BR112019017741A2 - usos de pirimidopirimidinonas como inibidores de sik - Google Patents

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Publication number

BR112019017741A2

BR112019017741A2 BR112019017741A BR112019017741A BR112019017741A2 BR 112019017741 A2 BR112019017741 A2 BR 112019017741A2 BR 112019017741 A BR112019017741 A BR 112019017741A BR 112019017741 A BR112019017741 A BR 112019017741A BR 112019017741 A2 BR112019017741 A2 BR 112019017741A2

Authority

BR

Brazil

Prior art keywords

substituted

unsubstituted

pharmaceutically acceptable

acceptable salt

certain embodiments

Prior art date

2017-02-28

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• 239000003112 inhibitor Substances 0.000 title claims description 35
• RLJCWYYOGHGGBV-UHFFFAOYSA-N 1h-pyrimido[5,4-d]pyrimidin-2-one Chemical class C1=NC=C2NC(=O)N=CC2=N1 RLJCWYYOGHGGBV-UHFFFAOYSA-N 0.000 title 1
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• 239000003757 phosphotransferase inhibitor Substances 0.000 claims abstract 3
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 227
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• 239000001257 hydrogen Substances 0.000 claims description 190
• 125000003118 aryl group Chemical group 0.000 claims description 181
• 125000004429 atom Chemical group 0.000 claims description 175
• 229910052757 nitrogen Inorganic materials 0.000 claims description 173
• 125000000304 alkynyl group Chemical group 0.000 claims description 165
• 125000003342 alkenyl group Chemical group 0.000 claims description 161
• 229910052717 sulfur Inorganic materials 0.000 claims description 157
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 154
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 152
• 229910052736 halogen Inorganic materials 0.000 claims description 132
• 150000002367 halogens Chemical class 0.000 claims description 132
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• 239000001301 oxygen Substances 0.000 claims description 118
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• 125000001424 substituent group Chemical group 0.000 claims description 89
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 87
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