MX343756B - Microorganismo que produce o-fosfoserina y metodo para producir l-cisteina o derivados de la misma a partir de o-fosfoserina usando los mismos. - Google Patents

Microorganismo que produce o-fosfoserina y metodo para producir l-cisteina o derivados de la misma a partir de o-fosfoserina usando los mismos.

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Publication number
MX343756B
MX343756B MX2013004495A MX2013004495A MX343756B MX 343756 B MX343756 B MX 343756B MX 2013004495 A MX2013004495 A MX 2013004495A MX 2013004495 A MX2013004495 A MX 2013004495A MX 343756 B MX343756 B MX 343756B
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MX
Mexico
Prior art keywords
phosphoserine
producing
cysteine
derivatives
same
Prior art date
Application number
MX2013004495A
Other languages
English (en)
Other versions
MX2013004495A (es
Inventor
An Shin Soo
Bin Yang Eun
Won Um Hye
Ae Bae Hyun
Hoo Jhon Sung
Sook Chang Jin
Hyun Jo Jae
Kim Sol
Cheol Byeong
Min Lee Kyoung
Uk Shin Yong
Won Kim Hye
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Priority claimed from PCT/KR2011/007732 external-priority patent/WO2012053794A2/en
Publication of MX2013004495A publication Critical patent/MX2013004495A/es
Publication of MX343756B publication Critical patent/MX343756B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01065—O-Phosphoserine sulfhydrylase (2.5.1.65)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03003—Phosphoserine phosphatase (3.1.3.3)

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  • Chemical & Material Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un método para producir cisteína, caracterizado porque comprende; a) cultivar un microorganismo recombinante en el cual la actividad de fosfoserina fosfatasa endógena (SerB) está reducida, para producir O-fosfoserina (OPS), en donde el microorganismo recombinante es Escherichia sp., Erwinia sp., Serratia sp., Providencia sp., Corynebacterium sp., o Brevibacterium sp; y 2) hacer reaccionar la POS de la etapa 1) conun sulfuro en presencia de O-fosfoserina sulfhidrilasa (OPSS) o un microorganismo que expresa OPSS, para producir cisteína. El método caracterizado porque la fosfoserina fosfatasa tienen una secuencia de aminoácidos de SEQ ID NO: 1 o 2. Un microorganismo recombinante, caracterizado porque la actividad de SerB endógeno está reducida, y la actividad de SerA o SerC está además aumentada, en donde el microorganismo recombinante es Escherichia sp., Erwinia sp., Serratia sp., Providencia sp., Corynebacterium sp., o Brevibacterium sp.
MX2013004495A 2010-10-20 2011-10-18 Microorganismo que produce o-fosfoserina y metodo para producir l-cisteina o derivados de la misma a partir de o-fosfoserina usando los mismos. MX343756B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20100102664 2010-10-20
KR1020110086081A KR101381048B1 (ko) 2010-10-20 2011-08-26 Ｏ-포스포세린 생산 균주 및 이로부터 생산된 ｏ-포스포세린으로부터 ｌ-시스테인 또는 이의 유도체의 생산방법
PCT/KR2011/007732 WO2012053794A2 (en) 2010-10-20 2011-10-18 Microorganism producing o-phosphoserine and method of producing l-cysteine or derivatives thereof from o-phosphoserine using the same

Publications (2)

Publication Number Publication Date
MX2013004495A MX2013004495A (es) 2014-04-14
MX343756B true MX343756B (es) 2016-11-18

Family

ID=46140801

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004495A MX343756B (es) 2010-10-20 2011-10-18 Microorganismo que produce o-fosfoserina y metodo para producir l-cisteina o derivados de la misma a partir de o-fosfoserina usando los mismos.

