BR112015023473A2 - mutações acetil-coa carboxilase - Google Patents

mutações acetil-coa carboxilase

Info

Publication number
BR112015023473A2
BR112015023473A2 BR112015023473A BR112015023473A BR112015023473A2 BR 112015023473 A2 BR112015023473 A2 BR 112015023473A2 BR 112015023473 A BR112015023473 A BR 112015023473A BR 112015023473 A BR112015023473 A BR 112015023473A BR 112015023473 A2 BR112015023473 A2 BR 112015023473A2
Authority
BR
Brazil
Prior art keywords
mutations
coa carboxylase
acetyl coa
provides
present
Prior art date
Application number
BR112015023473A
Other languages
English (en)
Other versions
BR112015023473B1 (pt
Inventor
Patrick Mercogliano Chrisopher
Colie Spindler Eileen
Liao Hans
Lynch Michael
Tai Man Louie Michael
LIPSCOMP Tanya
Robert Wolter Travis
Kathleen Ribble Wendy
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Publication of BR112015023473A2 publication Critical patent/BR112015023473A2/pt
Publication of BR112015023473B1 publication Critical patent/BR112015023473B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01059—3-Hydroxypropionate dehydrogenase (1.1.1.59)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

resumo mutações acetil-coa carboxilase a presente invenção provê várias combinações de modificações genéticas para uma célula hospedeira transformada que propicia aumento de conversão de carbono para um produto químico. a presente invenção também provê métodos de fermentação e métodos de fabricar vários produtos químicos.
BR112015023473-9A 2013-03-15 2014-03-15 Microrganismo geneticamente modificado e método de produzir um produto BR112015023473B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361791743P 2013-03-15 2013-03-15
US201361852387P 2013-03-15 2013-03-15
US61/791743 2013-03-15
US61/852387 2013-03-15
PCT/US2014/030074 WO2014145334A1 (en) 2013-03-15 2014-03-15 Acetyl-coa carboxylase mutations

Publications (2)

Publication Number Publication Date
BR112015023473A2 true BR112015023473A2 (pt) 2017-10-10
BR112015023473B1 BR112015023473B1 (pt) 2023-04-11

Family

ID=51537956

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112015023472A BR112015023472A2 (pt) 2013-03-15 2014-03-15 método de produção de um produto químico, método de bioprodução de um produto químico, organismo geneticamente modificado e produto
BR112015023473-9A BR112015023473B1 (pt) 2013-03-15 2014-03-15 Microrganismo geneticamente modificado e método de produzir um produto

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112015023472A BR112015023472A2 (pt) 2013-03-15 2014-03-15 método de produção de um produto químico, método de bioprodução de um produto químico, organismo geneticamente modificado e produto

Country Status (7)

