BR9707016A - Métodos e composições para analisar moléculas de ácido nuclêico utilizando técnicas dimensionamento. - Google Patents

Métodos e composições para analisar moléculas de ácido nuclêico utilizando técnicas dimensionamento.

Info

Publication number
BR9707016A
BR9707016A BR9707016-5A BR9707016A BR9707016A BR 9707016 A BR9707016 A BR 9707016A BR 9707016 A BR9707016 A BR 9707016A BR 9707016 A BR9707016 A BR 9707016A
Authority
BR
Brazil
Prior art keywords
nucleic acid
acid molecules
compositions
methods
sizing techniques
Prior art date
Application number
BR9707016-5A
Other languages
English (en)
Inventor
Jeffrey Van Ness
John C Tabone
J Jeffry Howbert
John T Mulligan
Original Assignee
Rapigene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rapigene Inc filed Critical Rapigene Inc
Publication of BR9707016A publication Critical patent/BR9707016A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

"MéTODOS E COMPOSIçõES PARA ANALISAR MOLéCULAS DE áCIDO NUCLêICO UTILIZANDO TéCNICAS DE DIMENSIONAMENTO". Marcadores e elementos de ligação especificamente configurados para uma grande variedade de reações de ácido nuclêico são descritos, que são adequados para uma grande variedade de reações de ácido nuclêico onde é necessário a separação das moléculas de ácido nuclêico baseada em tamanho.
BR9707016-5A 1996-01-23 1997-01-23 Métodos e composições para analisar moléculas de ácido nuclêico utilizando técnicas dimensionamento. BR9707016A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1453696P 1996-01-23 1996-01-23
US2048796P 1996-06-04 1996-06-04
PCT/US1997/001046 WO1997027325A2 (en) 1996-01-23 1997-01-23 Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques

Publications (1)

Publication Number Publication Date
BR9707016A true BR9707016A (pt) 2000-01-04

Family

ID=26686209

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9707016-5A BR9707016A (pt) 1996-01-23 1997-01-23 Métodos e composições para analisar moléculas de ácido nuclêico utilizando técnicas dimensionamento.

Country Status (18)

Country Link
EP (2) EP0840804B1 (pt)
JP (2) JP2000503845A (pt)
KR (1) KR100482915B1 (pt)
CN (1) CN1202260C (pt)
AT (2) ATE191515T1 (pt)
AU (1) AU717945B2 (pt)
BR (1) BR9707016A (pt)
CA (1) CA2243546C (pt)
CZ (1) CZ228598A3 (pt)
DE (2) DE69701612T2 (pt)
DK (1) DK0840804T3 (pt)
ES (1) ES2145580T3 (pt)
GR (1) GR3033887T3 (pt)
HU (1) HUP9901856A3 (pt)
NZ (1) NZ331043A (pt)
PL (1) PL328239A1 (pt)
PT (1) PT840804E (pt)
WO (1) WO1997027325A2 (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6401267B1 (en) 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
WO1997027327A2 (en) * 1996-01-23 1997-07-31 Rapigene, Inc. Methods and compositions for detecting binding of ligand pair using non-fluorescent label
ATE340869T1 (de) * 1997-01-15 2006-10-15 Xzillion Gmbh & Co Kg Massenmarkierte hybridisierungssonden
US6699668B1 (en) 1997-01-15 2004-03-02 Xzillion Gmbh & Co. Mass label linked hybridisation probes
AU6186398A (en) * 1997-02-24 1998-09-09 Tm Technologies, Inc. Process for selecting anti-sense oligonucleotides
ES2200355T3 (es) * 1997-07-22 2004-03-01 Qiagen Genomics Inc Metodos y composiciones para analizar acidos nucleicos por espectrometria de masas.
AU9400398A (en) * 1997-09-19 1999-04-05 Genetrace Systems, Inc. Dna typing by mass spectrometry with polymorphic dna repeat markers
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
KR20020037042A (ko) * 1999-08-31 2002-05-17 퀴아젠 지노믹스 인크. 광절단가능한 결합(들)을 갖는 에난티오머적으로-농축된화합물 및 이와 관련된 방법
US6379889B1 (en) 1999-11-04 2002-04-30 Agilent Technologies, Inc. Multiplexing methods for identifying nucleic acids using denaturing liquid chromatography
DE10021204A1 (de) * 2000-04-25 2001-11-08 Epigenomics Ag Verfahren zur hochparallelen Analyse von Polymorphismen
US7160735B2 (en) 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7771929B2 (en) 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US6716634B1 (en) 2000-05-31 2004-04-06 Agilent Technologies, Inc. Increasing ionization efficiency in mass spectrometry
DE10027040A1 (de) * 2000-06-02 2001-12-06 Basf Lynx Bioscience Ag Verfahren zur Herstellung von DNA-Arrays
EP1170379A1 (en) * 2000-06-30 2002-01-09 Centre National de Genotypage Sample generation for genotyping by mass spectrometry
FI115139B (fi) 2001-01-10 2005-03-15 Valtion Teknillinen Menetelmä ja testipakkaus solu- tai kudosnäytteissä olevien polynukleotidien määrässä tapahtuvien vaihteluiden kvantitatiiviseen ja/tai vertailevaan arvioimiseen
DE10108453B4 (de) * 2001-02-22 2005-10-20 Bruker Daltonik Gmbh Massenspektrometrische Mutationsanalyse mit photolytisch spaltbaren Primern
DE10112387B4 (de) * 2001-03-15 2004-03-25 Bruker Daltonik Gmbh Massenspektrometrische Genotypisierung
CZ20033143A3 (en) 2001-05-21 2004-04-14 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
US7041459B2 (en) 2001-05-21 2006-05-09 Monogram Biosciences, Inc. Analyzing phosphorylated proteins
WO2002097112A2 (en) 2001-05-26 2002-12-05 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
JP2005517900A (ja) * 2001-11-21 2005-06-16 アプレラ コーポレイション デジタルアッセイ
US7192560B2 (en) 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US7347976B2 (en) 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
EP1978108A3 (en) 2002-01-08 2009-01-07 Siemens Healthcare Diagnostics GmbH Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy
DE60219132T2 (de) * 2002-02-01 2007-12-13 Bruker Daltonik Gmbh Mutationsanalyse mittels PCR und Massenspektrometrie
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7402397B2 (en) 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
FI20021325A0 (fi) * 2002-07-05 2002-07-05 Valtion Teknillinen Menetelmä ja reagenssipakkaus yksittäisten polynukleotidien määrän määrittämiseksi
US7981600B2 (en) 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
GB0518585D0 (en) 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
EP1936369A1 (en) * 2006-12-20 2008-06-25 Agilent Technologies, Inc. Selective excitation of OH-containing solvents
GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
GB0809488D0 (en) 2008-05-23 2008-07-02 Electrophoretics Ltd Mass spectrometric analysis
GB0811574D0 (en) * 2008-06-24 2008-07-30 Trillion Genomics Ltd Characterising planar samples by mass spectrometry
EP2180065A1 (en) * 2008-10-24 2010-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method of reducing the molecular weight of at least one PCR product for its detection while maintaining its identity
JP5283178B2 (ja) * 2009-03-05 2013-09-04 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
GB0921665D0 (en) 2009-12-10 2010-01-27 Trillion Genomics Ltd Phobes
DK2588144T3 (en) 2010-07-02 2018-07-23 Ventana Med Syst Inc Detection of targets using mass markers and mass spectrometry
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
GB201322567D0 (en) 2013-12-19 2014-02-05 Electrophoretics Ltd Mass labels
CN110687191A (zh) * 2019-10-22 2020-01-14 宁波大学 基于基质辅助激光解吸电离飞行时间质谱与ftir光谱联用的微生物鉴定和分型方法
CN113607829B (zh) * 2021-06-11 2023-05-30 南京品生医学检验实验室有限公司 一种检测血清中5-羟色胺和褪黑素浓度的方法
CN115337665B (zh) * 2022-09-14 2023-05-30 洛阳理工学院 微通道萃取装置辅助从黄岑根中高效分离黄芩苷的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516931A (en) * 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US5346670A (en) * 1986-12-24 1994-09-13 British Technology Group U.S.A. Inc. Phthalocyanine and tetrabenztriazaporphyrin reagents
FI80476C (fi) * 1987-10-09 1990-06-11 Orion Yhtymae Oy Foerbaettrat hybridisationsfoerfarande, vid foerfarandet anvaent redskap och reagensfoerpackning.
CA1323553C (en) * 1987-11-03 1993-10-26 Timothy George Helentjaris Method and device for improved restriction fragment length polymorphism analysis
US5003059A (en) * 1988-06-20 1991-03-26 Genomyx, Inc. Determining DNA sequences by mass spectrometry
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
WO1993005183A1 (en) * 1991-09-09 1993-03-18 Baylor College Of Medicine Method and device for rapid dna or rna sequencing determination by a base addition sequencing scheme
AU3919293A (en) * 1992-03-27 1993-11-08 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
HUT72495A (en) * 1992-10-01 1996-05-28 Cold Spring Harbor Lab Complex combinatorial chemical libraries encoded with tags
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
ATE267877T1 (de) * 1993-01-07 2004-06-15 Sequenom Inc Dns - sequenzierung durch massenspektronomie
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
WO1997027327A2 (en) * 1996-01-23 1997-07-31 Rapigene, Inc. Methods and compositions for detecting binding of ligand pair using non-fluorescent label
ATE191750T1 (de) * 1996-01-23 2000-04-15 Rapigene Inc Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekulen

Also Published As

Publication number Publication date
WO1997027325A2 (en) 1997-07-31
HUP9901856A3 (en) 2001-10-29
KR100482915B1 (ko) 2005-09-12
AU717945B2 (en) 2000-04-06
CN1202260C (zh) 2005-05-18
KR19990081924A (ko) 1999-11-15
DE69701612D1 (de) 2000-05-11
DE69739465D1 (de) 2009-07-30
PL328239A1 (en) 1999-01-18
DK0840804T3 (da) 2000-07-17
PT840804E (pt) 2000-10-31
HUP9901856A2 (hu) 1999-09-28
EP0840804A1 (en) 1998-05-13
JP2000503845A (ja) 2000-04-04
CN1212020A (zh) 1999-03-24
ATE434054T1 (de) 2009-07-15
EP0962537A2 (en) 1999-12-08
AU2244897A (en) 1997-08-20
EP0962537A3 (en) 2004-02-11
JP2008200040A (ja) 2008-09-04
DE69701612T2 (de) 2000-08-31
CA2243546A1 (en) 1997-07-31
WO1997027325A3 (en) 1998-04-02
CA2243546C (en) 2008-04-15
NZ331043A (en) 1999-01-28
ATE191515T1 (de) 2000-04-15
EP0962537B1 (en) 2009-06-17
CZ228598A3 (cs) 1998-12-16
GR3033887T3 (en) 2000-11-30
ES2145580T3 (es) 2000-07-01
EP0840804B1 (en) 2000-04-05

Similar Documents

Publication Publication Date Title
BR9707016A (pt) Métodos e composições para analisar moléculas de ácido nuclêico utilizando técnicas dimensionamento.
PT990047E (pt) Metodos e composicoes para a analise de acidos nucleicos por espectroscopia de massa.
BR9709495A (pt) Sonda para análise de ácidos nucleicos
BR9707056A (pt) Processos e composições para determinar a sequência de moléculas de ácido nucleico
PT831879E (pt) Metodo para identificar ou isolar uma molecula e moleculas assim identificadas
ATE211174T1 (de) Thymidin-kinase-mutanten
ATE316152T1 (de) Komplexitätsmanagement und analyse genomischer dna
BR9813968B1 (pt) moléculas de ácido nucléico que codificam proteìnas tendo atividade frutosil transferase e processos para produzir inulina de cadeia longa.
DK1199569T3 (da) Pröveanalysesystem
ID27815A (id) Metoda dan peralatan untuk menyediakan berkas-berkas celah ortogonal, sektor-sektor dan pikosel
DE68901632D1 (de) Reaktionsgefaess zur durchfuehrung von aufeinanderfolgenden analytischen testen.
BR9906714A (pt) Método e aparelho para otimizar a geração de consulta pela utilização seletiva de atributos ou valores de código
BR9909312B1 (pt) processos para separar ácido acrìlico, e para preparar um acrilato, ou uma mistura de dois ou mais do mesmo.
FI970832A (fi) Biologisen materiaalin, kuten nukleiinihapon, erottamiseen käytettävä laite
BR0301722A (pt) Dados subdivididos de guia de programa
DE60212804D1 (de) Sicherheitssystem
DE69832052D1 (de) MENSCHLICHE KALZIUMKANÄLE ALFA1i UNTEREINHEITEN UND VERWANDTE PROBEN, ZELLLINIEN UND VERAHREN
NO20006192L (no) Angiostatin-bindingsprotein
PT1005532E (pt) Moleculas de acido nucleico isoladas que codificam para membros da familia ssx e suas utilizacoes
BR9811747A (pt) Inibidores de metaloproteinase de matriz à base de ácido malÈnico
BR9813897A (pt) Derivados de bifenila como farmacêuticos
ES2166598T3 (es) Metodo para discriminar las interacciones factor de transcripcion-coactivador.
WO2003035844A3 (en) Novel histone methyltransferase and methods of its use
Coe et al. Upregulation of keratinocyte lipid binding protein (KLBP) in fat cells of adipocyte lipid binding protein (aP2) knockout mice
DK0868535T3 (da) Fremgangsmåder og sammensætninger til bestemmelse af sekvensen for nukleinsyremolekyler

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR.