BR112020003899A8 - Método para produzir polissulfato de pentosano, polissulfato de pentosano, e, anticoagulante - Google Patents

Método para produzir polissulfato de pentosano, polissulfato de pentosano, e, anticoagulante

Info

Publication number
BR112020003899A8
BR112020003899A8 BR112020003899A BR112020003899A BR112020003899A8 BR 112020003899 A8 BR112020003899 A8 BR 112020003899A8 BR 112020003899 A BR112020003899 A BR 112020003899A BR 112020003899 A BR112020003899 A BR 112020003899A BR 112020003899 A8 BR112020003899 A8 BR 112020003899A8
Authority
BR
Brazil
Prior art keywords
pentosan polysulfate
producing
anticoagulant
plant
xylooligosaccharide
Prior art date
Application number
BR112020003899A
Other languages
English (en)
Other versions
BR112020003899A2 (pt
BR112020003899B1 (pt
Inventor
Ishikawa Kotaro
KASHIWAMURA Takuro
Kato Takuya
Koga Toru
Ishikawa Suguru
Original Assignee
Oji Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oji Holdings Corp filed Critical Oji Holdings Corp
Publication of BR112020003899A2 publication Critical patent/BR112020003899A2/pt
Publication of BR112020003899A8 publication Critical patent/BR112020003899A8/pt
Publication of BR112020003899B1 publication Critical patent/BR112020003899B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0057—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Xylans, i.e. xylosaccharide, e.g. arabinoxylan, arabinofuronan, pentosans; (beta-1,3)(beta-1,4)-D-Xylans, e.g. rhodymenans; Hemicellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Sustainable Development (AREA)
  • Epidemiology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

A presente invenção provê um método para produzir polissulfato de pentosano, o método incluindo uma primeira etapa de obtenção de um xilo-oligossacarídeo ácido de uma matéria-prima derivada de planta, e uma segunda etapa de obtenção de polissulfato de pentosano do xilo-oligossacarídeo ácido. A primeira etapa inclui uma etapa de despolimerização da matéria-prima derivada de planta. A segunda etapa inclui uma etapa de sulfatação do xilo-oligossacarídeo ácido. O método adicionalmente inclui uma etapa de desacetilação de adicionar uma base para alcançar um pH de 11 ou superior. A etapa de desacetilação é uma etapa realizada após a etapa de despolimerização. O método de produção da presente invenção pode prover polissulfato de pentosano com baixo teor de grupo acetil, e também produzir polissulfato de pentosano com alto rendimento de forma barata e eficiente.
BR112020003899-7A 2016-08-31 2017-08-31 Método para produzir polissulfato de pentosano, polissulfato de pentosano, e, anticoagulante BR112020003899B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016169710 2016-08-31
JP2017035917 2017-02-28
PCT/JP2017/031434 WO2018043668A1 (ja) 2016-08-31 2017-08-31 ポリ硫酸ペントサンの製造方法

Publications (3)

Publication Number Publication Date
BR112020003899A2 BR112020003899A2 (pt) 2020-09-01
BR112020003899A8 true BR112020003899A8 (pt) 2023-03-07
BR112020003899B1 BR112020003899B1 (pt) 2023-04-18

Family

ID=61305336

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020003899-7A BR112020003899B1 (pt) 2016-08-31 2017-08-31 Método para produzir polissulfato de pentosano, polissulfato de pentosano, e, anticoagulante

Country Status (11)

Country Link
US (1) US11312790B2 (pt)
EP (1) EP3677599A4 (pt)
JP (2) JP6225321B1 (pt)
KR (1) KR102591794B1 (pt)
CN (1) CN111065654B (pt)
AU (1) AU2017321818B2 (pt)
BR (1) BR112020003899B1 (pt)
CA (1) CA3074419C (pt)
MX (1) MX2020002287A (pt)
SG (1) SG11202001822WA (pt)
WO (1) WO2018043668A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017321817B2 (en) 2016-08-31 2022-12-15 Oji Holdings Corporation Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide
JP6225321B1 (ja) 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
JP6281659B1 (ja) * 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
SG11201911318SA (en) 2017-05-31 2020-01-30 Oji Holdings Corp Moisturizing topical preparation
WO2019054344A1 (ja) 2017-09-12 2019-03-21 王子ホールディングス株式会社 ポリ硫酸ペントサン及びポリ硫酸ペントサンの製造方法
CN111511773B (zh) * 2017-12-20 2023-01-13 王子控股株式会社 戊聚糖多硫酸酯以及含有戊聚糖多硫酸酯的药物
EP3842048A4 (en) * 2018-08-20 2022-03-30 ReqMed Company, Ltd. NOVEL PENTOSAN POLYSULFATE PREPARATION

