DK3058078T3 - Manipulation af carbonhydridmetabolisme i gær - Google Patents

Manipulation af carbonhydridmetabolisme i gær Download PDF

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Publication number
DK3058078T3
DK3058078T3 DK14853593T DK14853593T DK3058078T3 DK 3058078 T3 DK3058078 T3 DK 3058078T3 DK 14853593 T DK14853593 T DK 14853593T DK 14853593 T DK14853593 T DK 14853593T DK 3058078 T3 DK3058078 T3 DK 3058078T3
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DK
Denmark
Prior art keywords
hydradic
yesterday
metabolism
manipulation
carbon
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Application number
DK14853593T
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English (en)
Inventor
Jens Nielsen
Verena Siewers
Teixeira Paulo Alexandre Goncalves
Yongjin Zhou
Nicolaas A A Buijs
Florian David
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Biopetrolia Ab
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Publication of DK3058078T3 publication Critical patent/DK3058078T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0095—Oxidoreductases (1.) acting on iron-sulfur proteins as donor (1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01042—Hexadecanal dehydrogenase (acylating) (1.2.1.42), i.e. fatty acyl-CoA reductase

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK14853593T 2013-10-18 2014-10-17 Manipulation af carbonhydridmetabolisme i gær DK3058078T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361893125P 2013-10-18 2013-10-18
PCT/SE2014/051229 WO2015057155A1 (en) 2013-10-18 2014-10-17 Engineering of hydrocarbon metabolism in yeast

Publications (1)

Publication Number Publication Date
DK3058078T3 true DK3058078T3 (da) 2019-11-18

Family

ID=52828464

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14853593T DK3058078T3 (da) 2013-10-18 2014-10-17 Manipulation af carbonhydridmetabolisme i gær

Country Status (4)

Country Link
US (2) US9777283B2 (da)
EP (1) EP3058078B1 (da)
DK (1) DK3058078T3 (da)
WO (1) WO2015057155A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3058078B1 (en) * 2013-10-18 2019-10-09 Biopetrolia AB Engineering of hydrocarbon metabolism in yeast
ES2579384B1 (es) * 2015-02-10 2017-07-07 Neol Biosolutions, S.A. Producción de alcoholes grasos
CN105567621B (zh) * 2016-02-03 2019-10-11 武汉科技大学 一种促进细胞内辅酶nadph再生的基因工程集胞藻及其应用
WO2017192920A1 (en) * 2016-05-04 2017-11-09 The Regents Of The University Of California System and method for biosynthesis
WO2018109163A1 (en) 2016-12-16 2018-06-21 Danmarks Tekniske Universitet Methods for producing fatty alcohols and derivatives thereof in yeast
CN110291193B (zh) 2016-12-16 2024-03-08 丹麦科技大学 在酵母中产生去饱和脂肪醇和去饱和脂肪醇乙酸酯
JP6607204B2 (ja) * 2017-01-17 2019-11-20 トヨタ自動車株式会社 アルカン合成能を有する組換え微生物及びアルカンの製造方法
US10557152B2 (en) 2017-05-12 2020-02-11 The Regents Of The University Of California Yeast host cells and methods for producing fatty alcohols
CN113621630B (zh) * 2021-08-05 2023-03-24 昆明理工大学 3-酮脂酰-CoA硫解酶基因RkACAA1-1及其应用
CN113652440B (zh) * 2021-08-05 2023-04-21 昆明理工大学 3-酮脂酰辅酶a硫解酶基因rkacaa1-2及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011062987A2 (en) * 2009-11-17 2011-05-26 Ls9, Inc. Methods and compositions for producing hydrocarbons
ES2739894T3 (es) * 2010-02-12 2020-02-04 Gevo Inc Microorganismos de levadura con una acumulación reducida de subproductos para una mejor producción de combustibles, productos químicos y aminoácidos
AR084377A1 (es) 2010-04-08 2013-05-15 Ls9 Inc Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico
JP5761352B2 (ja) 2011-08-15 2015-08-12 トヨタ自動車株式会社 アルカンの製造方法及びアルカン合成能を有する組換え微生物
US9096834B2 (en) * 2012-02-24 2015-08-04 Exxonmobil Research And Engineering Company Recombinant microorganisms comprising thioesterase and lysophosphatidic acid acyltransferase genes for fatty acid production
WO2013124439A2 (en) * 2012-02-24 2013-08-29 Shell Internationale Research Maatschappij B.V. Method for preparing a hydrocarbon
CA2888197C (en) 2012-10-15 2023-03-07 Genomatica, Inc. Microorganisms and methods for production of specific length fatty alcohols and related compounds
EP3058078B1 (en) * 2013-10-18 2019-10-09 Biopetrolia AB Engineering of hydrocarbon metabolism in yeast

Also Published As

Publication number Publication date
EP3058078A4 (en) 2017-05-24
US9957513B2 (en) 2018-05-01
US20160237444A1 (en) 2016-08-18
US20180030460A1 (en) 2018-02-01
US9777283B2 (en) 2017-10-03
WO2015057155A1 (en) 2015-04-23
EP3058078A1 (en) 2016-08-24
EP3058078B1 (en) 2019-10-09

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