BR112017002214B1 - Composto de fórmula (i), e uso de um composto - Google Patents

Composto de fórmula (i), e uso de um composto Download PDF

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BR112017002214B1
BR112017002214B1 BR112017002214-1A BR112017002214A BR112017002214B1 BR 112017002214 B1 BR112017002214 B1 BR 112017002214B1 BR 112017002214 A BR112017002214 A BR 112017002214A BR 112017002214 B1 BR112017002214 B1 BR 112017002214B1
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Brazil
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group
substituted
alkyl
unsubstituted
hydrogen
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BR112017002214-1A
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English (en)
Portuguese (pt)
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BR112017002214A2 (pt
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Sanne Schrøder Glad
Kim Birkebæk Jensen
Niels Grøn Nørager
Ian SARVARY
Mikkel VESTERGAARD
Alex Haahr Gouliaev
Lene Teuber
Luigi Piero Stasi
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Nuevolution A/S
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Publication of BR112017002214A2 publication Critical patent/BR112017002214A2/pt
Publication of BR112017002214B1 publication Critical patent/BR112017002214B1/pt

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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201700777VA (en) 2014-08-04 2017-02-27 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
US10450300B2 (en) 2015-10-08 2019-10-22 Suzhou Yunxuan Yiyao Keji Youxian Gongsi Wnt signaling pathway inhibitors and therapeutic applications thereof
EA034514B1 (ru) 2015-12-15 2020-02-14 Астразенека Аб Изоиндольные соединения
EP3638661A1 (fr) 2017-06-14 2020-04-22 Astrazeneca AB 2,3-dihydroisoindole-1-carboxamides utiles en tant que modulateurs de ror-gamma
WO2019168874A1 (fr) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Compositions de difluorométhoxylation et de trifluorométhoxylation et leurs procédés de synthèse
WO2020035556A1 (fr) 2018-08-17 2020-02-20 Leo Pharma A/S Nouveaux modulateurs hétéroaromatiques du récepteur gamma orphelin associé au rétinoïde
WO2020035557A1 (fr) 2018-08-17 2020-02-20 Leo Pharma A/S Nouveaux modulateurs hétéroaromatiques du récepteur gamma orphelin associé au rétinoïde
EP3883929A4 (fr) * 2018-11-19 2022-10-12 11949098 Canada Inc. Modulateurs de 4,5,6,7-tétrahydro-l-benzothiophène de récepteurs nucléaires orphelins (ror) liés au récepteur de l'acide rétinoïque (rar)
CN114728170B (zh) * 2019-12-20 2024-03-01 纽韦卢森公司 对核受体具有活性的化合物
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
WO2021198955A1 (fr) 2020-03-31 2021-10-07 Nuevolution A/S Composés actifs vis-à-vis des récepteurs nucléaires
JP2023519605A (ja) 2020-03-31 2023-05-11 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
EP4153177A1 (fr) * 2020-05-19 2023-03-29 Florida State University Research Foundation, Inc. Composés antifibrotiques et méthodes associées
CA3230199A1 (fr) * 2021-08-30 2023-03-09 Amgen Inc. Procede de synthese de derives de naphtyridine et d'intermediaires de ceux-ci

Family Cites Families (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236972A (en) * 1963-12-31 1966-02-22 Hudson Lamp Company Noise level increaser for snap-action devices
US4298602A (en) 1978-10-13 1981-11-03 The Dow Chemical Company Heterocyclic substituted triazolyl phosphorous compounds and their use as insecticides
DE3737748A1 (de) 1987-11-03 1989-05-18 Schering Ag 3-arylsulfonylamino-1h-1,2,4-triazole, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider und wachstumsregulierender wirkung
DE3905714A1 (de) 1989-02-24 1990-09-06 Bayer Ag Sulfonylimino-azinylheteroazole, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als herbizide
DE3928605A1 (de) 1989-08-30 1991-03-07 Bayer Ag Substituierte sulfonylaminoazole
GB8929022D0 (en) 1989-12-22 1990-02-28 Ici Plc Diazine derivatives
JPH04348326A (ja) 1990-07-09 1992-12-03 Sumitomo Electric Ind Ltd 有機非線形光学材料
DE4124942A1 (de) 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0624159B1 (fr) 1992-01-13 1998-11-25 Smithkline Beecham Corporation Imidazoles a substitution par pyridyle
AU4288293A (en) 1992-04-27 1993-11-29 E.I. Du Pont De Nemours And Company Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines
JPH06220059A (ja) 1993-01-28 1994-08-09 Tanabe Seiyaku Co Ltd 縮合ピリミジン誘導体及びその製法
DE4427529A1 (de) 1994-08-04 1996-02-08 Bayer Ag Verfahren zur Herstellung von 1,2,4-Triazin-3,5-dionen
ES2203642T3 (es) 1995-06-07 2004-04-16 Pfizer Inc. Derivados de pirimidina heterociclicos con anillos condensados.
