MX2015012484A - Mutaciones de acetil-coa carboxilasa. - Google Patents

Mutaciones de acetil-coa carboxilasa.

Info

Publication number
MX2015012484A
MX2015012484A MX2015012484A MX2015012484A MX2015012484A MX 2015012484 A MX2015012484 A MX 2015012484A MX 2015012484 A MX2015012484 A MX 2015012484A MX 2015012484 A MX2015012484 A MX 2015012484A MX 2015012484 A MX2015012484 A MX 2015012484A
Authority
MX
Mexico
Prior art keywords
mutations
acetyl
coa carboxylase
present
methods
Prior art date
Application number
MX2015012484A
Other languages
English (en)
Inventor
Hans Liao
Christopher Patrick Mercogliano
Travis Robert Wolter
Michael Tai Man Louie
Wendy Kathleen Ribble
Eileen Colie Spindler
Michael Lynch
Tanya Lipscomb
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Publication of MX2015012484A publication Critical patent/MX2015012484A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01059—3-Hydroxypropionate dehydrogenase (1.1.1.59)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

Abstract

La presente invención proporciona diversas combinaciones de modificaciones genéticas a una célula hospedera transformada, que proporciona un aumento de la conversación de carbono a un producto químico. La presente invención proporciona, además, métodos de fermentación y métodos para producir diversos productos químicos.
MX2015012484A 2013-03-15 2014-03-15 Mutaciones de acetil-coa carboxilasa. MX2015012484A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361852387P 2013-03-15 2013-03-15
US201361791743P 2013-03-15 2013-03-15
PCT/US2014/030074 WO2014145334A1 (en) 2013-03-15 2014-03-15 Acetyl-coa carboxylase mutations

Publications (1)

Publication Number Publication Date
MX2015012484A true MX2015012484A (es) 2016-04-20

Family

ID=51537956

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015012484A MX2015012484A (es) 2013-03-15 2014-03-15 Mutaciones de acetil-coa carboxilasa.
MX2015012487A MX2015012487A (es) 2013-03-15 2014-03-15 Control de fases de producción por inducción del crecimiento.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2015012487A MX2015012487A (es) 2013-03-15 2014-03-15 Control de fases de producción por inducción del crecimiento.

Country Status (7)

Country Link
US (1) US20150064754A1 (es)
EP (2) EP2970988A4 (es)
KR (2) KR20150129007A (es)
CN (2) CN105189757A (es)
BR (2) BR112015023473B1 (es)
MX (2) MX2015012484A (es)
WO (5) WO2014145344A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3287519B1 (en) 2010-11-22 2020-03-18 Cargill, Incorporated Compositions and methods for 3-hydroxypropionic acid production
WO2014026162A1 (en) 2012-08-10 2014-02-13 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
US10442749B2 (en) 2013-03-15 2019-10-15 Cargill, Incorporated Recovery of 3-hydroxypropionic acid
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
KR101493154B1 (ko) * 2013-05-10 2015-02-13 씨제이제일제당 (주) 신규 ＲｈｔＢ 단백질 변이체 및 이를 이용한 Ｏ-포스포세린의 생산방법
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
RU2706535C2 (ru) 2015-06-04 2019-11-19 СиДжей ЧеилДжеданг Корпорейшн Микроорганизм, продуцирующий O-ацетилгомосерин, и способ получения O-ацетилгомосерина с использованием этого микроорганизма
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
CN108728471B (zh) * 2017-04-14 2020-01-31 中国科学院微生物研究所 产3-羟基丙酸的重组菌及其制备方法与应用
CN109391373B (zh) * 2017-08-11 2022-01-28 中兴通讯股份有限公司 数据重传方法、基站，终端及系统
CN108085288B (zh) * 2017-12-22 2021-03-09 广东清大智兴生物技术有限公司 一种利用重组微生物发酵生产1,3-丙二醇的方法
CN109593697B (zh) * 2018-12-18 2022-07-12 江苏师范大学 一种产3-羟基丙酸的重组假单胞菌及其构建方法
WO2021162809A2 (en) * 2020-01-09 2021-08-19 Duke University Compositions and methods for auto-inducible cellular lysis and nucleotide hydrolysis
KR102284729B1 (ko) * 2021-01-29 2021-08-02 씨제이제일제당 주식회사 신규한 시아네이트 트랜스포터 패밀리 단백질변이체 및 이를 이용한 l-트립토판 생산 방법
CN113481136B (zh) * 2021-07-19 2022-08-09 天津大学 重组嗜盐单胞菌及构建方法及催化柠檬酸制备衣康酸的应用

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2798053A (en) 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US3687885A (en) 1970-04-15 1972-08-29 Du Pont Water base paints having an improved balance of anti-drip and leveling qualities
US3872037A (en) 1970-12-11 1975-03-18 Polysar Ltd Improved carboxylic latex for paper coating utilizing butadiene-styrene-acrylic acid-acrolein tetrapolymers
GB1349586A (en) 1970-12-11 1974-04-03 Polysar Ltd Latex composition and process for producing the same
US3904685A (en) 1973-07-20 1975-09-09 Celanese Corp Polyacrylic acid having high chelation value and its production
US3891591A (en) 1973-08-13 1975-06-24 Du Pont Coating compositions
US3915921A (en) 1974-07-02 1975-10-28 Goodrich Co B F Unsaturated carboxylic acid-long chain alkyl ester copolymers and tri-polymers water thickening agents and emulsifiers
US4029577A (en) 1975-11-17 1977-06-14 Betz Laboratories, Inc. Polymers for use in water treatment
DE2757329C2 (de) 1977-12-22 1980-02-07 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Polymerisaten der Acrylsäure oder Methacrylsäure
US4268641A (en) 1979-04-24 1981-05-19 Union Carbide Corporation Acrylic acid-acrylate copolymer thickening agents
US4431547A (en) 1981-08-24 1984-02-14 Nalco Chemical Company Use of acrylamide/acrylic acid copolymers for prevention of fouling by Ca3 (PO4)2
US4985518A (en) 1981-10-26 1991-01-15 American Colloid Company Process for preparing water-absorbing resins
JPS58180233A (ja) 1982-04-19 1983-10-21 Nippon Shokubai Kagaku Kogyo Co Ltd 吸収剤
US4685915A (en) 1984-04-06 1987-08-11 The Procter & Gamble Company Disposable diaper having density and basis weight profiled absorbent core
US4734478A (en) 1984-07-02 1988-03-29 Nippon Shokubai Kagaku Kogyo Co., Ltd. Water absorbing agent
US4708997A (en) 1985-07-22 1987-11-24 The Dow Chemical Company Suspending agent for the suspension polymerization of water-soluble monomers
DE3544770A1 (de) 1985-12-18 1987-06-19 Stockhausen Chem Fab Gmbh Verfahren und vorrichtung zum kontinuierlichen herstellen von polymerisaten und copolymerisaten der acrylsaeure und/oder methacrylsaeure
US5009653A (en) 1988-03-31 1991-04-23 The Procter & Gamble Company Thin, flexible sanitary napkin
US5135677A (en) 1988-04-11 1992-08-04 Nippon Shokubai Co., Ltd. Process for producing acid-type maleic acid polymer and water-treating agent and detergent additive containing said polymer
IT1229506B (it) 1989-01-26 1991-09-03 Sigma Prodotti Chimici Srl Polimero dell'acido acrilico esente da solventi residui e procedimento per la sua preparazione.
US5145906A (en) 1989-09-28 1992-09-08 Hoechst Celanese Corporation Super-absorbent polymer having improved absorbency properties
JP2938920B2 (ja) 1990-01-31 1999-08-25 住友精化株式会社 吸水性樹脂の製造方法
US5350799A (en) 1990-05-31 1994-09-27 Hoechst Celanese Corporation Process for the conversion of fine superabsorbent polymer particles into larger particles
US5342899A (en) 1991-05-16 1994-08-30 The Dow Chemical Company Process for recycling aqueous fluid absorbents fines to a polymerizer
DE4138408A1 (de) 1991-11-22 1993-05-27 Cassella Ag Hydrophile, hochquellfaehige hydrogele
US5827255A (en) 1992-07-27 1998-10-27 The Procter & Gamble Company Sanitary napkin comprising an absorbent core having a density gradient
US5405913A (en) 1993-03-22 1995-04-11 The University Of Akron Free radical copper(II)-enolate polymerization initiators
US5510307A (en) 1993-04-08 1996-04-23 Isp Investments Inc. Free radical initiator delivery system
US5558656A (en) 1993-12-20 1996-09-24 The Procter & Gamble Company Sanitary napkin having an internal shaping component
US7125938B2 (en) 1997-03-11 2006-10-24 Carnegie Mellon University Atom or group transfer radical polymerization
US6306636B1 (en) * 1997-09-19 2001-10-23 Arch Development Corporation Nucleic acid segments encoding wheat acetyl-CoA carboxylase
WO2000039287A2 (en) * 1998-12-31 2000-07-06 Millennium Pharmaceuticals, Inc. A. fumigatus acetyl coenzyme-a carboxylase genes and polypeptides and uses thereof
AU1981802A (en) * 2000-11-20 2002-06-03 Cargill Inc 3-hydroxypropionic acid and other organic compounds
US6709919B2 (en) 2002-05-15 2004-03-23 Taiwan Semiconductor Manufacturing Company Method for making auto-self-aligned top electrodes for DRAM capacitors with improved capacitor-to-bit-line-contact overlay margin
WO2004044210A2 (en) * 2002-11-06 2004-05-27 University Of Florida Materials and methods for the efficient production of acetate and other products
DE102005048818A1 (de) * 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
US20070219390A1 (en) 2006-03-15 2007-09-20 Battelle Memorial Institute Method and apparatus for conversion of beta-hydroxy carbonyl compounds
CA2675026A1 (en) * 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
DE102007015583A1 (de) * 2007-03-29 2008-10-02 Albert-Ludwigs-Universität Freiburg Ein Enzym zur Herstellung von Methylmalonyl-Coenzym A oder Ethylmalonyl-Coenzym A sowie dessen Verwendung
CN101679187B (zh) * 2007-06-01 2013-06-05 赢创罗姆有限责任公司 用于制备甲基丙烯酸或甲基丙烯酸酯的方法
US20110190513A1 (en) 2008-07-08 2011-08-04 Lynch Michael D Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
US20120094386A1 (en) * 2009-03-11 2012-04-19 Sapphire Energy, Inc. Engineering salt tolerance in photosynthetic microorganisms
SI3392340T1 (sl) * 2009-06-04 2022-05-31 Genomatica, Inc. Mikroorganizmi za proizvodnjo 1,4-BUTANDIOLA in pripadajoči postopki
IN2012DN01696A (es) * 2009-09-15 2015-06-05 Sapphire Energy Inc
MX2012003604A (es) * 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
EP2488652A4 (en) * 2009-10-13 2014-04-09 Genomatica Inc MICRO-ORGANISMS FOR THE PREPARATION OF 1,4-BANDANDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCIN AND CORRESPONDING COMPOUNDS, AND CORRESPONDING METHODS
US20110125118A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an Organic Acid and/or Related Chemicals
EP2501820A4 (en) 2009-11-20 2014-05-14 Opx Biotechnologies Inc METHODS, SYSTEMS AND COMPOSITION FOR THE MICROBIAL BIOHODULATION OF BIOMOLECULES USING SYNAMIC COMPONENTS OR SUGAR AS RAW MATERIALS
CA2779884A1 (en) * 2009-11-23 2011-05-26 Butamax(Tm) Advanced Biofuels Llc Method for producing butanol using extractive fermentation with electrolyte addition
GB2492256A (en) * 2010-01-27 2012-12-26 Opx Biotechnologies Inc Microorganism production of high-valve chemical products, and related compositions, methods and systems
JP5605597B2 (ja) * 2010-11-22 2014-10-15 フロリダ大学 リサーチファウンデーション インコーポレイティッド Ｄ（−）−乳酸生成のための耐熱性Ｂａｃｉｌｌｕｓｃｏａｇｕｌａｎｓの遺伝子操作
CA2868113A1 (en) * 2011-03-22 2012-09-27 Opx Biotechnologies, Inc. Microbial production of chemical products and related compositions, methods and systems
KR20120108538A (ko) * 2011-03-24 2012-10-05 삼성전자주식회사 말로닉 세미알데히드 환원 경로를 이용한 3-하이드록시프로피온산의 생산방법
CN102787135B (zh) * 2011-05-18 2014-04-16 中国科学院青岛生物能源与过程研究所 一种提高工程大肠杆菌间苯三酚合成能力的方法
US20140230091A1 (en) * 2011-06-28 2014-08-14 Brookhaven Science Associates, Llc Modified plants with increased oil content
US8349587B2 (en) * 2011-10-31 2013-01-08 Ginkgo Bioworks, Inc. Methods and systems for chemoautotrophic production of organic compounds
US8790901B2 (en) * 2011-12-14 2014-07-29 Pronutria, Inc. Microorganisms and methods for producing unsaturated fatty acids
KR102166271B1 (ko) * 2012-04-02 2020-10-16 알이지 라이프 사이언시스, 엘엘씨 지방산 유도체들의 개선된 생산
AU2013243602B2 (en) * 2012-04-02 2016-11-24 Genomatica, Inc. Car enzymes and improved production of fatty alcohols
US9447438B2 (en) * 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
US10066245B2 (en) * 2013-06-14 2018-09-04 Technical University Of Denmark Microbial production of 3-hydroxypropionic acid

Also Published As

Publication number Publication date
KR102349070B1 (ko) 2022-01-10
WO2014146047A1 (en) 2014-09-18
EP2970982A4 (en) 2016-11-23
WO2014145343A9 (en) 2014-12-18
EP2970988A2 (en) 2016-01-20
BR112015023473A2 (pt) 2017-10-10
WO2014145334A1 (en) 2014-09-18
EP2970982B1 (en) 2020-10-28
WO2014145332A1 (en) 2014-09-18
WO2014145344A2 (en) 2014-09-18
CN105189757A (zh) 2015-12-23
WO2014146047A9 (en) 2014-11-06
BR112015023473B1 (pt) 2023-04-11
KR20150129013A (ko) 2015-11-18
WO2014145344A3 (en) 2014-11-06
EP2970988A4 (en) 2016-12-07
WO2014145334A9 (en) 2015-01-29
BR112015023472A2 (pt) 2017-12-05
WO2014145343A1 (en) 2014-09-18
CN105189758A (zh) 2015-12-23
WO2014145332A9 (en) 2014-10-30
EP2970982A1 (en) 2016-01-20
WO2014145344A9 (en) 2015-03-12
US20150064754A1 (en) 2015-03-05
KR20150129007A (ko) 2015-11-18
MX2015012487A (es) 2016-04-20

Similar Documents

Publication Publication Date Title
MX2015012484A (es) Mutaciones de acetil-coa carboxilasa.
PH12017502026A1 (en) Nuclease-mediated regulation of gene expression
AU356754S (en) Lid
AU364341S (en) Container
SG10201900948PA (en) Modified nucleotide linkers
AU365435S (en) Lid for a container
AU356380S (en) Container
AU364441S (en) Lid for a container
WO2015073683A3 (en) Nuclease-mediated regulation of gene expression
AU344891S (en) Torch
EP3101158A4 (en) Electrochemical reactor for producing oxyhydrogen gas
NZ702030A (en) Variants of chymosin with improved milk-clotting properties
AU343147S (en) Easel
AU344890S (en) Torch
EP3080243A4 (en) Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-coa and bacteria expressing same
PL3359655T3 (pl) Komórka eukariotyczna ze zwiększonym wytwarzaniem produktu fermentacji
EP2951300A4 (en) ROBUST AND EASY IMMOBILIZED ENZYME REACTORS TO BE USED
PH12015501390A1 (en) Tablets with improved acceptance and good storage stability
AU343145S (en) Desk
AU344364S (en) Planting system
PT3194568T (pt) Estirpes de clostridium acetobutylicum incapazes de produzir hidrogénio e úteis para a produção contínua de produtos químicos e combustíveis
EP3090041A4 (en) Biomass productivity regulator
CA144335S (en) Snack container
AU359152S (en) Sliding door trolley
AU347555S (en) Vessel