BR112018014146A2 - métodos de teste rápido de suscetibilidade antimicrobiana - Google Patents
métodos de teste rápido de suscetibilidade antimicrobianaInfo
- Publication number
- BR112018014146A2 BR112018014146A2 BR112018014146A BR112018014146A BR112018014146A2 BR 112018014146 A2 BR112018014146 A2 BR 112018014146A2 BR 112018014146 A BR112018014146 A BR 112018014146A BR 112018014146 A BR112018014146 A BR 112018014146A BR 112018014146 A2 BR112018014146 A2 BR 112018014146A2
- Authority
- BR
- Brazil
- Prior art keywords
- antimicrobial susceptibility
- testing methods
- susceptibility testing
- rapid antimicrobial
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
Abstract
a presente invenção refere-se, em parte, a método e kits para rapidamente determinar a suscetibilidade antimicrobiana de microrganismos. os métodos e kits usam um agente de sinalização que liga especificamente ou não especificamente à superfície dos microrganismos. preferencialmente, os agentes de sinalização possuem um grupo amplificador, como o complexo de coordenação de európio.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662281698P | 2016-01-21 | 2016-01-21 | |
US201662298821P | 2016-02-23 | 2016-02-23 | |
US201662326545P | 2016-04-22 | 2016-04-22 | |
US201662338376P | 2016-05-18 | 2016-05-18 | |
US201662370579P | 2016-08-03 | 2016-08-03 | |
US201662383198P | 2016-09-02 | 2016-09-02 | |
PCT/US2017/014343 WO2017127684A1 (en) | 2016-01-21 | 2017-01-20 | Methods for rapid antimicrobial susceptibility testing |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018014146A2 true BR112018014146A2 (pt) | 2018-12-11 |
Family
ID=58018224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018014146A BR112018014146A2 (pt) | 2016-01-21 | 2017-01-20 | métodos de teste rápido de suscetibilidade antimicrobiana |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP3845663A1 (pt) |
JP (2) | JP7046833B2 (pt) |
CN (1) | CN109072280B (pt) |
AU (1) | AU2017210215B2 (pt) |
BR (1) | BR112018014146A2 (pt) |
CA (1) | CA3010895A1 (pt) |
ES (1) | ES2862345T3 (pt) |
IL (1) | IL260466B (pt) |
MX (1) | MX2018008906A (pt) |
WO (1) | WO2017127684A1 (pt) |
ZA (1) | ZA201804498B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2862345T3 (es) * | 2016-01-21 | 2021-10-07 | Selux Diagnostics Inc | Métodos rápidos para probar la susceptibilidad antimicrobiana |
SI3436054T2 (sl) | 2016-09-13 | 2022-09-30 | Allergan, Inc. | Stabilizirani neproteinski sestavki klostridijskih toksinov |
KR102136696B1 (ko) * | 2017-10-18 | 2020-07-22 | 주식회사 인퓨전텍 | 동형2기능성 이미도에스터를 이용한 병원체 농축 방법 |
AU2019301054A1 (en) * | 2018-07-11 | 2021-02-04 | SeLux Diagnostics, Inc. | Assays and reagents for antimicrobial susceptibility testing |
ES2862190T3 (es) * | 2018-07-16 | 2021-10-07 | Bacteromic Sp Z O O | Método y sistema para robar rápidamente la susceptibilidad antimicrobiana |
CN109283347A (zh) * | 2018-09-14 | 2019-01-29 | 浙江大学 | 基于免疫磁珠和荧光量子点的纳米生物传感器快速检测肉鸡中恩诺沙星的方法 |
FR3088652A1 (fr) * | 2018-11-21 | 2020-05-22 | Nanotracks Diagnostics | Détection in vitro de la présence d’au moins un agent pathogène microbien dans un échantillon biologique |
CN109682915A (zh) * | 2019-01-16 | 2019-04-26 | 徐州立兴佳正医药科技有限公司 | 一种液质联用测定血浆中吡嗪酰胺浓度的方法 |
CN109997794B (zh) * | 2019-04-15 | 2021-10-29 | 华南农业大学 | 磺胺嘧啶对感染Wolbachia的短管赤眼蜂生殖行为中的应用 |
US20200393377A1 (en) * | 2019-06-11 | 2020-12-17 | Pocared Diagnostics Ltd. | Microscopy for Rapid Antibiotic Susceptibility Test Using Membrane Fluorescence Staining and Spectral Intensity Ratio |