Country Link
US (1) US20150064754A1 (pt)
EP (2) EP2970982B1 (pt)
KR (2) KR20150129007A (pt)
CN (2) CN105189758A (pt)
BR (2) BR112015023472A2 (pt)
MX (2) MX2015012484A (pt)
WO (5) WO2014145332A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2818499A1 (en) 2010-11-22 2012-06-07 Novozymes, Inc. Compositions and methods for 3-hydroxypropionic acid production
US20140051136A1 (en) 2012-08-10 2014-02-20 Opx Biotechnologies, Inc. Micoorganisms and Methods for the Production of Fatty Acids and Fatty Acid Derived Products
US10442748B2 (en) 2013-03-15 2019-10-15 Cargill, Incorporated Recovery of 3-hydroxypropionic acid
US10047383B2 (en) 2013-03-15 2018-08-14 Cargill, Incorporated Bioproduction of chemicals
KR101493154B1 (ko) * 2013-05-10 2015-02-13 씨제이제일제당 (주) 신규 ＲｈｔＢ 단백질 변이체 및 이를 이용한 Ｏ-포스포세린의 생산방법
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US10337038B2 (en) 2013-07-19 2019-07-02 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
US10400256B2 (en) 2015-06-04 2019-09-03 Cj Cheiljedang Corporation Polypeptide having the activity of exporting O-acetyl-homoserine
JP2020506702A (ja) 2017-02-02 2020-03-05 カーギル インコーポレイテッド Ｃ６−ｃ１０脂肪酸誘導体を生成する遺伝子組み換え細胞
CN108728471B (zh) * 2017-04-14 2020-01-31 中国科学院微生物研究所 产3-羟基丙酸的重组菌及其制备方法与应用
CN109391373B (zh) * 2017-08-11 2022-01-28 中兴通讯股份有限公司 数据重传方法、基站，终端及系统
CN108085288B (zh) * 2017-12-22 2021-03-09 广东清大智兴生物技术有限公司 一种利用重组微生物发酵生产1,3-丙二醇的方法
CN109593697B (zh) * 2018-12-18 2022-07-12 江苏师范大学 一种产3-羟基丙酸的重组假单胞菌及其构建方法
US20230220438A1 (en) * 2020-01-09 2023-07-13 Duke University Compositions and methods for auto-inducible cellular lysis and nucleotide hydrolysis
KR102284729B1 (ko) * 2021-01-29 2021-08-02 씨제이제일제당 주식회사 신규한 시아네이트 트랜스포터 패밀리 단백질변이체 및 이를 이용한 l-트립토판 생산 방법
CN113481136B (zh) * 2021-07-19 2022-08-09 天津大学 重组嗜盐单胞菌及构建方法及催化柠檬酸制备衣康酸的应用
CN115948318B (zh) * 2022-12-26 2024-08-27 天津科技大学 利用弱化了rhaB基因的大肠杆菌提高细胞内ATP水平的方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2798053A (en) 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US3687885A (en) 1970-04-15 1972-08-29 Du Pont Water base paints having an improved balance of anti-drip and leveling qualities
US3872037A (en) 1970-12-11 1975-03-18 Polysar Ltd Improved carboxylic latex for paper coating utilizing butadiene-styrene-acrylic acid-acrolein tetrapolymers
GB1349586A (en) 1970-12-11 1974-04-03 Polysar Ltd Latex composition and process for producing the same
US3904685A (en) 1973-07-20 1975-09-09 Celanese Corp Polyacrylic acid having high chelation value and its production
US3891591A (en) 1973-08-13 1975-06-24 Du Pont Coating compositions
CH606154A5 (pt) 1974-07-02 1978-11-15 Goodrich Co B F
US4029577A (en) 1975-11-17 1977-06-14 Betz Laboratories, Inc. Polymers for use in water treatment
DE2757329C2 (de) 1977-12-22 1980-02-07 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Polymerisaten der Acrylsäure oder Methacrylsäure
US4268641A (en) 1979-04-24 1981-05-19 Union Carbide Corporation Acrylic acid-acrylate copolymer thickening agents
US4431547A (en) 1981-08-24 1984-02-14 Nalco Chemical Company Use of acrylamide/acrylic acid copolymers for prevention of fouling by Ca3 (PO4)2
US4985518A (en) 1981-10-26 1991-01-15 American Colloid Company Process for preparing water-absorbing resins
JPS58180233A (ja) 1982-04-19 1983-10-21 Nippon Shokubai Kagaku Kogyo Co Ltd 吸収剤
US4685915A (en) 1984-04-06 1987-08-11 The Procter & Gamble Company Disposable diaper having density and basis weight profiled absorbent core
US4734478A (en) 1984-07-02 1988-03-29 Nippon Shokubai Kagaku Kogyo Co., Ltd. Water absorbing agent
US4708997A (en) 1985-07-22 1987-11-24 The Dow Chemical Company Suspending agent for the suspension polymerization of water-soluble monomers
DE3544770A1 (de) 1985-12-18 1987-06-19 Stockhausen Chem Fab Gmbh Verfahren und vorrichtung zum kontinuierlichen herstellen von polymerisaten und copolymerisaten der acrylsaeure und/oder methacrylsaeure
US5009653A (en) 1988-03-31 1991-04-23 The Procter & Gamble Company Thin, flexible sanitary napkin
US5135677A (en) 1988-04-11 1992-08-04 Nippon Shokubai Co., Ltd. Process for producing acid-type maleic acid polymer and water-treating agent and detergent additive containing said polymer
IT1229506B (it) 1989-01-26 1991-09-03 Sigma Prodotti Chimici Srl Polimero dell'acido acrilico esente da solventi residui e procedimento per la sua preparazione.
US5145906A (en) 1989-09-28 1992-09-08 Hoechst Celanese Corporation Super-absorbent polymer having improved absorbency properties
JP2938920B2 (ja) 1990-01-31 1999-08-25 住友精化株式会社 吸水性樹脂の製造方法
US5350799A (en) 1990-05-31 1994-09-27 Hoechst Celanese Corporation Process for the conversion of fine superabsorbent polymer particles into larger particles