DE19536891A1 (de) 1995-10-04 1997-04-10 Basf Ag Neue Aminosäurederivate, ihre Herstellung und Verwendung
ZA973884B (en) 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
CA2272705C (fr) 1996-11-27 2003-03-18 Pfizer Inc. Derives de pyrimidines bicycliques fusionnes
JPH10251255A (ja) 1997-03-14 1998-09-22 Nissan Chem Ind Ltd アジン誘導体
JP2000086663A (ja) 1998-09-09 2000-03-28 Taisho Pharmaceut Co Ltd アリールテトラヒドロピリジン誘導体
EP1396489A1 (fr) 1999-01-27 2004-03-10 Pfizer Products Inc. Composés hétéroaromatiques bicycliques a activité anticancereuse
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
JP2003104971A (ja) * 1999-08-12 2003-04-09 Wakunaga Pharmaceut Co Ltd 新規アニリド誘導体又はその塩及びこれを含有する医薬
ATE311385T1 (de) 1999-10-27 2005-12-15 Novartis Pharma Gmbh Thiazol und imidazo(4,5-b)pyridin verbindungen und ihre verwendung als pharmazeutika
JP2003519143A (ja) 1999-12-28 2003-06-17 ファーマコピーア，インコーポレーティッド ピリミジン及びトリアジン系キナーゼ阻害剤
ATE372337T1 (de) 2000-02-01 2007-09-15 Abbott Gmbh & Co Kg Heterozyklische verbindungen und deren anwendung als parp-inhibitoren
AU2001294557A1 (en) 2000-09-11 2002-03-26 Merck And Co., Inc. Thrombin inhibitors
JP2002284779A (ja) 2001-01-18 2002-10-03 Sankyo Co Ltd ヘテロアリール置換ピロール誘導体を含有する医薬
DE10108480A1 (de) 2001-02-22 2002-09-05 Bayer Ag Pyrazolylpyrimidine
WO2003011836A1 (fr) 2001-08-01 2003-02-13 Merck & Co., Inc. Inhibiteurs de tyrosine kinase
US20030191121A1 (en) 2001-08-09 2003-10-09 Miller Ross A. Piperazine carboxamide intermediates of HIV protease inhibitors and processes for their preparation
GB0127929D0 (en) 2001-11-21 2002-01-16 Celltech R&D Ltd Chemical compounds
MXPA04007612A (es) 2002-02-05 2004-11-10 Novo Nordisk As Aril- y heteroarilpiperazinas novedosas.
