BR112015026122A8 - agente de polietileno glicol-il-10 (peg-il-10), seu uso, composição farmacêutica, contentor estéril e kit - Google Patents
agente de polietileno glicol-il-10 (peg-il-10), seu uso, composição farmacêutica, contentor estéril e kit Download PDFInfo
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- BR112015026122A8 BR112015026122A8 BR112015026122A BR112015026122A BR112015026122A8 BR 112015026122 A8 BR112015026122 A8 BR 112015026122A8 BR 112015026122 A BR112015026122 A BR 112015026122A BR 112015026122 A BR112015026122 A BR 112015026122A BR 112015026122 A8 BR112015026122 A8 BR 112015026122A8
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Abstract
abstract: methods of using interleukin-10 for treating diseases and disorders methods of treating subjects having a disease or disorder responsive to il-10, including methods of administration and dosing regimens associated therewith, are provided. _______________________________________________________________________ resumo métodos para usar interleucina-10 para tratar doenças e desordens métodos para tratar sujeitos tendo uma doença ou desordem responsiva a il-10, incluindo métodos de administração e regimes de dosagem associados aos mesmos, são providos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361813563P | 2013-04-18 | 2013-04-18 | |
PCT/US2014/034247 WO2014172392A1 (en) | 2013-04-18 | 2014-04-15 | Methods of using interleukin-10 for treating diseases and disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015026122A2 BR112015026122A2 (pt) | 2017-07-25 |
BR112015026122A8 true BR112015026122A8 (pt) | 2020-01-21 |
Family
ID=51731807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015026122A BR112015026122A8 (pt) | 2013-04-18 | 2014-04-15 | agente de polietileno glicol-il-10 (peg-il-10), seu uso, composição farmacêutica, contentor estéril e kit |
Country Status (11)
Country | Link |
---|---|
US (3) | US9943568B2 (pt) |
EP (1) | EP2986306A4 (pt) |
JP (2) | JP2016519108A (pt) |
CN (2) | CN106913865A (pt) |
AU (1) | AU2014254019B2 (pt) |
BR (1) | BR112015026122A8 (pt) |
CA (1) | CA2908198A1 (pt) |
HK (1) | HK1215681A1 (pt) |
MX (1) | MX2015014438A (pt) |
RU (1) | RU2679889C2 (pt) |
WO (1) | WO2014172392A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE037936T2 (hu) * | 2008-12-17 | 2018-09-28 | Merck Sharp & Dohme | Mono- és di-pegil IL-10 elõállítása és alkalmazása |
EP2986306A4 (en) | 2013-04-18 | 2016-12-07 | Armo Biosciences Inc | METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING |
CA2914837A1 (en) | 2013-06-17 | 2014-12-24 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
EP3038642A4 (en) * | 2013-08-30 | 2017-01-18 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
JP6660297B2 (ja) | 2013-11-11 | 2020-03-11 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 疾患及び障害を処置するためのインターロイキン−10の使用方法 |
WO2015187295A2 (en) | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
WO2016060996A2 (en) | 2014-10-14 | 2016-04-21 | Armo Biosciences, Inc. | Interleukin-15 compositions and uses thereof |
JP6675394B2 (ja) * | 2014-10-22 | 2020-04-01 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 疾患及び障害の治療のためにインターロイキン−10を使用する方法 |
WO2016126615A1 (en) * | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
AU2016268403A1 (en) * | 2015-05-28 | 2017-12-07 | Armo Biosciences, Inc. | Pegylated interleukin-10 for use in treating cancer |
CA2986774A1 (en) * | 2015-05-29 | 2016-12-08 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
EP3341012A4 (en) * | 2015-08-25 | 2019-03-20 | Armo Biosciences, Inc. | METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING |
EP3400067A4 (en) * | 2016-01-05 | 2019-08-21 | Armo Biosciences, Inc. | METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING |
EP3402512A4 (en) | 2016-01-11 | 2019-09-25 | Armo Biosciences, Inc. | INTERLEUKIN-10 FOR USE IN THE PRODUCTION OF ANTIGEN-SPECIFIC CD8 + T LYMPHOCYTES AND METHODS OF USE THEREOF |
WO2020198831A1 (pt) | 2019-04-05 | 2020-10-08 | Universidade Federal de Uberlândia | Peptídeos sintéticos com afinidade ao receptor de interleucina-10, composição farmacêutica e uso dos mesmos como imunomuduladores no tratamento de doenças autoimunes, inflamatórias ou alérgicas |
CN110724204B (zh) * | 2019-11-18 | 2021-10-22 | 广东菲鹏制药股份有限公司 | Fc融合蛋白的纯化方法 |
US11673930B2 (en) | 2020-05-12 | 2023-06-13 | Regeneran Pharmaceuticals, Inc. | IL10 agonists and methods of use thereof |
WO2023114958A1 (en) * | 2021-12-16 | 2023-06-22 | Xalud Therapeutics, Inc. | Dosing regimen for il-10 encoding expression construct |
WO2023137227A1 (en) * | 2022-01-14 | 2023-07-20 | Karma Biotechnologies | Multi-vesicular lipid nanoparticle tolerogenic vaccines for induction of systemic immune tolerance in vivo |
WO2024058196A1 (en) * | 2022-09-13 | 2024-03-21 | Okinawa Institute Of Science And Technology School Corporation | New synthetic drugs for treating alzheimer's disease |
Family Cites Families (146)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63152393A (ja) | 1986-07-03 | 1988-06-24 | Takeda Chem Ind Ltd | グリコシル誘導体 |
US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
US5714585A (en) | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
US5032396A (en) | 1989-02-17 | 1991-07-16 | Immunex Corporation | IL-7 to stimulate platelet production |
US6217857B1 (en) | 1989-06-28 | 2001-04-17 | Schering Corporation | Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof |
US5231012A (en) | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
US5229115A (en) | 1990-07-26 | 1993-07-20 | Immunex Corporation | Adoptive immunotherapy with interleukin-7 |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
ATE124866T1 (de) | 1991-01-16 | 1995-07-15 | Schering Corp | Verwendung von interleukin-10 in der adoptive immunotherapie von krebs. |
EP0567576B1 (en) | 1991-01-16 | 1995-01-04 | Schering Corporation | Treatment of neoplastic disease with interleukin-10 |
US5624823A (en) | 1991-11-22 | 1997-04-29 | The General Hospital Corporation | DNA encoding procine interleukin-10 |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
WO1994004180A2 (en) * | 1992-08-20 | 1994-03-03 | Schering Corporation | Novel uses of il-4 and/or il-10, and antibodies against the same |
EP0681589A1 (en) * | 1993-02-01 | 1995-11-15 | Université Libre de Bruxelles | Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10 |
US5328989A (en) | 1993-03-05 | 1994-07-12 | Schering-Plough | Purification of human interleukin-10 from a cell culture medium |
US5552303A (en) | 1993-03-08 | 1996-09-03 | Immunex Corporation | DNA encoding epithelium-derived T-cell factor |
WO1994022473A1 (en) | 1993-04-01 | 1994-10-13 | University Of Washington | Use of interleukin 7 to improve vaccine potency |
US5665345A (en) | 1993-05-24 | 1997-09-09 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of inhibiting viral replication using IL-10 |
HUT73463A (en) | 1993-07-26 | 1996-08-28 | Schering Corp | Agonists and antagonists of human interleukin-10 |
GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
SK91696A3 (en) | 1994-01-20 | 1997-04-09 | Schering Plough Corp | Use of il-10 to stimulate peripheral blood mononuclear cell cytolytic activity |
US5696234A (en) | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6410008B1 (en) | 1994-12-12 | 2002-06-25 | Beth Israel Hospital Association | Chimeric IL-10 proteins and uses thereof |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5866134A (en) | 1995-03-24 | 1999-02-02 | Schering Corporation | Method for enhancing the antibody response to specific antigens with Interleukin-10 |
US20030026789A1 (en) | 1995-05-03 | 2003-02-06 | Richard J. Gregory | Gene therapy using replication competent targeted adenoviral vectors |
US5770190A (en) | 1995-07-14 | 1998-06-23 | Schering Corporation | Method of treatment of acute leukemia with inteleukin-10 |
GB2304047A (en) | 1995-08-09 | 1997-03-12 | Univ Manchester | Pharmaceutical compositions containing cytokines |
US5744451A (en) | 1995-09-12 | 1998-04-28 | Warner-Lambert Company | N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity |
US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
US20050025742A1 (en) | 1996-01-08 | 2005-02-03 | Canji, Inc. | Methods and compositions for interferon therapy |
US5789244A (en) | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
US6248514B1 (en) | 1996-07-09 | 2001-06-19 | Canji, Inc. | Methods for measuring viral infectivity |
US5759859A (en) | 1996-07-15 | 1998-06-02 | United States Of America As Represented By The Secretary Of The Army | Sensor and method for detecting trace underground energetic materials |
US5945097A (en) | 1996-09-06 | 1999-08-31 | Schering Corporation | Method for lowering cholesterol levels with interleukin-10 |
US5989867A (en) | 1996-09-23 | 1999-11-23 | Knappe; Andrea | DNA encoding IL-10-like homologue; related reagents |
US20030060434A1 (en) | 1997-02-18 | 2003-03-27 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
US6660258B1 (en) | 1997-05-09 | 2003-12-09 | Pharma Pacific Pty Ltd | Oromucosal cytokine compositions and uses thereof |
NZ502375A (en) | 1997-07-14 | 2001-11-30 | Bolder Biotechnology Inc | The addition of non-natural cysteine derivatives to cause the protein to act as antagonists of the GH family |
US5985263A (en) | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
CA2316834C (en) | 1998-01-07 | 2006-01-03 | Shearwater Polymers, Inc. | Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom |
US5994134A (en) | 1998-05-04 | 1999-11-30 | Canji, Inc. | Viral production process |
WO2000022124A2 (en) | 1998-10-15 | 2000-04-20 | Canji, Inc. | Methods and compositions to induce antitumor response |
ES2279636T3 (es) | 1998-10-15 | 2007-08-16 | Canji, Inc. | Vectores viricos de replicacion selectiva. |
US7001770B1 (en) | 1998-10-15 | 2006-02-21 | Canji, Inc. | Calpain inhibitors and their applications |
EP1131458A1 (en) | 1998-11-18 | 2001-09-12 | CANJI, Inc. | Viral vectors with late transgene expression |
US6428985B1 (en) | 1998-12-02 | 2002-08-06 | The Regents Of The University Of Michigan | Immunosuppressive structural definition of IL-10 |
US6685931B1 (en) | 1998-12-22 | 2004-02-03 | Schering Corporation | Treatment of hepatitis C virus infections with interleukin-10 |
US7666400B2 (en) * | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
WO2000071718A1 (en) | 1999-05-25 | 2000-11-30 | Canji, Inc. | Gene therapy of pulmonary disease |
WO2001005821A2 (en) | 1999-07-16 | 2001-01-25 | Maria Teresa Bejarano | Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis |
US6464976B1 (en) | 1999-09-07 | 2002-10-15 | Canji, Inc. | Methods and compositions for reducing immune response |
CA2386626A1 (en) | 1999-10-15 | 2001-04-26 | Richard Murphy | Targeted vectors |
US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
US20030186386A1 (en) | 2000-02-11 | 2003-10-02 | Hansen Christian Karsten | Interleukin 10 |
