ES2200355T3 - Metodos y composiciones para analizar acidos nucleicos por espectrometria de masas. - Google Patents
Metodos y composiciones para analizar acidos nucleicos por espectrometria de masas.Info
- Publication number
- ES2200355T3 ES2200355T3 ES98936928T ES98936928T ES2200355T3 ES 2200355 T3 ES2200355 T3 ES 2200355T3 ES 98936928 T ES98936928 T ES 98936928T ES 98936928 T ES98936928 T ES 98936928T ES 2200355 T3 ES2200355 T3 ES 2200355T3
- Authority
- ES
- Spain
- Prior art keywords
- compositions
- methods
- nucleic acids
- mass spectrometry
- analyze nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 238000004949 mass spectrometry Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
- B01J2219/00581—Mass
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00608—DNA chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Structural Engineering (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invención se refiere a marcadores y a segmentos de enlace concebidos para ser utilizados en una gran gama de reacciones que hacen intervenir ácidos nucleicos, en las que es necesario separar las moléculas de ácidos nucleicos en función de su dimensión.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/898,180 US6312893B1 (en) | 1996-01-23 | 1997-07-22 | Methods and compositions for determining the sequence of nucleic acid molecules |
US08/898,564 US6613508B1 (en) | 1996-01-23 | 1997-07-22 | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
US08/898,501 US6027890A (en) | 1996-01-23 | 1997-07-22 | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2200355T3 true ES2200355T3 (es) | 2004-03-01 |
Family
ID=27420575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98936928T Expired - Lifetime ES2200355T3 (es) | 1997-07-22 | 1998-07-22 | Metodos y composiciones para analizar acidos nucleicos por espectrometria de masas. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0990047B1 (es) |
JP (2) | JP4414086B2 (es) |
CN (1) | CN1270598A (es) |
AT (1) | ATE240408T1 (es) |
AU (1) | AU738237B2 (es) |
CA (1) | CA2297158C (es) |
DE (1) | DE69814629T2 (es) |
DK (1) | DK0990047T3 (es) |
ES (1) | ES2200355T3 (es) |
NZ (1) | NZ501919A (es) |
PT (1) | PT990047E (es) |
WO (1) | WO1999005319A2 (es) |
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WO2001046687A2 (en) * | 1999-12-22 | 2001-06-28 | Transgenomic, Inc. | System and method for automated matched ion polynucleotide chromatography |
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CN114984032B (zh) * | 2022-06-27 | 2023-07-07 | 四川大学 | Dna四面体框架核酸-绿原酸复合物及其在制备治疗肝纤维化的药物中的用途 |
CN115356411B (zh) * | 2022-08-09 | 2023-07-28 | 河北一品生物医药有限公司 | 一种高效液相色谱法检测l-哌啶甲酸盐酸盐有关物质的方法 |
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US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5547835A (en) * | 1993-01-07 | 1996-08-20 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
US5849542A (en) * | 1993-11-17 | 1998-12-15 | Amersham Pharmacia Biotech Uk Limited | Primer extension mass spectroscopy nucleic acid sequencing method |
WO1995025737A1 (en) * | 1994-03-23 | 1995-09-28 | The Penn State Research Foundation | Method for identifying members of combinatorial libraries |
DE69700902T2 (de) * | 1996-01-23 | 2000-07-20 | Rapigene Inc | Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit |
PT840804E (pt) * | 1996-01-23 | 2000-10-31 | Qiagen Genomics Inc | Metodos e composicoes para a analise de moleculas de acidos nocleicos usando tecnicas de separacao por dimensoes |
PT868535E (pt) * | 1996-01-23 | 2000-12-29 | Qiagen Genomics Inc | Metodos e composicoes para a determinacao de sequencias de moleculas de acido nucleico |
AU5794498A (en) * | 1996-12-10 | 1998-07-03 | Genetrace Systems, Inc. | Releasable nonvolatile mass-label molecules |
IL130885A (en) * | 1997-01-15 | 2005-05-17 | Xzillion Gmbh & Co Kg | Hybridisation probes comprising a base sequence cleavably linked to a mass label and uses thereof |
NZ502088A (en) * | 1997-07-11 | 2002-05-31 | Brax Group Ltd | Characterising nucleic acids using mass spectroscopy |
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1998
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- 1998-07-22 DE DE69814629T patent/DE69814629T2/de not_active Expired - Lifetime
- 1998-07-22 PT PT98936928T patent/PT990047E/pt unknown
- 1998-07-22 AU AU85765/98A patent/AU738237B2/en not_active Ceased
- 1998-07-22 DK DK98936928T patent/DK0990047T3/da active
- 1998-07-22 AT AT98936928T patent/ATE240408T1/de not_active IP Right Cessation
- 1998-07-22 EP EP98936928A patent/EP0990047B1/en not_active Expired - Lifetime
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- 1998-07-22 ES ES98936928T patent/ES2200355T3/es not_active Expired - Lifetime
- 1998-07-22 JP JP2000504286A patent/JP4414086B2/ja not_active Expired - Lifetime
- 1998-07-22 NZ NZ501919A patent/NZ501919A/en unknown
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EP0990047B1 (en) | 2003-05-14 |
DK0990047T3 (da) | 2003-09-15 |
JP2001511359A (ja) | 2001-08-14 |
WO1999005319A2 (en) | 1999-02-04 |
WO1999005319A9 (en) | 1999-06-17 |
CA2297158A1 (en) | 1999-02-04 |
DE69814629T2 (de) | 2004-03-25 |
AU738237B2 (en) | 2001-09-13 |
JP4414086B2 (ja) | 2010-02-10 |
JP2009159985A (ja) | 2009-07-23 |
NZ501919A (en) | 2001-11-30 |
CA2297158C (en) | 2009-12-22 |
PT990047E (pt) | 2003-10-31 |
JP4870791B2 (ja) | 2012-02-08 |
EP0990047A2 (en) | 2000-04-05 |
ATE240408T1 (de) | 2003-05-15 |
CN1270598A (zh) | 2000-10-18 |
DE69814629D1 (de) | 2003-06-18 |
AU8576598A (en) | 1999-02-16 |
WO1999005319A3 (en) | 1999-05-14 |
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