BR112016011096A2 - Aplicação de laminina à cultura de célula endotelial da córnea - Google Patents

Aplicação de laminina à cultura de célula endotelial da córnea

Info

Publication number
BR112016011096A2
BR112016011096A2 BR112016011096A BR112016011096A BR112016011096A2 BR 112016011096 A2 BR112016011096 A2 BR 112016011096A2 BR 112016011096 A BR112016011096 A BR 112016011096A BR 112016011096 A BR112016011096 A BR 112016011096A BR 112016011096 A2 BR112016011096 A2 BR 112016011096A2
Authority
BR
Brazil
Prior art keywords
corneal endothelial
present
laminin
cell culture
endothelial cells
Prior art date
Application number
BR112016011096A
Other languages
English (en)
Portuguese (pt)
Inventor
Koizumi Noriko
Okumura Naoki
Kinoshita Shigeru
E Kruse Friedrich
SCHLOETZER-SCHREHARDT Ursula
Original Assignee
Kyoto Prefectural Public Univ Corp
The Doshisha
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Prefectural Public Univ Corp, The Doshisha, Senju Pharma Co filed Critical Kyoto Prefectural Public Univ Corp
Publication of BR112016011096A2 publication Critical patent/BR112016011096A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0621Eye cells, e.g. cornea, iris pigmented cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/52Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR112016011096A 2013-11-27 2014-11-26 Aplicação de laminina à cultura de célula endotelial da córnea BR112016011096A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013244972 2013-11-27
PCT/JP2014/081917 WO2015080297A1 (en) 2013-11-27 2014-11-26 Application of laminin to corneal endothelial cell culture

Publications (1)

Publication Number Publication Date
BR112016011096A2 true BR112016011096A2 (pt) 2017-09-19

Family

ID=52432880

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016011096A BR112016011096A2 (pt) 2013-11-27 2014-11-26 Aplicação de laminina à cultura de célula endotelial da córnea

Country Status (10)

Country Link
US (1) US11624053B2 (https=)
EP (1) EP3074508B1 (https=)
JP (3) JP6470286B2 (https=)
CN (1) CN105814195A (https=)
BR (1) BR112016011096A2 (https=)
CA (1) CA2931280A1 (https=)
ES (1) ES2763433T3 (https=)
MX (1) MX2016006915A (https=)
RU (1) RU2704984C1 (https=)
WO (1) WO2015080297A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2858173C (en) 2011-12-06 2023-09-26 Advanced Cell Technology, Inc. Method of directed differentiation producing corneal endothelial cells, compositions thereof, and uses thereof
JP6770435B2 (ja) 2014-10-31 2020-10-14 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
RU2718062C2 (ru) 2014-10-31 2020-03-30 Сэндзю Фармасьютикал Ко., Лтд. Новое лечение роговицы с применением ламинина
JP6849957B2 (ja) * 2015-11-10 2021-03-31 国立大学法人京都大学 ラミニンフラグメント含有培地を用いる細胞培養方法
JP6605618B2 (ja) * 2015-11-10 2019-11-20 日機装株式会社 細胞支持複合体および細胞支持複合体の製造方法
EP4733316A3 (en) * 2017-01-31 2026-05-06 Osaka University Differentiation control method for pluripotent stem cells
WO2019079809A1 (en) * 2017-10-22 2019-04-25 The Johns Hopkins University BIOMIMETIC PLATFORMS FOR MODELING VASCULAR PHYSIOPATHOLOGY, DIAGNOSIS AND THERAPY
WO2019102593A1 (ja) * 2017-11-24 2019-05-31 株式会社Ihi 細胞培養装置
CA3109705A1 (en) * 2018-10-02 2020-04-09 The Doshisha Method and vessel for preserving corneal endothelial cells
JP6664755B1 (ja) * 2018-10-02 2020-03-13 学校法人同志社 角膜内皮細胞を保存するための方法および容器
CN113557059A (zh) * 2019-03-12 2021-10-26 日产化学株式会社 角膜疾病治疗剂
JP2023025311A (ja) * 2020-02-05 2023-02-22 味の素株式会社 タンパク質の製造方法
CN112522179A (zh) * 2020-12-23 2021-03-19 江苏艾尔康生物医药科技有限公司 一种角膜内皮细胞的分离培养方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783B1 (en) 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
EP1195372A1 (en) 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
JP3421217B2 (ja) 1995-11-20 2003-06-30 麒麟麦酒株式会社 Rho標的タンパク質Rhoキナーゼ
EP0954328A4 (en) 1996-06-05 2002-07-17 Gen Hospital Corp Laminin-5 and the production of a basement membrane structure
FR2765781B1 (fr) 1997-07-08 1999-09-24 Gioia Bruno Di Procede de fabrication d'un accessoire de mode, dispositif pour la mise en oeuvre du procede et accessoire de mode ainsi realise
US6042262A (en) 1997-07-29 2000-03-28 Stryker Technologies Corportion Apparatus for storing, mixing, and dispensing two-component bone cement
US6693169B1 (en) 1998-10-13 2004-02-17 The General Hospital Corporation Laminin 5, 13 and 14 and uses thereof
EP1177290A2 (en) 1999-04-30 2002-02-06 Biostratum, Inc. Recombinant laminin 5
US6635616B2 (en) 2000-05-01 2003-10-21 The General Hospital Corporation Laminin 15
US6933273B2 (en) 2000-12-21 2005-08-23 Karl Tryggvason Isolated laminin 10
PE20020958A1 (es) 2001-03-23 2002-11-14 Bayer Corp Inhibidores de la rho-quinasa
UY27224A1 (es) 2001-03-23 2002-10-31 Bayer Corp Inhibidores de la rho-quinasa
US7109208B2 (en) 2001-04-11 2006-09-19 Senju Pharmaceutical Co., Ltd. Visual function disorder improving agents
WO2002100833A1 (en) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
JP4505228B2 (ja) 2002-01-10 2010-07-21 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト Rho−キナーゼ阻害剤
MXPA04007196A (es) 2002-01-23 2005-06-08 Bayer Pharmaceuticals Corp Inhibidores de rho-quinasa.
JP2004024852A (ja) 2002-04-30 2004-01-29 Amniotec:Kk 角膜内皮様シート、及びその作製方法
WO2003092762A1 (en) * 2002-04-30 2003-11-13 Amniotec Inc. Corneal endothelium-like sheet and method of constructing the same
EP1541559A4 (en) 2002-07-22 2007-08-22 Asahi Kasei Pharma Corp 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE
CA2400996A1 (en) 2002-09-03 2004-03-03 Lisa Mckerracher 1,4-substituted cyclohexane derivatives
US7160894B2 (en) 2003-06-06 2007-01-09 Asahi Kasei Pharma Corporation Tricyclic compound
WO2005003101A2 (en) 2003-07-02 2005-01-13 Biofocus Discovery Limited Pyrazine and pyridine derivatives as rho kinase inhibitors
WO2005039564A1 (en) 2003-10-02 2005-05-06 Vertex Pharmaceuticals Incorporated Phthalimide compounds useful as protein kinase inhibitors
WO2005034866A2 (en) 2003-10-06 2005-04-21 Glaxo Group Limited Preparation of 1, 6, 7- trisubstituted azabenzimidazoles as kinase inhibitors
JP2007507547A (ja) 2003-10-06 2007-03-29 グラクソ グループ リミテッド キナーゼ阻害剤としての1,7−二置換アザベンゾイミダゾールの調製
