BR9907672A - Derivados de 5'-desoxicitidina - Google Patents

Derivados de 5'-desoxicitidina

Info

Publication number
BR9907672A
BR9907672A BR9907672-1A BR9907672A BR9907672A BR 9907672 A BR9907672 A BR 9907672A BR 9907672 A BR9907672 A BR 9907672A BR 9907672 A BR9907672 A BR 9907672A
Authority
BR
Brazil
Prior art keywords
lower alkyl
cycloalkyl
derivatives
alkyl
group
Prior art date
Application number
BR9907672-1A
Other languages
English (en)
Inventor
Kazuo Hattori
Tohru Ishikawa
Hideo Ishitsuka
Yasunori Kohchi
Nobuhiro Oikawa
Nobuo Shimma
Hitomi Suda
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9907672A publication Critical patent/BR9907672A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DA 5'-DESOXICITIDINA"<D>. Compostos da fórmula geral (I)na qual R¹ é de modo independente hidrogênio ou um grupo hidrolisável com facilidade sob condições fisiológicas; R² é -(CH~ 2~)~ n~ cicloalquila {em que a cicloalquila consiste em 3 a 5 átomos de carbono, n é um número inteiro a partir de 0 até 4} heteroaril (alquila inferior), (alcóxi inferior)-(alquila inferior) arilóxi -(alquila inferior), aralquilóxi- (alquila inferior, (alquiltio inferior - (alquila inferior), ariltio -(alquila inferior), aralquiltio -(alquila inferior), ozo - (alquila inferior), acilamino - (alquila inferior), amino cíclico - (alquila inferior), (2-amino oxocíclico) -(alquila inferior), na qual a cadeia alquileno pode ainda ser substituída com um ou mais grupo(s) de alquila inferior e R^ 3^ é iodo, um grupo vinila ou etinila [cujos grupos podem ser substituídos com um átomo(s) de halogênio, C~ 1-4~ alquila, cicloalquila ou um anel aromático que pode ter um ou mais hetero-átomo(s)], são úteis no tratamento de doenças malignas e também podem ser administrados em conjunto com o 5-fluoruracil ou derivados do mesmo para aumentar a atividade antitumor deste último.
BR9907672-1A 1998-02-06 1999-02-03 Derivados de 5'-desoxicitidina BR9907672A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98102080 1998-02-06
EP98108321 1998-05-07
PCT/EP1999/000710 WO1999040099A1 (en) 1998-02-06 1999-02-03 5'-deoxycytidine derivatives

Publications (1)

Publication Number Publication Date
BR9907672A true BR9907672A (pt) 2000-11-28

Family

ID=26149007

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907672-1A BR9907672A (pt) 1998-02-06 1999-02-03 Derivados de 5'-desoxicitidina

Country Status (19)

Country Link
US (1) US6005098A (pt)
EP (1) EP1060183B1 (pt)
JP (2) JP3625276B2 (pt)
KR (1) KR100381516B1 (pt)
CN (1) CN1260240C (pt)
AR (1) AR014539A1 (pt)
AT (1) ATE238335T1 (pt)
AU (1) AU757136B2 (pt)
BR (1) BR9907672A (pt)
CA (1) CA2318848C (pt)
CO (1) CO5070642A1 (pt)
DE (1) DE69907161T2 (pt)
DK (1) DK1060183T3 (pt)
ES (1) ES2195543T3 (pt)
MA (1) MA26606A1 (pt)
PE (1) PE20000244A1 (pt)
PT (1) PT1060183E (pt)
TR (1) TR200002297T2 (pt)
WO (1) WO1999040099A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119724A1 (en) * 1995-11-22 2003-06-26 Ts`O Paul O.P. Ligands to enhance cellular uptake of biomolecules
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives
ES2226647T3 (es) 1999-05-26 2005-04-01 F. Hoffmann-La Roche Ag Proceso para la preparacion de derivados de vinil pirimidina.
KR100631754B1 (ko) * 2000-08-09 2006-10-09 주식회사 코오롱 Ｎ-알킬옥시카르보닐-5-플루오로사이토신 유도체 및 그의제조방법
WO2002043771A2 (en) 2000-12-01 2002-06-06 Cell Works Inc. Conjugates of glycosylated/galactosylated peptide
CN100383128C (zh) * 2004-02-23 2008-04-23 上海迪赛诺医药发展有限公司 N4－氧羰基胞嘧啶衍生物及制备方法与应用
DE112006000873T5 (de) * 2005-04-12 2008-03-06 Elan Pharma International Ltd. Zusammensetzungen mit modifizierter Freisetzung, umfassend ein Fluorcytidin-Derivate zur Behandlung von Krebs
JP6866113B2 (ja) * 2016-11-01 2021-04-28 日本化薬株式会社 カペシタビンを有効成分とする医薬製剤
JP6792418B2 (ja) * 2016-11-08 2020-11-25 日本化薬株式会社 カペシタビンを有効成分とする医薬製剤の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
GB2016921B (en) * 1978-03-27 1982-08-18 Taiho Pharmaceutical Co Ltd Anti cancer compositions containing uracil derivatives
JPS54129131A (en) * 1978-03-27 1979-10-06 Taiho Pharmaceutical Co Ltd Antiimalignant tumor agent composition
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
JP3094036B2 (ja) * 1990-07-19 2000-10-03 ザ ウエルカム ファウンデーション リミテッド 酵素不活性化剤
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
KR0148589B1 (ko) * 1991-05-27 1998-11-02 고바야시 유끼오 항종양 효과의 상승 및 종양의 치료를 위한 조성물 및 키트
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (pt) * 1992-12-18 1995-08-21 Hoffmann La Roche
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives

Also Published As

Publication number Publication date
ATE238335T1 (de) 2003-05-15
AU2722799A (en) 1999-08-23
TR200002297T2 (tr) 2000-12-21
CO5070642A1 (es) 2001-08-28
AU757136B2 (en) 2003-02-06
WO1999040099A1 (en) 1999-08-12
EP1060183B1 (en) 2003-04-23
PE20000244A1 (es) 2000-04-10
PT1060183E (pt) 2003-08-29
US6005098A (en) 1999-12-21
MA26606A1 (fr) 2004-12-20
CN1260240C (zh) 2006-06-21
KR20010072543A (ko) 2001-07-31
EP1060183A1 (en) 2000-12-20
CA2318848C (en) 2008-09-02
AR014539A1 (es) 2001-02-28
JP2002502857A (ja) 2002-01-29
KR100381516B1 (ko) 2003-04-23
JP3625276B2 (ja) 2005-03-02
DK1060183T3 (da) 2003-08-11
DE69907161D1 (de) 2003-05-28
ES2195543T3 (es) 2003-12-01
CN1290269A (zh) 2001-04-04
JP2004339230A (ja) 2004-12-02
DE69907161T2 (de) 2004-02-05
CA2318848A1 (en) 1999-08-12

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.