WO2001058950A1 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | Improved interleukin 10 |
AU8640501A (en) * | 2000-07-31 | 2002-02-13 | Univ Yale | Innate immune system-directed vaccines |
US7052686B2 (en) | 2000-09-29 | 2006-05-30 | Schering Corporation | Pegylated interleukin-10 |
US20020081736A1 (en) | 2000-11-03 | 2002-06-27 | Conroy Susan E. | Nucleic acid delivery |
JP2002142770A (ja) | 2000-11-08 | 2002-05-21 | Dnavec Research Inc | 循環系への遺伝子送達用パラミクソウイルスベクター |
US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
EP1234583A1 (en) | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
AU2002307497A1 (en) | 2001-04-23 | 2002-11-05 | The Regents Of The University Of California | Methods of using interleukin-7 to modulate physiological processes in mammalian pulmonary fibroblasts |
GB0212648D0 (en) | 2002-05-31 | 2002-07-10 | Immunoclin Lab Ltd | Treatment with cytokines |
EP1391513A1 (en) | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
CA2498319A1 (en) | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
US20040142893A1 (en) * | 2002-10-21 | 2004-07-22 | Uichi Ikeda | Methods for treating and preventing vascular disease |
WO2004044006A1 (en) | 2002-11-14 | 2004-05-27 | Maxygen, Inc. | Conjugates of interleukin-10 and polymers |
ATE404196T1 (de) | 2002-11-29 | 2008-08-15 | Maria Grazia Roncarolo | Rapamycin und il-10 zur behandlung von autoimmunerkrankungen |
AU2003303222A1 (en) | 2002-12-19 | 2004-07-14 | Universiteit Gent | Mutant proteins showing increased secretion |
JP4511943B2 (ja) | 2002-12-23 | 2010-07-28 | ワイス エルエルシー | Pd−1に対する抗体およびその使用 |
TWI364295B (en) | 2002-12-26 | 2012-05-21 | Mountain View Pharmaceuticals | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
SI2949658T1 (sl) | 2003-03-03 | 2018-10-30 | Dyax Corp. | Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe |
WO2004091517A2 (en) | 2003-04-15 | 2004-10-28 | Smithkline Beecham Corporation | Conjugates comprising human il-18 and substitution mutants thereof |
US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
WO2005033307A1 (ja) | 2003-09-30 | 2005-04-14 | Kyowa Hakko Kogyo Co., Ltd. | 新規のリフォールディング方法およびその方法によって得られたタンパク質 |
US8133700B2 (en) | 2003-11-28 | 2012-03-13 | The University Of Sydney | Latent phase viral interleukin-10-(VII-10) and uses thereof |
CA2551915C (en) | 2003-12-30 | 2015-06-23 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Il-7 fusion proteins |
US20060078942A1 (en) | 2004-03-10 | 2006-04-13 | Pepgen Corporation | Method of treatment using interferon-tau |
WO2005092928A1 (en) | 2004-03-11 | 2005-10-06 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
EP2409713B1 (en) | 2004-08-10 | 2015-07-22 | Genzyme Corporation | Oligonucleotides for use in modulating lipoprotein and cholesterol levels in humans |
US20060046961A1 (en) | 2004-09-02 | 2006-03-02 | Mckay William F | Controlled and directed local delivery of anti-inflammatory compositions |
CN100334112C (zh) | 2004-10-15 | 2007-08-29 | 上海海欣生物技术有限公司 | 人白细胞介素15与Fc融合蛋白 |
RU2437893C2 (ru) | 2004-12-09 | 2011-12-27 | Мерк Патент Гмбх | Варианты il-7 со сниженной иммуногенностью |
EP1831352B1 (en) | 2004-12-13 | 2011-07-13 | CANJI, Inc. | Cell lines for production of replication-defective adenovirus |
GB0500643D0 (en) | 2005-01-13 | 2005-02-23 | Renovo Ltd | Medicaments |
WO2006094530A1 (en) | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
KR101324451B1 (ko) * | 2005-03-15 | 2013-10-31 | 가니얼 이뮤노테라퓨틱스 인코포레이티드 | 면역 조절제 활성을 갖는 화합물 |
AR052741A1 (es) | 2005-04-08 | 2007-03-28 | Noxxon Pharma Ag | Acidos nucleicos de union a ghrelin |
WO2006119170A2 (en) | 2005-05-02 | 2006-11-09 | Avigen, Inc. | Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease |
EP1891103B1 (en) * | 2005-05-31 | 2009-12-23 | The Regents of the University of Colorado | Mutant il-10 |
US8945857B2 (en) | 2005-07-01 | 2015-02-03 | John Schrader | Methods of isolating cells and generating monoclonal antibodies |
EP1746161A1 (en) | 2005-07-20 | 2007-01-24 | Cytheris | Glycosylated IL-7, preparation and uses |
PL1931704T3 (pl) | 2005-10-04 | 2011-06-30 | Zymogenetics L L C | Wytwarzanie i oczyszczanie IL-29 |
WO2007061657A2 (en) | 2005-11-14 | 2007-05-31 | The Brigham & Women's Hospital, Inc. | Interleukin-10 compositions for the treatment of adenocarcinomas |
JP5097714B2 (ja) | 2005-12-12 | 2012-12-12 | カンジ,インコーポレイテッド | E1領域内の発現カセットと不活性化されたe2bポリメラーゼを有するアデノウイルス発現ベクター |
US7868139B2 (en) | 2006-01-24 | 2011-01-11 | Uab Research Foundation | Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases |
WO2007139178A1 (ja) * | 2006-05-31 | 2007-12-06 | Dnavec Corporation | アルツハイマー病治療薬 |
NZ597098A (en) | 2006-09-28 | 2013-05-31 | Merck Sharp & Dohme | Use of pegylated il-10 to treat cancer |
JP2010504979A (ja) | 2006-09-29 | 2010-02-18 | カンジ,インコーポレイテッド | 遺伝子治療のための方法および組成物 |
WO2008041953A2 (en) | 2006-10-05 | 2008-04-10 | Agency For Science, Technology And Research | Dengue diagnosis and treatment |
ES2409756T3 (es) | 2006-12-04 | 2013-06-27 | Promedior, Inc. | Combinación de SAP y de enalapril para su uso en tratamiento de trastornos fibróticos o fibroproliferativos |
JP2010516707A (ja) | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | ペプチド組成物の安定性および送達効率を上昇させるための修飾方法 |
US20090028857A1 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
DE08786222T1 (de) | 2007-07-31 | 2010-11-25 | Affibody Ab | Neue albuminbindende zusammensetzungen, verfahren und anwendungen |
WO2009036568A1 (en) | 2007-09-19 | 2009-03-26 | University Health Network | Methods and compositions for treating tumors and viral infections |
WO2009052454A2 (en) | 2007-10-19 | 2009-04-23 | University Of California | Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss |
WO2009062151A1 (en) | 2007-11-08 | 2009-05-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
GB0724231D0 (en) | 2007-12-12 | 2008-01-30 | Renono Ltd | Methods for inhibiting scarring |
WO2010059315A1 (en) | 2008-11-18 | 2010-05-27 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
HUE037936T2 (hu) | 2008-12-17 | 2018-09-28 | Merck Sharp & Dohme | Mono- és di-pegil IL-10 elõállítása és alkalmazása |
WO2011020024A2 (en) | 2009-08-13 | 2011-02-17 | The Johns Hopkins University | Methods of modulating immune function |
CA2777053A1 (en) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
BR112012008665A2 (pt) | 2009-10-12 | 2016-11-22 | Pfizer | tratamento de câncer |
CN105567699A (zh) | 2009-10-30 | 2016-05-11 | 诺维信生物制药丹麦公司 | 白蛋白变体 |
CN102711829B (zh) | 2009-11-30 | 2016-03-16 | 生物测试股份公司 | 治疗系统性红斑狼疮(sle)的人源化抗il-10抗体 |
CA3083324A1 (en) | 2010-03-05 | 2011-09-09 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
AU2011268310A1 (en) | 2010-06-16 | 2013-01-10 | Abbvie Inc. | Comparison of protein samples |
JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体 |
KR101884654B1 (ko) | 2010-07-09 | 2018-08-02 | 애피바디 에이비 | 폴리펩타이드 |
US8759617B2 (en) | 2010-09-21 | 2014-06-24 | National Institute Of Agrobiological Sciences | Method for extraction and purification of recombinant proteins from transgenic plants |
ES2641869T3 (es) | 2010-09-28 | 2017-11-14 | Aegerion Pharmaceuticals, Inc. | Polipéptidos de fusión de leptina-ABD con duración de acción aumentada |
CN103370083B (zh) | 2010-09-28 | 2016-11-16 | 艾米琳制药有限责任公司 | 具有增强的作用持续时间的工程化多肽 |