US11845976B2 (en) | 2019-08-27 | 2023-12-19 | SeLux Diagnostics, Inc. | Systems and methods for performing antimicrobial susceptibility testing |
CN110551497B (zh) * | 2019-09-15 | 2022-06-10 | 四川农业大学 | 一种分子印迹量子点磷光探针的制备方法及其应用 |
CN110850077A (zh) * | 2019-11-06 | 2020-02-28 | 迪瑞医疗科技股份有限公司 | 妥布霉素化学发光检测试剂盒及其制备方法 |
CN112725403A (zh) * | 2021-01-25 | 2021-04-30 | 宁夏医科大学总医院 | 一种血流感染病原阴性菌微量肉汤荧光药敏方法 |
EP4305423A1 (en) * | 2021-03-08 | 2024-01-17 | Cobio Diagnostics Inc. | Method and kit for identifying antimicrobial agents and effective concentrations thereof |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3798320A (en) | 1970-09-18 | 1974-03-19 | South African Inventions | Precipitation of bacterial cells with polymers |
US4283382A (en) | 1977-12-28 | 1981-08-11 | Eastman Kodak Company | Fluorescent labels comprising rare earth chelates |
SE425439B (sv) | 1981-04-30 | 1982-09-27 | Wallac Oy | Immunologisk analys med lantanidkelatkomplex som markor |
SE441009B (sv) | 1982-03-08 | 1985-09-02 | Kjell Nilsson | Sett att immobilisera levande biomaterial i perlformiga polymerer |
SE8301395L (sv) | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
FR2570703B1 (fr) | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
US5220012A (en) | 1984-09-26 | 1993-06-15 | Compagnie Oris Industrie Sa | Macropolycyclic rare earth complexes and application as fluorescent tracers |
US4735907A (en) | 1985-03-18 | 1988-04-05 | Eastman Kodak Company | Stabilized fluorescent rare earth labels and labeled physiologically reactive species |
US4719182A (en) | 1985-03-18 | 1988-01-12 | Eastman Kodak Company | Fluorescent labels and labeled species and their use in analytical elements and determinations |
US5162508A (en) | 1987-12-18 | 1992-11-10 | Compagnie Oris Industrie | Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers |
FR2624862B1 (fr) | 1987-12-18 | 1990-06-08 | Oris Ind | Cryptates de terres rares, procedes d'obtention, intermediaires de synthese et application a titre de marqueurs fluorescents |
CA1340527C (en) | 1988-05-31 | 1999-05-04 | Lidia Vallarino | Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities |
US5202423A (en) | 1988-07-08 | 1993-04-13 | Wallac Oy | Terpyridine derivatives |
FR2664702B1 (fr) | 1990-07-13 | 1993-08-06 | Cis Bio Int | Procede de reduction d'interferences dans un dosage par fluorescence. |
FR2664699B1 (fr) | 1990-07-13 | 1995-08-18 | Cis Bio Int | Procede d'amplification du signal d'emission d'un compose luminescent. |
FR2672128B1 (fr) | 1991-01-28 | 1995-08-18 | Cis Bio Int | Procede de mesure de la luminescence emise dans un dosage par luminescence. |
US5491068A (en) | 1991-02-14 | 1996-02-13 | Vicam, L.P. | Assay method for detecting the presence of bacteria |
US5696240A (en) | 1991-03-15 | 1997-12-09 | Vallarino; Lidia M. | Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities |
IL100096A (en) | 1991-11-20 | 1996-03-31 | Univ Ramot | Method for entrapment of active materials in chitosan |
GB9411572D0 (en) | 1994-06-09 | 1994-08-03 | Amersham Int Plc | Magnetic bead precipitation method |
US20070020715A1 (en) * | 1995-03-20 | 2007-01-25 | The Regents Of The University Of California | Novel fluorogenic substrates for beta-lactamase gene expression |
US5847120A (en) | 1996-07-22 | 1998-12-08 | Carnegie Mellon University | Long-lived homogenous oxidation catalysts |
GB9712483D0 (en) | 1997-06-17 | 1997-08-20 | Kathirgamanathan Poopathy | Fabrication of light emitting devices from chelates of transition metals, lanthanides and actinides |