AU2003212634A1 (en) 2002-03-11 2003-09-22 Zetiq Technologies Ltd. Compounds useful in the treatment of cancer
AU2003230367A1 (en) 2002-05-10 2003-11-11 Neurocrine Biosciences, Inc. Substituted piperazine as melanocortin receptors ligands
GB0212785D0 (en) 2002-05-31 2002-07-10 Glaxo Group Ltd Compounds
SE0201980D0 (sv) 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
AU2003249539A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors
EP1556360B1 (fr) 2002-10-30 2008-01-23 Ciba SC Holding AG Dispositif electroluminescent
US20040097492A1 (en) 2002-11-01 2004-05-20 Pratt John K Anti-infective agents
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
AU2003269399A1 (en) 2002-11-01 2004-05-25 Pfizer Products Inc. Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination
SE0203712D0 (sv) 2002-12-13 2002-12-13 Astrazeneca Ab Novel compounds
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7569591B2 (en) 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7078419B2 (en) 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
US7122557B2 (en) 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
GB0306329D0 (en) 2003-03-19 2003-04-23 Glaxo Group Ltd Compounds
CN102584813B (zh) 2003-05-14 2016-07-06 Ngc药物公司 化合物及其在调节淀粉样蛋白β中的用途
DE10322469A1 (de) 2003-05-19 2004-12-16 Bayer Healthcare Ag Heterocyclische Verbindungen
JP2007507529A (ja) 2003-09-30 2007-03-29 サイオス・インコーポレーテツド 複素環式アミドおよびスルホンアミド
WO2005040119A1 (fr) 2003-10-01 2005-05-06 Bayer Healthcare Ag Tetrahydro-naphtalene et derives d'uree
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
WO2005068457A1 (fr) 2004-01-02 2005-07-28 University Of Chicago Reaction hetero diels-alder impliquant un dienophile c-nitroso heteroaromatique : nouveau procede de synthese d'amino-alcools non racemiques chiraux
US20050187389A1 (en) 2004-01-13 2005-08-25 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
JP4102939B2 (ja) 2004-02-13 2008-06-18 萬有製薬株式会社 縮環４−オキソ−ピリミジン誘導体
AU2005219438B2 (en) 2004-03-03 2011-02-17 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8076338B2 (en) 2004-04-23 2011-12-13 Exelixis, Inc. Kinase modulators and methods of use
MXPA06012595A (es) 2004-04-29 2007-05-09 Abbott Lab Analogos de amino-tetrazoles y metodos de uso.
US7285545B2 (en) 2004-05-03 2007-10-23 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
FR2870541B1 (fr) 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine
SE0401342D0 (sv) 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds
PE20060530A1 (es) * 2004-06-04 2006-06-28 Arena Pharm Inc Aril y heteroaril derivados sustituidos como moduladores del metabolismo de la glucosa
MY144903A (en) 2004-06-17 2011-11-30 Novartis Ag Pyrrolopyridine derivatives and their use as crth2 antagonists
JP4116671B2 (ja) 2004-06-28 2008-07-09 インサイト コーポレイション ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド
EP1763351B9 (fr) 2004-06-28 2017-05-31 Incyte Holdings Corporation 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de la chimiokine
EP1812429A4 (fr) 2004-09-29 2010-07-21 Portola Pharm Inc 2h-1,3-benzoxazin-4(3h)-ones substitues
MX2007005159A (es) 2004-10-29 2007-06-26 Tibotec Pharm Ltd Derivados de pirimidina biciclicos inhibidores del vih.
WO2006074057A2 (fr) 2004-12-30 2006-07-13 Exelixis, Inc. Modulateurs de kinase et procedes d'utilisation
US7652041B2 (en) 2005-01-14 2010-01-26 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity
TWI382015B (zh) 2005-02-25 2013-01-11 Serenex Inc 苯、吡啶及噠嗪衍生物
US7470693B2 (en) 2005-04-21 2008-12-30 Bristol-Myers Squibb Company Oxalamide derivatives as kinase inhibitors
US7931909B2 (en) 2005-05-10 2011-04-26 Allergan, Inc. Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates
DE102005023943A1 (de) 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln
CA2612227C (fr) 2005-06-14 2014-04-22 Taigen Biotechnology Co., Ltd. Composes pyrimidine
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
FR2889189A1 (fr) 2005-07-28 2007-02-02 Cerep Sa Composes derives d'hydantoine et leur utilistion en tant qu'antagonistes de mchr-1
US7615569B2 (en) 2005-08-16 2009-11-10 Icagen, Inc. Inhibitors of ion channels
EP1931658A2 (fr) 2005-09-07 2008-06-18 Plexxikon, Inc. Derives d'indole disubstitue en 1,4 et 1,5 pour utilisation comme composes agissant sur les recepteurs au facteur active de proliferation des peroxysomes (ppar)
JP4531027B2 (ja) * 2005-09-29 2010-08-25 田辺三菱製薬株式会社 医薬組成物
JP2007126551A (ja) 2005-11-02 2007-05-24 Fujifilm Corp 蛍光性重合体微粒子、蛍光検出キット及び蛍光検出方法
GB0525337D0 (en) 2005-12-13 2006-01-18 Novartis Ag Organic compounds
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
NL2000323C2 (nl) 2005-12-20 2007-11-20 Pfizer Ltd Pyrimidine-derivaten.
