BR9910449A - Composições orais de 8-cloro-6,11-diidro-11-(4-piperidilideno)-5h-benzo[5,6]c icloepta[1,2-b]piridina - Google Patents

Composições orais de 8-cloro-6,11-diidro-11-(4-piperidilideno)-5h-benzo[5,6]c icloepta[1,2-b]piridina

Info

Publication number
BR9910449A
BR9910449A BR9910449-0A BR9910449A BR9910449A BR 9910449 A BR9910449 A BR 9910449A BR 9910449 A BR9910449 A BR 9910449A BR 9910449 A BR9910449 A BR 9910449A
Authority
BR
Brazil
Prior art keywords
piperidylidene
benzo
pyridine
icloepta
dihydro
Prior art date
Application number
BR9910449-0A
Other languages
English (en)
Inventor
Jim H Kou
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22348307&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9910449(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9910449A publication Critical patent/BR9910449A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>''COMPOSIçõES ORAIS DE 8-CLORO-6,11-DIIDRO-11-(4-PIPERIDILIDENO)-5H-BENZO[5,6]C ICLOEPTA[1,2-b]PIRIDINA''<D>. São descritas composições farmacêuticas estáveis contendo 8-cloro-6,11-diidro-11-(4-piperidilideno)-5H-benzo[5,6]-cicloepta[1,2- b]piridina (''DCL") e uma quantidade protetora de DCL de um sal básico farmaceuticamente aceitável tal como fosfato dibásico de cálcio e uma quantidade de pelo menos um desintegrante, de preferência dois desintegrantes tais como celulose microcristalina e amido suficiente para prover dissolução de pelo menos cerca de 80% em peso da composição farmacêutica em cerca de 45 minutos e adequado para a administração oral para tratar reações alérgicas em mamíferos tal como ser humano.
BR9910449-0A 1998-07-10 1999-07-08 Composições orais de 8-cloro-6,11-diidro-11-(4-piperidilideno)-5h-benzo[5,6]c icloepta[1,2-b]piridina BR9910449A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11323298A 1998-07-10 1998-07-10
PCT/US1999/012368 WO2000002560A1 (en) 1998-07-10 1999-07-08 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO[5,6]CYCLOHEPTA[1,2-b]PYRIDINE ORAL COMPOSITIONS

Publications (1)

Publication Number Publication Date
BR9910449A true BR9910449A (pt) 2001-01-02

Family

ID=22348307

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910449-0A BR9910449A (pt) 1998-07-10 1999-07-08 Composições orais de 8-cloro-6,11-diidro-11-(4-piperidilideno)-5h-benzo[5,6]c icloepta[1,2-b]piridina

Country Status (28)

Country Link
EP (3) EP1380297B1 (pt)
JP (4) JP3224379B1 (pt)
KR (1) KR100420641B1 (pt)
CN (1) CN1145485C (pt)
AR (4) AR016044A1 (pt)
AT (2) ATE432075T1 (pt)
AU (1) AU741201B2 (pt)
BR (1) BR9910449A (pt)
CA (2) CA2325014C (pt)
CY (1) CY1109279T1 (pt)
CZ (1) CZ300843B6 (pt)
DE (2) DE69940932D1 (pt)
DK (2) DK1380297T3 (pt)
ES (2) ES2326214T3 (pt)
HK (1) HK1030361A1 (pt)
HU (1) HU228448B1 (pt)
ID (1) ID28645A (pt)
IL (1) IL139407A0 (pt)
MY (1) MY116038A (pt)
NO (1) NO331454B1 (pt)
NZ (2) NZ512916A (pt)
PE (1) PE20000761A1 (pt)
PL (1) PL199390B1 (pt)
PT (2) PT1073438E (pt)
SK (1) SK288240B6 (pt)
TW (1) TW575424B (pt)
WO (1) WO2000002560A1 (pt)
ZA (1) ZA200006224B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001045668A2 (en) 1999-12-20 2001-06-28 Schering Corporation Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine
AU2276801A (en) 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
US7507714B2 (en) 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
BRPI0513417A (pt) * 2004-07-16 2008-05-06 Cipla Ltd composição farmacêutica estável, usos de um poliol, e de uma composição, processo para preparar uma composição farmacêutica, e, método para tratar uma condição responsiva à administração de uma anti-histamina
EP2181994B1 (en) 2006-03-31 2014-05-28 Research Foundation Itsuu Laboratory Antimicrobial compounds
CN101868228B (zh) 2007-11-21 2016-12-07 大日本住友制药株式会社 口腔内崩解片
TR200806298A2 (tr) 2008-08-22 2010-03-22 Bi̇lgi̇ç Mahmut Farmasötik formülasyon
ATE525064T1 (de) 2009-07-01 2011-10-15 Tiefenbacher Alfred E Gmbh & Co Kg Pharmazeutische zusammensetzung mit desloratadin
ES2709487T3 (es) 2010-05-10 2019-04-16 Lesvi Laboratorios Sl Formulaciones farmacéuticas estables que contienen un antihistamínico

