BR112016012747A2 - - Google Patents
Info
- Publication number
- BR112016012747A2 BR112016012747A2 BR112016012747A BR112016012747A BR112016012747A2 BR 112016012747 A2 BR112016012747 A2 BR 112016012747A2 BR 112016012747 A BR112016012747 A BR 112016012747A BR 112016012747 A BR112016012747 A BR 112016012747A BR 112016012747 A2 BR112016012747 A2 BR 112016012747A2
- Authority
- BR
- Brazil
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
- C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911214P | 2013-12-03 | 2013-12-03 | |
| US61/911,214 | 2013-12-03 | ||
| PCT/US2014/067117 WO2015084622A1 (en) | 2013-12-03 | 2014-11-24 | Methods of manufacturing benzoquinoline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016012747A2 true BR112016012747A2 (https=) | 2017-08-08 |
| BR112016012747B1 BR112016012747B1 (pt) | 2022-07-12 |
Family
ID=53264424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016012747-1A BR112016012747B1 (pt) | 2013-12-03 | 2014-11-24 | Processo de preparação de uma mistura racêmica de (rr,ss)-d6-tetrabenazina |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US20150152099A1 (https=) |
| EP (2) | EP3076970A4 (https=) |
| JP (1) | JP6542222B2 (https=) |
| KR (1) | KR102391134B1 (https=) |
| CN (1) | CN105873589B (https=) |
| AU (4) | AU2014357518A1 (https=) |
| BR (1) | BR112016012747B1 (https=) |
| CA (1) | CA2930744A1 (https=) |
| EA (2) | EA201791466A1 (https=) |
| HK (1) | HK1224222A1 (https=) |
| IL (1) | IL245539B (https=) |
| MX (1) | MX369956B (https=) |
| NZ (1) | NZ720301A (https=) |
| WO (1) | WO2015084622A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104684555A (zh) | 2012-09-18 | 2015-06-03 | 奥斯拜客斯制药有限公司 | 囊泡单胺转运体2的氘化苯并喹啉抑制剂的制剂药代动力学 |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| EA201791466A1 (ru) | 2013-12-03 | 2017-11-30 | Оспекс Фармасьютикалз, Инк. | Способы получения соединений бензохинолина |
| HRP20221106T1 (hr) | 2015-03-06 | 2022-11-25 | Auspex Pharmaceuticals, Inc. | Postupci liječenja abnormalnih nevoljnih poremećaja pokreta |
| US10479787B2 (en) * | 2016-04-22 | 2019-11-19 | Lupin Limited | Process for preparation of tetrabenazine and deutetrabenazine |
| EP3568394A1 (en) | 2017-01-10 | 2019-11-20 | Sandoz AG | Crystalline valbenazine free base |
| CA3054238A1 (en) | 2017-02-27 | 2018-08-30 | Sandoz Ag | Crystalline forms of valbenazine salts |
| UA127052C2 (uk) * | 2017-03-15 | 2023-03-29 | Оспекс Фармасьютікалс, Інк. | Аналоги деутетрабеназину, їхнє отримання та застосування |
| WO2019130252A2 (en) * | 2017-12-29 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing deutetrabenazine |
| US11505549B2 (en) * | 2018-02-01 | 2022-11-22 | Lakshmi Prasad ALAPARTHI | Process for preparation of Deutetrabenazine |
| PL3866931T3 (pl) | 2018-10-18 | 2023-06-19 | Oncopeptides Ab | Związki zawierające deuter |
| WO2020086765A1 (en) * | 2018-10-24 | 2020-04-30 | Neurocrine Biosciences, Inc. | Processes for preparing a vmat2 inhibitor |
| CN111960999B (zh) * | 2020-07-20 | 2021-11-02 | 暨明医药科技（苏州）有限公司 | 一种丁苯那嗪中间体的合成方法 |
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| CN104684555A (zh) | 2012-09-18 | 2015-06-03 | 奥斯拜客斯制药有限公司 | 囊泡单胺转运体2的氘化苯并喹啉抑制剂的制剂药代动力学 |
| CN102936246A (zh) * | 2012-11-08 | 2013-02-20 | 江苏暨明医药科技有限公司 | 丁苯那嗪的合成方法 |
| EA202091397A1 (ru) | 2013-01-31 | 2020-09-04 | Ауспекс Фармацетикалс, Инк. | Бензохинолоновые ингибиторы vmat2 |
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| WO2015077521A1 (en) | 2013-11-22 | 2015-05-28 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| EA201791466A1 (ru) | 2013-12-03 | 2017-11-30 | Оспекс Фармасьютикалз, Инк. | Способы получения соединений бензохинолина |
| EA201691512A1 (ru) | 2014-01-27 | 2017-01-30 | Оспекс Фармасьютикалз, Инк. | Бензохинолиновые ингибиторы везикулярного переносчика моноамина 2 |
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2014
- 2014-11-24 EA EA201791466A patent/EA201791466A1/ru unknown
- 2014-11-24 WO PCT/US2014/067117 patent/WO2015084622A1/en not_active Ceased
- 2014-11-24 CN CN201480066154.9A patent/CN105873589B/zh active Active
- 2014-11-24 JP JP2016536571A patent/JP6542222B2/ja active Active
- 2014-11-24 US US14/551,909 patent/US20150152099A1/en not_active Abandoned
- 2014-11-24 EP EP14867514.3A patent/EP3076970A4/en not_active Withdrawn
- 2014-11-24 CA CA2930744A patent/CA2930744A1/en not_active Abandoned
- 2014-11-24 AU AU2014357518A patent/AU2014357518A1/en not_active Abandoned
- 2014-11-24 NZ NZ720301A patent/NZ720301A/en unknown
- 2014-11-24 KR KR1020167017402A patent/KR102391134B1/ko active Active
- 2014-11-24 EA EA201691162A patent/EA032920B1/ru not_active IP Right Cessation
- 2014-11-24 MX MX2016007056A patent/MX369956B/es active IP Right Grant
- 2014-11-24 HK HK16112664.2A patent/HK1224222A1/zh unknown
- 2014-11-24 BR BR112016012747-1A patent/BR112016012747B1/pt active IP Right Grant
- 2014-11-24 EP EP18179389.4A patent/EP3424504A1/en not_active Withdrawn
-
2016
- 2016-05-08 IL IL245539A patent/IL245539B/en active IP Right Grant
-
2017
- 2017-03-21 US US15/464,938 patent/US20170190654A1/en not_active Abandoned
- 2017-03-29 US US15/472,779 patent/US10513488B2/en active Active
-
2018
- 2018-04-12 US US15/952,031 patent/US20180230083A1/en not_active Abandoned
- 2018-11-30 US US16/205,525 patent/US20190092719A1/en not_active Abandoned
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2019
- 2019-11-12 US US16/680,674 patent/US20200331846A1/en not_active Abandoned
-
2020
- 2020-02-14 AU AU2020201091A patent/AU2020201091B2/en active Active
- 2020-04-15 US US16/849,603 patent/US20200347008A1/en not_active Abandoned
-
2021
- 2021-07-26 AU AU2021209150A patent/AU2021209150A1/en not_active Abandoned
-
2022
- 2022-08-02 US US17/879,600 patent/US12077487B2/en active Active
-
2023
- 2023-05-23 AU AU2023203246A patent/AU2023203246B2/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
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| B25D | Requested change of name of applicant approved |
Owner name: AUSPEX PHARMACEUTICALS LLC (US) |
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| B25G | Requested change of headquarter approved |
Owner name: AUSPEX PHARMACEUTICALS LLC (US) |