MEP1008A (xx) 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina
KR20080083188A (ko) 2006-01-11 2008-09-16 아스트라제네카 아베 모르폴리노 피리미딘 유도체 및 요법에서의 그 유도체의용도
JP2007186580A (ja) 2006-01-12 2007-07-26 Fujifilm Corp 重合体粒子、蛍光性重合体微粒子、重合体微粒子の製造方法、蛍光性重合体微粒子の製造方法、蛍光検出キット及び蛍光検出方法
UY30117A1 (es) 2006-01-31 2007-06-29 Tanabe Seiyaku Co Compuesto amina trisustituido
FR2897061B1 (fr) 2006-02-03 2010-09-03 Sanofi Aventis Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.
ATE470665T1 (de) 2006-03-22 2010-06-15 Janssen Pharmaceutica Nv Cycloalkylaminderivate als inhibitoren der wechselwirkung zwischen mdm2 und p53
DOP2007000068A (es) 2006-04-12 2007-10-31 Sanofi Aventis Us Llc Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2
WO2008005368A2 (fr) 2006-06-30 2008-01-10 Abbott Laboratories Pipérazines en tant qu'antagonistes de p2x7
WO2008005538A2 (fr) 2006-07-05 2008-01-10 Exelixis, Inc. Procédés d'utilisation de modulateurs de kinase igf1r et abl
US20080021063A1 (en) 2006-07-18 2008-01-24 Kazantsev Aleksey G Compositions and methods for modulating sirtuin activity
WO2008023180A1 (fr) 2006-08-24 2008-02-28 Astrazeneca Ab Dérivés de morpholino pyrimidine utiles dans le traitement de désordres prolifératifs
MX2009002046A (es) 2006-08-24 2009-03-06 Astrazeneca Ab Derivados de morfolino pirimidina utiles en el tratamiento de trastornos proliferativos.
JP4776473B2 (ja) 2006-08-25 2011-09-21 株式会社ミツトヨ 光軸偏向型レーザ干渉計、その校正方法、補正方法、及び、測定方法
JP2008074892A (ja) 2006-09-19 2008-04-03 Fujifilm Corp 蛍光性重合体微粒子セット、蛍光検出用複合体セット、蛍光性重合体微粒子組成物及び蛍光検出方法
GB0625196D0 (en) 2006-12-18 2007-01-24 7Tm Pharma As Modulators of cannabinoid receptor
EP2137158A4 (fr) 2007-02-28 2012-04-18 Methylgene Inc Inhibiteurs à petite molécule de protéines arginine méthyltransférases (prmt)
JP2010522194A (ja) 2007-03-20 2010-07-01 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼ阻害薬として有用なアミノピリミジン
EP2014657A1 (fr) * 2007-06-21 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Diaminopyrimidine en tant que modulateurs du récepteur EP2
US20100227858A1 (en) 2007-07-09 2010-09-09 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
AU2008273891B2 (en) 2007-07-09 2012-01-12 Astrazeneca Ab Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K
US20100261723A1 (en) 2007-07-09 2010-10-14 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
AU2008273889B2 (en) 2007-07-09 2012-03-08 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
TW200902513A (en) 2007-07-13 2009-01-16 Astrazeneca Ab New pyridine analogues
ES2395081T3 (es) 2007-07-26 2013-02-08 Vitae Pharmaceuticals, Inc. Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1
WO2009055331A2 (fr) 2007-10-22 2009-04-30 Schering Corporation Dérivés hétérocycliques bicycliques et leurs procédés d'utilisation
JP2011506487A (ja) 2007-12-21 2011-03-03 ザ・ユニバーシティ・オブ・シドニー トランスロケータータンパク質リガンド
WO2009086303A2 (fr) 2007-12-21 2009-07-09 University Of Rochester Procédé permettant de modifier la durée de vie d'organismes eucaryotes
FR2926556B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
JP4665052B2 (ja) 2008-02-08 2011-04-06 株式会社資生堂 美白剤及び皮膚外用剤
WO2009102736A1 (fr) 2008-02-12 2009-08-20 Dow Agrosciences Llc Compositions pesticides
EP2262783A2 (fr) 2008-02-21 2010-12-22 Sanofi-Aventis Sondes d'imagerie à liaison covalente
US8563715B2 (en) 2008-03-31 2013-10-22 Zenyaku Kogyo Kabushikikaisha Pyrimidine derivative having cell protecting effect and uses thereof
JP5372138B2 (ja) 2008-04-18 2013-12-18 テウン ファーマシューティカル カンパニー，リミテッド 新規ベンゾオキサジンベンズイミダゾール誘導体、これを含む薬学組成物およびこの用途
US8242111B2 (en) 2008-05-01 2012-08-14 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
MX2010012848A (es) 2008-06-03 2011-03-01 Intermune Inc Compuestos y metodos para tratar trastornos inflamatorios y fibroticos.
