DK0990047T3 - Fremgangsmåder og sammensætninger til analyse af nukleinsyrer ved hjælp af massespektrometri - Google Patents

Fremgangsmåder og sammensætninger til analyse af nukleinsyrer ved hjælp af massespektrometri

Info

Publication number
DK0990047T3
DK0990047T3 DK98936928T DK98936928T DK0990047T3 DK 0990047 T3 DK0990047 T3 DK 0990047T3 DK 98936928 T DK98936928 T DK 98936928T DK 98936928 T DK98936928 T DK 98936928T DK 0990047 T3 DK0990047 T3 DK 0990047T3
Authority
DK
Denmark
Prior art keywords
compositions
methods
nucleic acids
mass spectrometry
analyzing nucleic
Prior art date
Application number
DK98936928T
Other languages
English (en)
Inventor
Ness Jeffrey Van
John C Tabone
Jeffry Howbert
John T Mulligan
Original Assignee
Qiagen Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/898,564 external-priority patent/US6613508B1/en
Priority claimed from US08/898,501 external-priority patent/US6027890A/en
Priority claimed from US08/898,180 external-priority patent/US6312893B1/en
Application filed by Qiagen Genomics Inc filed Critical Qiagen Genomics Inc
Application granted granted Critical
Publication of DK0990047T3 publication Critical patent/DK0990047T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00581—Mass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
DK98936928T 1997-07-22 1998-07-22 Fremgangsmåder og sammensætninger til analyse af nukleinsyrer ved hjælp af massespektrometri DK0990047T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/898,564 US6613508B1 (en) 1996-01-23 1997-07-22 Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US08/898,501 US6027890A (en) 1996-01-23 1997-07-22 Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US08/898,180 US6312893B1 (en) 1996-01-23 1997-07-22 Methods and compositions for determining the sequence of nucleic acid molecules
PCT/US1998/015008 WO1999005319A2 (en) 1997-07-22 1998-07-22 Methods and compounds for analyzing nucleic acids by mass spectrometry

Publications (1)

Publication Number Publication Date
DK0990047T3 true DK0990047T3 (da) 2003-09-15

Family

ID=27420575

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98936928T DK0990047T3 (da) 1997-07-22 1998-07-22 Fremgangsmåder og sammensætninger til analyse af nukleinsyrer ved hjælp af massespektrometri

Country Status (12)

