BR112017024265A2 - sistemas e métodos para crescimento de um biofilme de bactérias probióticas em partículas sólidas para colonização de bactérias no intestino - Google Patents

sistemas e métodos para crescimento de um biofilme de bactérias probióticas em partículas sólidas para colonização de bactérias no intestino

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Publication number
BR112017024265A2
BR112017024265A2 BR112017024265A BR112017024265A BR112017024265A2 BR 112017024265 A2 BR112017024265 A2 BR 112017024265A2 BR 112017024265 A BR112017024265 A BR 112017024265A BR 112017024265 A BR112017024265 A BR 112017024265A BR 112017024265 A2 BR112017024265 A2 BR 112017024265A2
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Brazil
Prior art keywords
bacteria
biofilm
population
colonization
gut
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BR112017024265A
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English (en)
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BR112017024265B1 (pt
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Baram David
Daboush David
Diamant Rachel
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Mybiotics Pharma Ltd
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Publication of BR112017024265A2 publication Critical patent/BR112017024265A2/pt
Publication of BR112017024265B1 publication Critical patent/BR112017024265B1/pt

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    • C—CHEMISTRY; METALLURGY
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C12N11/12—Cellulose or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/169—Plantarum
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

a presente invenção fornece um método, sendo que o método forma um biofilme, em que o biofilme compreende uma população de pelo menos uma cepa bacteriana afixada às partículas, em que o biofilme é configurado para colonizar um intestino de um indivíduo que precisa do mesmo por pelo menos cinco dias, quando for ingerido pelo indivíduo, sendo que o método compreende: a. obter uma população que compreende pelo menos uma cepa de bactérias; b. inocular um meio de crescimento que contém partículas com a população que compreende pelo menos uma cepa de bactérias; c. incubar as partículas com a população que compreende pelo menos uma cepa bacteriana por tempo suficiente para a população de pelo menos uma cepa de bactérias se afixar às partículas; e d. cultivar a população que compreende pelo menos uma cepa de bactérias afixada às partículas em um meio de crescimento por tempo suficiente para formar um biofilme.
BR112017024265-6A 2015-05-11 2016-05-09 Métodos para crescimento de um biofilme de bactérias probióticas em partículas sólidas BR112017024265B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562159849P 2015-05-11 2015-05-11
US201562159846P 2015-05-11 2015-05-11
US62/159,846 2015-05-11
US62/159,849 2015-05-11
PCT/IB2016/000933 WO2016181228A2 (en) 2015-05-11 2016-05-09 Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut

Publications (2)

Publication Number Publication Date
BR112017024265A2 true BR112017024265A2 (pt) 2018-07-24
BR112017024265B1 BR112017024265B1 (pt) 2022-08-09

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BR112017024265-6A BR112017024265B1 (pt) 2015-05-11 2016-05-09 Métodos para crescimento de um biofilme de bactérias probióticas em partículas sólidas

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Country Link
US (4) US10793847B2 (pt)
EP (1) EP3294073B1 (pt)
JP (2) JP6990922B2 (pt)
CN (2) CN114990099A (pt)
AU (1) AU2016259871B2 (pt)
BR (1) BR112017024265B1 (pt)
CA (1) CA2985729C (pt)
DK (1) DK3294073T3 (pt)
ES (1) ES2929893T3 (pt)
IL (2) IL255583B (pt)
WO (1) WO2016181228A2 (pt)

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