BR9900856A - Antibioticos macrolideos de 3,6-cetal e enol-éter - Google Patents
Antibioticos macrolideos de 3,6-cetal e enol-éterInfo
- Publication number
- BR9900856A BR9900856A BR9900856-4A BR9900856A BR9900856A BR 9900856 A BR9900856 A BR 9900856A BR 9900856 A BR9900856 A BR 9900856A BR 9900856 A BR9900856 A BR 9900856A
- Authority
- BR
- Brazil
- Prior art keywords
- formulas
- compounds
- enol
- ether
- parasitic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Patente de Invenção: <B>"ANTIBIóTICOS MACROLìDEOS DE 3,6-CETAL E ENOL-éTER"<D>. Esta invenção refere-se a compostos de fórmulas <MU>1<MV> e <MU>2<MV> e aos seus sais e solvatos farmaceuticamente aceitáveis, em que X, X^ 1^, R^ 1^, R^ 2^, R^ 7^, R^ 17^ e R^ 19^ são conforme acima definidos. Os compostos de fórmulas <MU>1<MV> e <MU>2<MV> podem ser úteis no tratamento de infecções bacterianas, parasíticas e protozoárias, bem como em distúrbios relacionados com infecções bacterianas, parasíticas e protozoárias, em mamíferos, peixes e aves. A invenção também diz respeito a composições farmacêuticas que contêm os compostos de fórmulas <MU>1<MV> e <MU>2<MV> e a métodos de tratamento de infecções bacterianas, parasíticas e protozoárias pela administração dos compostos de fórmulas <MU>1<MV> e <MU>2<MV>.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7663098P | 1998-03-03 | 1998-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9900856A true BR9900856A (pt) | 2000-04-25 |
Family
ID=22133253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9900856-4A BR9900856A (pt) | 1998-03-03 | 1999-03-03 | Antibioticos macrolideos de 3,6-cetal e enol-éter |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6043226A (pt) |
| EP (1) | EP0941998B1 (pt) |
| JP (1) | JP3666788B2 (pt) |
| CN (1) | CN1244532A (pt) |
| AR (1) | AR016715A1 (pt) |
| AT (1) | ATE275151T1 (pt) |
| AU (1) | AU741435B2 (pt) |
| BR (1) | BR9900856A (pt) |
| CA (1) | CA2263203C (pt) |
| DE (1) | DE69919769T2 (pt) |
| DK (1) | DK0941998T3 (pt) |
| ES (1) | ES2226282T3 (pt) |
| HU (1) | HUP9900492A3 (pt) |
| NO (1) | NO312366B1 (pt) |
| NZ (1) | NZ334442A (pt) |
| PT (1) | PT941998E (pt) |
| ZA (1) | ZA991664B (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| PL348114A1 (en) * | 1998-11-03 | 2002-05-06 | Pfizer Prod Inc | Novel macrolide antibiotics |
| US6590083B1 (en) * | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| JP2003523938A (ja) | 1999-04-16 | 2003-08-12 | コーサン バイオサイエンシーズ， インコーポレイテッド | マクロライド系抗感染剤 |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6514944B2 (en) * | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| OA11945A (en) * | 1999-05-24 | 2006-04-13 | Pfizer Prod Inc | 13-Methyl erythromycin derivatives. |
| EP1146051A3 (en) * | 2000-04-10 | 2001-10-31 | Pfizer Products Inc. | Erythromycin A derivatives |
| WO2002038750A1 (en) * | 2000-11-07 | 2002-05-16 | Morphotek Inc. | Methods for isolating novel antimicrobial agents from hypermutable mammalian cells |
| US8063021B2 (en) * | 2002-01-17 | 2011-11-22 | Kosan Biosciences Incorporated | Ketolide anti-infective compounds |
| ITMI20021726A1 (it) | 2002-08-01 | 2004-02-02 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
| ITMI20022292A1 (it) * | 2002-10-29 | 2004-04-30 | Zambon Spa | 9a-azalidi ad attivita' antiinfiammatoria. |
| WO2004073492A2 (en) * | 2003-02-14 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof |
| EP1836211B1 (en) * | 2004-12-21 | 2010-03-03 | Pfizer Products Inc. | Macrolides |
| US7517859B2 (en) * | 2005-05-04 | 2009-04-14 | Enanta Pharmaceuticals, Inc. | Spirocyclic bicyclolides |
| ES2691252T3 (es) * | 2007-09-17 | 2018-11-26 | Enanta Pharmaceuticals, Inc. | Macrólidos de biarilo con puente en 6,11 |
| WO2018193116A1 (en) * | 2017-04-20 | 2018-10-25 | Novintum Biotechnology Gmbh | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| WO2018193111A1 (en) * | 2017-04-20 | 2018-10-25 | Novintum Biotechnology Gmbh | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| GB201706299D0 (en) * | 2017-04-20 | 2017-06-07 | Novintum Biotechnology Gmbh | Compounds |
| EP3612543B1 (en) | 2017-04-20 | 2022-11-23 | Rising Tide Foundation | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| US11427606B2 (en) | 2017-04-20 | 2022-08-30 | Rising Tide Foundation | Azithromycin derivatives containing a phosphonium ion as anticancer agents |
| WO2018193126A1 (en) * | 2017-04-20 | 2018-10-25 | Novintum Biotechnology Gmbh | Azithromycin derivatives containing a phosphonium ion as antibacterial agents |
| EP3612187B1 (en) | 2017-04-21 | 2022-04-13 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| EP3612177A4 (en) | 2017-04-21 | 2021-01-13 | Lunella Biotech, Inc. | TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY |
| EP3624840A4 (en) | 2017-05-19 | 2021-03-10 | Lunella Biotech, Inc. | ANTIMITOSCINE: TARGETED INHIBITORS OF MITOCHONDRIAL BIOGENESIS TO DESCRIBE CANCER STEM CELLS |
| US11667639B2 (en) | 2017-06-26 | 2023-06-06 | Lunella Biotech, Inc. | Mitoketoscins: mitochondrial-based therapeutics targeting ketone metabolism in cancer cells |
| GB201817083D0 (en) * | 2018-10-19 | 2018-12-05 | Novintum Biotechnology Gmbh | Compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8721165D0 (en) * | 1987-09-09 | 1987-10-14 | Beecham Group Plc | Chemical compounds |
| EP0344106A3 (de) * | 1988-05-24 | 1990-01-31 | Ciba-Geigy Ag | Blaue Dispersionsfarbstoffe und Mischungen blauer Dispersionsfarbstoffe |
| US5302705A (en) * | 1989-10-07 | 1994-04-12 | Taisho Pharmaceutical Co., Ltd. | 6-O-methylerythromycin a oxime derivatives |
| WO1994017088A1 (en) * | 1993-01-26 | 1994-08-04 | Taisho Pharmaceutical Co., Ltd. | 5-o-desosaminylerythronolide derivative |
| JP2000509712A (ja) * | 1996-05-07 | 2000-08-02 | アボツト・ラボラトリーズ | ６―ｏ―置換エリスロマイシン及びその製造方法 |
-
1999
- 1999-02-23 DE DE69919769T patent/DE69919769T2/de not_active Expired - Fee Related
- 1999-02-23 PT PT99301325T patent/PT941998E/pt unknown
- 1999-02-23 ES ES99301325T patent/ES2226282T3/es not_active Expired - Lifetime
- 1999-02-23 EP EP99301325A patent/EP0941998B1/en not_active Expired - Lifetime
- 1999-02-23 AT AT99301325T patent/ATE275151T1/de not_active IP Right Cessation
- 1999-02-23 DK DK99301325T patent/DK0941998T3/da active
- 1999-02-25 US US09/257,709 patent/US6043226A/en not_active Expired - Fee Related
- 1999-03-01 AR ARP990100858A patent/AR016715A1/es unknown
- 1999-03-01 CA CA002263203A patent/CA2263203C/en not_active Expired - Fee Related
- 1999-03-02 JP JP05371599A patent/JP3666788B2/ja not_active Expired - Fee Related
- 1999-03-02 HU HU9900492A patent/HUP9900492A3/hu unknown
- 1999-03-02 ZA ZA9901664A patent/ZA991664B/xx unknown
- 1999-03-02 NZ NZ334442A patent/NZ334442A/xx unknown
- 1999-03-02 NO NO19991012A patent/NO312366B1/no not_active IP Right Cessation
- 1999-03-03 BR BR9900856-4A patent/BR9900856A/pt not_active IP Right Cessation
- 1999-03-03 AU AU18562/99A patent/AU741435B2/en not_active Ceased
- 1999-03-03 CN CN99105681A patent/CN1244532A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE275151T1 (de) | 2004-09-15 |
| AU1856299A (en) | 1999-09-16 |
| CN1244532A (zh) | 2000-02-16 |
| DK0941998T3 (da) | 2004-09-20 |
| HUP9900492A2 (hu) | 1999-09-28 |
| AR016715A1 (es) | 2001-07-25 |
| NO312366B1 (no) | 2002-04-29 |
| PT941998E (pt) | 2004-12-31 |
| JP3666788B2 (ja) | 2005-06-29 |
| CA2263203C (en) | 2002-09-03 |
| EP0941998B1 (en) | 2004-09-01 |
| AU741435B2 (en) | 2001-11-29 |
| NO991012L (no) | 1999-09-06 |
| US6043226A (en) | 2000-03-28 |
| EP0941998A3 (en) | 1999-10-06 |
| HUP9900492A3 (en) | 2001-08-28 |
| DE69919769T2 (de) | 2005-01-27 |
| HU9900492D0 (en) | 1999-04-28 |
| CA2263203A1 (en) | 1999-09-03 |
| NZ334442A (en) | 2000-03-27 |
| NO991012D0 (no) | 1999-03-02 |
| EP0941998A2 (en) | 1999-09-15 |
| ZA991664B (en) | 2000-10-12 |
| DE69919769D1 (de) | 2004-10-07 |
| JPH11315093A (ja) | 1999-11-16 |
| ES2226282T3 (es) | 2005-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO1976 DE 18/11/2008. |