BR112017011258A2 - formulação de microvesículas enchidas com gás alvejado - Google Patents

formulação de microvesículas enchidas com gás alvejado

Info

Publication number
BR112017011258A2
BR112017011258A2 BR112017011258A BR112017011258A BR112017011258A2 BR 112017011258 A2 BR112017011258 A2 BR 112017011258A2 BR 112017011258 A BR112017011258 A BR 112017011258A BR 112017011258 A BR112017011258 A BR 112017011258A BR 112017011258 A2 BR112017011258 A2 BR 112017011258A2
Authority
BR
Brazil
Prior art keywords
bleached
formulation
gas filled
filled microvesicles
gas
Prior art date
Application number
BR112017011258A
Other languages
English (en)
Other versions
BR112017011258B1 (pt
Inventor
Lassus Anne
Bussat Philippe
Original Assignee
Bracco Suisse Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse Sa filed Critical Bracco Suisse Sa
Publication of BR112017011258A2 publication Critical patent/BR112017011258A2/pt
Publication of BR112017011258B1 publication Critical patent/BR112017011258B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Acoustics & Sound (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

a presente invenção refere-se a uma suspensão de microvesículas enchidas com gás compreendendo um ligante-alvo para ligação a kdr ou complexo vegf/kdr. a suspensão é obtida através de reconstituição de um resíduo secado ? congelado com uma solução contendo carboidrato na presença de um gás fisiologicamente aceitável e é estabilizada pela presença de histidina.
BR112017011258-2A 2014-12-18 2015-12-17 Suspensão aquosa de microvesículas enchidas com gás e kit farmacêutico BR112017011258B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14199057 2014-12-18
EP14199057.2 2014-12-18
PCT/EP2015/080199 WO2016097130A1 (en) 2014-12-18 2015-12-17 Targeted gas-filled microvesicles formulation

Publications (2)

Publication Number Publication Date
BR112017011258A2 true BR112017011258A2 (pt) 2018-04-03
BR112017011258B1 BR112017011258B1 (pt) 2024-02-06

Family

ID=52292644

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017011258-2A BR112017011258B1 (pt) 2014-12-18 2015-12-17 Suspensão aquosa de microvesículas enchidas com gás e kit farmacêutico

Country Status (15)

Country Link
US (3) US10682429B2 (pt)
EP (1) EP3233136B8 (pt)
JP (1) JP6803839B2 (pt)
KR (1) KR102190157B1 (pt)
CN (2) CN107206110B (pt)
BR (1) BR112017011258B1 (pt)
CA (1) CA2968478C (pt)
DK (1) DK3233136T3 (pt)
ES (1) ES2726924T3 (pt)
HU (1) HUE043680T2 (pt)
IL (1) IL252960A0 (pt)
RU (1) RU2725808C2 (pt)
SG (1) SG11201704165VA (pt)
SI (1) SI3233136T1 (pt)
WO (1) WO2016097130A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108697664A (zh) * 2015-12-21 2018-10-23 努沃克斯制药有限责任公司 氟碳化合物纳米乳液的组合物及其制备方法和用途
WO2018140425A1 (en) * 2017-01-24 2018-08-02 Nuvox Pharma Llc Iso-osmotic and near iso-osmotic oxygen therapeutic formulations and methods thereof
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof
US20210389320A1 (en) * 2018-12-21 2021-12-16 Bracco Suisse Sa Gas-filled microvesicles with ligand
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
EP4103152A1 (en) * 2020-02-11 2022-12-21 Bracco Suisse SA Gas-filled microvesicles for therapeutic use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (pt) 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
ES2197986T3 (es) 1996-02-19 2004-01-16 Amersham Health As Mejoras introducidas en o relacionadas con agentes de contraste.
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
JP2005519980A (ja) 2002-03-01 2005-07-07 ブラッコ インターナショナル ビー．ヴイ． 治療および診断用途の多価構成物
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
DE602004029010D1 (de) 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
CA2826960A1 (en) * 2005-12-09 2007-06-14 Bracco Suisse Sa Targeting vector-phospholipid conjugates
JP5484059B2 (ja) * 2006-10-06 2014-05-07 エスシーアイエル テクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 脊髄核インプラント
CN103079599B (zh) * 2010-08-09 2017-05-10 博莱科瑞士股份有限公司 靶向气体填充微囊

Also Published As

Publication number Publication date
ES2726924T3 (es) 2019-10-10
IL252960A0 (en) 2017-08-31
US12070512B2 (en) 2024-08-27
CA2968478C (en) 2021-10-12
EP3233136A1 (en) 2017-10-25
US11071792B2 (en) 2021-07-27
KR20170097672A (ko) 2017-08-28
RU2017125459A3 (pt) 2019-06-19
US20200330620A1 (en) 2020-10-22
JP2018500294A (ja) 2018-01-11
WO2016097130A1 (en) 2016-06-23
JP6803839B2 (ja) 2020-12-23
DK3233136T3 (da) 2019-05-20
US10682429B2 (en) 2020-06-16
RU2017125459A (ru) 2019-01-21
KR102190157B1 (ko) 2020-12-14
BR112017011258B1 (pt) 2024-02-06
EP3233136B1 (en) 2019-02-20
EP3233136B8 (en) 2019-04-10
RU2725808C2 (ru) 2020-07-06
US20210386872A1 (en) 2021-12-16
CN107206110B (zh) 2021-07-20
US20180008731A1 (en) 2018-01-11
HUE043680T2 (hu) 2019-09-30
SG11201704165VA (en) 2017-07-28
SI3233136T1 (sl) 2019-08-30
CA2968478A1 (en) 2016-06-23
CN107206110A (zh) 2017-09-26
CN113209316A (zh) 2021-08-06

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/12/2015, OBSERVADAS AS CONDICOES LEGAIS