Country Link
EP (1) EP0990047B1 (da)
JP (2) JP4414086B2 (da)
CN (1) CN1270598A (da)
AT (1) ATE240408T1 (da)
AU (1) AU738237B2 (da)
CA (1) CA2297158C (da)
DE (1) DE69814629T2 (da)
DK (1) DK0990047T3 (da)
ES (1) ES2200355T3 (da)
NZ (1) NZ501919A (da)
PT (1) PT990047E (da)
WO (1) WO1999005319A2 (da)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751737B2 (en) * 1997-10-30 2002-08-29 Transgenomic, Inc. Method for high resolution liquid chromatographic separation of polynucleotides
GB9815164D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry
US7225079B2 (en) 1998-08-04 2007-05-29 Transgenomic, Inc. System and method for automated matched ion polynucleotide chromatography
WO2001016090A1 (en) * 1999-08-31 2001-03-08 Qiagen Genomics, Inc. Enantiomerically-enriched compounds having photocleavable bond(s) and methods related thereto
WO2001046687A2 (en) * 1999-12-22 2001-06-28 Transgenomic, Inc. System and method for automated matched ion polynucleotide chromatography
MXPA02007771A (es) * 2000-02-08 2003-03-10 Univ Michigan Mapeo de proteinas.
JP2001218598A (ja) * 2000-02-09 2001-08-14 Asahi Breweries Ltd ペクチネータス属菌の特異的ならびに定量的検出方法
US6713258B2 (en) 2000-03-29 2004-03-30 Center For The Application Of Molecular Biology To International Agriculture (Cambia) Methods for genotyping by hybridization analysis
US7160735B2 (en) 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7771929B2 (en) 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
AU8356201A (en) * 2000-08-11 2002-02-25 Agilix Corp Ultra-sensitive detection systems
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121313A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in organs for transplantation
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
EP1950305A1 (en) 2001-05-09 2008-07-30 Monsanto Technology, LLC Tyr a genes and uses thereof
HUP0501021A3 (en) 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
WO2002095356A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
AU2002344221A1 (en) 2001-05-26 2002-12-09 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
WO2003033741A1 (en) 2001-10-16 2003-04-24 Aclara Biosciences, Inc. Universal e-tag primer and probe compositions and methods
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
ATE515702T1 (de) 2003-01-30 2011-07-15 Life Technologies Corp Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung
US6997031B2 (en) 2003-05-01 2006-02-14 Waters Corporation Fraction collector for composition analysis
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20120122096A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
JP4838725B2 (ja) * 2003-11-26 2011-12-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド クワイエットゾーン中の質量スペクトルデータの分析
DE10350484B4 (de) * 2003-12-20 2006-02-02 Ehrfeld Mikrotechnik Bts Gmbh Verfahren und Vorrichtung zur Markierung von Proteinen
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP1766659A4 (en) 2004-05-24 2009-09-30 Ibis Biosciences Inc MASS SPECTROMETRY WITH SELECTIVE ION FILTRATION THROUGH DIGITAL THRESHOLD COMPARISON
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
CA2600184A1 (en) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
JP2009502137A (ja) 2005-07-21 2009-01-29 アイシス ファーマシューティカルズ インコーポレイティッド 核酸変種の迅速な同定および定量のための方法
EP2010679A2 (en) 2006-04-06 2009-01-07 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
CA2663029C (en) * 2006-09-14 2016-07-19 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
WO2008104002A2 (en) 2007-02-23 2008-08-28 Ibis Biosciences, Inc. Methods for rapid forensic dna analysis
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
KR101322624B1 (ko) * 2007-06-13 2013-10-29 삼성전자주식회사 흡착 매개체를 이용하는 전계 효과 트랜지스터 기반 생분자검출 장치와 그 방법
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
CN101251511B (zh) * 2008-03-14 2012-06-06 毅新兴业（北京）科技有限公司 一种利用限制性内切酶双酶切检测snp的方法
CN101251510B (zh) * 2008-03-14 2012-06-06 毅新兴业（北京）科技有限公司 一种联合限制性酶切法和质谱法以检测snp的方法
CN101246142B (zh) * 2008-04-03 2012-06-20 毅新兴业（北京）科技有限公司 一种检测单核苷酸多态性的方法
WO2010033625A1 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
EP2347254A2 (en) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
US8550694B2 (en) 2008-09-16 2013-10-08 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
US8158936B2 (en) 2009-02-12 2012-04-17 Ibis Biosciences, Inc. Ionization probe assemblies
WO2010104798A1 (en) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Bioagent detection methods
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
WO2011008971A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
WO2011017656A2 (en) 2009-08-06 2011-02-10 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
