BR9709845A - Preparação aquosa de insulina formulação farmacêutica parenteral e processo para aumentar a estabilidade química de uma preparação de insulina - Google Patents
Preparação aquosa de insulina formulação farmacêutica parenteral e processo para aumentar a estabilidade química de uma preparação de insulinaInfo
- Publication number
- BR9709845A BR9709845A BR9709845A BR9709845A BR9709845A BR 9709845 A BR9709845 A BR 9709845A BR 9709845 A BR9709845 A BR 9709845A BR 9709845 A BR9709845 A BR 9709845A BR 9709845 A BR9709845 A BR 9709845A
- Authority
- BR
- Brazil
- Prior art keywords
- insulin
- preparation
- chemical stability
- increase
- pharmaceutical formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK68596 | 1996-06-20 | ||
PCT/DK1997/000268 WO1997048414A1 (en) | 1996-06-20 | 1997-06-19 | INSULIN PREPARATIONS CONTAINING NaCl |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9709845A true BR9709845A (pt) | 1999-08-10 |
BR9709845B1 BR9709845B1 (pt) | 2008-11-18 |
Family
ID=8096378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9709845-0A BR9709845B1 (pt) | 1996-06-20 | 1997-06-19 | preparaÇço aquosa de insulina, formulaÇço farmacÊutica parenteral, e, processso para aumentar a estabilidade quÍmica de uma preparaÇço de insulina. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0921812B2 (pt) |
JP (2) | JP4404380B2 (pt) |
KR (1) | KR100451778B1 (pt) |
CN (1) | CN1120019C (pt) |
AT (1) | ATE208208T1 (pt) |
AU (1) | AU720484B2 (pt) |
BR (1) | BR9709845B1 (pt) |
CA (1) | CA2258097C (pt) |
CZ (1) | CZ297937B6 (pt) |
DE (1) | DE69708121T3 (pt) |
DK (1) | DK0921812T4 (pt) |
ES (1) | ES2167751T5 (pt) |
HU (1) | HU228094B1 (pt) |
IL (2) | IL127366A0 (pt) |
NO (1) | NO324430B1 (pt) |
PL (1) | PL189964B1 (pt) |
PT (1) | PT921812E (pt) |
RU (1) | RU2182015C2 (pt) |
UA (1) | UA49890C2 (pt) |
WO (1) | WO1997048414A1 (pt) |
ZA (1) | ZA975470B (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1870099A (en) | 1998-01-09 | 1999-07-26 | Novo Nordisk A/S | Stabilised insulin compositions |
US6489292B1 (en) | 1998-11-18 | 2002-12-03 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
EP1131089B1 (en) * | 1998-11-18 | 2004-02-18 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
WO2000043034A2 (en) * | 1999-01-26 | 2000-07-27 | Eli Lilly And Company | Monodisperse hexameric acylated insulin analog formulations |
EP1165063A1 (en) * | 1999-04-05 | 2002-01-02 | Verteletsky, Pavel Vasilievich | Use of succinic acid or salts thereof for the treatment of diabetes mellitus and wound healing |
US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
EP1523993A1 (en) * | 1999-12-16 | 2005-04-20 | Eli Lilly & Company | Polypeptide compositions with improved stability |
EA004631B1 (ru) * | 1999-12-16 | 2004-06-24 | Эли Лилли Энд Компани | Полипептидные композиции, обладающие повышенной стабильностью |
DK2918286T3 (da) | 2004-10-05 | 2020-03-30 | Novo Nordisk As | En farmaceutisk formulering |
DK2349324T3 (en) | 2008-10-17 | 2017-12-11 | Sanofi Aventis Deutschland | COMBINATION OF AN INSULIN AND A GLP-1 AGONIST |
PT2498802E (pt) | 2009-11-13 | 2015-04-13 | Sanofi Aventis Deutschland | Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina |
PE20121316A1 (es) | 2009-11-13 | 2012-10-05 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1 y metionina |
HUE031181T2 (en) | 2010-08-30 | 2017-06-28 | Sanofi Aventis Deutschland | Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
