BR9707601A - Composição farmacêutica para tratar de um distúrbio hepático e composto derivado de triterpeno. - Google Patents
Composição farmacêutica para tratar de um distúrbio hepático e composto derivado de triterpeno.Info
- Publication number
- BR9707601A BR9707601A BR9707601-5A BR9707601A BR9707601A BR 9707601 A BR9707601 A BR 9707601A BR 9707601 A BR9707601 A BR 9707601A BR 9707601 A BR9707601 A BR 9707601A
- Authority
- BR
- Brazil
- Prior art keywords
- triterpene
- treat
- pharmaceutical composition
- compound derived
- coor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA PARA TRATAR DE UM DISTúRBIO HEPáTICO E COMPOSTO DERIVADO DE TRITERPENO". é apresentado um derivado truterpeno útil para o tratamento de distúrbios hepáticos. Este composto compreende como um ingrediente ativo um derivado triterpeno representado pela seguinte fórmula (I) ou um seu sal: em que R^ 1^ representa um grupo hidroxila, arilmetilóxi, alcóxi inferior ou alcanoilóxi inferior, R^ 2^ representa alquila inferior, alquenila inferior, -CH~ 2~OR~ 5~, formila, -COOR^ 6^ ou CH~ 2~N(R^ 7^)R^ 8^, ou R^ 1^ e R^ 2^ podem combinar-se entre si para formarem -O-C(R^ 9)R^ 10^ -O-CH~ 2~, R^ 3^ e R^ 4^, que podem ser os mesmos ou diferentes, representam um átomo de hidrogênio, um grupo hidroxila, alquila inferior, alquenila inferior, arila, hidroximetila, -N(R^ 11^)R^ 12^, formila, -COOR^ 6^ ou -OR^ 13^, ou R^ 3^ e R^ 4^ podem combinar-se entre si para formarem oxo, hidroxiimino ou alquilideno, e X representa O, CH~ 2~ ou NH.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3782996 | 1996-02-26 | ||
| PCT/JP1997/000555 WO1997031014A1 (fr) | 1996-02-26 | 1997-02-26 | Derives triterpeniques et remedes pour maladies hepatiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9707601A true BR9707601A (pt) | 2000-01-04 |
Family
ID=12508425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9707601-5A BR9707601A (pt) | 1996-02-26 | 1997-02-26 | Composição farmacêutica para tratar de um distúrbio hepático e composto derivado de triterpeno. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6201018B1 (pt) |
| EP (1) | EP0889051B1 (pt) |
| JP (1) | JP3727353B2 (pt) |
| KR (1) | KR100400601B1 (pt) |
| CN (1) | CN100334104C (pt) |
| AU (1) | AU1811597A (pt) |
| BR (1) | BR9707601A (pt) |
| CA (1) | CA2247327A1 (pt) |
| DE (1) | DE69706037T2 (pt) |
| DK (1) | DK0889051T3 (pt) |
| ES (1) | ES2161439T3 (pt) |
| RU (1) | RU2168517C2 (pt) |
| TW (1) | TW505653B (pt) |
| WO (1) | WO1997031014A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100530278B1 (ko) * | 1997-02-28 | 2006-04-06 | 동국제약 주식회사 | 아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제 |
| WO2005021007A1 (fr) * | 2003-08-28 | 2005-03-10 | Obschestvo S Ogranichennoi Otvetstvennostju 'berezovy Mir' | Prevention et traitement de l'hepatite virale b |
| US20060293388A1 (en) * | 2003-10-02 | 2006-12-28 | Universidade Federal Do Rio De Janeiro | Pomolic acid, its isomers, derivatives and their uses, pharmaceutical composition, method to prepare the pharmaceutical composition and method for treating multidrug resistant tumours |
| JPWO2011074607A1 (ja) | 2009-12-15 | 2013-04-25 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | トリテルペン誘導体およびｃ型慢性肝炎の予防または治療のための薬剤 |
| TW201136946A (en) * | 2009-12-15 | 2011-11-01 | Meiji Seika Kaisha | Prophylactic or therapeutic agent for chronic hepatitis c |
| WO2012133733A1 (ja) * | 2011-03-30 | 2012-10-04 | 学校法人久留米大学 | がん細胞増殖抑制剤 |
| US20120307467A1 (en) * | 2011-06-03 | 2012-12-06 | Navarro Luis A | Oxygen-Barrier Packaged Surface Mount Device |
| EP2723357A4 (en) | 2011-06-21 | 2015-04-01 | Bvw Holding Ag | MEDICAL DEVICE COMPRISING BOSWELLIC ACID |
| KR102138743B1 (ko) | 2012-04-27 | 2020-07-29 | 싸이톰스 테라퓨틱스, 인크. | 표피 성장 인자 수용체에 결합하는 활성화가능한 항체 및 이의 사용 방법 |
| US9540440B2 (en) | 2013-10-30 | 2017-01-10 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| US9737623B2 (en) | 2013-12-11 | 2017-08-22 | Cytomx Therapeutics, Inc. | Antibodies that bind activatable antibodies and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU528415B2 (en) * | 1978-03-31 | 1983-04-28 | Otsuka Pharmaceutical Co., Ltd. | Anticomplementary agents |
| JPS6185344A (ja) | 1984-10-03 | 1986-04-30 | Otsuka Pharmaceut Co Ltd | トリテルペン誘導体 |
| US5064823A (en) * | 1988-08-24 | 1991-11-12 | Research Triangle Institute | Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers |
| US5723149A (en) * | 1990-11-21 | 1998-03-03 | Lvmh Recherche | Use of medicago saponins for the preparation of cosmetic or pharmaceutical compositions, especially dermatological compositions, promoting renewal of the epidermis, stimulating hair regrowth or delaying hair loss |
| JPH07583B2 (ja) * | 1990-11-21 | 1995-01-11 | 北海道糖業株式会社 | 水溶性五環性トリテルペン包接化合物及びその製造方法並びにそれを利用した食品、飲料、口腔用組成物 |
| FR2669225B1 (fr) | 1990-11-21 | 1993-11-12 | Lvmh Recherche Gie | Utilisation de saponines de medicago pour la preparation de compositions cosmetiques ou pharmaceutiques, notamment dermatologiques. |
| CA2226346C (en) * | 1995-07-07 | 2007-08-28 | Meiji Seika Kaisha, Ltd. | Triterpene derivatives and pharmaceuticals for treating hepatic disorders |
| US5650167A (en) * | 1995-11-16 | 1997-07-22 | Dawa Incorporated | Method and composition for treating hepatitis B |
-
1997
- 1997-02-25 TW TW086102256A patent/TW505653B/zh not_active IP Right Cessation
- 1997-02-26 KR KR10-1998-0706677A patent/KR100400601B1/ko not_active IP Right Cessation
- 1997-02-26 ES ES97903610T patent/ES2161439T3/es not_active Expired - Lifetime
- 1997-02-26 CA CA002247327A patent/CA2247327A1/en not_active Abandoned
- 1997-02-26 WO PCT/JP1997/000555 patent/WO1997031014A1/ja active IP Right Grant
- 1997-02-26 JP JP53000597A patent/JP3727353B2/ja not_active Expired - Fee Related
- 1997-02-26 DK DK97903610T patent/DK0889051T3/da active
- 1997-02-26 DE DE69706037T patent/DE69706037T2/de not_active Expired - Lifetime
- 1997-02-26 EP EP97903610A patent/EP0889051B1/en not_active Expired - Lifetime
- 1997-02-26 RU RU98117785/04A patent/RU2168517C2/ru not_active IP Right Cessation
- 1997-02-26 CN CNB971926123A patent/CN100334104C/zh not_active Expired - Fee Related
- 1997-02-26 US US09/125,776 patent/US6201018B1/en not_active Expired - Lifetime
- 1997-02-26 AU AU18115/97A patent/AU1811597A/en not_active Abandoned
- 1997-02-26 BR BR9707601-5A patent/BR9707601A/pt not_active Application Discontinuation
-
2001
- 2001-08-06 US US09/921,983 patent/US6593364B2/en not_active Expired - Fee Related
-
2003
- 2003-02-24 US US10/370,710 patent/US7153979B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2161439T3 (es) | 2001-12-01 |
| US20030195182A1 (en) | 2003-10-16 |
| US7153979B2 (en) | 2006-12-26 |
| RU2168517C2 (ru) | 2001-06-10 |
| DE69706037T2 (de) | 2002-06-06 |
| EP0889051A4 (en) | 1999-06-16 |
| AU1811597A (en) | 1997-09-10 |
| CA2247327A1 (en) | 1997-08-28 |
| EP0889051A1 (en) | 1999-01-07 |
| JP3727353B2 (ja) | 2005-12-14 |
| TW505653B (en) | 2002-10-11 |
| DK0889051T3 (da) | 2001-10-15 |
| KR19990087275A (ko) | 1999-12-15 |
| US6201018B1 (en) | 2001-03-13 |
| WO1997031014A1 (fr) | 1997-08-28 |
| US20020016481A1 (en) | 2002-02-07 |
| EP0889051B1 (en) | 2001-08-08 |
| KR100400601B1 (ko) | 2004-02-18 |
| CN1212702A (zh) | 1999-03-31 |
| DE69706037D1 (de) | 2001-09-13 |
| CN100334104C (zh) | 2007-08-29 |
| US6593364B2 (en) | 2003-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO, DE ACORDO COM ARTIGO 8O DA LPI |