BR112016011700B1 - Processo para as sínteses de pomalidomida - Google Patents

Processo para as sínteses de pomalidomida Download PDF

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Publication number
BR112016011700B1
BR112016011700B1 BR112016011700-0A BR112016011700A BR112016011700B1 BR 112016011700 B1 BR112016011700 B1 BR 112016011700B1 BR 112016011700 A BR112016011700 A BR 112016011700A BR 112016011700 B1 BR112016011700 B1 BR 112016011700B1
Authority
BR
Brazil
Prior art keywords
pomalidomide
solvent
process according
group
dione
Prior art date
Application number
BR112016011700-0A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112016011700A2 (pt
Inventor
Vinayak Gore
Vinay Kumar Shukla
Dhananjay Shinde
Bansode Prakash
Original Assignee
Mylan Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Limited filed Critical Mylan Laboratories Limited
Priority claimed from IN5409CH2013 external-priority patent/IN2013CH05409A/en
Publication of BR112016011700A2 publication Critical patent/BR112016011700A2/pt
Publication of BR112016011700B1 publication Critical patent/BR112016011700B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BR112016011700-0A 2013-11-25 2014-11-24 Processo para as sínteses de pomalidomida BR112016011700B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN5409/CHE/2013 2013-11-25
IN424/CHE/2014 2014-01-30
IN424CH2014 2014-01-30
IN5409CH2013 IN2013CH05409A (enExample) 2013-11-25 2014-11-24
PCT/IB2014/066285 WO2015075694A1 (en) 2013-11-25 2014-11-24 Improved process for the preparation of pomalidomide and its purification

Publications (2)

Publication Number Publication Date
BR112016011700A2 BR112016011700A2 (pt) 2017-10-10
BR112016011700B1 true BR112016011700B1 (pt) 2022-08-23

Family

ID=52350154

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016011700-0A BR112016011700B1 (pt) 2013-11-25 2014-11-24 Processo para as sínteses de pomalidomida

Country Status (9)

Country Link
US (1) US20160362391A1 (enExample)
EP (1) EP3074383B1 (enExample)
JP (1) JP6644685B2 (enExample)
AU (1) AU2014351354B2 (enExample)
BR (1) BR112016011700B1 (enExample)
CA (1) CA2931606A1 (enExample)
ES (1) ES2694512T3 (enExample)
TR (1) TR201816539T4 (enExample)
WO (1) WO2015075694A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104557858B (zh) * 2013-10-29 2018-06-01 上海医药工业研究院 一种泊利度胺的制备方法
HU231259B1 (hu) 2016-02-04 2022-06-28 Egyt Gyogyszervegyeszeti Gyar Eljárás pomalidomide elõállítására
CN105924426B (zh) * 2016-06-20 2019-03-08 浙江海正药业股份有限公司 一种泊马度胺的结晶工艺
CN105866297B (zh) * 2016-06-24 2019-01-04 合肥久诺医药科技有限公司 一种泊马度胺有关物质的高效液相色谱分析方法
CN106565668B (zh) * 2016-10-27 2020-01-10 扬子江药业集团有限公司 一种高纯度泊马度胺的制备方法
WO2018154516A1 (en) * 2017-02-23 2018-08-30 Sun Pharmaceutical Industries Limited Process for the preparation of pomalidomide
CN114605381A (zh) * 2020-12-03 2022-06-10 南京海辰药业股份有限公司 一种泊马度胺的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281230B1 (en) * 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US6660736B2 (en) * 2002-03-27 2003-12-09 Hoffmann-La Roche Inc. Phthalimido derivatives and a process for their preparation
DK2380887T3 (da) * 2005-06-30 2013-10-07 Celgene Corp Fremgangsmåder til fremstilling af 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindolin-1,3-dion-forbindelser
US20120302605A1 (en) * 2010-11-18 2012-11-29 Deuteria Pharmaceuticals, Llc 3-deutero-pomalidomide
US20140221427A1 (en) * 2011-06-22 2014-08-07 Celgene Corporation Isotopologues of pomalidomide
WO2013126326A1 (en) * 2012-02-21 2013-08-29 Celgene Corporation Solid forms of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, compositions and methods of use thereof
WO2014170909A2 (en) * 2013-04-01 2014-10-23 Hetero Research Foundation Process for pomalidomide
CN103275062B (zh) * 2013-05-17 2016-04-13 宁波百思佳医药科技有限公司 一种Pomalidomide的纯化方法
CN103288797B (zh) * 2013-05-17 2016-03-02 宁波百思佳医药科技有限公司 一种用亚砜类溶剂纯化Pomalidomide的方法

Also Published As

Publication number Publication date
US20160362391A1 (en) 2016-12-15
JP2017505286A (ja) 2017-02-16
WO2015075694A1 (en) 2015-05-28
JP6644685B2 (ja) 2020-02-12
CA2931606A1 (en) 2015-05-28
EP3074383B1 (en) 2018-10-10
ES2694512T3 (es) 2018-12-21
BR112016011700A2 (pt) 2017-10-10
AU2014351354B2 (en) 2018-11-08
AU2014351354A1 (en) 2016-06-16
EP3074383A1 (en) 2016-10-05
TR201816539T4 (tr) 2018-11-21

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 401/04

Ipc: C07D 401/04 (2006.01), A61P 35/00 (2006.01), A61P

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2014, OBSERVADAS AS CONDICOES LEGAIS

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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