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
US4657716A (en) 1984-03-19 1987-04-14 Lim Kunststoff Technologie Gesellschaft Method of making elastomeric shoe soles
US4990535A (en) * 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
US5595997A (en) 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
PE71699A1 (es) * 1997-02-07 1999-08-03 Sepracor Inc Composicion farmaceutica de descarboetoxiloratadina sin lactosa, no higroscopica y anhidra

Also Published As

Publication number Publication date
ATE432075T1 (de) 2009-06-15
JP2010265329A (ja) 2010-11-25
JP4160739B2 (ja) 2008-10-08
DK1073438T3 (da) 2004-05-10
ZA200006224B (en) 2001-11-01
CZ20004056A3 (cs) 2001-03-14
EP1073438A1 (en) 2001-02-07
JP3224379B1 (ja) 2001-10-29
EP1073438B1 (en) 2004-03-31
KR20010043402A (ko) 2001-05-25
AU741201B2 (en) 2001-11-22
CN1145485C (zh) 2004-04-14
NZ512916A (en) 2003-03-28
NO20005485L (no) 2001-03-09
CA2377178A1 (en) 2000-01-20
PT1380297E (pt) 2009-07-06
ATE262904T1 (de) 2004-04-15
IL139407A0 (en) 2001-11-25
TW575424B (en) 2004-02-11
NO20005485D0 (no) 2000-10-31
ID28645A (id) 2001-06-21
PL344045A1 (en) 2001-09-24
NZ507885A (en) 2001-08-31
JP2002068983A (ja) 2002-03-08
JP2005298524A (ja) 2005-10-27
AU4953199A (en) 2000-02-01
WO2000002560A1 (en) 2000-01-20
PL199390B1 (pl) 2008-09-30
CN1303284A (zh) 2001-07-11
EP1380297B1 (en) 2009-05-27
HUP0101900A2 (hu) 2001-11-28
AR021159A1 (es) 2002-06-12
CZ300843B6 (cs) 2009-08-26
EP2055303A2 (en) 2009-05-06
CA2325014A1 (en) 2000-01-20
PE20000761A1 (es) 2000-08-31
SK288240B6 (sk) 2015-02-03
DE69916042D1 (de) 2004-05-06
HUP0101900A3 (en) 2003-01-28
DE69916042T2 (de) 2004-11-11
HU228448B1 (en) 2013-03-28
DE69940932D1 (de) 2009-07-09
AR021157A2 (es) 2002-06-12
KR100420641B1 (ko) 2004-03-02
MY116038A (en) 2003-10-31
AR016044A1 (es) 2001-06-20
EP2055303A3 (en) 2009-12-16
EP1380297A1 (en) 2004-01-14
CA2325014C (en) 2002-05-28
SK17112000A3 (sk) 2001-12-03
PT1073438E (pt) 2004-07-30
JP4621082B2 (ja) 2011-01-26
DK1380297T3 (da) 2009-08-17
CY1109279T1 (el) 2012-05-23
JP2002520285A (ja) 2002-07-09
ES2326214T3 (es) 2009-10-05
AR021158A2 (es) 2002-06-12
ES2214871T3 (es) 2004-09-16
IL139407A (en) 2001-10-31
NO331454B1 (no) 2012-01-09
HK1030361A1 (en) 2001-05-04

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL.8: A61K 31/4545, A61K 31/4523, A61K 9/20, A61K 47/38, A61P 37/08

Ipc: A61K 31/4545 (2007.10), A61K 31/4523 (2007.10), A6

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA COMO ESTABELECIDO PELOS ARTIGOS 8O E 13 DA LPI ( LEI 9729/96 )

B12B Appeal against refusal [chapter 12.2 patent gazette]
B15Z Prolongation of time limit refused

Free format text: INTERESSADO: ACHE LABORATORIOS FARMACEUTICOS S/A DESPACHO: NEGADA A DEVOLUCAO DE PRAZO SOLICITADADE ACORDO COM O ARTIGO 2O, PARAGRAFO UNICO, DA RESOLUCAO NO116/04.

B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B25G Requested change of headquarter approved

Owner name: MERCK SHARP AND DOHME CORP. (US)