US8895536B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating chronic inflammation and inflammatory diseases |
GB201018289D0 (en) * | 2010-10-29 | 2010-12-15 | Biocopea Ltd | Treatment of respiratory disorders |
BR112013024395B1 (pt) | 2011-03-23 | 2021-10-26 | Fred Hutchinson Cancer Research Center | Composições adotivas de imunoterapia celular e método para fabricação da dita composição |
CN102145178B (zh) | 2011-04-15 | 2012-09-26 | 北京凯因科技股份有限公司 | Peg化白介素15 |
EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
WO2013012414A1 (en) | 2011-07-18 | 2013-01-24 | Medimmune, Llc | Dosing regimens for treatment of cea-expressing cancers |
US20140256626A1 (en) | 2011-10-18 | 2014-09-11 | Prolynx Llc | Peg conjugates of exenatide |
US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
US9714276B2 (en) | 2012-01-26 | 2017-07-25 | Amgen Inc. | Growth differentiation factor 15 (GDF-15) polypeptides |
WO2013130913A1 (en) | 2012-02-29 | 2013-09-06 | Ambrx, Inc. | Interleukin-10 polypeptide conjugates and their uses |
WO2013169971A1 (en) | 2012-05-10 | 2013-11-14 | Bristol-Myers Squibb Company | Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients |
EP2947111B1 (en) | 2013-01-17 | 2018-03-07 | Xiamen Sinopeg Biotech Co., Ltd. | Monofunctional branched polyethyleneglycol and bio-related substance modified by same |
EP2986306A4 (en) | 2013-04-18 | 2016-12-07 | Armo Biosciences Inc | METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING |
JP6660297B2 (ja) | 2013-11-11 | 2020-03-11 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 疾患及び障害を処置するためのインターロイキン−10の使用方法 |
WO2015108785A1 (en) | 2014-01-15 | 2015-07-23 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
EP4303229A3 (en) | 2014-01-21 | 2024-04-17 | Novartis AG | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
MA39711A (fr) | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
US20190290733A1 (en) | 2015-03-11 | 2019-09-26 | Nektar Therapeutics | Conjugates of an il-7 moiety and a polymer |
AU2016268403A1 (en) | 2015-05-28 | 2017-12-07 | Armo Biosciences, Inc. | Pegylated interleukin-10 for use in treating cancer |
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2014
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- 2014-04-15 WO PCT/US2014/034247 patent/WO2014172392A1/en active Application Filing
- 2014-04-15 CA CA2908198A patent/CA2908198A1/en not_active Abandoned
- 2014-04-15 BR BR112015026122A patent/BR112015026122A8/pt not_active IP Right Cessation
- 2014-04-15 JP JP2016509037A patent/JP2016519108A/ja active Pending
- 2014-04-15 MX MX2015014438A patent/MX2015014438A/es unknown
- 2014-04-15 US US14/779,929 patent/US9943568B2/en active Active
- 2014-04-15 RU RU2015149387A patent/RU2679889C2/ru active
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- 2014-04-15 CN CN201710248972.6A patent/CN106913865A/zh active Pending
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AU2014254019B2 (en) | 2018-09-27 |
MX2015014438A (es) | 2016-05-18 |
EP2986306A1 (en) | 2016-02-24 |
US20160058838A1 (en) | 2016-03-03 |
JP2019123719A (ja) | 2019-07-25 |
EP2986306A4 (en) | 2016-12-07 |
CN106913865A (zh) | 2017-07-04 |
CN105209054A (zh) | 2015-12-30 |
RU2679889C2 (ru) | 2019-02-14 |
AU2014254019A1 (en) | 2015-10-29 |
BR112015026122A2 (pt) | 2017-07-25 |
WO2014172392A1 (en) | 2014-10-23 |
US20180250364A1 (en) | 2018-09-06 |
JP2016519108A (ja) | 2016-06-30 |
RU2015149387A (ru) | 2017-05-19 |
US20190314456A1 (en) | 2019-10-17 |
US9943568B2 (en) | 2018-04-17 |
CA2908198A1 (en) | 2014-10-23 |
US10357545B2 (en) | 2019-07-23 |
HK1215681A1 (zh) | 2016-09-09 |
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