07 ZA ZA200507178A patent/ZA200507178B/xx unknown
- 2005-09-12 IS IS8019A patent/IS2859B/is unknown
- 2005-09-20 EC EC2005006032A patent/ECSP056032A/es unknown
- 2005-09-22 IL IL171067A patent/IL171067A/en active IP Right Grant
- 2005-10-21 NO NO20054889A patent/NO341527B1/no active Protection Beyond IP Right Term
-
2006
- 2006-10-18 HK HK06111479.1A patent/HK1090953A1/xx not_active IP Right Cessation
-
2007
- 2007-07-19 US US11/879,905 patent/US7482428B2/en not_active Expired - Lifetime
-
2015
- 2015-11-30 NL NL300772C patent/NL300772I1/nl unknown
- 2015-12-04 FR FR15C0079C patent/FR15C0079I2/fr active Active
-
2018
- 2018-03-27 NO NO2018010C patent/NO2018010I1/no unknown
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