US5342899A (en) 1991-05-16 1994-08-30 The Dow Chemical Company Process for recycling aqueous fluid absorbents fines to a polymerizer
DE4138408A1 (de) 1991-11-22 1993-05-27 Cassella Ag Hydrophile, hochquellfaehige hydrogele
US5827255A (en) 1992-07-27 1998-10-27 The Procter & Gamble Company Sanitary napkin comprising an absorbent core having a density gradient
US5405913A (en) 1993-03-22 1995-04-11 The University Of Akron Free radical copper(II)-enolate polymerization initiators
US5510307A (en) 1993-04-08 1996-04-23 Isp Investments Inc. Free radical initiator delivery system
US5558656A (en) 1993-12-20 1996-09-24 The Procter & Gamble Company Sanitary napkin having an internal shaping component
US7125938B2 (en) 1997-03-11 2006-10-24 Carnegie Mellon University Atom or group transfer radical polymerization
US6306636B1 (en) * 1997-09-19 2001-10-23 Arch Development Corporation Nucleic acid segments encoding wheat acetyl-CoA carboxylase
EP1141268A2 (en) * 1998-12-31 2001-10-10 Millennium Pharmaceuticals, Inc. $i(A. FUMIGATUS) ACETYL COENZYME-A CARBOXYLASE GENES AND POLYPEPTIDES AND USES THEREOF
MXPA03004324A (es) * 2000-11-20 2004-01-26 Cargill Inc Acido 3-hidroxipropionico y otros compuestos organicos.
US6709919B2 (en) 2002-05-15 2004-03-23 Taiwan Semiconductor Manufacturing Company Method for making auto-self-aligned top electrodes for DRAM capacitors with improved capacitor-to-bit-line-contact overlay margin
WO2004044210A2 (en) * 2002-11-06 2004-05-27 University Of Florida Materials and methods for the efficient production of acetate and other products
DE102005048818A1 (de) * 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
US20070219390A1 (en) 2006-03-15 2007-09-20 Battelle Memorial Institute Method and apparatus for conversion of beta-hydroxy carbonyl compounds
JP2010515465A (ja) * 2007-01-12 2010-05-13 ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド，ア ボディー コーポレート 微生物によって生成される有機化学物質の生成に対する耐性を高めるための組成物および方法
DE102007015583A1 (de) * 2007-03-29 2008-10-02 Albert-Ludwigs-Universität Freiburg Ein Enzym zur Herstellung von Methylmalonyl-Coenzym A oder Ethylmalonyl-Coenzym A sowie dessen Verwendung
CA2688292C (en) * 2007-06-01 2015-01-27 Evonik Roehm Gmbh A process for preparing methacrylic acid or methacrylic esters
WO2010006076A2 (en) 2008-07-08 2010-01-14 Opx Biotechnologies Inc. Methods, compositions and systems for biosynthetic bio production of 1,4-butanediol
AU2010224029B2 (en) * 2009-03-11 2015-10-22 Sapphire Energy, Inc. Engineering salt tolerance in photosynthetic microorganisms
MY195387A (en) * 2009-06-04 2023-01-18 Genomatica Inc Microorganisms for the Production of 1,4-Butanediol and Related Methods
US9133489B2 (en) * 2009-09-15 2015-09-15 Sapphire Energy, Inc. Acetyl CoA carboxylases
MX2012003604A (es) * 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
JP2013507145A (ja) * 2009-10-13 2013-03-04 ゲノマチカ， インク． １，４−ブタンジオール、４−ヒドロキシブタナール、４−ヒドロキシブチリル−ＣｏＡ、プトレシン及び関連化合物の生成のための微生物体並びに関連する方法
WO2011063363A2 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
US20110124063A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Methods, Systems, and Compositions for Microbial Bio-Production of Biomolecules Using Syngas Components, or Sugars, as Feedstocks
WO2011063391A1 (en) * 2009-11-23 2011-05-26 Butamax(Tm) Advanced Biofuels Llc Method for producing butanol using extractive fermentation with electrolyte addition
MX2012008700A (es) * 2010-01-27 2012-10-05 Univ Colorado Regents Reduccion con microorganismos de productos quimicos de alto valor y composiciones, metodos y sistemas relacionados.
CN103547671A (zh) * 2010-11-22 2014-01-29 美国佛罗里达大学研究基金会公司 制造d型乳酸的耐热凝结芽孢杆菌的基因工程
CN103562398A (zh) * 2011-03-22 2014-02-05 Opx生物工艺学公司 化学产品的微生物生产以及相关的组合物、方法和系统
KR20120108538A (ko) * 2011-03-24 2012-10-05 삼성전자주식회사 말로닉 세미알데히드 환원 경로를 이용한 3-하이드록시프로피온산의 생산방법
CN102787135B (zh) * 2011-05-18 2014-04-16 中国科学院青岛生物能源与过程研究所 一种提高工程大肠杆菌间苯三酚合成能力的方法
CA2840525A1 (en) * 2011-06-28 2013-01-03 Brookhaven Science Associates, Llc Modified plants with increased oil content
US8349587B2 (en) * 2011-10-31 2013-01-08 Ginkgo Bioworks, Inc. Methods and systems for chemoautotrophic production of organic compounds
US8790901B2 (en) * 2011-12-14 2014-07-29 Pronutria, Inc. Microorganisms and methods for producing unsaturated fatty acids
EP3674399B1 (en) * 2012-04-02 2021-09-22 Genomatica, Inc. Car enzymes and improved production of fatty alcohols
WO2013152051A2 (en) * 2012-04-02 2013-10-10 Ls9, Inc. Improved production of fatty acid derivatives
US10047383B2 (en) * 2013-03-15 2018-08-14 Cargill, Incorporated Bioproduction of chemicals
US10066245B2 (en) * 2013-06-14 2018-09-04 Technical University Of Denmark Microbial production of 3-hydroxypropionic acid

Also Published As

Publication number Publication date
BR112015023473B1 (pt) 2023-04-11
EP2970982A4 (en) 2016-11-23
WO2014145334A9 (en) 2015-01-29
WO2014145344A3 (en) 2014-11-06
EP2970988A4 (en) 2016-12-07
KR102349070B1 (ko) 2022-01-10
KR20150129007A (ko) 2015-11-18
WO2014145344A9 (en) 2015-03-12
EP2970982A1 (en) 2016-01-20
WO2014145334A1 (en) 2014-09-18
CN105189758A (zh) 2015-12-23
US20150064754A1 (en) 2015-03-05
BR112015023472A2 (pt) 2017-12-05
KR20150129013A (ko) 2015-11-18
EP2970982B1 (en) 2020-10-28
WO2014145332A1 (en) 2014-09-18
WO2014145332A9 (en) 2014-10-30
WO2014145344A2 (en) 2014-09-18
EP2970988A2 (en) 2016-01-20
WO2014146047A1 (en) 2014-09-18
MX2015012484A (es) 2016-04-20
WO2014146047A9 (en) 2014-11-06
WO2014145343A1 (en) 2014-09-18
CN105189757A (zh) 2015-12-23
WO2014145343A9 (en) 2014-12-18
MX2015012487A (es) 2016-04-20

Similar Documents

Publication Publication Date Title
BR112015023473A2 (pt) mutações acetil-coa carboxilase
CY1121630T1 (el) Ρυθμιση της εκφρασης γονιδιου σφαιρινης διαμεσολαβουμενη απο νουκλεασες
CR20140576A (es) Sintesis de compuestos heterociclicos
CU24425B1 (es) Amino-heteroaril-benzamidas como inhibidores de cinasa
BR112013023241A2 (pt) melhorias para entidades biológicas imobilizadas
EP3080289A4 (en) Modified nucleic acid molecules and uses thereof
UY4211Q (es) Pizarra para marcadores
UY34453A (es) Moléculas de unión para bcma y cd3
BR112014012543A2 (pt) métodos e materiais para síntese enzimática de compostos de mogrosídeo
UY34484A (es) Benzotienilo-pirrolotriazinas disustituidas y sus usos
DK3351620T3 (da) Metabolsk optimeret cellekultur
CL2013002068A1 (es) Linea celular de ratón con genes inactivados nav1.7 global viable; metodo para generar ratón con dichos genes inactivados; hibridoma.
AR093446A1 (es) Anticuerpos de antihemaglutinina y metodos de uso
AR095048A1 (es) Proceso electroquímico para el acoplamiento de fenol a anilina
UY34167A (es) Pirrolotriazinas sustituidas con hidroximetilarilo y sus usos
UY4268Q (es) Botella
UY34371A (es) Moléculas de ácido nucleico que se dirigen a rps6 y confieren resistencia a plagas de coleópteros.
BR112015003294A2 (pt) caldeira de armazenamento
UY34373A (es) Moléculas de ácido nucleico que se dirigen a pp1-87b y confieren resistencia a plagas de coleópteros.
UY34726A (es) Proceso de montaje de tanques y dispositivos para realizarlo
DK3058078T3 (da) Manipulation af carbonhydridmetabolisme i gær
BR112014032203A2 (pt) vedação intermediária para aplicações em águas ultraprofundas
DK2890819T4 (da) Tane med udvidelsesorganer
UY34372A (es) Moléculas de ácido nucleico que se dirigen a rpa70 y confieren resistencia a plagas de coleópteros.
BR112015019624A2 (pt) quinazolinas como inibidores de quinase

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2014, OBSERVADAS AS CONDICOES LEGAIS