BR112015023089A2 - célula hospedeira, método para produzir um isoprenoide, e método para aumentar a produção de acetil-coa ou um composto derivado de acetil-coa - Google Patents
célula hospedeira, método para produzir um isoprenoide, e método para aumentar a produção de acetil-coa ou um composto derivado de acetil-coaInfo
- Publication number
- BR112015023089A2 BR112015023089A2 BR112015023089A BR112015023089A BR112015023089A2 BR 112015023089 A2 BR112015023089 A2 BR 112015023089A2 BR 112015023089 A BR112015023089 A BR 112015023089A BR 112015023089 A BR112015023089 A BR 112015023089A BR 112015023089 A2 BR112015023089 A2 BR 112015023089A2
- Authority
- BR
- Brazil
- Prior art keywords
- acetyl
- coa
- host cell
- isoprenoid
- producing
- Prior art date
Links
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000003505 terpenes Chemical class 0.000 title abstract 3
- 108010032776 glycerol-1-phosphatase Proteins 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 abstract 2
- -1 acetyl-coa derivative compound Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 108700023175 Phosphate acetyltransferases Proteins 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 108010004621 phosphoketolase Proteins 0.000 abstract 1
- 229930001119 polyketide Natural products 0.000 abstract 1
- 125000000830 polyketide group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/02—Aldehyde-lyases (4.1.2)
- C12Y401/02009—Phosphoketolase (4.1.2.9)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/54—Acetic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03021—Glycerol-1-phosphatase (3.1.3.21)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800356P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/028421 WO2014144135A2 (en) | 2013-03-15 | 2014-03-14 | Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015023089A2 true BR112015023089A2 (pt) | 2017-11-21 |
Family
ID=50391556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015023089A BR112015023089A2 (pt) | 2013-03-15 | 2014-03-14 | célula hospedeira, método para produzir um isoprenoide, e método para aumentar a produção de acetil-coa ou um composto derivado de acetil-coa |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9410214B2 (enExample) |
| EP (1) | EP2971027B1 (enExample) |
| JP (2) | JP6595449B2 (enExample) |
| KR (1) | KR102159691B1 (enExample) |
| CN (1) | CN105189772B (enExample) |
| AU (1) | AU2014227811C1 (enExample) |
| BR (1) | BR112015023089A2 (enExample) |
| CA (1) | CA2903053C (enExample) |
| ES (1) | ES2721920T3 (enExample) |
| MX (1) | MX364748B (enExample) |
| MY (1) | MY171958A (enExample) |
| WO (1) | WO2014144135A2 (enExample) |
| ZA (1) | ZA201506406B (enExample) |
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| CA2891455C (en) | 2012-11-20 | 2022-07-05 | Lallemand Hungary Liquidity Management Llc | An electron consuming ethanol production pathway to displace glycerol formation in s. cerevisiae |
| US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
| WO2015077752A1 (en) | 2013-11-25 | 2015-05-28 | Genomatica, Inc. | Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol |
| EP3077501B1 (en) | 2013-12-03 | 2021-07-28 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| BR112017005665A2 (pt) * | 2014-09-18 | 2017-12-12 | Genomatica Inc | organismos microbianos não naturais com eficiência energética melhorada |
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| WO2017051930A1 (en) * | 2015-09-25 | 2017-03-30 | Ajinomoto Co., Inc. | Method of producing isoprenoid compound |
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| WO2018094110A2 (en) * | 2016-11-16 | 2018-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for identifying and expressing gene clusters |
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| JP2019041712A (ja) * | 2017-09-05 | 2019-03-22 | 株式会社デンソー | 組み換え体及びスクアレンの製造方法 |
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| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| WO2011015985A2 (en) | 2009-08-04 | 2011-02-10 | Evogene Ltd. | Polynucleotides and polypeptides for increasing desirable plant qualities |
| JP5056897B2 (ja) | 2010-05-14 | 2012-10-24 | トヨタ自動車株式会社 | ２−ブタノールの製造方法及び２−ブタノール生産能を有する組換え微生物 |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| WO2012098662A1 (ja) * | 2011-01-20 | 2012-07-26 | トヨタ自動車株式会社 | 組換え酵母及びこれを用いた物質生産方法 |
| US9121038B2 (en) * | 2011-04-29 | 2015-09-01 | The Goodyear Tire & Rubber Company | Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids |
| EP2546336A1 (en) * | 2011-07-11 | 2013-01-16 | DSM IP Assets B.V. | Yeast strains that consume uronic acids and produce fermentation products such as ethanol |
| CN104039974B (zh) | 2011-11-09 | 2016-10-12 | 阿迈瑞斯公司 | 乙酰辅酶a衍生的类异戊二烯的生产 |
| US9163263B2 (en) * | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
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2014
- 2014-03-14 AU AU2014227811A patent/AU2014227811C1/en active Active
- 2014-03-14 ES ES14714149T patent/ES2721920T3/es active Active
- 2014-03-14 EP EP14714149.3A patent/EP2971027B1/en active Active
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- 2014-03-14 US US14/214,062 patent/US9410214B2/en active Active
- 2014-03-14 CA CA2903053A patent/CA2903053C/en active Active
- 2014-03-14 WO PCT/US2014/028421 patent/WO2014144135A2/en not_active Ceased
- 2014-03-14 BR BR112015023089A patent/BR112015023089A2/pt not_active Application Discontinuation
- 2014-03-14 KR KR1020157028637A patent/KR102159691B1/ko active Active
- 2014-03-14 MX MX2015012365A patent/MX364748B/es active IP Right Grant
- 2014-03-14 MY MYPI2015703178A patent/MY171958A/en unknown
- 2014-03-14 JP JP2016502782A patent/JP6595449B2/ja active Active
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Also Published As
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|---|---|
| KR102159691B1 (ko) | 2020-09-24 |
| JP2016512047A (ja) | 2016-04-25 |
| CN105189772A (zh) | 2015-12-23 |
| ZA201506406B (en) | 2017-01-25 |
| AU2014227811A1 (en) | 2015-09-24 |
| MY171958A (en) | 2019-11-08 |
| WO2014144135A3 (en) | 2014-10-23 |
| EP2971027B1 (en) | 2019-01-30 |
| JP6595449B2 (ja) | 2019-10-23 |
| JP2019213558A (ja) | 2019-12-19 |
| MX2015012365A (es) | 2016-04-15 |
| CA2903053C (en) | 2023-01-17 |
| AU2014227811C1 (en) | 2018-09-27 |
| US20140273144A1 (en) | 2014-09-18 |
| CA2903053A1 (en) | 2014-09-18 |
| AU2014227811B2 (en) | 2018-03-22 |
| US9410214B2 (en) | 2016-08-09 |
| CN105189772B (zh) | 2019-09-13 |
| KR20150132310A (ko) | 2015-11-25 |
| MX364748B (es) | 2019-05-06 |
| EP2971027A2 (en) | 2016-01-20 |
| WO2014144135A2 (en) | 2014-09-18 |
| ES2721920T3 (es) | 2019-08-06 |
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