BRPI0212028B8 - sistema terapêutico transdérmico (tts) e seu processo de produção - Google Patents

sistema terapêutico transdérmico (tts) e seu processo de produção

Info

Publication number
BRPI0212028B8
BRPI0212028B8 BRPI0212028A BRPI0212028B8 BR PI0212028 B8 BRPI0212028 B8 BR PI0212028B8 BR PI0212028 A BRPI0212028 A BR PI0212028A BR PI0212028 B8 BRPI0212028 B8 BR PI0212028B8
Authority
BR
Brazil
Prior art keywords
active substance
transdermal therapeutic
tts
therapeutic system
fentanyl
Prior art date
Application number
Other languages
English (en)
Inventor
Mueller Walter
Original Assignee
Lts Lohmann Therapie Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie Systeme Ag filed Critical Lts Lohmann Therapie Systeme Ag
Publication of BR0212028A publication Critical patent/BR0212028A/pt
Publication of BRPI0212028B1 publication Critical patent/BRPI0212028B1/pt
Publication of BRPI0212028B8 publication Critical patent/BRPI0212028B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

sistema terapêutico transdérmico (tts) com a substância ativa fentanila. a presente invenção refere-se a sistemas terapêuticos transdérmicos com fentanila ou com um derivado análogo à fentanila como substância ativa. para excluir superdosagens inadvertidas pela liberação descontrolada da substância ativa como conseqüência de um dano, a substância ativa está contida em microrreservatórios enchidos com líquido da camada contendo substância ativa. eventualmente, a camada contendo substância ativa pode ser provida de uma membrana.
BR0212028-3 2001-08-24 2002-07-10 sistema terapêutico transdérmico (tts) e seu processo de produção BRPI0212028B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10141651A DE10141651B4 (de) 2001-08-24 2001-08-24 Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
PCT/EP2002/007663 WO2003018071A1 (de) 2001-08-24 2002-07-10 Transdermales therapeutisches system (tts) mit dem wirkstoff fentanyl

Publications (3)

Publication Number Publication Date
BR0212028A BR0212028A (pt) 2004-08-03
BRPI0212028B1 BRPI0212028B1 (pt) 2020-11-24
BRPI0212028B8 true BRPI0212028B8 (pt) 2021-05-25

Family

ID=7696569

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212028-3 BRPI0212028B8 (pt) 2001-08-24 2002-07-10 sistema terapêutico transdérmico (tts) e seu processo de produção

Country Status (24)

Country Link
US (2) US7390500B2 (pt)
EP (1) EP1418951B1 (pt)
JP (1) JP4628673B2 (pt)
KR (1) KR100895188B1 (pt)
CN (1) CN100438859C (pt)
AT (1) ATE455541T1 (pt)
AU (1) AU2002321199B2 (pt)
BR (1) BRPI0212028B8 (pt)
CA (1) CA2457245C (pt)
CY (1) CY1109954T1 (pt)
DE (2) DE10141651B4 (pt)
DK (1) DK1418951T3 (pt)
ES (1) ES2339640T3 (pt)
HK (1) HK1069534A1 (pt)
HU (1) HU229942B1 (pt)
IL (2) IL160515A0 (pt)
MX (1) MXPA04001679A (pt)
NZ (1) NZ530795A (pt)
PL (1) PL204348B1 (pt)
PT (1) PT1418951E (pt)
RU (1) RU2311908C2 (pt)
TW (1) TW570815B (pt)
WO (1) WO2003018071A1 (pt)
ZA (1) ZA200400473B (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US20040086551A1 (en) 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
MXPA05008366A (es) * 2003-02-07 2005-11-04 Lohmann Therapie Syst Lts Sistema terapeutico transdermico adecuado para la aplicacion de calor para promover la penetracion de sustancias activas y el uso del mismo.
EP1613297B1 (en) * 2003-04-14 2007-06-06 LTS Lohmann Therapie-Systeme AG Therapeutic patch with polysiloxane matrix comprising capsaicin
US20110086086A1 (en) * 2005-07-26 2011-04-14 Pfizer Inc Transdermal system for varenicline
DE102006019293A1 (de) * 2006-04-21 2007-10-25 LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH Pflaster, enthaltend ein Fentanyl Analogum
GB0615429D0 (en) * 2006-08-03 2006-09-13 Chowdhury Dewan F H Transdermal drug delivery with temporal control
DE102006054731B4 (de) 2006-11-21 2013-02-28 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie
DE102006054732B4 (de) * 2006-11-21 2010-12-30 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren
DE102008016804B4 (de) * 2008-04-02 2012-01-05 Lts Lohmann Therapie-Systeme Ag Selbstzerstörendes transdermales therapeutisches System mit verbesserter Funktionalität und Wirksamkeit sowie seine Verwendung
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
US10632082B2 (en) * 2009-07-21 2020-04-28 Mylan Inc. Process for the continuous manufacture of a polyisobutylene based transdermal patch
US9822088B2 (en) 2011-03-30 2017-11-21 The United States Of America As Represented By The Administrator Of Nasa Anisotropic copoly(imide oxetane) coatings and articles of manufacture, copoly(imide oxetane)s containing pendant fluorocarbon moieties, oligomers and processes therefor
DE102011080390B3 (de) * 2011-08-03 2012-07-12 Acino Ag Applikationshilfe
MX352795B (es) 2011-12-12 2017-12-07 Lts Lohmann Therapie Systeme Ag Sistema de administracion transdermica que comprende buprenorfina.
TW201431570A (zh) * 2012-11-22 2014-08-16 Ucb Pharma Gmbh 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
GB2529789A (en) 2013-06-04 2016-03-02 Lohmann Therapie Syst Lts Transdermal Delivery system
CA2916183C (en) 2013-07-03 2022-03-29 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with electronic component
CA2948221C (en) 2014-05-20 2022-11-22 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system including an interface mediator
WO2015177204A1 (en) 2014-05-20 2015-11-26 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system containing rotigotine
EP3145503A1 (en) 2014-05-20 2017-03-29 LTS Lohmann Therapie-Systeme AG Method for adjusting the release of active agent in a transdermal delivery system
US9962340B2 (en) 2015-06-09 2018-05-08 Life Tech Global, Llc Device and method for the transdermal delivery of cannabidiol
US10272125B2 (en) * 2015-09-14 2019-04-30 Life Tech Global, Llc Transdermal delivery of cannabidiol with other active moieties including cannabinoids
US9650338B1 (en) 2016-07-29 2017-05-16 VDM Biochemicals, Inc. Opioid antagonist compounds and methods of making and using
DE102017107468B4 (de) 2017-04-06 2019-02-21 Lts Lohmann Therapie-Systeme Ag Verfahren zur herstellung eines, insbesondere oralen, wirkstofflaminats und wirkstofflaminat, insbesondere orales wirkstofflaminat
EP3612495B1 (en) 2017-04-18 2022-07-13 Breakthrough Technologies, LLC Sulfur production
EP3678646B1 (en) * 2017-09-04 2021-09-29 LTS Lohmann Therapie-Systeme AG Transdermal delivery system including an emulsifier
JP6912122B2 (ja) * 2019-02-28 2021-07-28 日本臓器製薬株式会社 経皮投与製剤

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US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US6110488A (en) * 1986-08-28 2000-08-29 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
US4822802A (en) * 1987-02-24 1989-04-18 Alza Corporation Method of fentanly administration for postoperative pain relief
US4849224A (en) * 1987-11-12 1989-07-18 Theratech Inc. Device for administering an active agent to the skin or mucosa
FR2623718B1 (fr) * 1987-11-27 1994-04-15 Fabre Medicament Pierre Dispositif therapeutique transdermique et son procede de preparation
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
DE3905051A1 (de) * 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i)
DE3910543A1 (de) * 1989-04-01 1990-10-11 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung
SE8904296D0 (sv) * 1989-12-21 1989-12-21 Pharmacia Ab Transdermal system
JP3202777B2 (ja) * 1992-01-24 2001-08-27 リンテック株式会社 経皮吸収促進剤及びテープ製剤
ES2164286T3 (es) * 1993-04-20 2002-02-16 Hexal Ag Emplasto con sustancias activas.
CN1094972A (zh) * 1993-05-21 1994-11-16 深圳广信生物工程公司 控释透皮治疗系统及其制备与应用
JP3240496B2 (ja) * 1993-09-30 2001-12-17 タキロン株式会社 経皮吸収製剤
US5665378A (en) * 1994-09-30 1997-09-09 Davis; Roosevelt Transdermal therapeutic formulation
JP4346696B2 (ja) * 1996-05-28 2009-10-21 久光製薬株式会社 経皮治療用装置
DE19728517C2 (de) * 1997-07-04 1999-11-11 Sanol Arznei Schwarz Gmbh TTS zur Verabreichung von Sexualsteroidhormonen und Verfahren zu seiner Herstellung
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Also Published As

Publication number Publication date
TW570815B (en) 2004-01-11
NZ530795A (en) 2005-08-26
US20040234583A1 (en) 2004-11-25
HK1069534A1 (pt) 2005-05-27
IL160515A0 (en) 2004-07-25
WO2003018071A1 (de) 2003-03-06
BRPI0212028B1 (pt) 2020-11-24
US7390500B2 (en) 2008-06-24
MXPA04001679A (es) 2004-05-31
DK1418951T3 (da) 2010-05-10
BR0212028A (pt) 2004-08-03
CA2457245C (en) 2010-09-07
DE10141651A1 (de) 2003-03-13
HUP0401512A3 (en) 2012-08-28
EP1418951B1 (de) 2010-01-20
CN100438859C (zh) 2008-12-03
US20080274167A1 (en) 2008-11-06
CY1109954T1 (el) 2012-05-23
EP1418951A1 (de) 2004-05-19
KR20040029021A (ko) 2004-04-03
JP4628673B2 (ja) 2011-02-09
PL204348B1 (pl) 2010-01-29
IL160515A (en) 2009-09-22
PL366857A1 (en) 2005-02-07
ES2339640T3 (es) 2010-05-24
JP2005501865A (ja) 2005-01-20
CN1545407A (zh) 2004-11-10
RU2311908C2 (ru) 2007-12-10
HUP0401512A2 (hu) 2004-12-28
RU2004108849A (ru) 2005-05-10
KR100895188B1 (ko) 2009-04-24
HU229942B1 (en) 2015-01-28
ATE455541T1 (de) 2010-02-15
ZA200400473B (en) 2004-10-14
DE50214184D1 (de) 2010-03-11
DE10141651B4 (de) 2007-02-15
PT1418951E (pt) 2010-04-07
AU2002321199B2 (en) 2007-08-16
CA2457245A1 (en) 2003-03-06

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: A61K 9/70

Ipc: A61K 31/4468 (2011.01), A61K 9/70 (2011.01), A61P

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/11/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/07/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 20A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2678 DE 03-05-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.