Country Status (12)

Country Link
US (4) US8557549B2 (es)
JP (1) JP5805202B2 (es)
KR (1) KR101381048B1 (es)
CN (2) CN104862352B (es)
AU (1) AU2011318810B2 (es)
BR (1) BR112013009746A8 (es)
DK (1) DK2444481T3 (es)
ES (1) ES2711830T3 (es)
LT (1) LT2444481T (es)
MX (1) MX343756B (es)
MY (1) MY159614A (es)
RU (1) RU2536250C1 (es)

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KR20220062542A (ko) 2020-06-09 2022-05-17 씨제이제일제당 (주) O-포스포세린 배출 단백질 변이체 및 이를 이용한 o-포스포세린, 시스테인 및 이의 유도체의 생산방법
KR102414743B1 (ko) 2020-09-09 2022-06-29 씨제이제일제당 주식회사 신규 o-포스포세린 배출 단백질 및 이를 이용한 o-포스포세린, 시스테인 및 이의 유도체의 생산 방법
KR20220163754A (ko) 2021-06-03 2022-12-12 씨제이제일제당 (주) 신규한 YhhS 변이체 및 이를 이용한 O-포스포세린, 시스테인 및 이의 유도체의 생산방법
KR20220166947A (ko) 2021-06-11 2022-12-20 씨제이제일제당 (주) 신규한 MdtH 변이체 및 이를 이용한 O-포스포세린, 시스테인 및 이의 유도체의 생산방법
KR102654301B1 (ko) 2021-06-23 2024-04-04 씨제이제일제당 주식회사 NADH:quinone 산화환원효소의 발현이 조절된 재조합 미생물 및 이를 이용한 O-포스포세린, 시스테인 및 이의 유도체의 생산방법
KR20230103229A (ko) * 2021-12-31 2023-07-07 씨제이제일제당 (주) O-포스포세린 생산 미생물 및 이를 이용한 o-포스포세린 또는 l-시스테인 생산 방법
CN114381417B (zh) * 2022-03-24 2022-06-24 中国科学院天津工业生物技术研究所 一种提高谷氨酸棒杆菌对抑制物耐受性的方法
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KR100620092B1 (ko) 2004-12-16 2006-09-08 씨제이 주식회사 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법
CN101374940A (zh) * 2005-02-07 2009-02-25 代谢探索者公司 包含表达低γ-消除活性的酶的微生物
JP2006304673A (ja) * 2005-04-28 2006-11-09 National Institute Of Advanced Industrial & Technology システイン合成酵素のホスホセリンに対する基質特異性を高める方法
AU2006261356A1 (en) * 2005-06-17 2006-12-28 Microbia, Inc. Improved amino acid and metabolite biosynthesis
RU2394913C2 (ru) * 2005-10-26 2010-07-20 Е.И.Дюпон Де Немур Энд Компани Ферментативное получение четырехуглеродных спиртов
KR100905381B1 (ko) * 2006-07-28 2009-06-30 씨제이제일제당 (주) Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법

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LT2444481T (lt) 2019-02-25
KR20120041115A (ko) 2012-04-30
JP2013543723A (ja) 2013-12-09
BR112013009746A8 (pt) 2018-07-03
JP5805202B2 (ja) 2015-11-04
AU2011318810B2 (en) 2015-09-24
RU2536250C1 (ru) 2014-12-20
DK2444481T3 (en) 2019-03-25
CN104862352B (zh) 2021-10-26
US20120190081A1 (en) 2012-07-26
RU2013122805A (ru) 2014-11-27
AU2011318810A1 (en) 2013-05-02
MY159614A (en) 2017-01-13
US8557549B2 (en) 2013-10-15
US9689009B2 (en) 2017-06-27
BR112013009746A2 (pt) 2016-11-22
CN104862352A (zh) 2015-08-26
MX2013004495A (es) 2014-04-14
ES2711830T3 (es) 2019-05-07
US20120190082A1 (en) 2012-07-26
CN102906272B (zh) 2016-07-06
KR101381048B1 (ko) 2014-04-14
CN102906272A (zh) 2013-01-30
US20170073715A1 (en) 2017-03-16

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