BR112017024265B1 - Métodos para crescimento de um biofilme de bactérias probióticas em partículas sólidas - Google Patents
Métodos para crescimento de um biofilme de bactérias probióticas em partículas sólidas Download PDFInfo
- Publication number
- BR112017024265B1 BR112017024265B1 BR112017024265-6A BR112017024265A BR112017024265B1 BR 112017024265 B1 BR112017024265 B1 BR 112017024265B1 BR 112017024265 A BR112017024265 A BR 112017024265A BR 112017024265 B1 BR112017024265 B1 BR 112017024265B1
- Authority
- BR
- Brazil
- Prior art keywords
- biofilm
- particles
- bacteria
- population
- strain
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims abstract description 103
- 241000894006 Bacteria Species 0.000 title claims abstract description 99
- 238000000034 method Methods 0.000 title claims abstract description 46
- 239000006041 probiotic Substances 0.000 title claims abstract description 11
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 11
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 11
- 239000007787 solid Substances 0.000 title abstract description 8
- 230000001580 bacterial effect Effects 0.000 claims abstract description 62
- 210000000936 intestine Anatomy 0.000 claims abstract description 51
- 239000001963 growth medium Substances 0.000 claims abstract description 23
- 238000012258 culturing Methods 0.000 claims abstract description 9
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 18
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 17
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 16
- 239000001506 calcium phosphate Substances 0.000 claims description 16
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 16
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 13
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 10
- 229940072056 alginate Drugs 0.000 claims description 10
- 235000010443 alginic acid Nutrition 0.000 claims description 10
- 229920000615 alginic acid Polymers 0.000 claims description 10
- 239000004927 clay Substances 0.000 claims description 8
- 239000004576 sand Substances 0.000 claims description 8
- 239000001913 cellulose Substances 0.000 claims description 7
- 229920002678 cellulose Polymers 0.000 claims description 7
- 230000001419 dependent effect Effects 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 241000186660 Lactobacillus Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 229940039696 lactobacillus Drugs 0.000 claims description 2
- 241000589220 Acetobacter Species 0.000 claims 1
- 241000755920 Christensenella Species 0.000 claims 1
- -1 seeds Substances 0.000 claims 1
- 240000006024 Lactobacillus plantarum Species 0.000 description 27
- 241000699670 Mus sp. Species 0.000 description 25
- 241000219991 Lythraceae Species 0.000 description 19
- 235000014360 Punica granatum Nutrition 0.000 description 19
- 235000013305 food Nutrition 0.000 description 15
- 230000003068 static effect Effects 0.000 description 15
- 239000011159 matrix material Substances 0.000 description 14
- 241000027100 Corticarina minuta Species 0.000 description 10
- 241000588724 Escherichia coli Species 0.000 description 10
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 8
- 244000288157 Passiflora edulis Species 0.000 description 8
- 235000000370 Passiflora edulis Nutrition 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 229940072205 lactobacillus plantarum Drugs 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 238000004108 freeze drying Methods 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 241000923672 Acetobacter pomorum Species 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 239000004005 microsphere Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 241001529936 Murinae Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 241000589516 Pseudomonas Species 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 230000032770 biofilm formation Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000002550 fecal effect Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 235000003642 hunger Nutrition 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000006872 mrs medium Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000037351 starvation Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012364 cultivation method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 244000005709 gut microbiome Species 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000012612 static experiment Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- C12N11/12—Cellulose or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562159849P | 2015-05-11 | 2015-05-11 | |
US201562159846P | 2015-05-11 | 2015-05-11 | |
US62/159,846 | 2015-05-11 | ||
US62/159,849 | 2015-05-11 | ||
PCT/IB2016/000933 WO2016181228A2 (fr) | 2015-05-11 | 2016-05-09 | Systèmes et procédés pour faire croître un biofilm de bactéries probiotiques sur des particules solides pour la colonisation de l'intestin par les bactéries |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017024265A2 BR112017024265A2 (pt) | 2018-07-24 |
BR112017024265B1 true BR112017024265B1 (pt) | 2022-08-09 |
Family
ID=57248945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017024265-6A BR112017024265B1 (pt) | 2015-05-11 | 2016-05-09 | Métodos para crescimento de um biofilme de bactérias probióticas em partículas sólidas |
Country Status (11)
Country | Link |
---|---|
US (4) | US10793847B2 (fr) |
EP (1) | EP3294073B1 (fr) |
JP (2) | JP6990922B2 (fr) |
CN (2) | CN114990099A (fr) |
AU (1) | AU2016259871B2 (fr) |
BR (1) | BR112017024265B1 (fr) |
CA (1) | CA2985729C (fr) |
DK (1) | DK3294073T3 (fr) |
ES (1) | ES2929893T3 (fr) |
IL (2) | IL255583B (fr) |
WO (1) | WO2016181228A2 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014071182A1 (fr) | 2012-11-01 | 2014-05-08 | Massachusetts Institute Of Technology | Évolution dirigée d'une batterie de gènes synthétiques |
CN114990099A (zh) | 2015-05-11 | 2022-09-02 | 迈彼欧提克斯制药有限公司 | 用于使益生菌在使细菌于肠道中定植用途的固体颗粒上生长成益生菌生物膜的系统和方法 |
WO2017011602A1 (fr) | 2015-07-13 | 2017-01-19 | Pivot Bio, Inc. | Procédés et compositions pour améliorer les caractéristiques d'une plante |
WO2017062412A1 (fr) | 2015-10-05 | 2017-04-13 | Massachusetts Institute Of Technology | Fixation d'azote à l'aide d'agrégats nif remodelés |
RU2022101485A (ru) * | 2016-05-25 | 2022-04-27 | Майбиотикс Фарма Лтд. | Композиция и способы для микробиотной терапии |
WO2018220630A1 (fr) * | 2017-05-29 | 2018-12-06 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Procédé de génération de compositions bactériennes comprenant un biofilm avec des bactéries bénéfiques |
JP6998892B2 (ja) | 2016-05-29 | 2022-02-04 | ザ ステート オブ イスラエル, ミニストリー オブ アグリカルチャー アンド ルーラル ディヴェロプメント, アグリカルチュラル リサーチ オーガニゼーション (エーアールオー) (ボルカニ センター) | 細菌組成物の作製方法 |
KR102320673B1 (ko) * | 2016-12-28 | 2021-11-01 | 인벤사스 본딩 테크놀로지스 인코포레이티드 | 적층된 기판의 처리 |
UY37566A (es) | 2017-01-12 | 2018-07-31 | Pivot Bio Inc | Métodos y composiciones para mejorar características en plantas |
KR20200088342A (ko) | 2017-10-25 | 2020-07-22 | 피벗 바이오, 인크. | 질소를 고정하는 유전자조작 미생물을 개선하는 방법 및 조성물 |
MX2020013875A (es) | 2018-06-27 | 2021-08-11 | Pivot Bio Inc | Composiciones agricolas que comprenden microbios remodelados de fijacion de nitrogeno. |
AR116964A1 (es) * | 2018-11-01 | 2021-06-30 | Pivot Bio Inc | Composiciones de biopelículas con estabilidad mejorada para fijación del nitrógeno en productos microbianos |
CN110051698A (zh) * | 2019-03-18 | 2019-07-26 | 天津大学 | 基于微囊化处理的肠道原生菌基因改造的方法 |
KR20220016042A (ko) * | 2019-03-28 | 2022-02-08 | 마이바이오틱스 파마 엘티디. | 프로바이오틱 생물막 조성물 및 이의 제조 방법 |
CN114728026A (zh) | 2019-08-28 | 2022-07-08 | 未知君有限责任公司 | 包含细菌物种的组合物及与其相关的方法 |
CN111012804B (zh) * | 2019-12-16 | 2022-05-17 | 南京大学 | 益生菌矿物材料复合制剂、矿物材料在制备抑制恶性肿瘤生长药物中的应用 |
IL286748A (en) * | 2021-09-27 | 2023-04-01 | Mybiotics Pharma Ltd | Antimicrobial preparations and methods for their preparation |
WO2023119287A1 (fr) * | 2021-12-22 | 2023-06-29 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) | Bactéries nomades et leurs utilisations |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5391113A (en) | 1977-01-21 | 1978-08-10 | Meiji Seika Kaisha Ltd | Preparation of suppository of antibiotics |
US5443826A (en) | 1988-08-02 | 1995-08-22 | Borody; Thomas J. | Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli |
CA2285430C (fr) * | 1997-04-01 | 2008-11-18 | Cap Biotechnology, Inc. | Microsupports et microspheres a base de phosphate de calcium |
NZ512275A (en) | 1998-12-11 | 2003-11-28 | Urex Biotech Inc | Probiotic therapy delivered to women by oral administration of selected lactobascilli that have antagonistic properties against urogenital pathogens |
US20020192742A1 (en) | 1999-12-17 | 2002-12-19 | Masashi Ushiyama | Microorganism incubator and microorganism culture medium comprising the same |
KR100375422B1 (ko) | 1999-12-21 | 2003-03-10 | 한국과학기술연구원 | 다공성 키토산 구슬 및 그의 제조 방법 |
US6599696B2 (en) * | 2000-04-17 | 2003-07-29 | University Technologies International, Inc. | Effects of materials and surface coatings on encrustation and biofilm formation |
FR2808689B1 (fr) | 2000-05-11 | 2004-09-03 | Agronomique Inst Nat Rech | Utilisation de souches acetogenes hydrogenotrophes pour la prevention ou le traitement de troubles digestifs |
US7214370B2 (en) | 2000-12-18 | 2007-05-08 | Probiohealth, Llc | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
BR0214162A (pt) | 2001-11-16 | 2004-09-28 | Phytoculture Control Co Ltd | Aparelho para cultura de organismo e processo para cultura de organismo |
US20050186633A9 (en) | 2002-05-15 | 2005-08-25 | Christophe Lacroix | In vitro gastrointestinal model system and uses thereof |
CN1461734A (zh) * | 2002-05-30 | 2003-12-17 | 上海鸿宝绿色水产科技发展有限公司 | 微胶囊益生净水复合菌修复水产养殖环境的方法 |
AU2003268033A1 (en) | 2002-07-26 | 2004-02-16 | The General Hospital Corporation | Systems and methods for cell preservation |
IL151660A0 (en) | 2002-09-09 | 2003-04-10 | Univ Ben Gurion | Method for isolating and culturing unculturable microorganisms |
GB0330009D0 (en) | 2003-12-24 | 2004-01-28 | Ferrosan As | Probiotic tablet formulations |
ITRM20040166A1 (it) | 2004-03-31 | 2004-06-30 | Alberto Cresci | Ceppi batterici lab con proprieta' probiotiche e composizioni che contengono gli stessi. |
JP4811760B2 (ja) | 2004-12-27 | 2011-11-09 | 独立行政法人農業・食品産業技術総合研究機構 | ダイゼイン資化によるエコール生成能を改善するための腸内細菌およびその利用 |
EP1776877A1 (fr) | 2005-10-21 | 2007-04-25 | N.V. Nutricia | Méthode de stimulation de la flore intestinale |
