BR9708099B8 - Microgotícula de propofol e composição farmacêutica compreendendo a referida microgotícula. - Google Patents

Microgotícula de propofol e composição farmacêutica compreendendo a referida microgotícula.

Info

Publication number
BR9708099B8
BR9708099B8 BRPI9708099-3B8A BR9708099A BR9708099B8 BR 9708099 B8 BR9708099 B8 BR 9708099B8 BR 9708099 A BR9708099 A BR 9708099A BR 9708099 B8 BR9708099 B8 BR 9708099B8
Authority
BR
Brazil
Prior art keywords
propofol
microgothicle
pharmaceutical composition
pml
devoid
Prior art date
Application number
BRPI9708099-3B8A
Other languages
English (en)
Other versions
BR9708099B1 (pt
BR9708099A (pt
Inventor
Duncan H Haynes
Original Assignee
Res Triangle Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24469788&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9708099(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Res Triangle Pharm Ltd filed Critical Res Triangle Pharm Ltd
Publication of BR9708099A publication Critical patent/BR9708099A/pt
Publication of BR9708099B1 publication Critical patent/BR9708099B1/pt
Publication of BR9708099B8 publication Critical patent/BR9708099B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Motorcycle And Bicycle Frame (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)
BRPI9708099-3B8A 1996-03-19 1997-03-17 Microgotícula de propofol e composição farmacêutica compreendendo a referida microgotícula. BR9708099B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/616,511 US5637625A (en) 1996-03-19 1996-03-19 Propofol microdroplet formulations
US616511 1996-03-19
PCT/US1997/004168 WO1997034588A1 (en) 1996-03-19 1997-03-17 Propofol microdroplet formulations

Publications (3)

Publication Number Publication Date
BR9708099A BR9708099A (pt) 2000-01-04
BR9708099B1 BR9708099B1 (pt) 2010-02-23
BR9708099B8 true BR9708099B8 (pt) 2014-04-29

Family

ID=24469788

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9708099-3B8A BR9708099B8 (pt) 1996-03-19 1997-03-17 Microgotícula de propofol e composição farmacêutica compreendendo a referida microgotícula.

Country Status (19)

Country Link
US (1) US5637625A (pt)
EP (1) EP0796616B1 (pt)
JP (1) JP2000507244A (pt)
KR (1) KR100484516B1 (pt)
CN (1) CN1124845C (pt)
AT (1) ATE182074T1 (pt)
AU (1) AU719756B2 (pt)
BR (1) BR9708099B8 (pt)
CA (1) CA2249375C (pt)
DE (1) DE69700317T2 (pt)
DK (1) DK0796616T3 (pt)
ES (1) ES2135969T3 (pt)
FI (1) FI982009A0 (pt)
GR (1) GR3031414T3 (pt)
HU (1) HU225046B1 (pt)
NO (1) NO324498B1 (pt)
NZ (1) NZ331669A (pt)
RU (1) RU2186564C2 (pt)
WO (1) WO1997034588A1 (pt)