US7078224B1 (en) | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
CA2322072A1 (en) | 1998-12-28 | 2000-07-06 | Sapporo Breweries Ltd. | Method of apparatus for enumerating microbes by counting luminous points on a digitized pixilated image |
US6340744B1 (en) | 1999-01-19 | 2002-01-22 | Robert C. Leif | Reagent system and method for increasing the luminescence of lanthanide(III) macrocyclic complexes |
GB9901971D0 (en) | 1999-02-01 | 1999-03-17 | South Bank Univ Entpr Ltd | Electroluminescent material |
DE60044030D1 (de) | 1999-10-08 | 2010-04-29 | Robert C Leif | Markerkomplexe aus konjugierten polymeren |
AT410601B (de) | 2000-12-29 | 2003-06-25 | Hoffmann La Roche | Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet |
US6844028B2 (en) | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
DE10230147A1 (de) | 2001-10-09 | 2004-01-15 | Profos Ag | Verfahren zur unspezifischen Anreicherung von Bakterienzellen |
JP2005531295A (ja) * | 2002-01-08 | 2005-10-20 | シガ・テクノロジーズ,インコーポレイテッド | オルトポックスウイルス抗ウイルス薬のスクリーニング方法 |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7465747B2 (en) | 2002-03-08 | 2008-12-16 | Kazuko Matsumoto | Fluorescent label compounds |
EP1648286B1 (en) | 2003-07-12 | 2017-12-20 | Accelerate Diagnostics, Inc. | Sensitive and rapid biodetection |
US20120077206A1 (en) | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
US7341841B2 (en) | 2003-07-12 | 2008-03-11 | Accelr8 Technology Corporation | Rapid microbial detection and antimicrobial susceptibility testing |
KR100532106B1 (ko) | 2003-08-08 | 2005-11-29 | 삼성전자주식회사 | 아조 모이어티를 포함하는 금속착물 착색제 |
CA2550074A1 (en) | 2003-12-18 | 2005-06-30 | Wallac Oy | Novel chelating agents and highly luminescent and stable chelates and their use |
ES2491891T3 (es) * | 2004-01-16 | 2014-09-08 | Carnegie Mellon University | Marcaje celular para técnicas de resonancia magnética nuclear |
US7393599B2 (en) | 2004-05-18 | 2008-07-01 | The University Of Southern California | Luminescent compounds with carbene ligands |
DE102005020384A1 (de) * | 2005-05-02 | 2006-11-09 | Therainvention Gmbh | Spektroskopisches Verfahren zum Nachweis von Analyten |
US8193174B2 (en) | 2005-05-11 | 2012-06-05 | University Of Durham | Responsive luminescent lanthanide complexes |
JP5070057B2 (ja) | 2005-08-31 | 2012-11-07 | 独立行政法人科学技術振興機構 | 新規な蛍光標識化合物 |
US7968904B2 (en) | 2006-02-06 | 2011-06-28 | Fujifilm Corporation | Organic electroluminescence device |
JP4896544B2 (ja) | 2006-03-06 | 2012-03-14 | 富士フイルム株式会社 | 有機電界発光素子 |
US20090148870A1 (en) * | 2006-05-18 | 2009-06-11 | Ericson Daniel G | Rapid Detection of Mycobacterium Tuberculosis and Antimicrobial Drug Resistance |
US9012034B2 (en) | 2006-09-28 | 2015-04-21 | Udc Ireland Limited | Organic electroluminescence element |
WO2008064241A2 (en) * | 2006-11-20 | 2008-05-29 | Microphage Incorporated | Method and apparatus for enhanced bacteriophage-based diagnostic assay |
US9193746B2 (en) | 2006-12-07 | 2015-11-24 | Biotium, Inc. | Luminescent metal complexes and associated technology |
JP5130001B2 (ja) | 2007-07-27 | 2013-01-30 | 富士フイルム株式会社 | 有機電界発光素子 |
JP2009032989A (ja) | 2007-07-27 | 2009-02-12 | Fujifilm Corp | 有機電界発光素子 |
JP2009076865A (ja) | 2007-08-29 | 2009-04-09 | Fujifilm Corp | 有機電界発光素子 |
FI120538B (fi) | 2007-09-05 | 2009-11-30 | Wallac Oy | Kelaatit, kelatoivat aineet sekä niistä johdetut konjugaatit |
US8067100B2 (en) | 2007-10-04 | 2011-11-29 | Universal Display Corporation | Complexes with tridentate ligands |
US8383249B2 (en) | 2007-10-04 | 2013-02-26 | Universal Display Corporation | Complexes with tridentate ligands |