MX2010014572A (es) 2008-06-27 2011-03-24 Novartis Ag Compuestos organicos.
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
JP2010030970A (ja) 2008-07-31 2010-02-12 Bayer Cropscience Ag 殺虫性ベンゼンジカルボキサミド誘導体
CA2734487A1 (fr) 2008-08-20 2010-02-25 Southern Research Institute Derives de pyridine et de pyrimidine a substitution ethylyle et leur utilisation dans le traitement d'infections virales
AR072939A1 (es) 2008-08-20 2010-09-29 Schering Corp Derivados de piridina y pirimidina sustituidas con etenilo y su uso en el tratamiento de infecciones virales
TWI409265B (zh) 2008-08-20 2013-09-21 Merck Sharp & Dohme 經取代之吡啶及嘧啶衍生物及彼等於治療病毒感染之用途
GB0815369D0 (en) 2008-08-22 2008-10-01 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
WO2010036316A1 (fr) 2008-09-24 2010-04-01 Yangbo Feng Composés d’urée et de carbamate et analogues utilisés comme inhibiteurs de kinase
CA2740366A1 (fr) 2008-10-21 2010-04-29 Metabolex, Inc. Agonistes de recepteur gpr120 aryl et utilisations de ceux-ci
GB2465405A (en) 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
EP2378878A4 (fr) 2008-12-17 2012-08-01 Via Pharmaceuticals Inc Inhibiteurs de la diacylglycérol acyltransférase
RS54230B1 (en) 2009-01-08 2015-12-31 Curis Inc. 3-KINASE PHOSPHOINOSITIDE INHIBITORS WITH ZINC BINDING PART
CA2753679C (fr) 2009-02-27 2021-03-02 Cellular Dynamics International, Inc. Differenciation de cellules pluripotentes
WO2010100127A1 (fr) 2009-03-04 2010-09-10 Novartis Ag Dérivés d'imidazole disubstitués en tant que modulateurs de la protéine kinase raf
TW201100428A (en) 2009-03-31 2011-01-01 Arqule Inc Substituted indolo-piperidine compounds
EP2414348B1 (fr) 2009-04-03 2013-11-20 Merck Sharp & Dohme Corp. Dérivés de pipéridine et de pipérazine bicycliques en tant que modulateurs de rcpg pour le traitement de l'obésité, du diabète et d'autres troubles métaboliques
WO2010120994A2 (fr) 2009-04-17 2010-10-21 Wyeth Llc Composés d'uréido-aryl-pyrimidine et de carbamoylaryl-morpholino-pyrimidine, leur utilisation comme inhibiteurs de la kinase mtor et de la kinase pi-3, et leur synthèse
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
KR101705158B1 (ko) 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
WO2010135470A1 (fr) 2009-05-19 2010-11-25 Intermune, Inc. Dérivés de pirfénidone pour le traitement de l'asthme
US8674109B2 (en) 2009-08-07 2014-03-18 Dow Agrosciences, Llc. Pesticidal compositions
KR101906146B1 (ko) 2009-08-17 2018-10-10 메모리얼 슬로안-케터링 캔서 센터 열 충격 단백질 결합 화합물, 조성물, 및 이의 제조 방법 및 사용 방법
US9029359B2 (en) 2009-09-04 2015-05-12 Biogen Idec Ma, Inc. Heteroaryl Btk inhibitors
ES2711936T3 (es) 2009-09-04 2019-05-08 Biogen Ma Inc Inhibidores de la tirosina cinasa de Bruton
EA022119B1 (ru) 2009-10-19 2015-11-30 Синта Фармасьютиклз Корп. Комбинированная терапия раковых заболеваний с помощью соединений - ингибиторов hsp90
KR20110049217A (ko) 2009-11-04 2011-05-12 다우어드밴스드디스플레이머티리얼 유한회사 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자
US8476225B2 (en) 2009-12-04 2013-07-02 Gilead Sciences, Inc. Antiviral compounds
US8609866B2 (en) 2009-12-18 2013-12-17 Activesite Pharmaceuticals, Inc. Prodrugs of inhibitors of plasma kallikrein
WO2011078143A1 (fr) 2009-12-22 2011-06-30 塩野義製薬株式会社 Dérivés de pyrimidine et composition pharmaceutique les contenant
EP2529238A4 (fr) 2010-01-28 2014-10-08 The Regents Of The University Of Michigan Dispositifs, systèmes et/ou procédés pour cultures en gouttes suspendues
WO2011105572A1 (fr) 2010-02-26 2011-09-01 持田製薬株式会社 Nouveau dérivé hétéroaryle
CA2793223A1 (fr) 2010-03-16 2011-09-22 Aventis Pharmaceuticals Inc. Pyrimidines substituees en tant qu'antagonistes du recepteur d2 de prostaglandines
CN102985422A (zh) 2010-05-12 2013-03-20 Abbvie公司 激酶的吡咯并吡啶和吡咯并嘧啶抑制剂
MX2012013128A (es) 2010-05-13 2013-03-20 Amgen Inc Compuestos heterociclicos de nitrogeno como inhibidores de la fosfodiesterasa 10.
WO2011153553A2 (fr) 2010-06-04 2011-12-08 The Regents Of The University Of California Méthodes et compositions pour l'inhibition de kinases
TWI617560B (zh) 2010-09-14 2018-03-11 伊塞利克斯公司 PI3Kδ 抑制劑以及其應用和生產方法
AR083200A1 (es) 2010-09-29 2013-02-06 Intervet Int Bv Compuestos de n-heteroarilo
ES2624845T3 (es) 2010-09-29 2017-07-17 Intervet International B.V. Compuestos de N-heteroarilo con unidad de puente cíclico para el tratamiento de enfermedades parasitarias
US9040525B2 (en) 2010-10-08 2015-05-26 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
DE102010050558A1 (de) 2010-11-05 2012-05-10 Merck Patent Gmbh 1H-Pyrrolo[2,3-b]pyridinderivate
US8729102B2 (en) 2010-11-30 2014-05-20 Takeda Pharmaceutical Company Limited Bicyclic compound
WO2012074022A1 (fr) 2010-12-01 2012-06-07 旭硝子株式会社 Complexe cationique d'iridium et composition émettant de la lumière
WO2012103336A1 (fr) 2011-01-26 2012-08-02 University Of Rochester Inhibiteurs d'arnse à petites molécules et méthodes d'utilisation
CA2827161A1 (fr) 2011-03-16 2012-09-20 F. Hoffmann-La Roche Ag Composes d'alcool propargylique 6,5-heterocycliques et utilisations de ceux-ci
EP2697196A1 (fr) 2011-04-13 2014-02-19 Activesite Pharmaceuticals, Inc. Promédicaments d'inhibiteurs de la kallicréine plasmatique
WO2012147890A1 (fr) 2011-04-27 2012-11-01 持田製薬株式会社 Nouveau dérivé d'azole
AU2012248627A1 (en) 2011-04-28 2013-11-14 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
AP2013007263A0 (en) 2011-05-27 2013-11-30 Achillion Pharmaceuticals Inc Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenesuseful for treating HCV infections
SG194770A1 (en) 2011-05-27 2013-12-30 Probiodrug Ag Radiolabelled glutaminyl cyclase inhibitors
EP2554544A1 (fr) 2011-08-01 2013-02-06 Almirall, S.A. Dérivés de pyridin-2(1h)-one en tant qu'inhibiteurs de JAK
WO2013019824A2 (fr) 2011-08-02 2013-02-07 Dow Agrosciences Llc Compositions pesticides et procédés associés
EP2739143B1 (fr) 2011-08-05 2018-07-11 Gary A. Flynn Préparation et procédés d'utilisation d'ortho-aryle hétéroaryle à 5 chaînons -carboxamide contenant des inhibiteurs de kinases multicibles