US20110200995A1 (en) 2009-09-04 2011-08-18 Intelligent Medical Devices, Inc. Optimized probes and primers and methods of using same for the detection, screening, isolation and sequencing of vancomycin resistance genes and vancomycin resistant enterococci
US9890408B2 (en) 2009-10-15 2018-02-13 Ibis Biosciences, Inc. Multiple displacement amplification
WO2011115840A2 (en) 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
TWI510781B (zh) * 2010-10-29 2015-12-01 Scinopharm Taiwan Ltd 即時監測固相胜肽合成反應之質譜系統
WO2012138470A2 (en) 2011-04-04 2012-10-11 Intelligent Medical Devices, Inc. Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantitation, monitoring, screening, and sequencing of group b streptococcus
US9588095B2 (en) 2012-07-24 2017-03-07 Massachusetts Institute Of Technology Reagents for oxidizer-based chemical detection
US9891193B2 (en) 2012-07-24 2018-02-13 Massachusetts Institute Of Technology Reagent impregnated swipe for chemical detection
WO2014058508A2 (en) * 2012-07-24 2014-04-17 Massachusetts Institute Of Technology Reagents for oxidizer-based chemical detection
WO2014066749A2 (en) 2012-10-25 2014-05-01 Intelligent Medical Devices, Inc. Optimized probes and primers and methods of using same for the binding, detection, differentiation, isolation and sequencing of influenza a; influenza b and respiratory syncytial virus
WO2014137906A1 (en) 2013-03-05 2014-09-12 Intelligent Medical Devices, Inc. Optimized probes and primers and methods of using same for the detection, screening, isolation and sequencing of mrsa, mssa, staphylococcus markers, and the antibiotic resistance gene mec a
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
US10816530B2 (en) 2013-07-23 2020-10-27 Massachusetts Institute Of Technology Substrate containing latent vaporization reagents
WO2015154087A1 (en) 2014-04-04 2015-10-08 Massachusetts Institute Of Technology Reagents for enhanced detection of low volatility analytes
US10370673B2 (en) 2014-09-26 2019-08-06 Purecircle Sdn Bhd Single nucleotide polymorphism (SNP) markers for stevia
KR101701998B1 (ko) * 2014-10-23 2017-02-03 한국과학기술연구원 기체크로마토그래피-전기분무/고분해능 질량분석기와 이를 이용한 기체상태 유기화합물의 이온화 방법
CN107208162B (zh) * 2015-02-26 2020-12-29 株式会社日立高新技术 核酸分子的构建方法
US20180265887A1 (en) 2017-03-16 2018-09-20 Jacobs Farm Del Cabo Basil Plants With High Tolerance to Downy Mildew
CN106979942B (zh) * 2017-05-04 2020-07-07 华中师范大学 一种对固相合成化合物组合库个体定量的拉曼光谱分析方法及其用途
EP3802821A4 (en) * 2018-05-25 2022-06-08 New York Institute of Technology DIRECT NUCLEIC ACID SEQUENCING METHOD
CN111208300B (zh) * 2018-11-21 2021-10-29 中国科学院大连化学物理研究所 一种赖氨酸氮连接磷酸化翻译后修饰富集和鉴定的方法
CN111239402B (zh) * 2018-11-29 2021-07-09 北京大学 一种可用于疾病标志物检测的质谱免疫分析方法及应用
CN113075114B (zh) * 2019-12-17 2022-07-01 北京大学 一种用于单细胞分析的有机质谱流式分析方法
MX2022014605A (es) 2020-05-19 2022-12-16 Cybin Irl Ltd Derivados de triptamina deuterada y metodos de uso.
CN114984032B (zh) * 2022-06-27 2023-07-07 四川大学 Dna四面体框架核酸-绿原酸复合物及其在制备治疗肝纤维化的药物中的用途
CN115356411B (zh) * 2022-08-09 2023-07-28 河北一品生物医药有限公司 一种高效液相色谱法检测l-哌啶甲酸盐酸盐有关物质的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5547835A (en) * 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
WO1995014108A1 (en) * 1993-11-17 1995-05-26 Amersham International Plc Primer extension mass spectroscopy nucleic acid sequencing method
JPH09510711A (ja) * 1994-03-23 1997-10-28 ザ ペン ステート リサーチ ファウンデーション 組合せライブラリー中の化合物を同定する方法
DE69700902T2 (de) * 1996-01-23 2000-07-20 Rapigene Inc Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit
EP0962537B1 (en) * 1996-01-23 2009-06-17 Operon Biotechnologies, Inc. Methods for analyzing nucleic acid molecules utilizing sizing techniques
ATE425175T1 (de) * 1996-01-23 2009-03-15 Operon Biotechnologies Inc Verfahren und zusammensetzungen zur bestimmung von sequenzen von nukleinsäure-molekülen
DE69735445T2 (de) * 1996-12-10 2006-08-10 Sequenom, Inc., San Diego Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
CA2441655A1 (en) * 1997-01-15 1998-07-23 Xzillion Gmbh & Co Kg Mass label linked hybridisation probes
US7056659B1 (en) * 1997-07-11 2006-06-06 Xzillion Gmbh & Co. Characterizing nucleic acids

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EP0990047A2 (en) 2000-04-05
JP2001511359A (ja) 2001-08-14
AU8576598A (en) 1999-02-16
ES2200355T3 (es) 2004-03-01
CN1270598A (zh) 2000-10-18
JP4870791B2 (ja) 2012-02-08
WO1999005319A9 (en) 1999-06-17
PT990047E (pt) 2003-10-31
CA2297158A1 (en) 1999-02-04
EP0990047B1 (en) 2003-05-14
AU738237B2 (en) 2001-09-13
CA2297158C (en) 2009-12-22
WO1999005319A3 (en) 1999-05-14
DE69814629T2 (de) 2004-03-25
NZ501919A (en) 2001-11-30
ATE240408T1 (de) 2003-05-15
WO1999005319A2 (en) 1999-02-04
JP2009159985A (ja) 2009-07-23
JP4414086B2 (ja) 2010-02-10
DE69814629D1 (de) 2003-06-18

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