JP2009211892A (ja) | 2008-03-03 | 2009-09-17 | Fujifilm Corp | 有機電界発光素子 |
JP5288967B2 (ja) | 2008-09-22 | 2013-09-11 | ユー・ディー・シー アイルランド リミテッド | 発光素子及びその製造方法、並びに該発光素子を備えるディスプレイ |
US8288763B2 (en) | 2008-12-10 | 2012-10-16 | Fujifilm Corporation | Organic electroluminescence device |
JP5457847B2 (ja) | 2009-01-23 | 2014-04-02 | ユー・ディー・シー アイルランド リミテッド | 有機電界発光素子 |
JP2010182449A (ja) | 2009-02-03 | 2010-08-19 | Fujifilm Corp | 有機el表示装置 |
JP2010205650A (ja) | 2009-03-05 | 2010-09-16 | Fujifilm Corp | 有機el表示装置 |
CN102639998B (zh) * | 2009-04-30 | 2014-12-03 | Cis-生物国际公司 | 用于检测调节vft域膜蛋白二聚体的化合物的方法 |
AU2010245860B2 (en) * | 2009-05-07 | 2015-07-16 | Biomerieux, Inc. | Methods for antimicrobial resistance determination |
US8722881B2 (en) | 2009-10-13 | 2014-05-13 | Board Of Trustees Of The University Of Arkansas | Method of synthesis of tetradentate amide macrocycle ligand and its metal-complex |
TWI477579B (zh) | 2010-02-12 | 2015-03-21 | Nippon Steel & Sumikin Chem Co | Organic electroluminescent elements |
TWI510488B (zh) | 2010-09-13 | 2015-12-01 | Nippon Steel & Sumikin Chem Co | Organic electroluminescent elements |
WO2012050003A1 (ja) | 2010-10-13 | 2012-04-19 | 新日鐵化学株式会社 | 有機電界発光素子 |
EP2645444B1 (en) | 2010-11-25 | 2018-04-25 | Nippon Steel & Sumikin Chemical Co., Ltd. | Organic electroluminescent element |
WO2012077520A1 (ja) | 2010-12-09 | 2012-06-14 | 新日鐵化学株式会社 | 有機電界発光素子 |
JP2014509585A (ja) | 2011-03-11 | 2014-04-21 | ベー・エル・アー・ハー・エム・エス・ゲーエムベーハー | フェナントロリン化合物を配位子とする希土類金属錯体 |
KR101978165B1 (ko) | 2011-03-14 | 2019-05-14 | 도레이 카부시키가이샤 | 발광 소자 재료 및 발광 소자 |
JP5655666B2 (ja) | 2011-03-31 | 2015-01-21 | 大日本印刷株式会社 | 有機エレクトロルミネッセンス素子、有機エレクトロルミネッセンス素子の製造方法および電子注入輸送層用塗工液 |
BR112013027966A2 (pt) | 2011-05-12 | 2017-01-17 | Toray Industries | material do dispositivo emissor de luz e dispositivo emissor de luz |
US8754206B2 (en) | 2011-06-21 | 2014-06-17 | Council Of Scientific & Industrial Research | Metal (III) complex of biuret-amide based macrocyclic ligand as green oxidation catalyst |
CA3149018A1 (en) * | 2011-07-18 | 2013-01-24 | President And Fellows Of Harvard College | Engineered microbe-targeting molecules and uses thereof |
EP2617833A1 (en) | 2012-01-18 | 2013-07-24 | Centre National de la Recherche Scientifique (CNRS) | A method for specifically detecting living bacteria |
AU2013225823A1 (en) * | 2012-02-29 | 2014-09-18 | President And Fellows Of Harvard College | Rapid antibiotic susceptibility testing |
US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
EP3146064A1 (en) | 2014-05-23 | 2017-03-29 | Accelerate Diagnostics, Inc. | Methods of microorganism immobilization |
EP3172569A1 (en) | 2014-07-25 | 2017-05-31 | Selux Diagnostics Inc. | Assay methods involving dissociable nanoparticles |
ES2862345T3 (es) * | 2016-01-21 | 2021-10-07 | Selux Diagnostics Inc | Métodos rápidos para probar la susceptibilidad antimicrobiana |
-
2017
- 2017-01-20 ES ES17704867T patent/ES2862345T3/es active Active
- 2017-01-20 CN CN201780019958.7A patent/CN109072280B/zh active Active
- 2017-01-20 EP EP21158888.4A patent/EP3845663A1/en not_active Withdrawn
- 2017-01-20 AU AU2017210215A patent/AU2017210215B2/en active Active
- 2017-01-20 JP JP2018557290A patent/JP7046833B2/ja active Active
- 2017-01-20 CA CA3010895A patent/CA3010895A1/en active Pending
- 2017-01-20 WO PCT/US2017/014343 patent/WO2017127684A1/en active Application Filing
- 2017-01-20 BR BR112018014146A patent/BR112018014146A2/pt not_active Application Discontinuation