EP1978821B2 (fr) | 2005-12-29 | 2019-02-06 | Hill's Pet Nutrition, Inc. | Methode permettant de modifier la flore intestinale chez des animaux |
ITMI20061421A1 (it) | 2006-07-20 | 2008-01-21 | Velleja Res Srl | Composizioni farmaceutiche topiche vaginali |
EP2186890A1 (fr) * | 2007-07-31 | 2010-05-19 | Nihon University | Procédé de production d'un biofilm |
WO2009092810A2 (fr) | 2008-01-24 | 2009-07-30 | Bacterfield Oü | Composition pharmaceutique unique contenant des antibiotiques et des probiotiques |
CN101368154B (zh) | 2008-06-18 | 2012-02-01 | 华中农业大学 | 一种人肠道菌群连续培养的系统及方法 |
US20120247993A1 (en) | 2008-11-14 | 2012-10-04 | Unistraw Patent Holdings Limited | Probiotic Compositions, Methods and Apparatus for Their Administration |
CN101440395A (zh) | 2008-12-15 | 2009-05-27 | 浙江大学 | 一种肠道细菌培养方法及其培养基 |
WO2010102198A1 (fr) * | 2009-03-06 | 2010-09-10 | Tamarisk Technologies, L.L.C. | Agents bioactifs microencapsulés pour administration orale et méthodes d'utilisation associées |
IT1400821B1 (it) | 2009-03-09 | 2013-07-02 | Probiotical Spa | Sospensione oleosa contenente batteri probiotici per uso pediatrico |
GB0906236D0 (en) | 2009-04-14 | 2009-05-20 | Univ Gent | Technology and method to study microbial growth and adhesion to host-related surfaces and the host-microbiota interaction |
EP2421544B1 (fr) | 2009-04-22 | 2015-06-03 | Ofir Menashe | Micro-organisme comprenant des particules et ses utilisations |
JP5561642B2 (ja) | 2009-05-14 | 2014-07-30 | 株式会社みすずコーポレーション | ヨーグルト |
JPWO2010137404A1 (ja) | 2009-05-28 | 2012-11-12 | 株式会社アルプスビジネスクリエーション | 細菌のバイオフィルムを接種した種子 |
GB0916335D0 (en) | 2009-09-17 | 2009-10-28 | Martin W J | Medicaments |
TWI461213B (zh) * | 2009-11-05 | 2014-11-21 | Fmc Corp | 作為藥物賦形劑之微晶纖維素及磷酸鈣之組合物 |
EP2338476B1 (fr) | 2009-12-02 | 2012-06-20 | Bettina Heil | Suppositoire pour administration rectale, vaginale ou urétrale contenant un probiotique, un antibiotique et un acide gras insaturé non-estérifié |
CN101724622B (zh) * | 2009-12-07 | 2011-12-14 | 天津科技大学 | 一种干酪乳杆菌微胶囊的制备方法 |
PT3564357T (pt) | 2010-02-01 | 2022-06-14 | Rebiotix Inc | Bacterioterapia para colite por clostridium difficile |
EP3311825A1 (fr) | 2010-08-04 | 2018-04-25 | Thomas Julius Borody | Compositions permettant la transplantation de flore fécale et leurs procédés de préparation et d'utilisation |
WO2012058630A2 (fr) | 2010-10-29 | 2012-05-03 | The Regents Of The Unviversity Of California | Procédé permettant de produire de nouvelles molécules bioactives |
IT1403661B1 (it) | 2011-01-28 | 2013-10-31 | Probiotical Spa | Composizione effervescente in forma solida per uso in applicazioni vaginali per il trattamento di infezioni vaginali. |
ES2636439T3 (es) | 2011-03-09 | 2017-10-05 | Regents Of The University Of Minnesota | Composiciones y métodos para el trasplante de microbiota de colon |
US10173937B2 (en) | 2011-06-06 | 2019-01-08 | Cool Planet Energy Systems, Inc. | Biochar as a microbial carrier |
US20130022575A1 (en) | 2011-07-19 | 2013-01-24 | Microbial Rx | Systems and methods of replacing intestinal flora |
JP2013150599A (ja) * | 2011-12-27 | 2013-08-08 | Nihon Univ | 抗菌物質生産菌と発酵菌を共培養する発酵法 |
ITMI20120131A1 (it) | 2012-02-01 | 2013-08-02 | Probiotical Spa | Batteri probiotici microincapsulati multistrato, loro produzione ed uso |
CN105473152A (zh) | 2013-06-05 | 2016-04-06 | 雷柏奥提斯有限公司 | 菌群恢复疗法(mrt)、组合物和制造方法 |
DE202013103204U1 (de) | 2013-07-17 | 2013-07-26 | Pharmaceutical Biotechnology S.R.O. | Präparat, welches eine probiotische Kultur enthält |
EP3536168A3 (fr) | 2014-03-06 | 2019-10-16 | The Research Institute at Nationwide Children's Hospital | Formulations probiotiques et procédés d'utilisation |
CN114990099A (zh) | 2015-05-11 | 2022-09-02 | 迈彼欧提克斯制药有限公司 | 用于使益生菌在使细菌于肠道中定植用途的固体颗粒上生长成益生菌生物膜的系统和方法 |
RU2580002C1 (ru) | 2015-05-19 | 2016-04-10 | Дмитрий Евгеньевич Денисов | Способ получения аутопробиотика, содержащего живые бифидобактерии и лактобактерии |
CN105193856A (zh) | 2015-09-25 | 2015-12-30 | 南昌大学 | 一种人工培养粪便菌群移植在肠道疾病治疗中的应用 |
AU2016353091B2 (en) | 2015-11-10 | 2022-07-14 | Probiotech Llc | Probiotic delivery systems |
CN109803666A (zh) | 2015-11-30 | 2019-05-24 | 医迈霖科技公司 | 包括益生菌的组合物及其使用方法 |
RU2022101485A (ru) | 2016-05-25 | 2022-04-27 | Майбиотикс Фарма Лтд. | Композиция и способы для микробиотной терапии |
JP6998892B2 (ja) | 2016-05-29 | 2022-02-04 | ザ ステート オブ イスラエル, ミニストリー オブ アグリカルチャー アンド ルーラル ディヴェロプメント, アグリカルチュラル リサーチ オーガニゼーション (エーアールオー) (ボルカニ センター) | 細菌組成物の作製方法 |
US11260086B2 (en) | 2016-07-11 | 2022-03-01 | The Brigham And Women's Hospital, Inc. | Medicinal vaginal lactobacillus cocktail |
US20180030403A1 (en) | 2016-07-28 | 2018-02-01 | Bobban Subhadra | Devices, systems and methods for the production of humanized gut commensal microbiota |
US10258567B1 (en) | 2016-11-17 | 2019-04-16 | Grace Procurements Llc | Vaginal probiotic products and related processes |
US20190209626A1 (en) | 2018-01-05 | 2019-07-11 | Human Longevity, Inc. | Probiotic compositions comprising bacteria from bacteroids and firmicutes phyla |
CA3095749A1 (fr) | 2018-04-02 | 2019-10-10 | President And Fellows Of Harvard College | Microbiome intestinal humain complexe cultive dans un intestin humain anaerobie-sur-puce |
WO2020086487A1 (fr) | 2018-10-22 | 2020-04-30 | Research Institute At Nationwide Children's Hospital | Compositions et méthodes de prévention et de traitement de pathologies induites par des antibiotiques à l'aide de probiotiques à l'état de biofilm |
WO2020180037A1 (fr) | 2019-03-04 | 2020-09-10 | 경북대학교 산학협력단 | Composition pour la culture d'un mimétique du microbiome intestinal humain, procédé de culture d'un mimétique du microbiome intestinal humain à l'aide d'un système de culture anaérobie, agent microbien préparé à l'aide de ce dernier, et son utilisation |
CA3130816A1 (fr) | 2019-04-15 | 2020-10-22 | Josep M. Sune Negre | Composition de microbiote fecal vivant stable a long terme |
BR112022024128A2 (pt) | 2020-06-01 | 2022-12-27 | Ferring Bv | Composição de microbiota vaginal, e, método para tratar uma infecção |
-
2016
- 2016-05-09 CN CN202210612650.6A patent/CN114990099A/zh active Pending
- 2016-05-09 CA CA2985729A patent/CA2985729C/fr active Active
- 2016-05-09 JP JP2018511533A patent/JP6990922B2/ja active Active
- 2016-05-09 BR BR112017024265-6A patent/BR112017024265B1/pt active IP Right Grant
- 2016-05-09 ES ES16792262T patent/ES2929893T3/es active Active
- 2016-05-09 WO PCT/IB2016/000933 patent/WO2016181228A2/fr active Application Filing
- 2016-05-09 US US15/572,972 patent/US10793847B2/en active Active
- 2016-05-09 CN CN201680038473.8A patent/CN108135240B/zh active Active
- 2016-05-09 EP EP16792262.4A patent/EP3294073B1/fr active Active
- 2016-05-09 AU AU2016259871A patent/AU2016259871B2/en active Active
- 2016-05-09 DK DK16792262.4T patent/DK3294073T3/da active
-
2017
- 2017-11-09 IL IL255583A patent/IL255583B/en unknown
-
2020
- 2020-09-24 US US17/031,436 patent/US11001828B2/en active Active
- 2020-09-24 US US17/031,271 patent/US11680257B2/en active Active
-
2021
- 2021-04-01 JP JP2021062868A patent/JP2021104042A/ja active Pending
