BR112017024548A2 - laser pulsado e sistema bioanalítico - Google Patents

laser pulsado e sistema bioanalítico

Info

Publication number
BR112017024548A2
BR112017024548A2 BR112017024548A BR112017024548A BR112017024548A2 BR 112017024548 A2 BR112017024548 A2 BR 112017024548A2 BR 112017024548 A BR112017024548 A BR 112017024548A BR 112017024548 A BR112017024548 A BR 112017024548A BR 112017024548 A2 BR112017024548 A2 BR 112017024548A2
Authority
BR
Brazil
Prior art keywords
optical pulses
instrument
pulsed laser
bioanalytical system
commensurate
Prior art date
Application number
BR112017024548A
Other languages
English (en)
Other versions
BR112017024548B1 (pt
Inventor
M. Rothberg Jonathan
W. SICKLER Jason
C. West Lawrence
Ahmad Faisal
E. Glenn Paul
jewell Jack
glenn John
Camara Jose
christopher jordan Jeremy
Rearick Todd
GHASEMI Farshid
C. SCHULTZ Jonathan
G. Fife Keith
Original Assignee
Quantum-Si Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/821,688 external-priority patent/US9885657B2/en
Priority claimed from US14/821,656 external-priority patent/US9759658B2/en
Application filed by Quantum-Si Incorporated filed Critical Quantum-Si Incorporated
Publication of BR112017024548A2 publication Critical patent/BR112017024548A2/pt
Publication of BR112017024548B1 publication Critical patent/BR112017024548B1/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
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    • G01N21/64—Fluorescence; Phosphorescence
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    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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    • H01S3/108—Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling devices placed within the cavity using non-linear optical devices, e.g. exhibiting Brillouin or Raman scattering
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    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/069—Supply of sources
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    • G01N2201/0697—Pulsed lasers
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    • H01S3/0092—Nonlinear frequency conversion, e.g. second harmonic generation [SHG] or sum- or difference-frequency generation outside the laser cavity
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    • H01S3/14—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range characterised by the material used as the active medium
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    • H01S3/1611—Solid materials characterised by an active (lasing) ion rare earth neodymium
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    • H01S5/0657—Mode locking, i.e. generation of pulses at a frequency corresponding to a roundtrip in the cavity
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  • Physics & Mathematics (AREA)
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Electromagnetism (AREA)
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  • Analytical Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nonlinear Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Lasers (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

a presente invenção refere-se a aparelho e métodos para produção de pulsos ópticos ultracurtos (1-110). um laser de modo passivamente bloqueado, de estado sólido, de alta potência (1-110) pode ser fabricado em um módulo compacto que pode ser incorporado a um instrumento portátil para análises biológicas ou químicas. o laser pulsado pode produzir pulsos ópticos sub-100-ps em uma taxa de repetição comensurada com taxas de aquisição de dados eletrônicos. os pulsos ópticos podem excitar amostras em câmaras de reação do instrumento e ser usados para gerar um clock de referência para operação de eletrônicos de aquisição de sinal e processamento de sinal do instrumento.
BR112017024548-5A 2015-05-20 2016-05-20 Laser de modo bloqueado, método para sequenciamento de dna e instrumento bioanalítico BR112017024548B1 (pt)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201562164506P 2015-05-20 2015-05-20
US201562164464P 2015-05-20 2015-05-20
US201562164485P 2015-05-20 2015-05-20
US201562164482P 2015-05-20 2015-05-20
US62/164,464 2015-05-20
US62/164,506 2015-05-20
US14/821,688 US9885657B2 (en) 2014-08-08 2015-08-07 Integrated device with external light source for probing detecting and analyzing molecules
US14/821,688 2015-08-07
US14/821,656 2015-08-07
US14/821,656 US9759658B2 (en) 2014-08-08 2015-08-07 Integrated device for temporal binning of received photons
US201662289019P 2016-01-29 2016-01-29
US201662310398P 2016-03-18 2016-03-18
US62/310,398 2016-03-18
PCT/US2016/033576 WO2016187564A1 (en) 2015-05-20 2016-05-20 Pulsed laser and bioanalytic system

Publications (2)

Publication Number Publication Date
BR112017024548A2 true BR112017024548A2 (pt) 2018-07-24
BR112017024548B1 BR112017024548B1 (pt) 2022-05-31

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BR112017024548-5A BR112017024548B1 (pt) 2015-05-20 2016-05-20 Laser de modo bloqueado, método para sequenciamento de dna e instrumento bioanalítico

Country Status (11)

Country Link
EP (1) EP3298388A1 (pt)
JP (3) JP6878306B2 (pt)
KR (1) KR20180009772A (pt)
CN (2) CN107923850B (pt)
AU (2) AU2016264737B2 (pt)
BR (1) BR112017024548B1 (pt)
CA (1) CA2986151A1 (pt)
HK (1) HK1252484A1 (pt)
MX (1) MX2017014817A (pt)
TW (1) TWI693400B (pt)
WO (1) WO2016187564A1 (pt)

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EP3298388A1 (en) 2018-03-28
CN107923850B (zh) 2022-08-30
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BR112017024548B1 (pt) 2022-05-31
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TWI693400B (zh) 2020-05-11
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AU2021282473B2 (en) 2023-12-07
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