MX367578B - Proceso para producir derivado de diazabiciclooctano y su intermediario. - Google Patents
Proceso para producir derivado de diazabiciclooctano y su intermediario.Info
- Publication number
- MX367578B MX367578B MX2016003867A MX2016003867A MX367578B MX 367578 B MX367578 B MX 367578B MX 2016003867 A MX2016003867 A MX 2016003867A MX 2016003867 A MX2016003867 A MX 2016003867A MX 367578 B MX367578 B MX 367578B
- Authority
- MX
- Mexico
- Prior art keywords
- production method
- intermediary body
- diazabicyclooctane derivative
- isoindole
- dioxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención proporciona un proceso para producir un derivado de diazabiciclooctano representado por la fórmula (IV) y sus intermediarios: (ver Fórmulas) (en donde P es un grupo protector NH capaz de ser removido con ácido; R1 es 2,5-dioxopirrolidin-1-ilo, 1,3-dioxo-3a,4,7,7a-tetrahidro-1H-isoin dol-2(3H)-ilo, 1,3-dioxohexahidro-1H-isoindol-2(3H)-ilo o 3,5-dioxo-4-azatriciclo[5.2.1.02.6]dec-8-en-4-ilo; R2 es hidrógeno, CICO- o CI3COCO-; R3 es alquilo C1-6 o heterociclilo o forma un anillo heterocíclico de 3 a 7 miembros junto con el -O-NH- al que está unido; y OBn es benciboxi).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013197110 | 2013-09-24 | ||
| PCT/JP2014/075203 WO2015046207A1 (ja) | 2013-09-24 | 2014-09-24 | ジアザビシクロオクタン誘導体の製造法とその中間体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016003867A MX2016003867A (es) | 2016-08-04 |
| MX367578B true MX367578B (es) | 2019-08-27 |
Family
ID=52743343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016003867A MX367578B (es) | 2013-09-24 | 2014-09-24 | Proceso para producir derivado de diazabiciclooctano y su intermediario. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10000491B2 (es) |
| EP (1) | EP3050883B1 (es) |
| JP (1) | JP6453222B2 (es) |
| KR (1) | KR102239725B1 (es) |
| CN (2) | CN107501264A (es) |
| AR (1) | AR097744A1 (es) |
| AU (1) | AU2014324302B2 (es) |
| BR (1) | BR112016006246B8 (es) |
| CA (1) | CA2924953C (es) |
| DK (1) | DK3050883T3 (es) |
| ES (1) | ES2793201T3 (es) |
| HK (2) | HK1219473A1 (es) |
| HU (1) | HUE049027T2 (es) |
| IL (1) | IL244740B (es) |
| MX (1) | MX367578B (es) |
| MY (2) | MY193210A (es) |
| NZ (1) | NZ718009A (es) |
| RU (1) | RU2719480C2 (es) |
| SG (1) | SG11201602256UA (es) |
| TW (1) | TWI644908B (es) |
| WO (1) | WO2015046207A1 (es) |
| ZA (1) | ZA201602053B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2857401T1 (sl) | 2012-05-30 | 2020-01-31 | Meiji Seika Pharma Co., Ltd. | Novi inhibitor beta-laktamaze in metoda za proizvajanje le-tega |
| AR097744A1 (es) | 2013-09-24 | 2016-04-13 | Meiji Seika Pharma Co Ltd | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| NZ719568A (en) | 2013-10-08 | 2018-06-29 | Meiji Seika Pharma Co Ltd | Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative |
| ES2821826T3 (es) | 2014-12-05 | 2021-04-27 | Meiji Seika Pharma Co Ltd | Método para producir cristales de derivado de diazabiciclooctano y preparación liofilizada estable |
| CA2944306C (en) | 2015-10-30 | 2023-11-14 | The Toronto-Dominion Bank | Validating encrypted data from a multi-layer token |
| US11216808B2 (en) | 2015-11-04 | 2022-01-04 | The Toronto-Dominion Bank | Token-based system for excising data from databases |
| JP2020011901A (ja) * | 2016-10-20 | 2020-01-23 | 協和キリン株式会社 | ピロリジン化合物の製造方法 |
| CN106699756B (zh) * | 2016-12-30 | 2019-10-29 | 淄博鑫泉医药技术服务有限公司 | β内酰胺酶抑制剂阿维巴坦的合成方法 |
| EP3687992A1 (en) | 2017-09-27 | 2020-08-05 | Meiji Seika Pharma Co., Ltd. | Crystalline forms of diazabicyclooctane derivatives and production process thereof |
| TW201920174A (zh) | 2017-09-27 | 2019-06-01 | 瑞士商羅氏大藥廠股份有限公司 | 二氮雜雙環辛烷衍生物之醫藥形式及其製法 |
| EP3687504A1 (en) | 2017-09-27 | 2020-08-05 | Fedora Pharmaceuticals Inc. | Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same |
| CN109678856B (zh) * | 2017-10-18 | 2020-09-25 | 新发药业有限公司 | 一种阿维巴坦中间体的制备方法 |
| JP7289836B2 (ja) | 2017-11-23 | 2023-06-12 | エフ． ホフマン－ラ ロシュ アーゲー | プロリンヒドロキシラーゼ、ならびにそれに伴う使用、方法および生成物 |
| US11957690B2 (en) | 2018-07-16 | 2024-04-16 | Brown University | Chromogenic beta-lactamase substrate |
| CA3113606A1 (en) * | 2018-09-21 | 2020-03-26 | Api Corporation | Method for producing amino acid derivatives |