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4843100B1 (pt) 1969-09-05 1973-12-17
JPS4843100A (pt) 1971-09-30 1973-06-22
US4168742A (en) 1978-03-27 1979-09-25 Hudson Products Corporation Tube bundle
FR2538404B1 (pt) 1982-12-28 1985-08-23 Anic Spa
FR2543145B1 (fr) 1983-03-24 1986-10-17 Sanofi Sa Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante
JPS60112708A (ja) 1983-11-24 1985-06-19 Maruho Kk 皮膚用保湿剤
FR2572731B1 (fr) 1984-11-07 1987-03-06 Sanofi Sa Nouveaux sulfates de xylanes de bas poids moleculaires, leur procede de preparation et leur activite antithrombotique et hypolipemiante par voie orale
JPS61130302A (ja) 1984-11-30 1986-06-18 Tokyo Univ 抗凝血活性を有する硫酸化リボフラナン及びその製造法
JPS61130301A (ja) 1984-11-30 1986-06-18 Tokyo Univ 抗凝血活性を有する硫酸化キシロフラナン及びその製造法
US5672334A (en) 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
FR2645745B1 (fr) 1989-04-12 1991-09-27 Anben Ste Civile Compositions therapeutiques pour le traitement ou la prevention du ronflement
DE3917982A1 (de) 1989-06-02 1990-12-06 Behringwerke Ag Verwendung von xylanpolyhydrogensulfaten zur therapie von zellproliferations-bedingten erkrankungen
FR2648463B1 (fr) 1989-06-14 1993-01-22 Inst Fs Rech Expl Mer Polysaccharides sulfates, agent anticoagulant et agent anticomplementaire obtenus a partir de fucanes d'algues brunes et leur procede d'obtention
JPH0776175B2 (ja) 1990-04-26 1995-08-16 サイトアーレクス・コーポレーシヨン 損傷されたかまたは病気になった組織の局所的処置用の組成物および方法
US20010005720A1 (en) 1995-06-07 2001-06-28 U.S.A. As Represented By The Secretary Department Of Health And Human Services Method of treating chronic progressive vascular scarring diseases
DE19632840A1 (de) 1996-08-14 1998-02-19 Landsberger Albert Vitamin A-haltige Zusammensetzung
JPH10195107A (ja) 1997-01-10 1998-07-28 Shiseido Co Ltd オリゴ硫酸化ヒアルロン酸
JP4336905B2 (ja) 1997-12-19 2009-09-30 マルホ株式会社 硫酸化多糖類含有皮膚保湿乳剤性ローション剤
US6593310B1 (en) 2000-11-21 2003-07-15 Arthropharm Pty. Ltd. Treatment of osteoporosis
DE10141106A1 (de) 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
JP4073661B2 (ja) 2001-12-20 2008-04-09 王子製紙株式会社 酸性キシロオリゴ糖組成物の製造方法
JP3772749B2 (ja) 2002-01-25 2006-05-10 王子製紙株式会社 メラニン生成抑制剤
JP2003221339A (ja) 2002-01-29 2003-08-05 Oji Paper Co Ltd 抗炎症剤
ITMI20031618A1 (it) * 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
EP1748781B1 (en) * 2004-05-27 2012-12-19 Baxter International Inc. Methods for treating bleeding disorders using sulfated polysaccharides
ES2308536T3 (es) 2004-08-05 2008-12-01 Ivax Drug Research Institute Ltd Glicosidos polisulfatados y sales de los mismos.
US20060194759A1 (en) 2005-02-25 2006-08-31 Eidelson Stewart G Topical compositions and methods for treating pain and inflammation
CA2616230A1 (en) 2005-07-22 2007-02-01 Trf Pharma, Inc. Method for treating sickle cell disease and sickle cell disease sequelae
PT2010220T (pt) 2006-04-03 2022-05-20 Ceva Animal Health Pty Ltd Formulações de polisulfato de pentosano estabilizado (pps)
GB0610350D0 (en) * 2006-05-25 2006-07-05 Univ Liverpool prevention and/or treatment of neuodegenerative disorders
US20100055060A1 (en) 2006-11-27 2010-03-04 Naoyuki Yoshida Cosmetic composition
WO2008107906A1 (en) 2007-03-06 2008-09-12 Alembic Limited Process for the preparation of pentosan polysulfate or salts thereof
FI121811B (fi) 2007-06-01 2011-04-29 Upm Kymmene Corp Uudet dispersiot ja menetelmä niiden valmistamiseksi
HUP0900072A2 (hu) 2009-02-06 2010-09-28 Egis Gyogyszergyar Nyilvanosan Transzdermális gyógyszerkészítmények
WO2009087581A1 (en) 2008-01-04 2009-07-16 Alembic Limited An improved process for the preparation of pentosan polysulfate or salts thereof
JP2009196915A (ja) 2008-02-20 2009-09-03 Ezaki Glico Co Ltd 化粧品用組成物
AU2008100730B4 (en) 2008-07-04 2008-10-02 Parnell Technologies Pty Ltd Sulfated polysaccharide compound for clinical use and the preparation thereof
FR2935386B1 (fr) 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
JP4884559B2 (ja) 2009-02-02 2012-02-29 大塚化学株式会社 低分子量多硫酸化ヒアルロン酸誘導体及びこれを含有する医薬
CN102061323B (zh) 2010-11-10 2013-09-25 山东龙力生物科技股份有限公司 一种植物木质纤维素的综合利用工艺
WO2012101544A1 (en) 2011-01-29 2012-08-02 Alembic Pharmaceuticals Limited An improved process for the preparation of pentosan polysulfate or salts thereof
WO2012114349A1 (en) 2011-02-23 2012-08-30 Cadila Healthcare Limited An improved process for the preparation of pentosan polysulfate sodium
CN102766225B (zh) 2011-05-06 2015-08-05 上海医药工业研究院 一种戊聚糖聚硫酸钠的制备方法以及一种寡聚木糖
WO2013186857A1 (ja) 2012-06-12 2013-12-19 株式会社リボミック Ｆｇｆ２に対するアプタマー及びその使用
ITMI20130112A1 (it) * 2013-01-24 2014-07-25 Chemi Spa Metodo di qualificazione di preparazioni di pentosan polifosfato, sue materie prime e processi di produzione
JO3529B1 (ar) 2013-02-08 2020-07-05 Amgen Res Munich Gmbh مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
JP6132302B2 (ja) 2013-05-28 2017-05-24 リーディアント・バイオサイエンシーズ・ソシエタ・アノニマＬｅａｄｉａｎｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｓ．Ａ． 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
CN103320548A (zh) 2013-06-24 2013-09-25 稼禾生物股份有限公司 一种利用农作物秸秆制备低聚木糖和纤维素的方法
JP6403317B2 (ja) 2013-07-19 2018-10-10 学校法人慶應義塾 抗腫瘍剤
ES2907126T3 (es) * 2015-05-20 2022-04-22 Chemi Spa Proceso para la preparación de polisacáridos
AU2016267264A1 (en) 2015-05-27 2017-12-07 Vanguard Therapeutics, Inc. Pentosan polysulfate sodium for the treatment of sickle cell disease
CN106832020A (zh) * 2015-12-04 2017-06-13 长春工业大学 一种玉米秸秆戊聚糖硫酸酯的制备工艺
CN105907896B (zh) * 2016-05-16 2019-11-12 中国科学院广州能源研究所 一种利用木质纤维原料联产高浓度木糖和低聚木糖的方法
JP6225321B1 (ja) 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
AU2017321817B2 (en) 2016-08-31 2022-12-15 Oji Holdings Corporation Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide
JP6281659B1 (ja) 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤

Also Published As

Publication number Publication date
JPWO2018043668A1 (ja) 2018-08-30
CN111065654A (zh) 2020-04-24
EP3677599A1 (en) 2020-07-08
KR102591794B1 (ko) 2023-10-19
JP6432709B2 (ja) 2018-12-05
AU2017321818A1 (en) 2020-03-26
BR112020003899A2 (pt) 2020-09-01
KR20200044896A (ko) 2020-04-29
CA3074419C (en) 2023-09-26
WO2018043668A1 (ja) 2018-03-08
SG11202001822WA (en) 2020-04-29
JP2018039973A (ja) 2018-03-15
CA3074419A1 (en) 2018-03-08
US11312790B2 (en) 2022-04-26
BR112020003899B1 (pt) 2023-04-18
AU2017321818B2 (en) 2022-12-08
US20200332027A1 (en) 2020-10-22
CN111065654B (zh) 2022-08-26
MX2020002287A (es) 2020-07-14
JP6225321B1 (ja) 2017-11-08
EP3677599A4 (en) 2021-03-31

Similar Documents

Publication Publication Date Title
BR112020003899A8 (pt) Método para produzir polissulfato de pentosano, polissulfato de pentosano, e, anticoagulante
BR112017025388A2 (pt) plantas cannabis tendo expressão modificada de thca sintase
BR112018071060A2 (pt) produção de monômeros de lignina durante a despolimerização de uma composição contendo lignocelulose
CO2018001290A2 (es) Proceso para la producción de cannabidiol y delta-9-tetrahidrocannabinol
DOP2021000179A (es) Procedimiento de preparación de 5-fluoro-1h-pirazolopiridinas sustituidas
MX2020002288A (es) Metodo de produccion para xilooligosacarido acido y xilooligosacarido acido.
BR112017008283A2 (pt) método para cetonização de material biológico
BR112015017606A2 (pt) composição, método de produzir a composição, utilização da composição e combustível obtido a partir da composição
BR112018011801A2 (pt) ?método de produção de composições, composição e produto ingerível?
BR112016027851A2 (pt) composições de fibra e de carboidrato, produto alimentício, métodos de produção de composição, de redução do índice glicêmico e de inibição da elevação do nível de açúcar, composição de baixa cariogenicidade e uso da composição
BR112017005997A2 (pt) método
BR112014005018A8 (pt) composição aquosa de ligante, ligante, método de produção de uma composição aquosa de ligante e método de fabricação de um produto selecionado de um grupo
BR112012010057A2 (pt) ácido 3-fenilpropiônico substituído e sua aplicação.
PH12015500435A1 (en) Laxative compositions and methods for treating constipation and related gastrointestinal diseases and conditions
BR112016029388A2 (pt) métodos, reagentes e células para biossintetizar compostos
BR112018012245A2 (pt) ?método para pré-tratar e hidrolisar biomassa lignocelulósica, e, sistema para produzir um produto de fermentação?
BR112016013316A8 (pt) método para a produção de furfural e uso de ácido metanossulfônico
BR112016026956A2 (pt) método para a produção enzimática de d-eritrose e acetilfosfato".
BR112017027048A2 (pt) processo para extração de pectina e uso da pectina
WO2014201325A3 (en) Systems and methods for the depolymerization of a biopolymer
BR112017010010A2 (pt) método para produzir 3-oxo-5-hidroxipentanoil-coa, método para biossintetizar 1,3-butanodiol, hospedeiro recombinante, produto bioderivado, produto biobaseado ou produto derivado de fermentação, retícula bioquímica de ocorrência não natural, construto de ácido nucleico ou vetor de expressão e composição
BR112019006226A2 (pt) método para condicionamento de tratamento com ácido de um catalisador na produção de glicóis
BR112017008656A2 (pt) composição, método de produção da composição, usos da composição, método de preparo de combustível, e combustível
BR112017004231A2 (pt) processo para produzir um precipitado estável enriquecido em ficobiliproteínas
BR112015014895A2 (pt) processo para produção de produtos de biomassa

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C08B 37/00

Ipc: C08B 37/00 (2006.01), C08B 37/08 (2006.01), A61K 3

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/08/2017, OBSERVADAS AS CONDICOES LEGAIS