BR112023017365A2 - Glicano e método para produzir medicamento contendo glicano - Google Patents
Glicano e método para produzir medicamento contendo glicanoInfo
- Publication number
- BR112023017365A2 BR112023017365A2 BR112023017365A BR112023017365A BR112023017365A2 BR 112023017365 A2 BR112023017365 A2 BR 112023017365A2 BR 112023017365 A BR112023017365 A BR 112023017365A BR 112023017365 A BR112023017365 A BR 112023017365A BR 112023017365 A2 BR112023017365 A2 BR 112023017365A2
- Authority
- BR
- Brazil
- Prior art keywords
- glycan
- producing
- new
- biantennary
- oligosaccharide
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 9
- 150000004676 glycans Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 7
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 150000002772 monosaccharides Chemical class 0.000 abstract 2
- 229920001542 oligosaccharide Polymers 0.000 abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 150000002016 disaccharides Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
glicano e método para produzir medicamento contendo glicano. a presente invenção trata do problema de fornecer: um novo método para produção quimicamente pura de um n-glicano biantenário com uma estrutura de ácido 2,6-siálico em cada extremidade não redutora, o método tendo excelente produção, seletividade e eficiência; e um método para produzir um novo monossacarídeo ou oligossacarídeo, que são úteis no método, e, por exemplo, intermediários, bem como, um novo método para produzir a glicoproteína ou similares usando o método. são fornecidos: um novo método para produção quimicamente pura de um n-glicano biantenário com uma estrutura de ácido 2,6-siálico em cada extremidade não redutora de tal modo que para ligação glicosídica, a construção direta que é difícil usando envolvimento de grupo adjacente, os blocos dissacarídeos são construídos individualmente e estão ligados estereosseletivamente a outro bloco de açúcar neste esquema de síntese; e um método para produzir um novo monossacarídeo ou oligossacarídeo, que são úteis no método, e, por exemplo, intermediários, bem como, um novo método para produzir a glicoproteína ou similares usando o método. [figura 1]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021040164 | 2021-03-12 | ||
| PCT/JP2022/010851 WO2022191313A1 (ja) | 2021-03-12 | 2022-03-11 | 糖鎖及び糖鎖を含む医薬品の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023017365A2 true BR112023017365A2 (pt) | 2023-10-03 |
Family
ID=83228168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023017365A BR112023017365A2 (pt) | 2021-03-12 | 2022-03-11 | Glicano e método para produzir medicamento contendo glicano |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4306546A1 (pt) |
| JP (1) | JPWO2022191313A1 (pt) |
| KR (1) | KR20230157983A (pt) |
| CN (1) | CN116917341A (pt) |
| BR (1) | BR112023017365A2 (pt) |
| CA (1) | CA3212691A1 (pt) |
| IL (1) | IL305816A (pt) |
| WO (1) | WO2022191313A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024053574A1 (ja) * | 2022-09-09 | 2024-03-14 | 第一三共株式会社 | 新規なオリゴ糖、該オリゴ糖の製造中間体、及びそれらの製造方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| EP0727216B1 (en) | 1994-07-15 | 2003-05-28 | TAIYO KAGAKU Co., LTD. | Medicinal composition containing sialic acid derivative |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| ATE446317T1 (de) | 2001-05-11 | 2009-11-15 | Ludwig Inst For Cancer Res Ltd | Spezifische bindungsproteine und ihre verwendung |
| MXPA05000403A (es) | 2002-07-15 | 2005-07-22 | Genentech Inc | Metodos para identificar tumores que responden al tratamiento con anticuerpos contra erbb2. |
| DE602004027888D1 (de) | 2003-02-20 | 2010-08-12 | Seattle Genetics Inc | Anti-cd70 antikörper-arzneimittelkonjugate und ihr |
| CA2623236A1 (en) | 2005-09-26 | 2007-04-05 | Medarex, Inc. | Human monoclonal antibodies to cd70 |
| JP2009155353A (ja) * | 2006-03-30 | 2009-07-16 | Yokohama City Univ | 糖鎖化合物の製造方法 |
| WO2009028639A1 (ja) | 2007-08-30 | 2009-03-05 | Daiichi Sankyo Company, Limited | 抗ｅｐｈａ２抗体 |
| US8809496B2 (en) | 2009-09-03 | 2014-08-19 | The Noguchi Institute | Production method of 11-sugar sialylglycopeptide |
| US10851174B2 (en) * | 2011-03-03 | 2020-12-01 | University Of Maryland, Baltimore | Core fucosylated glycopeptides and glycoproteins: chemoenzymatic synthesis and uses thereof |
| WO2012135049A1 (en) * | 2011-03-25 | 2012-10-04 | University Of Georgia Research Foundation, Inc. | Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans |
| DK2907824T3 (en) | 2012-10-11 | 2018-07-23 | Daiichi Sankyo Co Ltd | ANTIBODY-drug conjugate |
| TW201442721A (zh) * | 2013-01-23 | 2014-11-16 | Daiichi Sankyo Co Ltd | 糖鏈修飾心房利尿鈉肽 |
| TW201534613A (zh) | 2013-06-28 | 2015-09-16 | Daiichi Sankyo Co Ltd | 寡糖胜肽之純化方法 |
| WO2015080603A1 (en) * | 2013-11-28 | 2015-06-04 | Antony John Fairbanks | Glycoproteins |
| SI3088419T1 (sl) | 2013-12-25 | 2019-01-31 | Daiichi Sankyo Company | Zdravilni konjugat anti trop2 protitelesa |
| US11559581B2 (en) | 2015-01-09 | 2023-01-24 | Oxford University Innovation Limited | Antibody conjugates and methods of making the antibody conjugates |
| WO2017110984A1 (ja) | 2015-12-25 | 2017-06-29 | 第一三共株式会社 | 限外ろ過膜を用いたオリゴ糖ペプチドの精製法 |
| CN109462989A (zh) | 2016-07-01 | 2019-03-12 | 第三共株式会社 | Hanp-含fc分子缀合物 |
| JP6342968B2 (ja) * | 2016-07-25 | 2018-06-13 | 株式会社伏見製薬所 | 糖誘導体の製造方法及び新規糖誘導体 |
| TWI794230B (zh) | 2017-05-15 | 2023-03-01 | 日商第一三共股份有限公司 | 抗ｃｄｈ６抗體及抗ｃｄｈ６抗體-藥物結合物、以及其製造方法 |
| CN117003875A (zh) | 2017-09-29 | 2023-11-07 | 第一三共株式会社 | 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用 |
| KR20230122685A (ko) | 2018-09-06 | 2023-08-22 | 다이이찌 산쿄 가부시키가이샤 | 신규 고리형 디뉴클레오티드 유도체 및 그 항체 약물콘쥬게이트 |
-
2022
- 2022-03-11 KR KR1020237032327A patent/KR20230157983A/ko unknown
- 2022-03-11 IL IL305816A patent/IL305816A/en unknown
- 2022-03-11 CN CN202280019248.5A patent/CN116917341A/zh active Pending
- 2022-03-11 BR BR112023017365A patent/BR112023017365A2/pt unknown
- 2022-03-11 CA CA3212691A patent/CA3212691A1/en active Pending
- 2022-03-11 WO PCT/JP2022/010851 patent/WO2022191313A1/ja active Application Filing
- 2022-03-11 JP JP2023505652A patent/JPWO2022191313A1/ja active Pending
- 2022-03-11 EP EP22767267.2A patent/EP4306546A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022191313A1 (ja) | 2022-09-15 |
| KR20230157983A (ko) | 2023-11-17 |
| CN116917341A (zh) | 2023-10-20 |
| EP4306546A1 (en) | 2024-01-17 |
| CA3212691A1 (en) | 2022-09-15 |
| IL305816A (en) | 2023-11-01 |
| JPWO2022191313A1 (pt) | 2022-09-15 |
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