BR9911800A - Proteìnas de diacil glicerol acil transferase - Google Patents

Proteìnas de diacil glicerol acil transferase

Info

Publication number
BR9911800A
BR9911800A BR9911800-9A BR9911800A BR9911800A BR 9911800 A BR9911800 A BR 9911800A BR 9911800 A BR9911800 A BR 9911800A BR 9911800 A BR9911800 A BR 9911800A
Authority
BR
Brazil
Prior art keywords
dagat
proteins
diaglycerol
acyl transferase
methods
Prior art date
Application number
BR9911800-9A
Other languages
English (en)
Inventor
Kathyn Dennis Lardizabal
Deborah Hamkins
Gregory A Thompson
Original Assignee
Calgene Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calgene Llc filed Critical Calgene Llc
Publication of BR9911800A publication Critical patent/BR9911800A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Patente de Invenção: <B>"PROTEìNAS DE DIACIL GLICEROL ACIL TRANSFERASE"<D>. A invenção apresenta proteínas de diacil glicerol acil transferase (DAGAT), sendo que as ditas proteínas são ativas na formação de triacil glicerol de substratos de acila graxa e diacil glicerol. Em um aspecto, as proteínas de DAGAT de Mortierella ramanniana foram isoladas e têm pesos moleculares entre cerca de 36 e 37 kDa tal como medido por SDS-PAGE. A invenção também apresenta novas seq³ências de polinucleotídios e polipeptídios de DAGAT e métodos de produção desses polipeptídios com o uso de técnicas recombinantes. Além disso, métodos são providos para uso dessas seq³ências para alterar níveis de triacil glicerol em plantas e para tratar doenças associadas com a atividade ou expressão alterada da DAGAT.
BR9911800-9A 1998-07-02 1999-06-30 Proteìnas de diacil glicerol acil transferase BR9911800A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9163198P 1998-07-02 1998-07-02
US13082999P 1999-04-23 1999-04-23
PCT/US1999/015243 WO2000001713A2 (en) 1998-07-02 1999-06-30 Diacylglycerol acyl transferase proteins

Publications (1)

Publication Number Publication Date
BR9911800A true BR9911800A (pt) 2001-02-28

Family

ID=26784169

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911800-9A BR9911800A (pt) 1998-07-02 1999-06-30 Proteìnas de diacil glicerol acil transferase

Country Status (8)

Country Link
US (1) US6822141B2 (pt)
EP (1) EP1098962B1 (pt)
JP (1) JP4514952B2 (pt)
AT (1) ATE442435T1 (pt)
BR (1) BR9911800A (pt)
CA (1) CA2331329C (pt)
DE (1) DE69941390D1 (pt)
WO (1) WO2000001713A2 (pt)

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CN1266460A (zh) * 1997-06-05 2000-09-13 卡尔金有限责任公司 二酰甘油酰基转移酶蛋白

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US20030028923A1 (en) 2003-02-06
ATE442435T1 (de) 2009-09-15
EP1098962B1 (en) 2009-09-09
WO2000001713A9 (en) 2000-04-20
JP2002519051A (ja) 2002-07-02
DE69941390D1 (de) 2009-10-22
WO2000001713A3 (en) 2000-11-16
US6822141B2 (en) 2004-11-23
JP4514952B2 (ja) 2010-07-28
CA2331329C (en) 2011-08-30

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