- 2021-10-26 IL IL287585A patent/IL287585A/en unknown
-
2023
- 2023-03-26 US US18/126,459 patent/US20230227806A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2018517430A (ja) | 2018-07-05 |
DK3294073T3 (da) | 2022-11-14 |
EP3294073A4 (fr) | 2019-03-13 |
AU2016259871B2 (en) | 2020-04-16 |
IL255583A (en) | 2018-01-31 |
JP2021104042A (ja) | 2021-07-26 |
US20210002627A1 (en) | 2021-01-07 |
US10793847B2 (en) | 2020-10-06 |
BR112017024265A2 (pt) | 2018-07-24 |
US11680257B2 (en) | 2023-06-20 |
EP3294073A2 (fr) | 2018-03-21 |
IL287585A (en) | 2021-12-01 |
ES2929893T3 (es) | 2022-12-02 |
WO2016181228A3 (fr) | 2017-01-05 |
CN114990099A (zh) | 2022-09-02 |
WO2016181228A2 (fr) | 2016-11-17 |
US20210009985A1 (en) | 2021-01-14 |
US20180355343A1 (en) | 2018-12-13 |
EP3294073B1 (fr) | 2022-08-10 |
IL255583B (en) | 2021-10-31 |
US20230227806A1 (en) | 2023-07-20 |
US11001828B2 (en) | 2021-05-11 |
CA2985729A1 (fr) | 2016-11-17 |
CA2985729C (fr) | 2023-05-09 |
RU2017143181A3 (fr) | 2019-10-18 |
AU2016259871A1 (en) | 2018-01-04 |
JP6990922B2 (ja) | 2022-01-12 |
CN108135240B (zh) | 2022-06-17 |
RU2017143181A (ru) | 2019-06-13 |
CN108135240A (zh) | 2018-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112017024265B1 (pt) | Métodos para crescimento de um biofilme de bactérias probióticas em partículas sólidas | |
CN107997179B (zh) | 一种乳酸菌微胶囊的制备方法 | |
CN104232515B (zh) | 一种动物双歧杆菌及其应用 | |
Boran et al. | Bacterial diseases of cultured Mediterranean horse mackerel (Trachurus mediterraneus) in sea cages | |
CN112011481B (zh) | 一株防治畜禽细菌性腹泻的罗伊氏乳杆菌及其应用 | |
CN103932186A (zh) | 一种长双歧杆菌微胶囊及其制备方法 | |
CN107125767B (zh) | 一种短双歧杆菌、发酵乳杆菌和植物乳杆菌三菌复合微粒子的制备方法及应用 | |
CN102283334A (zh) | 可改善小型犬肠道微生态的复合益生菌微胶囊 | |
Piyadeatsoontorn et al. | Encapsulating viability of multi-strain Lactobacilli as potential probiotic in pigs | |
WO2016194427A1 (fr) | Probiotique ou prébiotique, procédé pour le produire, préparation microbienne, aliment santé et médicament | |
JP2016204355A (ja) | プロバイオティクス、あるいはプレバイオティクス、並びにその製造方法、微生物製剤、健康食品並びに医薬品 | |
KR100557397B1 (ko) | 유해미생물 억제 활성을 가지는 신규 내산성 락토바실러스 루테리 Probio-054 및 이를 함유하는 생균활성제 | |
CN117089487A (zh) | 一株副干酪乳杆菌dt33及其在制备微塑料吸附、清除及促进排便功能的产品中的应用 | |
CN117187113A (zh) | 一株副干酪乳杆菌dt11及其在制备微塑料吸附、清除及促进排便功能的产品中的应用 | |
Wang et al. | Efficacy of pea protein isolate–alginate encapsulation on viability of a probiotic bacterium in the porcine digestive tract | |
KR20190129054A (ko) | 단위 동물용 분말 프로바이오틱 제제를 제조하는 방법 | |
RU2773533C9 (ru) | Системы и способы для выращивания биоплёнки пробиотических бактерий на твёрдых частицах с целью колонизации кишечника бактериями | |
RU2773533C2 (ru) | Системы и способы для выращивания биоплёнки пробиотических бактерий на твёрдых частицах с целью колонизации кишечника бактериями | |
Kumar et al. | Isolation and characterization of endemic strains of Lactobacillus sp. and evaluation of their probiotic activity | |
RU2802073C1 (ru) | Кормовая добавка с пробиотической активностью для рыб | |
RU2761882C1 (ru) | Среда для получения пробиотической добавки для птицы | |
RU2752993C1 (ru) | Способ кормления перепелов | |
Starovoitova et al. | Probiotic strains with hypocholesterolemic activity as potential basis of functional food products for prevention and concomitant treatment of pathological conditions associated with high cholesterol levels | |
CN116098230A (zh) | 包埋益生菌的微胶囊的制备方法及改善宠物肠道菌群的日粮 | |
CN118006506A (zh) | 一种犬源罗伊氏乳杆菌、菌剂及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/05/2016, OBSERVADAS AS CONDICOES LEGAIS |