ES2161439T3 - Derivados triterpenicos medicamentos para enfermedades hepaticas. - Google Patents

Derivados triterpenicos medicamentos para enfermedades hepaticas.

Info

Publication number
ES2161439T3
ES2161439T3 ES97903610T ES97903610T ES2161439T3 ES 2161439 T3 ES2161439 T3 ES 2161439T3 ES 97903610 T ES97903610 T ES 97903610T ES 97903610 T ES97903610 T ES 97903610T ES 2161439 T3 ES2161439 T3 ES 2161439T3
Authority
ES
Spain
Prior art keywords
short chain
medicines
rent
triterpen
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903610T
Other languages
English (en)
Inventor
Kazue Sasaki
Nobuto Minowa
S Nishiyama
H Kuzuhara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of ES2161439T3 publication Critical patent/ES2161439T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN DERIVADO DE TRITERPENO UTIL PARA EL TRATAMIENTO DE TRASTORNOS HEPATICOS. ESTE COMPUESTO INCLUYE COMO PRINCIPIO ACTIVO UN DERIVADO TRITERPENO REPRESENTADO POR LA SIGUIENTE FORMULA (I) O UNA SAL DEL MISMO: DONDE R 1 REPRESENTA UN GRUPO HIDROXILO, ARILMETILOXI, ALCOXI DE CADENA CORTA, O ALCANOILOXI DE CADENA CORTA, R 2 REPRESENTA ALQUILO DE CAD ENA CORTA, ALQUENILO DE CADENA CORTA, CH 2 OR 5 , FORMILO, - COOR 6 , O CH 2 N(R 7 )R 8 , O R 1 Y R 2 PUEDEN COMBINARSE ENTRE SI PARA FORMAR UN - O - C(R9 )R 10 O - CH 2 -, R 3 Y R 4 , QUE PU EDEN SER IGUALES O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO, UN GRUPO HIDROXILO, UN ALQUILO DE CADENA CORTA, ALQUENILO DE CADENA CORTA, ARILO, HIDROXIMETILO, - N(R 11 )R 12 , FORMILO, COOR 6 , U - OR 13 , O R 3 Y R 4 PUEDEN COMBINARSE ENTRE SI PARA FORMAR OXO, HIDROXIIMINO, O ALQUILIDENO Y X REPRESENTA O, CH 2 O NH.
ES97903610T 1996-02-26 1997-02-26 Derivados triterpenicos medicamentos para enfermedades hepaticas. Expired - Lifetime ES2161439T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3782996 1996-02-26

Publications (1)

Publication Number Publication Date
ES2161439T3 true ES2161439T3 (es) 2001-12-01

Family

ID=12508425

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97903610T Expired - Lifetime ES2161439T3 (es) 1996-02-26 1997-02-26 Derivados triterpenicos medicamentos para enfermedades hepaticas.

Country Status (14)

Country Link
US (3) US6201018B1 (es)
EP (1) EP0889051B1 (es)
JP (1) JP3727353B2 (es)
KR (1) KR100400601B1 (es)
CN (1) CN100334104C (es)
AU (1) AU1811597A (es)
BR (1) BR9707601A (es)
CA (1) CA2247327A1 (es)
DE (1) DE69706037T2 (es)
DK (1) DK0889051T3 (es)
ES (1) ES2161439T3 (es)
RU (1) RU2168517C2 (es)
TW (1) TW505653B (es)
WO (1) WO1997031014A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100530278B1 (ko) * 1997-02-28 2006-04-06 동국제약 주식회사 아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제
WO2005021007A1 (fr) * 2003-08-28 2005-03-10 Obschestvo S Ogranichennoi Otvetstvennostju 'berezovy Mir' Prevention et traitement de l'hepatite virale b
US20060293388A1 (en) * 2003-10-02 2006-12-28 Universidade Federal Do Rio De Janeiro Pomolic acid, its isomers, derivatives and their uses, pharmaceutical composition, method to prepare the pharmaceutical composition and method for treating multidrug resistant tumours
TW201136946A (en) * 2009-12-15 2011-11-01 Meiji Seika Kaisha Prophylactic or therapeutic agent for chronic hepatitis c
CN102656181A (zh) 2009-12-15 2012-09-05 明治制果药业株式会社 三萜衍生物及用于预防或治疗c型慢性肝炎的药剂
WO2012133733A1 (ja) * 2011-03-30 2012-10-04 学校法人久留米大学 がん細胞増殖抑制剤
US20120307467A1 (en) * 2011-06-03 2012-12-06 Navarro Luis A Oxygen-Barrier Packaged Surface Mount Device
WO2012177825A1 (en) 2011-06-21 2012-12-27 Bvw Holding Ag Medical device comprising boswellic acid
RU2713121C2 (ru) 2012-04-27 2020-02-03 Сайтомкс Терапьютикс, Инк. Активируемые антитела, которые связываются с рецептором эпидермального фактора роста, и способы их применения
US9540440B2 (en) 2013-10-30 2017-01-10 Cytomx Therapeutics, Inc. Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
WO2015089283A1 (en) 2013-12-11 2015-06-18 Cytomx Therapeutics, Inc. Antibodies that bind activatable antibodies and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU528415B2 (en) * 1978-03-31 1983-04-28 Otsuka Pharmaceutical Co., Ltd. Anticomplementary agents
JPS6185344A (ja) * 1984-10-03 1986-04-30 Otsuka Pharmaceut Co Ltd トリテルペン誘導体
US5064823A (en) * 1988-08-24 1991-11-12 Research Triangle Institute Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers
FR2669225B1 (fr) 1990-11-21 1993-11-12 Lvmh Recherche Gie Utilisation de saponines de medicago pour la preparation de compositions cosmetiques ou pharmaceutiques, notamment dermatologiques.
JPH07583B2 (ja) * 1990-11-21 1995-01-11 北海道糖業株式会社 水溶性五環性トリテルペン包接化合物及びその製造方法並びにそれを利用した食品、飲料、口腔用組成物
US5723149A (en) * 1990-11-21 1998-03-03 Lvmh Recherche Use of medicago saponins for the preparation of cosmetic or pharmaceutical compositions, especially dermatological compositions, promoting renewal of the epidermis, stimulating hair regrowth or delaying hair loss
RU2182154C2 (ru) * 1995-07-07 2002-05-10 Мейдзи Сейка Кабусики Кайся Фармацевтическая композиция, производные тритерпена
US5650167A (en) * 1995-11-16 1997-07-22 Dawa Incorporated Method and composition for treating hepatitis B

Also Published As

Publication number Publication date
AU1811597A (en) 1997-09-10
EP0889051B1 (en) 2001-08-08
JP3727353B2 (ja) 2005-12-14
BR9707601A (pt) 2000-01-04
CA2247327A1 (en) 1997-08-28
KR100400601B1 (ko) 2004-02-18
DE69706037T2 (de) 2002-06-06
EP0889051A1 (en) 1999-01-07
CN1212702A (zh) 1999-03-31
RU2168517C2 (ru) 2001-06-10
US6201018B1 (en) 2001-03-13
DK0889051T3 (da) 2001-10-15
TW505653B (en) 2002-10-11
US7153979B2 (en) 2006-12-26
US20020016481A1 (en) 2002-02-07
WO1997031014A1 (fr) 1997-08-28
EP0889051A4 (en) 1999-06-16
US6593364B2 (en) 2003-07-15
CN100334104C (zh) 2007-08-29
KR19990087275A (ko) 1999-12-15
US20030195182A1 (en) 2003-10-16
DE69706037D1 (de) 2001-09-13

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