BR112016028000A8 - derivados de anel fundido de dihidropirimido como um inibidor de hbv - Google Patents

derivados de anel fundido de dihidropirimido como um inibidor de hbv

Info

Publication number
BR112016028000A8
BR112016028000A8 BR112016028000A BR112016028000A BR112016028000A8 BR 112016028000 A8 BR112016028000 A8 BR 112016028000A8 BR 112016028000 A BR112016028000 A BR 112016028000A BR 112016028000 A BR112016028000 A BR 112016028000A BR 112016028000 A8 BR112016028000 A8 BR 112016028000A8
Authority
BR
Brazil
Prior art keywords
dihydropyrimido
fused ring
hbv inhibitor
ring derivatives
hbv
Prior art date
Application number
BR112016028000A
Other languages
English (en)
Other versions
BR112016028000A2 (pt
BR112016028000B1 (pt
Inventor
He Haiying
Qin Hua
Li Jian
Zhou Kai
Chen Shuhui
Wang Xiaofei
Li Xiaolin
Chi Xuemei
Zhou Yuedong
Original Assignee
Medshine Discovery Inc
Qilu Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201410240665.XA external-priority patent/CN105153164B/zh
Application filed by Medshine Discovery Inc, Qilu Pharmaceutical Co Ltd filed Critical Medshine Discovery Inc
Publication of BR112016028000A2 publication Critical patent/BR112016028000A2/pt
Publication of BR112016028000A8 publication Critical patent/BR112016028000A8/pt
Publication of BR112016028000B1 publication Critical patent/BR112016028000B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

derivados de anel fundido de di-hidropirimido como um inibidor de hbv. é descrito um derivado de anel fundido de di-hidropirimido como um inibidor de hbv, e em particular refere-se a um composto mostrado como fórmula (i) ou um sal farmaceuticamente aceitável do mesmo. (i)
BR112016028000-8A 2014-05-30 2015-05-27 Derivado de alça de di-hidropirimido como um inibidor de hbv BR112016028000B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201410240665.X 2014-05-30
CN201410240665.XA CN105153164B (zh) 2014-05-30 2014-05-30 作为hbv抑制剂的二氢嘧啶并环衍生物
CN201410850212 2014-12-31
CN201410850212.9 2014-12-31
CN201510268946 2015-05-22
CN201510268946.0 2015-05-22
PCT/CN2015/079870 WO2015180631A1 (zh) 2014-05-30 2015-05-27 作为hbv抑制剂的二氢嘧啶并环衍生物

Publications (3)

Publication Number Publication Date
BR112016028000A2 BR112016028000A2 (pt) 2017-08-22
BR112016028000A8 true BR112016028000A8 (pt) 2021-07-20
BR112016028000B1 BR112016028000B1 (pt) 2022-05-17

Family

ID=54698105

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016028000-8A BR112016028000B1 (pt) 2014-05-30 2015-05-27 Derivado de alça de di-hidropirimido como um inibidor de hbv

Country Status (15)

Country Link
US (1) US9938301B2 (pt)
EP (1) EP3150600B1 (pt)
JP (1) JP6710642B2 (pt)
KR (1) KR102428878B1 (pt)
CN (1) CN106459061B (pt)
AU (1) AU2015266481B2 (pt)
BR (1) BR112016028000B1 (pt)
CA (1) CA2950807C (pt)
ES (1) ES2687606T3 (pt)
IL (1) IL249261B (pt)
NZ (1) NZ727601A (pt)
PH (1) PH12016502398A1 (pt)
RU (1) RU2693897C2 (pt)
TW (1) TWI568734B (pt)
WO (1) WO2015180631A1 (pt)

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Publication number Publication date
EP3150600A1 (en) 2017-04-05
CA2950807C (en) 2022-05-31
US9938301B2 (en) 2018-04-10
CN106459061B (zh) 2020-01-21
JP2017516816A (ja) 2017-06-22
NZ727601A (en) 2022-01-28
AU2015266481A2 (en) 2017-03-16
CN106459061A (zh) 2017-02-22
US20170197986A1 (en) 2017-07-13
IL249261B (en) 2019-03-31
PH12016502398A1 (en) 2017-02-20
RU2016151893A3 (pt) 2018-12-21
RU2693897C2 (ru) 2019-07-05
CA2950807A1 (en) 2015-12-03
AU2015266481B2 (en) 2018-06-07
JP6710642B2 (ja) 2020-06-17
KR20170006299A (ko) 2017-01-17
BR112016028000A2 (pt) 2017-08-22
EP3150600B1 (en) 2018-06-27
AU2015266481A1 (en) 2017-01-12
TWI568734B (zh) 2017-02-01
EP3150600A4 (en) 2017-04-05
RU2016151893A (ru) 2018-07-03
BR112016028000B1 (pt) 2022-05-17
TW201546073A (zh) 2015-12-16
WO2015180631A1 (zh) 2015-12-03
IL249261A0 (en) 2017-02-28
KR102428878B1 (ko) 2022-08-04
ES2687606T3 (es) 2018-10-26

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