EP2750699B1 (en) | 2011-08-29 | 2015-07-22 | Sanofi-Aventis Deutschland GmbH | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US20150246129A1 (en) * | 2012-12-26 | 2015-09-03 | Wockhardt Limited | Pharmaceutical composition |
TWI780236B (zh) | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
CN105899191B (zh) | 2014-01-09 | 2020-06-16 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂 |
RU2016132340A (ru) | 2014-01-09 | 2018-02-14 | Санофи | Стабилизированные фармацевтические составы на основе инсулина аспарта |
JP2020114861A (ja) * | 2014-01-09 | 2020-07-30 | サノフイSanofi | インスリンアナログおよび/またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤 |
MX2016008979A (es) | 2014-01-09 | 2016-10-04 | Sanofi Sa | Formulaciones farmaceuticas estabilizadas de analogos de insulina y/o derivados de insulina. |
JP2020143105A (ja) * | 2014-01-09 | 2020-09-10 | サノフイSanofi | インスリンアスパルトの安定化された医薬製剤 |
FI3229828T3 (fi) | 2014-12-12 | 2023-05-29 | Sanofi Aventis Deutschland | Glargiini-insuliinin/liksisenatidin vakiosuhteinen formulaatio |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK116527B (da) * | 1967-03-01 | 1970-01-19 | Nordisk Insulinlab | Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse. |
US4783441A (en) † | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
US4439181A (en) * | 1981-01-26 | 1984-03-27 | Regents Of The University Of Minnesota | Polyol-hormone mixture for use in chronic parenteral hormone administration |
AU550068B2 (en) † | 1981-03-10 | 1986-02-27 | Novo Nordisk A/S | Zinc insulin stabilized with calcium or magnesium salts |
US4839341A (en) * | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
NZ232375A (en) * | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
ATE176482T1 (de) * | 1993-06-21 | 1999-02-15 | Novo Nordisk As | Asp-b28-insulinkristalle |
DK0792290T3 (da) * | 1993-09-17 | 2001-10-01 | Novo Nordisk As | Acyleret insulin |
US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
-
1997
- 1997-06-19 WO PCT/DK1997/000268 patent/WO1997048414A1/en active IP Right Grant
- 1997-06-19 RU RU99101068/14A patent/RU2182015C2/ru active
- 1997-06-19 KR KR10-1998-0710429A patent/KR100451778B1/ko not_active IP Right Cessation
- 1997-06-19 BR BRPI9709845-0A patent/BR9709845B1/pt not_active IP Right Cessation
- 1997-06-19 HU HU9904031A patent/HU228094B1/hu unknown
- 1997-06-19 IL IL12736697A patent/IL127366A0/xx active IP Right Grant
- 1997-06-19 PL PL97330763A patent/PL189964B1/pl unknown
- 1997-06-19 JP JP50212998A patent/JP4404380B2/ja not_active Expired - Lifetime
- 1997-06-19 CN CN97195648A patent/CN1120019C/zh not_active Expired - Lifetime
- 1997-06-19 AU AU32536/97A patent/AU720484B2/en not_active Expired
- 1997-06-19 CA CA2258097A patent/CA2258097C/en not_active Expired - Lifetime
- 1997-06-19 ES ES97928123T patent/ES2167751T5/es not_active Expired - Lifetime
- 1997-06-19 PT PT97928123T patent/PT921812E/pt unknown
- 1997-06-19 CZ CZ0395698A patent/CZ297937B6/cs not_active IP Right Cessation
- 1997-06-19 EP EP97928123A patent/EP0921812B2/en not_active Expired - Lifetime
- 1997-06-19 DE DE69708121T patent/DE69708121T3/de not_active Expired - Lifetime
- 1997-06-19 UA UA98126686A patent/UA49890C2/uk unknown
- 1997-06-19 AT AT97928123T patent/ATE208208T1/de active
- 1997-06-19 DK DK97928123.5T patent/DK0921812T4/da active
- 1997-06-20 ZA ZA9705470A patent/ZA975470B/xx unknown
-
1998
- 1998-12-02 IL IL127366A patent/IL127366A/en not_active IP Right Cessation
- 1998-12-18 NO NO19985981A patent/NO324430B1/no not_active IP Right Cessation