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US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US6465016B2 (en) * 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
CH692322A5 (it) * 1997-05-26 2002-05-15 Westy Ag Formulazione iniettabile limpida di Propofol.
CN100462066C (zh) * 1997-06-27 2009-02-18 美国生物科学有限公司 药剂的新制剂及其制备和应用方法
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
CA2319810C (en) * 1998-02-10 2008-12-23 Gensia Sicor Inc. Propofol composition containing sulfite
IL137734A0 (en) * 1998-02-11 2001-10-31 Res Triangle Pharm Ltd Method and composition for treatment of inflammatory conditions
US6254853B1 (en) * 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
AU764001B2 (en) 1998-05-29 2003-08-07 Skyepharma Canada Inc. Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
JP4198318B2 (ja) * 1998-08-19 2008-12-17 ヤーゴテック アクチェンゲゼルシャフト プロポフォールの注射可能水性分散物
US6150423A (en) * 1998-10-15 2000-11-21 Phoenix Scientific, Inc. Propofol-based anesthetic and method of making same
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
CA2349203C (en) 1998-11-20 2013-05-21 Rtp Pharma Inc. Dispersible phospholipid stabilized microparticles
CN1151782C (zh) * 1999-01-28 2004-06-02 迪内希·尚蒂拉尔·帕特尔 一种具有哺乳动物麻醉的诱导和保持以及镇静用途的药用注射液
US6177477B1 (en) * 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
US6100302A (en) * 1999-04-05 2000-08-08 Baxter International Inc. Propofol formulation with enhanced microbial characteristics
GB2350297A (en) * 1999-05-27 2000-11-29 Abbott Lab Injectable halogenated anesthetic formulation in emulsion form
CN1174741C (zh) * 1999-09-21 2004-11-10 Rtp药品公司 生物活性物质的表面改性微粒组合物
US6071933A (en) * 1999-12-03 2000-06-06 Diversified Medical Innovations, Inc. Homogeneous remifentanil-propofol blend for patient controlled anesthesia and process for its use
GB2359747B (en) 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
EP1276465B1 (en) 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
US6726919B2 (en) 2000-06-16 2004-04-27 Rtp Pharma, Inc. Injectable dispersion of propofol
US6623765B1 (en) * 2000-08-01 2003-09-23 University Of Florida, Research Foundation, Incorporated Microemulsion and micelle systems for solubilizing drugs
ATE424811T1 (de) 2000-08-31 2009-03-15 Jagotec Ag Gemahlene partikel
AU2001255515A1 (en) * 2000-09-20 2002-04-02 Skyepharma Canada Inc. Stabilised fibrate microparticles
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
JP2004523552A (ja) * 2001-02-22 2004-08-05 スカイファーマ・カナダ・インコーポレーテッド 低減した摂食−絶食効果を伴うフィブラート−スタチンの組合わせ
EP1408932A4 (en) 2001-06-23 2009-02-25 Lyotropic Therapeutics Inc PARTICLES WITH ENHANCED SOLUBILIZATION CAPACITY
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
US6815555B2 (en) 2001-09-26 2004-11-09 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
JP2005504090A (ja) * 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
JP2005517679A (ja) * 2001-12-28 2005-06-16 ギルフォード ファーマシューティカルズ インコーポレイテッド プロポフォールの水溶性プロドラッグの水ベースの薬学的製剤
DE60309300T3 (de) * 2002-03-20 2011-02-24 Elan Pharma International Ltd. Nanopartikelzusammensetzungen von angiogeneseinhibitoren
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
PL373850A1 (en) * 2002-04-08 2005-09-19 Guilford Pharmaceuticals, Inc. Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same
US20040220283A1 (en) * 2002-07-29 2004-11-04 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
EP1539122B1 (en) * 2002-07-29 2014-01-29 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
CN1708270A (zh) * 2002-10-29 2005-12-14 转化医药公司 丙泊酚与半胱氨酸
CA2508441A1 (en) * 2002-12-06 2004-06-24 Otsuka Pharmaceutical Factory, Inc. Propofol-containing fat emulsions
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US7182948B2 (en) * 2003-08-04 2007-02-27 Ko Manufacturing, Inc. Topical veterinary compositions and methods for the treatment and prevention of infection
JP5032849B2 (ja) * 2004-01-14 2012-09-26 ギリアード サイエンシーズ， インコーポレイテッド 薬物送達に有用な脂質ベースの分散物
US7125954B2 (en) 2005-01-27 2006-10-24 General Electric Company Method for producing polyether polymers
MX2007015183A (es) * 2005-06-14 2008-02-19 Baxter Int Formulaciones farmaceuticas para minimizar las interacciones farmaco-farmaco.
CN101291658B (zh) * 2005-08-31 2014-04-16 阿布拉科斯生物科学有限公司 用于制备稳定性增加的水难溶性药物的组合物和方法
TWI417114B (zh) * 2005-08-31 2013-12-01 Abraxis Bioscience Llc 具有增強穩定性之弱水溶性藥物之組合物及其製備方法
EP1954245A2 (en) * 2005-11-15 2008-08-13 Baxter International Inc. Compositions of lipoxygenase inhibitors
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
RU2535001C1 (ru) * 2013-07-11 2014-12-10 Общество с ограниченной ответственностью "ВИК-здоровье животных" Микроколлоидный раствор пропофола для анестезии
CN107708670A (zh) * 2015-06-01 2018-02-16 奥托泰利克有限责任公司 磷脂包衣的治疗剂纳米颗粒和有关的方法
US20160346219A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
WO2017218630A2 (en) * 2016-06-15 2017-12-21 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
WO2021123117A1 (de) * 2019-12-20 2021-06-24 Fresenius Kabi Austria Gmbh Verfahren zur herstellung von öl-in-wasser-emulsionen
EP4056038A1 (en) * 2021-03-10 2022-09-14 Basf Se Microparticles containing active substances

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US4798846A (en) * 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
GB1472793A (en) * 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
US4725442A (en) * 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
US4622219A (en) * 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
DE4132677C2 (de) * 1991-10-01 1995-08-24 Braun Melsungen Ag Flüchtige Inhalationsnarkotika enthaltende Liposomen, ihre Herstellung und Verwendung
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US5496537A (en) * 1995-03-23 1996-03-05 Henry; Richard A. Propofol hydrofluorocarbon propellant formulations

Also Published As

Publication number Publication date
GR3031414T3 (en) 2000-01-31
AU719756B2 (en) 2000-05-18
NO324498B1 (no) 2007-10-29
JP2000507244A (ja) 2000-06-13
ATE182074T1 (de) 1999-07-15
US5637625A (en) 1997-06-10
DK0796616T3 (da) 1999-11-29
FI982009A (fi) 1998-09-17
FI982009A0 (fi) 1998-09-17
CA2249375C (en) 2002-06-18
WO1997034588A1 (en) 1997-09-25
BR9708099B1 (pt) 2010-02-23
CA2249375A1 (en) 1997-09-25
CN1124845C (zh) 2003-10-22
CN1218398A (zh) 1999-06-02
HUP9902553A3 (en) 2001-04-28
KR20000064762A (ko) 2000-11-06
ES2135969T3 (es) 1999-11-01
HUP9902553A2 (hu) 2000-10-28
NO984370D0 (no) 1998-09-18
EP0796616B1 (en) 1999-07-14
DE69700317T2 (de) 1999-12-02
KR100484516B1 (ko) 2005-09-02
RU2186564C2 (ru) 2002-08-10
NZ331669A (en) 2000-01-28
DE69700317D1 (de) 1999-08-19
BR9708099A (pt) 2000-01-04
EP0796616A1 (en) 1997-09-24
NO984370L (no) 1998-09-18
AU2329297A (en) 1997-10-10
HU225046B1 (hu) 2006-05-29

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: A61K 9/107, A61K 31/05, A61P 23/00

Ipc: A61K 31/05 (2008.04), A61K 9/107 (2008.04)

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/02/2010, OBSERVADAS AS CONDICOES LEGAIS.

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI-52400.061597/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132275-84.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: RAQUALIA PHARMA INC., RESEARCH TRIANGLE PHAMACEUTICALS LTD., SHIONOGI AND CO., LTD. E SIEMSENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI-52400.061597/2013 SECAO JUDICIARIA DO RIO DE JANEIRO-13A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO0132275-84.2013.4.02.5101 AUTOR: INPI-INSTITUTO NACIONAL DE PROPRIEDADE INDUSTRIAL REU(S): RAQUALIA PHARMA INC.,RESEARCH TRIANGLE PHARMACEUTICALS LTD.,SHIONOGIAND CO.,LTD.E SIEMSENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH DECISAO: HOMOLOGO OS ACORDOS FIRMADOS, JULGANDO EXTINTO O PROCESSO COM RESOLUCAO DE MERITO, FORTE NO ART.269,III DO CODIGO DE PROCESSO CIVIL

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: CONFORME DETERMINACAO DO MM. JUIZ DA 13A VARA FEDERAL DO RIO DE JANEIRO, O PRAZO DE VIGENCIA DA PATENTE CONCEDIDA EM 23/02/2010 ATRAVES DA RPI 2042, E RETIFICADO PARA 17/03/2017.