KR20140072090A (ko) 2011-09-09 2014-06-12 뉴욕 유니버시티 ＲＯＲγｔ 조정제로서의 아미도 화합물 및 이의 용도
WO2013052526A1 (fr) 2011-10-06 2013-04-11 Merck Sharp & Dohme Corp. Inhibiteurs triazolyles de pde10
UA111640C2 (uk) 2011-11-08 2016-05-25 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2
WO2013090912A1 (fr) 2011-12-16 2013-06-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Composés et méthode de prévention et de traitement des métastases tumorales et de la tumorigenèse
CN103159738B (zh) 2011-12-19 2016-09-07 上海泓博智源医药股份有限公司 炔基桥连的杂芳香化合物及其应用
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
WO2013117649A1 (fr) 2012-02-10 2013-08-15 Galapagos Nv Dérivés d'imidazo [4, 5-c] pyridine utiles pour le traitement de maladies dégénératives et inflammatoires
WO2013134467A1 (fr) 2012-03-07 2013-09-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibiteurs sélectifs d'histone désacétylase 6
IN2012CH01573A (fr) 2012-04-20 2015-07-10 Advinus Therapeutics Ltd
CN102786512A (zh) 2012-05-31 2012-11-21 中国人民解放军军事医学科学院毒物药物研究所 N-芳基不饱和稠环叔胺类化合物及其制备方法和抗肿瘤应用
JP2014078482A (ja) 2012-06-08 2014-05-01 Fujifilm Corp 非水電解液二次電池および非水電解液
CA2877326A1 (fr) 2012-06-28 2014-01-03 Abbvie Inc. Cyanoguanidines et leur utilisation comme agents antiviraux
WO2014011911A2 (fr) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisations
US9682958B2 (en) 2012-07-23 2017-06-20 Merck Patent Gmbh Ligands and their preparation
DK2878664T3 (en) 2012-07-24 2018-11-05 Nissan Chemical Corp CULTURE MEDIUM COMPOSITION AND PROCEDURE FOR CULTIVATING CELLS OR TISSUE USING THE COMPOSITION
WO2014015523A1 (fr) * 2012-07-27 2014-01-30 Hutchison Medipharma Limited Nouveaux composés hétéroaryliques et hétérocycliques et compositions et procédés s'y rapportant
ES2726833T3 (es) 2012-08-02 2019-10-09 Nerviano Medical Sciences Srl Pirroles sustituidos activos como inhibidores de cinasas
WO2014185358A1 (fr) 2013-05-14 2014-11-20 国立大学法人京都大学 Procédé efficace d'induction de cellules myocardiques
EP3569699A1 (fr) 2013-09-04 2019-11-20 Otsuka Pharmaceutical Factory, Inc. Procédé de préparation de cellules souches pluripotentes
CN103588795A (zh) 2013-11-27 2014-02-19 中国科学院福建物质结构研究所 一类离子型一价铜发光配合物及其应用
WO2015129263A1 (fr) 2014-02-25 2015-09-03 株式会社クラレ Dispositif de fabrication de sphéroïdes, et procédé de récupération et procédé de fabrication de sphéroïdes
SG11201700777VA (en) 2014-08-04 2017-02-27 Nuevolution As Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
TWI656121B (zh) 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
CR20170208A (es) 2014-11-21 2017-07-17 Merck Sharp & Dohme Agonistas parciales del receptor de insulina
MX370480B (es) 2014-11-21 2019-12-16 Akarna Therapeutics Ltd Compuestos bicíclicos fusionados para el tratamiento de enfermedades.
US9695280B2 (en) 2015-03-03 2017-07-04 Ricoh Co., Ltd. Methods for solid freeform fabrication

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