| US11751775B2 (en) | 2019-08-30 | 2023-09-12 | DePuy Synthes Products, Inc. | Electrical device for monitoring, prevention, and treatment of implant infections |
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| JPS5038509B1 (es) | 1970-10-21 | 1975-12-10 | ||
| JPS538509A (en) | 1976-07-13 | 1978-01-26 | Toshiba Corp | Impedance matching system for data transmission circuit |
| JPS6019759B2 (ja) | 1977-11-24 | 1985-05-17 | イ−ライ・リリ−・アンド・カンパニ− | 非経口投予用１１１１５１５２１３９１９９東京都中央区京橋２丁目３番１３号 |
| GB1589317A (en) | 1977-11-24 | 1981-05-13 | Lilly Co Eli | Freeze drying cephalothin sodium |
| JPS60255723A (ja) | 1984-05-31 | 1985-12-17 | Ono Pharmaceut Co Ltd | メシル酸ガベキサートの結晶性凍結乾燥製剤及びその製造方法 |
| JPH07117533B2 (ja) | 1985-08-28 | 1995-12-18 | 株式会社生体科学研究所 | トランスフエリンおよびその用途 |
| US20030220521A1 (en) | 1989-07-27 | 2003-11-27 | G.D. Searle & Co. | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension |
| TW264475B (es) | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
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| WO1995029913A1 (fr) | 1994-05-02 | 1995-11-09 | Shionogi & Co., Ltd. | Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production |
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| FR2815420B1 (fr) | 2000-10-16 | 2003-05-16 | Cit Alcatel | Compensation de la dispersion chromatique dans un systeme de transmission a fibre optique, et fibre de compensation |
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| US20120053350A1 (en) | 2009-04-30 | 2012-03-01 | Ian Mangion | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
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| US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
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| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| SI2857401T1 (sl) | 2012-05-30 | 2020-01-31 | Meiji Seika Pharma Co., Ltd. | Novi inhibitor beta-laktamaze in metoda za proizvajanje le-tega |
| AR097744A1 (es) | 2013-09-24 | 2016-04-13 | Meiji Seika Pharma Co Ltd | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| NZ719568A (en) | 2013-10-08 | 2018-06-29 | Meiji Seika Pharma Co Ltd | Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative |
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2014
- 2014-09-24 AR ARP140103525A patent/AR097744A1/es active IP Right Grant
- 2014-09-24 BR BR112016006246A patent/BR112016006246B8/pt active IP Right Grant
- 2014-09-24 CA CA2924953A patent/CA2924953C/en active Active
- 2014-09-24 DK DK14847854.8T patent/DK3050883T3/da active
- 2014-09-24 AU AU2014324302A patent/AU2014324302B2/en active Active
- 2014-09-24 TW TW103132937A patent/TWI644908B/zh active
- 2014-09-24 KR KR1020167009769A patent/KR102239725B1/ko active IP Right Grant
- 2014-09-24 CN CN201710665418.8A patent/CN107501264A/zh active Pending
- 2014-09-24 MY MYPI2019004461A patent/MY193210A/en unknown
- 2014-09-24 NZ NZ718009A patent/NZ718009A/en unknown
- 2014-09-24 JP JP2015539238A patent/JP6453222B2/ja active Active
- 2014-09-24 US US15/023,976 patent/US10000491B2/en active Active
- 2014-09-24 MX MX2016003867A patent/MX367578B/es active IP Right Grant
- 2014-09-24 RU RU2016115767A patent/RU2719480C2/ru active
- 2014-09-24 SG SG11201602256UA patent/SG11201602256UA/en unknown
- 2014-09-24 WO PCT/JP2014/075203 patent/WO2015046207A1/ja active Application Filing
- 2014-09-24 ES ES14847854T patent/ES2793201T3/es active Active
- 2014-09-24 CN CN201480052097.9A patent/CN105555787B/zh active Active
- 2014-09-24 MY MYPI2016700980A patent/MY176278A/en unknown
- 2014-09-24 HU HUE14847854A patent/HUE049027T2/hu unknown
- 2014-09-24 EP EP14847854.8A patent/EP3050883B1/en active Active
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2016
- 2016-03-23 IL IL244740A patent/IL244740B/en active IP Right Grant
- 2016-03-29 ZA ZA2016/02053A patent/ZA201602053B/en unknown
- 2016-06-24 HK HK16107390.3A patent/HK1219473A1/zh unknown
- 2016-06-24 HK HK18103950.2A patent/HK1244487A1/zh unknown
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2017
- 2017-06-05 US US15/613,620 patent/US10000492B2/en active Active
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