- 2017-01-20 EP EP17704867.5A patent/EP3405585B1/en active Active
- 2017-01-20 MX MX2018008906A patent/MX2018008906A/es unknown
-
2018
- 2018-07-05 ZA ZA2018/04498A patent/ZA201804498B/en unknown
- 2018-07-08 IL IL260466A patent/IL260466B/en unknown
-
2021
- 2021-12-15 JP JP2021203143A patent/JP2022050413A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA201804498B (en) | 2019-09-25 |
JP2022050413A (ja) | 2022-03-30 |
EP3405585A1 (en) | 2018-11-28 |
CN109072280B (zh) | 2022-10-14 |
EP3405585B1 (en) | 2021-03-03 |
CN109072280A (zh) | 2018-12-21 |
ES2862345T3 (es) | 2021-10-07 |
AU2017210215B2 (en) | 2022-09-08 |
AU2017210215A1 (en) | 2018-07-19 |
MX2018008906A (es) | 2019-01-10 |
CA3010895A1 (en) | 2017-07-27 |
WO2017127684A1 (en) | 2017-07-27 |
EP3845663A1 (en) | 2021-07-07 |
JP2019508062A (ja) | 2019-03-28 |
IL260466B (en) | 2022-03-01 |
JP7046833B2 (ja) | 2022-04-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018014146A2 (pt) | métodos de teste rápido de suscetibilidade antimicrobiana | |
BR112019008494A2 (pt) | anticorpos para pd-1 e usos dos mesmos | |
BR112018012138A2 (pt) | moléculas de anticorpo para pd-1 e usos das mesmas | |
BR112017010324A2 (pt) | método para tratar ou retardar a progressão de um câncer em um indivíduo, moléculas, métodos para aumentar a função imune em um indivíduo e para selecionar um paciente para tratamento, kits, composição farmacêutica e usos de uma combinação de uma molécula | |
BR112017017086A2 (pt) | monitoramento de produtos de escavação para equipamento de terraplenagem | |
EA202091540A1 (ru) | Антитела к lilrb2 | |
BR112018014759A2 (pt) | derivados de maitansinoide, conjugados dos mesmos e métodos de uso | |
BR112016027475A2 (pt) | kit, dispositivo e método para a detecção de câncer pancreático | |
MX2019007653A (es) | Métodos para la optimización de ensayos rápidos de susceptibilidad antimicrobiana. | |
BR112017020149A2 (pt) | derivados de maitansinoide, conjugados dos mesmos e métodos de uso | |
BR112016029634A2 (pt) | kit, dispositivo e método para a detecção de câncer de fígado | |
BR112016028944A2 (pt) | kit ou dispositivo para a detecção de câncer do trato biliar e método de detecção | |
WO2015094995A3 (en) | Gene signature biomarkers of tumor response to pd-1 antagonists | |
BR112016004305A2 (pt) | métodos diagnósticos e composições para tratamento de glioblastoma | |
BR112017006531A2 (pt) | composições, kits e métodos para induzir citorresistência adquirida utilizando indutores de proteínas de estresse | |
BR112016029521A2 (pt) | ?kit, dispositivo e método para a detecção de câncer de estômago? | |
BR112018069976A2 (pt) | anticorpo multiespecífico isolado ou um fragmento de ligação ao antígeno do mesmo, composição farmacêutica, kit, e, método para tratamento de um indivíduo. | |
WO2015094996A3 (en) | Pd-l1 gene signature biomarkers of tumor response to pd-1 antagonists | |
CO2018005393A2 (es) | Anticuerpos anti-htra1 y métodos de uso de los mismos | |
CL2017002604A1 (es) | Sondas duales silenciadoras | |
BR112018000187A2 (pt) | composto, composição, método, e, uso de um composto ou composição | |
BR112019020414A2 (pt) | composições e métodos para detectar e tratar câncer de próstata usando moléculas de ligação à progastrina | |
BR112018073178A2 (pt) | método, matriz e uso dos mesmos | |
BR112018075135A2 (pt) | combinações farmacêuticas para tratar câncer | |
MX2021004114A (es) | Anticuerpos dirigidos contra leucotoxinas de staphylococcus aureus. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |