BR112016006246B8 - Processos de produção de derivados de diazabiciclo-octano e compostos intermediários dos mesmos - Google Patents
Processos de produção de derivados de diazabiciclo-octano e compostos intermediários dos mesmosInfo
- Publication number
- BR112016006246B8 BR112016006246B8 BR112016006246A BR112016006246A BR112016006246B8 BR 112016006246 B8 BR112016006246 B8 BR 112016006246B8 BR 112016006246 A BR112016006246 A BR 112016006246A BR 112016006246 A BR112016006246 A BR 112016006246A BR 112016006246 B8 BR112016006246 B8 BR 112016006246B8
- Authority
- BR
- Brazil
- Prior art keywords
- diazabicyclo
- production processes
- intermediate compounds
- octane derivatives
- isoindol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013197110 | 2013-09-24 | ||
| JP2013-197110 | 2013-09-24 | ||
| PCT/JP2014/075203 WO2015046207A1 (ja) | 2013-09-24 | 2014-09-24 | ジアザビシクロオクタン誘導体の製造法とその中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112016006246A2 BR112016006246A2 (enExample) | 2017-08-22 |
| BR112016006246B1 BR112016006246B1 (pt) | 2021-09-08 |
| BR112016006246B8 true BR112016006246B8 (pt) | 2021-10-05 |
Family
ID=52743343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016006246A BR112016006246B8 (pt) | 2013-09-24 | 2014-09-24 | Processos de produção de derivados de diazabiciclo-octano e compostos intermediários dos mesmos |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10000491B2 (enExample) |
| EP (1) | EP3050883B1 (enExample) |
| JP (1) | JP6453222B2 (enExample) |
| KR (1) | KR102239725B1 (enExample) |
| CN (2) | CN105555787B (enExample) |
| AR (5) | AR097744A1 (enExample) |
| AU (1) | AU2014324302B2 (enExample) |
| BR (1) | BR112016006246B8 (enExample) |
| CA (1) | CA2924953C (enExample) |
| DK (1) | DK3050883T3 (enExample) |
| ES (1) | ES2793201T3 (enExample) |
| HK (1) | HK1244487A1 (enExample) |
| HU (1) | HUE049027T2 (enExample) |
| IL (1) | IL244740B (enExample) |
| MX (2) | MX367578B (enExample) |
| MY (2) | MY176278A (enExample) |
| NZ (1) | NZ718009A (enExample) |
| RU (1) | RU2719480C2 (enExample) |
| SG (1) | SG11201602256UA (enExample) |
| TW (1) | TWI644908B (enExample) |
| WO (1) | WO2015046207A1 (enExample) |
| ZA (1) | ZA201602053B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117734C2 (uk) | 2012-05-30 | 2018-09-25 | Мейдзі Сейка Фарма Ко., Лтд. | НОВИЙ ІНГІБІТОР β-ЛАКТАМАЗИ І СПОСІБ ЙОГО ОДЕРЖАННЯ |
| MY176278A (en) | 2013-09-24 | 2020-07-27 | Meiji Seika Pharma Co Ltd | Process for producing diazabicyclooctane derivative and intermediate thereof |
| NZ757221A (en) * | 2013-10-08 | 2021-12-24 | Meiji Seika Pharma Co Ltd | Crystalline forms of diazabicyclooctane derivative and production process thereof |
| BR112017010445B8 (pt) * | 2014-12-05 | 2024-02-27 | Meiji Seika Pharma Co Ltd | Processo de produção de cristais de derivado de diazabiciclo-octano e preparação liofilizada estável |
| CA2944306C (en) | 2015-10-30 | 2023-11-14 | The Toronto-Dominion Bank | Validating encrypted data from a multi-layer token |
| US11216808B2 (en) | 2015-11-04 | 2022-01-04 | The Toronto-Dominion Bank | Token-based system for excising data from databases |
| JP2020011901A (ja) * | 2016-10-20 | 2020-01-23 | 協和キリン株式会社 | ピロリジン化合物の製造方法 |
| CN106699756B (zh) * | 2016-12-30 | 2019-10-29 | 淄博鑫泉医药技术服务有限公司 | β内酰胺酶抑制剂阿维巴坦的合成方法 |
| CA3076959C (en) | 2017-09-27 | 2025-02-11 | Meiji Seika Pharma Co., Ltd. | CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND THEIR PRODUCTION PROCESS |
| TW201920174A (zh) | 2017-09-27 | 2019-06-01 | 瑞士商羅氏大藥廠股份有限公司 | 二氮雜雙環辛烷衍生物之醫藥形式及其製法 |
| KR20200091396A (ko) | 2017-09-27 | 2020-07-30 | 페도라 파마슈티칼스 인코포레이티드 | 디아자비시클로옥탄 유도체의 약제학적 형태 및 그의 제조 방법 |
| CN109678856B (zh) * | 2017-10-18 | 2020-09-25 | 新发药业有限公司 | 一种阿维巴坦中间体的制备方法 |
| WO2019101722A1 (en) | 2017-11-23 | 2019-05-31 | F. Hoffmann-La Roche Ag | Proline hydroxylases as well as uses, methods and products involving the same |
| US11957690B2 (en) | 2018-07-16 | 2024-04-16 | Brown University | Chromogenic beta-lactamase substrate |
| US11897844B2 (en) * | 2018-09-21 | 2024-02-13 | Api Corporation | Method for producing amino acid derivatives |
| US12195755B2 (en) | 2019-05-20 | 2025-01-14 | Brown University | Placental lipid bilayer for cell-free molecular interaction studies |
| WO2021038403A1 (en) | 2019-08-30 | 2021-03-04 | DePuy Synthes Products, Inc. | Electrical device for monitoring, prevention, and treatment of implant infections |
| CN121021508A (zh) * | 2025-10-29 | 2025-11-28 | 北京耀诚惠仁科技有限公司 | β-内酰胺酶抑制剂中间体共晶或盐及其制备方法和应用 |
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| JPS5038509B1 (enExample) | 1970-10-21 | 1975-12-10 | ||
| JPS538509A (en) | 1976-07-13 | 1978-01-26 | Toshiba Corp | Impedance matching system for data transmission circuit |
| JPS6019759B2 (ja) | 1977-11-24 | 1985-05-17 | イ−ライ・リリ−・アンド・カンパニ− | 非経口投予用１１１１５１５２１３９１９９東京都中央区京橋２丁目３番１３号 |
| GB1589317A (en) | 1977-11-24 | 1981-05-13 | Lilly Co Eli | Freeze drying cephalothin sodium |
| JPS60255723A (ja) | 1984-05-31 | 1985-12-17 | Ono Pharmaceut Co Ltd | メシル酸ガベキサートの結晶性凍結乾燥製剤及びその製造方法 |
| JPH07117533B2 (ja) | 1985-08-28 | 1995-12-18 | 株式会社生体科学研究所 | トランスフエリンおよびその用途 |
| US20030220521A1 (en) | 1989-07-27 | 2003-11-27 | G.D. Searle & Co. | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension |
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| CN1048248C (zh) | 1994-05-02 | 2000-01-12 | 盐野义制药株式会社 | 吡咯烷基硫基碳代青霉烯衍生物的结晶、含该结晶的冷冻干燥制剂及其制造方法 |
| FR2812635B1 (fr) | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| FR2815420B1 (fr) | 2000-10-16 | 2003-05-16 | Cit Alcatel | Compensation de la dispersion chromatique dans un systeme de transmission a fibre optique, et fibre de compensation |
| FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| FR2921060B1 (fr) | 2007-09-14 | 2012-06-15 | Novexel | Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires |
| SI2231667T1 (sl) | 2008-01-18 | 2013-12-31 | Merck Sharp & Dohme Corp. | Beta laktamazni inhibitorji |
| FR2930553B1 (fr) | 2008-04-29 | 2010-05-21 | Novexel | Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases |
| FR2936798B1 (fr) | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| WO2010126820A2 (en) | 2009-04-30 | 2010-11-04 | Merck Sharp & Dohme Corp. | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| JP2012122603A (ja) | 2010-11-15 | 2012-06-28 | Nifco Inc | コネクタ装置 |
| US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| CN104892490B (zh) * | 2010-12-22 | 2017-07-21 | 明治制果药业株式会社 | 用于制备光学活性二氮杂环辛烷衍生物的中间体化合物的化合物 |
| WO2012172368A1 (en) | 2011-06-17 | 2012-12-20 | Astrazeneca Ab | Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof |
| KR101512738B1 (ko) | 2011-08-27 | 2015-04-17 | 욱크하르트 리미티드 | 1,6-디아자-비시클로[3,2,1]옥탄-7-온 유도체 및 세균 감염 치료에서의 그 유도체의 용도 |
| JP5677634B2 (ja) | 2011-08-30 | 2015-02-25 | ウォックハート リミテッド | １，６−ジアザビシクロ［３，２，１］オクタン−７−オン誘導体および細菌感染の処置におけるそれらの使用 |
| EP3052497B1 (en) | 2011-09-13 | 2017-06-28 | Wockhardt Limited | Nitrogen containing compounds and their use |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| UA117734C2 (uk) | 2012-05-30 | 2018-09-25 | Мейдзі Сейка Фарма Ко., Лтд. | НОВИЙ ІНГІБІТОР β-ЛАКТАМАЗИ І СПОСІБ ЙОГО ОДЕРЖАННЯ |
| MY176278A (en) | 2013-09-24 | 2020-07-27 | Meiji Seika Pharma Co Ltd | Process for producing diazabicyclooctane derivative and intermediate thereof |
| NZ757221A (en) * | 2013-10-08 | 2021-12-24 | Meiji Seika Pharma Co Ltd | Crystalline forms of diazabicyclooctane derivative and production process thereof |
-
2014
- 2014-09-24 MY MYPI2016700980A patent/MY176278A/en unknown
- 2014-09-24 SG SG11201602256UA patent/SG11201602256UA/en unknown
- 2014-09-24 EP EP14847854.8A patent/EP3050883B1/en active Active
- 2014-09-24 US US15/023,976 patent/US10000491B2/en active Active
- 2014-09-24 MX MX2016003867A patent/MX367578B/es active IP Right Grant
- 2014-09-24 WO PCT/JP2014/075203 patent/WO2015046207A1/ja not_active Ceased
- 2014-09-24 MY MYPI2019004461A patent/MY193210A/en unknown
- 2014-09-24 AR ARP140103525A patent/AR097744A1/es active IP Right Grant
- 2014-09-24 JP JP2015539238A patent/JP6453222B2/ja active Active
- 2014-09-24 ES ES14847854T patent/ES2793201T3/es active Active
- 2014-09-24 DK DK14847854.8T patent/DK3050883T3/da active
- 2014-09-24 BR BR112016006246A patent/BR112016006246B8/pt active IP Right Grant
- 2014-09-24 CA CA2924953A patent/CA2924953C/en active Active
- 2014-09-24 AU AU2014324302A patent/AU2014324302B2/en active Active
- 2014-09-24 NZ NZ718009A patent/NZ718009A/en unknown
- 2014-09-24 HU HUE14847854A patent/HUE049027T2/hu unknown
- 2014-09-24 RU RU2016115767A patent/RU2719480C2/ru active
- 2014-09-24 CN CN201480052097.9A patent/CN105555787B/zh active Active
- 2014-09-24 CN CN201710665418.8A patent/CN107501264A/zh active Pending
- 2014-09-24 TW TW103132937A patent/TWI644908B/zh active
- 2014-09-24 MX MX2019006550A patent/MX372585B/es unknown
- 2014-09-24 KR KR1020167009769A patent/KR102239725B1/ko active Active
-
2016
- 2016-03-23 IL IL244740A patent/IL244740B/en active IP Right Grant
- 2016-03-29 ZA ZA2016/02053A patent/ZA201602053B/en unknown
- 2016-06-24 HK HK18103950.2A patent/HK1244487A1/zh unknown
-
2017
- 2017-06-05 US US15/613,620 patent/US10000492B2/en active Active
-
2023
- 2023-11-28 AR ARP230103205A patent/AR131186A2/es unknown
- 2023-11-28 AR ARP230103209A patent/AR131190A2/es unknown
- 2023-11-28 AR ARP230103207A patent/AR131188A2/es unknown
- 2023-11-28 AR ARP230103208A patent/AR131189A2/es unknown
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/09/2014, OBSERVADAS AS CONDICOES LEGAIS. |
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