ES2387780T3 (es) 2003-10-06 2012-10-01 Glaxosmithkline Llc Preparación de azabencimidazoles 1,6-disustituidos como inhibidores de quinasas
CN100560142C (zh) * 2003-10-10 2009-11-18 细胞生物工程公司 用于在生物聚合物上培养角膜内皮细胞和相关细胞以及产生人工角膜移植物的方法和组合物
US20070092550A1 (en) 2003-10-10 2007-04-26 Cellular Bioengineering, Inc. Methods and compositions for growing corneal endothelial and related cells on biopolymers and creation of artifical corneal transplants
CN1898377A (zh) 2003-10-10 2007-01-17 细胞生物工程公司 人角膜内皮细胞以及获得和培养用于角膜细胞移植的细胞的方法
JP2007015928A (ja) 2003-10-15 2007-01-25 Ube Ind Ltd 新規オレフィン誘導体
EP1679308B1 (en) 2003-10-15 2013-07-24 Ube Industries, Ltd. Novel indazole derivative
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
EP2929782A1 (en) 2004-01-23 2015-10-14 Ocata Therapeutics, Inc. Improved modalities for the treatment of degenerative diseases of the retina
US8039585B2 (en) 2004-02-12 2011-10-18 The United States Of America As Represented By The Department Of Health And Human Services Therapeutic administration of the scrambled anti-angiogenic peptide C16Y
CA2556589A1 (en) 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
AR049333A1 (es) 2004-04-02 2006-07-19 Vertex Pharma Azaindoles inhibidores de proteinquinasas rock y otras proteinas quinasas. composiciones farmaceuticas.
WO2006057270A1 (ja) 2004-11-26 2006-06-01 Asahi Kasei Pharma Corporation 含窒素3環化合物
CA2621181C (en) 2005-08-30 2011-04-19 Asahi Kasei Pharma Corporation 5-isoquinolinesulfonamide compounds
JP5255846B2 (ja) 2006-01-19 2013-08-07 千寿製薬株式会社 生体内で細胞増殖可能な角膜内皮製剤
US20090175835A1 (en) 2006-02-07 2009-07-09 Korea Institute Of Radiological & Medical Sciences Composition for treating damage of central or peripheral nerve system
US20100028407A1 (en) 2006-04-27 2010-02-04 University Of Louisville Research Foundation, Inc. Layered bio-adhesive compositions and uses thereof
US8951799B2 (en) 2007-01-04 2015-02-10 Biolamina Ab Composition and method for enabling proliferation of pluripotent stem cells
WO2009028631A1 (ja) 2007-08-29 2009-03-05 Senju Pharmaceutical Co., Ltd. 角膜内皮細胞接着促進剤
US20090306772A1 (en) 2008-04-18 2009-12-10 The Regents Of The University Of California Ocular Scaffolds and Methods for Subretinal Repair of Bruch's Membrane
US8680182B2 (en) 2009-06-04 2014-03-25 Clemson University Research Foundation Methods for promoting the revascularization and reenervation of CNS lesions
JP2011010653A (ja) 2009-06-05 2011-01-20 Kumamoto Univ 細胞の分化誘導方法
JP5590646B2 (ja) * 2009-10-08 2014-09-17 国立大学法人大阪大学 ヒト多能性幹細胞用培養基材およびその利用
RU2418067C1 (ru) 2009-12-03 2011-05-10 Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" Способ культивирования клеток
WO2011080984A1 (en) 2009-12-29 2011-07-07 Senju Pharmaceutical Co., Ltd. Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
BR112013017629A2 (pt) 2010-12-17 2017-04-18 Biolamina Ab laminina-521 recombinante
JPWO2012173207A1 (ja) 2011-06-14 2015-02-23 独立行政法人理化学研究所 網膜細胞への分化誘導方法
JP5761827B2 (ja) 2011-07-15 2015-08-12 国立大学法人大阪大学 角膜内皮細胞の調製方法
WO2013047763A1 (ja) 2011-09-29 2013-04-04 オリエンタル酵母工業株式会社 ラミニン511を含んだ系で哺乳類細胞を培養する方法
IL287381B2 (en) 2011-11-14 2024-04-01 Astellas Inst For Regenerative Medicine Pharmaceutical preparations of human rpe cells and uses thereof
EP2784152B1 (en) 2011-11-25 2019-04-10 Sumitomo Chemical Company, Limited Methods for producing retinal tissue and retina-related cell
JP5985207B2 (ja) 2011-11-25 2016-09-06 住友化学株式会社 網膜色素上皮細胞の製造方法
CA2858173C (en) * 2011-12-06 2023-09-26 Advanced Cell Technology, Inc. Method of directed differentiation producing corneal endothelial cells, compositions thereof, and uses thereof
WO2013148377A1 (en) 2012-03-25 2013-10-03 The Board Of Trustees Of The Leland Stanford Junior University Methods for modulating hair growth using truncated laminin-511
TR201807259T4 (tr) 2012-12-03 2018-06-21 Biolamina Ab Rpe hücreleri üretim yöntemleri.
JP6518878B2 (ja) 2013-10-09 2019-05-29 株式会社ヘリオス 網膜色素上皮細胞の製造方法
JP6770435B2 (ja) 2014-10-31 2020-10-14 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
RU2718062C2 (ru) 2014-10-31 2020-03-30 Сэндзю Фармасьютикал Ко., Лтд. Новое лечение роговицы с применением ламинина
EP3813853A4 (en) 2018-06-29 2022-04-06 Platelet Biogenesis, Inc. DELIVERY COMPOSITIONS AND METHODS OF USE

