BR112016011700A2 - processo aperfeiçoado para a preparação de pomalidomida e sua purificação - Google Patents
processo aperfeiçoado para a preparação de pomalidomida e sua purificaçãoInfo
- Publication number
- BR112016011700A2 BR112016011700A2 BR112016011700A BR112016011700A BR112016011700A2 BR 112016011700 A2 BR112016011700 A2 BR 112016011700A2 BR 112016011700 A BR112016011700 A BR 112016011700A BR 112016011700 A BR112016011700 A BR 112016011700A BR 112016011700 A2 BR112016011700 A2 BR 112016011700A2
- Authority
- BR
- Brazil
- Prior art keywords
- pomalidomide
- purification
- preparation
- improved process
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN5409/CHE/2013 | 2013-11-25 | ||
IN424CH2014 | 2014-01-30 | ||
IN424/CHE/2014 | 2014-01-30 | ||
PCT/IB2014/066285 WO2015075694A1 (en) | 2013-11-25 | 2014-11-24 | Improved process for the preparation of pomalidomide and its purification |
IN5409CH2013 IN2013CH05409A (pt) | 2013-11-25 | 2014-11-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112016011700A2 true BR112016011700A2 (pt) | 2017-10-10 |
BR112016011700B1 BR112016011700B1 (pt) | 2022-08-23 |
Family
ID=52350154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016011700-0A BR112016011700B1 (pt) | 2013-11-25 | 2014-11-24 | Processo para as sínteses de pomalidomida |
Country Status (9)
Country | Link |
---|---|
US (1) | US20160362391A1 (pt) |
EP (1) | EP3074383B1 (pt) |
JP (1) | JP6644685B2 (pt) |
AU (1) | AU2014351354B2 (pt) |
BR (1) | BR112016011700B1 (pt) |
CA (1) | CA2931606A1 (pt) |
ES (1) | ES2694512T3 (pt) |
TR (1) | TR201816539T4 (pt) |
WO (1) | WO2015075694A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104557858B (zh) * | 2013-10-29 | 2018-06-01 | 上海医药工业研究院 | 一种泊利度胺的制备方法 |
HU231259B1 (hu) | 2016-02-04 | 2022-06-28 | Egyt Gyogyszervegyeszeti Gyar | Eljárás pomalidomide elõállítására |
CN105924426B (zh) * | 2016-06-20 | 2019-03-08 | 浙江海正药业股份有限公司 | 一种泊马度胺的结晶工艺 |
CN105866297B (zh) * | 2016-06-24 | 2019-01-04 | 合肥久诺医药科技有限公司 | 一种泊马度胺有关物质的高效液相色谱分析方法 |
CN106565668B (zh) * | 2016-10-27 | 2020-01-10 | 扬子江药业集团有限公司 | 一种高纯度泊马度胺的制备方法 |
WO2018154516A1 (en) * | 2017-02-23 | 2018-08-30 | Sun Pharmaceutical Industries Limited | Process for the preparation of pomalidomide |
CN114605381A (zh) * | 2020-12-03 | 2022-06-10 | 南京海辰药业股份有限公司 | 一种泊马度胺的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6281230B1 (en) * | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
US6660736B2 (en) * | 2002-03-27 | 2003-12-09 | Hoffmann-La Roche Inc. | Phthalimido derivatives and a process for their preparation |
AU2006265019B2 (en) * | 2005-06-30 | 2011-10-13 | Celgene Corporation | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds |
US20120302605A1 (en) * | 2010-11-18 | 2012-11-29 | Deuteria Pharmaceuticals, Llc | 3-deutero-pomalidomide |
US20140221427A1 (en) * | 2011-06-22 | 2014-08-07 | Celgene Corporation | Isotopologues of pomalidomide |
WO2013126326A1 (en) * | 2012-02-21 | 2013-08-29 | Celgene Corporation | Solid forms of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, compositions and methods of use thereof |
EP2981532A4 (en) * | 2013-04-01 | 2016-12-14 | Hetero Research Foundation | PROCESS FOR THE PREPARATION OF POMALIDOMIDE |
CN103275062B (zh) * | 2013-05-17 | 2016-04-13 | 宁波百思佳医药科技有限公司 | 一种Pomalidomide的纯化方法 |
CN103288797B (zh) * | 2013-05-17 | 2016-03-02 | 宁波百思佳医药科技有限公司 | 一种用亚砜类溶剂纯化Pomalidomide的方法 |
-
2014
- 2014-11-14 US US15/038,977 patent/US20160362391A1/en not_active Abandoned
- 2014-11-24 EP EP14827535.7A patent/EP3074383B1/en active Active
- 2014-11-24 AU AU2014351354A patent/AU2014351354B2/en active Active
- 2014-11-24 TR TR2018/16539T patent/TR201816539T4/tr unknown
- 2014-11-24 JP JP2016534173A patent/JP6644685B2/ja active Active
- 2014-11-24 BR BR112016011700-0A patent/BR112016011700B1/pt active IP Right Grant
- 2014-11-24 ES ES14827535.7T patent/ES2694512T3/es active Active
- 2014-11-24 WO PCT/IB2014/066285 patent/WO2015075694A1/en active Application Filing
- 2014-11-24 CA CA2931606A patent/CA2931606A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2017505286A (ja) | 2017-02-16 |
US20160362391A1 (en) | 2016-12-15 |
JP6644685B2 (ja) | 2020-02-12 |
EP3074383A1 (en) | 2016-10-05 |
BR112016011700B1 (pt) | 2022-08-23 |
ES2694512T3 (es) | 2018-12-21 |
TR201816539T4 (tr) | 2018-11-21 |
AU2014351354A1 (en) | 2016-06-16 |
WO2015075694A1 (en) | 2015-05-28 |
CA2931606A1 (en) | 2015-05-28 |
AU2014351354B2 (en) | 2018-11-08 |
EP3074383B1 (en) | 2018-10-10 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 401/04 Ipc: C07D 401/04 (2006.01), A61P 35/00 (2006.01), A61P |
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B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2014, OBSERVADAS AS CONDICOES LEGAIS |