-
2009
- 2009-05-07 JP JP2009112970A patent/JP2009235075A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9709845A (pt) | Preparação aquosa de insulina formulação farmacêutica parenteral e processo para aumentar a estabilidade química de uma preparação de insulina | |
BR9709844A (pt) | Preparação aquosa de insulina formulação farmacêutica parenteral usos de um carboidrato n o-redutor ou reduzido e de manitol sorbitol xilitol inositol trealose sacarose ou qualquer sua mistura e processo de fabricação de uma preparação de insulina | |
PT1172114E (pt) | Preparacoes concentradas e estaveis de insulina para administracao pulmonar | |
EE04681B1 (et) | 3,6-poolketaalid 9a-asaliidide klassist, nende valmistamismeetod ja farmatseutiline kompositsioon | |
IT8847871A0 (it) | Ne e loro impiego come medicamenti derivati peptidici,loro preparazio- | |
IT8720260A0 (it) | Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti. | |
BR9404225A (pt) | Formulação de substância ativa, aplicação, composições, medicamentos e processo para a preparação das formulações | |
GR1001511B (el) | Στεροειδείς συν?έσεις. | |
IT1229491B (it) | Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali | |
IT1227436B (it) | Derivati di 1-azabicicloalcani, loro procedimento di preparazione e loro applicazione come farmaci | |
IT1233446B (it) | Derivati della 3 piperidinocarbaldeide ossima, loro procedimento di preparazione e loro applicazione come farmaci | |
ATE196914T1 (de) | Lh-rh analoge mit starrer konformation, deren verwendungen und pharmazeutische zusammensetzungen | |
ES2060440T3 (es) | Derivados de acidos 1,4-dihidropiridin-dicarboxilicos aril-quinolil substituidos, procedimiento para su fabricacion y su uso en medicamentos. | |
IT8748235A0 (it) | Peptidi e derivati peptidici, loro preparazione e loro impiego come medicamenti | |
BR9710629A (pt) | Composi-Æo farmac-utica processo para sua prepara-Æo composto para utiliza-Æo como agente terap-utico e utiliza-Æo e utiliza-Æo de um composto | |
IT1237783B (it) | Derivati di ferro-albumina biodisponibile, loro procedimento di preparazione e relative composizioni farmaceutiche. | |
BR9813037A (pt) | Composto, processo para sua preparação, uso do mesmo, preparação farmacêutica, e, combinação desta com pelo menos uma outra substância ativa | |
ATE204286T1 (de) | Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge | |
IT8620737A0 (it) | Composizioni farmaceutiche contenenti levodopa metil estere, loro procedimento di preparazione e relative applicazioni terapeutiche. | |
IT8719221A0 (it) | Composizioni farmaceutiche contenenti levodopa metil estere, loro prodecimento di preparazione e relative applicazioni terapeutiche. | |
FR2583755B1 (fr) | Derives de 10 a-methoxy-6-methyl-ergoline, leur preparation et leur application en tant que medicament | |
FR2702768B1 (fr) | Nouveaux mono-amides de la Carpaïne, leur préparation et leur application en tant que médicaments. | |
ES2079650T3 (es) | Acido 4-((tiofeno-2-carbonil)oxi)pirrolidin-2-carboxilico, su preparacion y su uso como agente antiinflamatorio y antidistrofico. | |
SE8503513D0 (sv) | Farmaceutiska och kosmetiska kompositioner, vilka som verksam bestandsdel innehaller acetyl-10-triacetoxi-1,8,9-antracen | |
IT1187729B (it) | Derivati fenilpiridinici,loro preparazione e relative formulazioni farmaceutiche |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/12/2008, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 02.12.2018 |