Also Published As

Publication number Publication date
WO2015080297A1 (en) 2015-06-04
ES2763433T3 (es) 2020-05-28
MX2016006915A (es) 2017-01-23
JP2019054828A (ja) 2019-04-11
RU2704984C1 (ru) 2019-11-01
CA2931280A1 (en) 2015-06-04
US20170002318A1 (en) 2017-01-05
RU2016125225A (ru) 2018-01-09
EP3074508B1 (en) 2019-11-06
JP2016539641A (ja) 2016-12-22
CN105814195A (zh) 2016-07-27
EP3074508A1 (en) 2016-10-05
US11624053B2 (en) 2023-04-11
JP2020188778A (ja) 2020-11-26
JP6470286B2 (ja) 2019-02-13

Similar Documents

Publication Publication Date Title
BR112016011096A2 (pt) Aplicação de laminina à cultura de célula endotelial da córnea
CL2017000646A1 (es) Composiciones que contengan células de bacilo recombinantes y otro agente de control biológico
BR112016025516A2 (pt) composições para controle de mosquito e usos das mesmas
AR090465A1 (es) Formas solidas de un profarmaco de nucleotidos de tiofosforamidato
BR112015001620A2 (pt) composição de meio de cultura, e método para cultivo de célula ou tecido usando-se dita composição
BR112015022545A2 (pt) compostos de pirazolo e os usos disso
BR112014030007A2 (pt) minivetores superenrolados como uma ferramenta para reparação, alteração e substituição de dna
MX2020002867A (es) Inhibidores de glucosilceramida sintasa.
BR112015007448A2 (pt) processo para preparar um amido inibido
BR112014030812A2 (pt) "compostos tricíclicos substituídos como inibidores de fgfr, seus usos, composição farmacêutica e método para inibir uma enzima fgfr"
CR20180503A (es) Composiciones y métodos para programar células terapéuticas utilizando nanoportadores de ácidos nucleicos dirigidos
BR112017005509A2 (pt) composições que compreendem células recombinantes de bacillus e um outro agente de controle biológico.
MX2016003486A (es) Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades.
BR112013028399A2 (pt) artigo para o tratamento de ferimentos
BR112017006469A2 (pt) composições e métodos para inibição de expressão do gene hao1 (hidroxiácido oxidase 1 (glicolato oxidase))
BR112014026740A2 (pt) anticorpo, composição, métodos para tratar um mamífero e para fornecer um anticorpo com adcc realçada, e, uso de um anticorpo
BR112017013394A2 (pt) fabricação de proteína
MX375836B (es) Composiciones y métodos para inhibir la expresión del gen de alfa-1 antitripsina.
BR112015009229A2 (pt) composição tendo como alvo a expressão de genes para plaquetas, célula tronco hematopoiética, uso da referida célula tronco e método in vitro ou ex vivo para gerar uma célula tronco modificada
BR112016017509A2 (pt) composições e métodos compreendendo uma variante da enzima xilanase
BR112016007562A2 (pt) interferência com repressão do fator de transcrição hd-zip de expressão gênica para produzir plantas com traços intensificados
BR112015002295A2 (pt) métodos e composições para indução in vivo de formação de célula beta pancreática
MX2016008258A (es) Celulas eucariotas novedosas y metodos para la expresion recombinante de un producto de interes.
BR112015014367A2 (pt) formulações inibidoras de lfa-1
HK1205952A1 (en) Modulators of acyl-coa lysocardiolipin acyltransferase 1 ( alcat1) and uses thereof

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION (J

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements