CA2903053C - Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds - Google Patents

Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds Download PDF

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Publication number
CA2903053C
CA2903053C CA2903053A CA2903053A CA2903053C CA 2903053 C CA2903053 C CA 2903053C CA 2903053 A CA2903053 A CA 2903053A CA 2903053 A CA2903053 A CA 2903053A CA 2903053 C CA2903053 C CA 2903053C
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Canada
Prior art keywords
coa
genetically modified
yeast cell
acetyl
enzyme
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CA2903053A
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English (en)
French (fr)
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CA2903053A1 (en
Inventor
Kristy Michelle Hawkins
Tina Tipawan MAHATDEJKUL-MEADOWS
Adam Leon Meadows
Lauren Barbara PICKENS
Anna TAI
Annie Ening Tsong
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TotalEnergies Marketing Services SA
Amyris Inc
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Total Marketing Services SA
Amyris Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/54—Acetic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03021—Glycerol-1-phosphatase (3.1.3.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02009—Phosphoketolase (4.1.2.9)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
CA2903053A 2013-03-15 2014-03-14 Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds Active CA2903053C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361800356P 2013-03-15 2013-03-15
US61/800,356 2013-03-15
PCT/US2014/028421 WO2014144135A2 (en) 2013-03-15 2014-03-14 Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds

Publications (2)

Publication Number Publication Date
CA2903053A1 CA2903053A1 (en) 2014-09-18
CA2903053C true CA2903053C (en) 2023-01-17

Family

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Application Number Title Priority Date Filing Date
CA2903053A Active CA2903053C (en) 2013-03-15 2014-03-14 Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds

Country Status (13)

Country Link
US (1) US9410214B2 (enExample)
EP (1) EP2971027B1 (enExample)
JP (2) JP6595449B2 (enExample)
KR (1) KR102159691B1 (enExample)
CN (1) CN105189772B (enExample)
AU (1) AU2014227811C1 (enExample)
BR (1) BR112015023089A2 (enExample)
CA (1) CA2903053C (enExample)
ES (1) ES2721920T3 (enExample)
MX (1) MX364748B (enExample)
MY (1) MY171958A (enExample)
WO (1) WO2014144135A2 (enExample)
ZA (1) ZA201506406B (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3339426B1 (en) 2011-10-07 2022-08-24 Danisco US Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
US9988650B2 (en) 2012-11-20 2018-06-05 Lallenmend Hungary Liquidity Management LLC Electron consuming ethanol production pathway to displace glycerol formation in S. cerevisiae
US9580758B2 (en) 2013-11-12 2017-02-28 Luc Montagnier System and method for the detection and treatment of infection by a microbial agent associated with HIV infection
US20160376600A1 (en) 2013-11-25 2016-12-29 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
WO2015084633A1 (en) 2013-12-03 2015-06-11 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
BR112017005665A2 (pt) * 2014-09-18 2017-12-12 Genomatica Inc organismos microbianos não naturais com eficiência energética melhorada
CN104372017B (zh) * 2014-11-05 2017-06-30 中国科学院青岛生物能源与过程研究所 一种提高基因工程菌异戊二烯及其衍生物产量的方法及应用
WO2017051930A1 (en) * 2015-09-25 2017-03-30 Ajinomoto Co., Inc. Method of producing isoprenoid compound
US11166968B2 (en) 2015-09-29 2021-11-09 Kimberly-Clark Worldwide, Inc. Synergistic composition for maintenance of healthy balance of microflora
GB201519088D0 (en) * 2015-10-28 2015-12-09 Metabogen Ab The use of bacteria formulations
JP6949838B2 (ja) 2015-10-29 2021-10-13 フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ 高甘味度甘味料
US10612032B2 (en) 2016-03-24 2020-04-07 The Board Of Trustees Of The Leland Stanford Junior University Inducible production-phase promoters for coordinated heterologous expression in yeast
JPWO2018079619A1 (ja) * 2016-10-28 2019-09-19 積水化学工業株式会社 組換え細胞、並びに、イソプレン又はテルペンの生産方法
CN118064425A (zh) 2016-11-16 2024-05-24 斯坦福大学托管董事会 用于鉴定和表达基因簇的系统和方法
CA3047268A1 (en) * 2016-12-16 2018-06-21 Danisco Us Inc. Bifunctional phosphoketolase-phosphotransacetylase fusion polypeptides
WO2018140652A1 (en) 2017-01-25 2018-08-02 Amyris, Inc. Co-production of a sesquiterpene and a carotenoid
KR102769558B1 (ko) 2017-02-28 2025-02-19 킴벌리-클라크 월드와이드, 인크. 미생물총의 건강한 균형을 유지하기 위한 상승적 조성물
EP3596199A1 (en) * 2017-03-13 2020-01-22 DSM IP Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
CN111108213B (zh) 2017-05-03 2024-12-13 弗门尼舍公司 制备高强度甜味剂的方法
US20200095621A1 (en) * 2017-05-16 2020-03-26 The Regents Of The University Of California Methods and compositions for 3-hydroxypropionate production
WO2019030007A1 (en) 2017-08-07 2019-02-14 Total Raffinage Chimie PROCESS FOR RECOVERING FERMENTATION PRODUCTS
WO2019030073A1 (en) 2017-08-07 2019-02-14 Total Raffinage Chimie PROCESS FOR RECOVERING ISOPRENOIDS PRODUCED BY MICROORGANISMS
JP2019041712A (ja) * 2017-09-05 2019-03-22 株式会社デンソー 組み換え体及びスクアレンの製造方法
CN111655855B (zh) 2017-09-14 2025-09-09 生命明疗法股份有限公司 人治疗靶标及其调节剂
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
RS65389B1 (sr) * 2018-03-06 2024-04-30 Danisco Us Inc Smanjenje proizvodnje acetata kod kvasaca koji prekomerno eksprimiraju pab1
US20210047660A1 (en) * 2018-03-06 2021-02-18 Danisco Us Inc. Compositions and methods for increasing ethanol production by yeast using gcy1 and dak1
CN112703251A (zh) 2018-07-12 2021-04-23 阿迈瑞斯公司 控制发酵进料速率的方法
US12338476B2 (en) 2018-11-07 2025-06-24 Firmenich Incorporated Methods for making high intensity sweeteners
CN113286523A (zh) 2018-11-07 2021-08-20 弗门尼舍公司 制备高强度甜味剂的方法
CN111378588A (zh) * 2018-12-29 2020-07-07 中国科学院青岛生物能源与过程研究所 一种转化纤维素水解液合成法尼烯的基因工程菌及其应用
KR20220018495A (ko) * 2019-05-08 2022-02-15 옥설리틱 리미티드 영양요구성 선택 방법
WO2021022097A1 (en) * 2019-08-01 2021-02-04 Danisco Us Inc Over-expression of adh5p for increased ethanol production by yeast
CN110628806B (zh) * 2019-09-23 2021-09-21 华南理工大学 一种高产β-紫罗兰酮基因工程菌及其构建方法和应用
CN111763662B (zh) * 2019-11-29 2023-12-19 上海京新生物医药有限公司 酮还原酶及其在替格瑞洛中间体合成中的应用
CN112342163A (zh) * 2020-11-13 2021-02-09 华中农业大学 一种伯克霍尔德菌及其应用
US11905544B2 (en) 2020-12-17 2024-02-20 Debut Biotechnology, Inc. Dehydratase variants with improved specific activity for the production of pyruvate from glycerate
US12006528B2 (en) 2020-12-18 2024-06-11 Debut Biotechnology, Inc. Cell-free production of geranyl pyrophosphate from glycerol in a cell-free manufacturing system
IL307636A (en) 2021-04-13 2023-12-01 Debut Biotechnology Inc Bioproduction of flavonoids and anthocyanin using microbial hosts
CN113430215B (zh) * 2021-06-03 2023-04-18 昆明理工大学 乙酰CoA合成酶基因RKACS1及其应用
CN114480158B (zh) * 2021-09-15 2023-02-03 安徽农业大学 一种戊糖片球菌及其在棉酚降解中的应用
WO2023244843A1 (en) 2022-06-16 2023-12-21 Amyris, Inc. HIGH pH METHODS AND COMPOSITIONS FOR CULTURING GENETICALLY MODIFIED HOST CELLS
NL2032683B1 (en) * 2022-07-18 2024-01-26 Sestina Bio Llc Bioproduction of isoprenoids
CN115305226B (zh) * 2022-09-22 2023-06-16 郑州轻工业大学 一株降解烟碱并产氢的抗辐射不动杆菌zj-22及其应用
CN116926092B (zh) * 2022-10-28 2024-04-26 昆明理工大学 一种泛酸激酶基因RkPank及其应用
CN116064266B (zh) * 2022-11-01 2024-06-14 四川大学 盐胁迫抗性增强的重组酿酒酵母菌及其构建方法与应用
US20260218213A1 (en) 2023-01-10 2026-07-30 Amyris, Inc. Production of canthaxanthin
KR20260010506A (ko) 2023-05-15 2026-01-20 디에스엠 아이피 어셋츠 비.브이. 발효 공정 중 에멀젼 형성 감소 방법
EP4743568A1 (en) * 2023-07-14 2026-05-20 Danstar Ferment Ag INCREASED PRODUCTION OF ACETYL-COENZYME A AND DERIVATIVES IN YEASTS
WO2025133860A1 (en) * 2023-12-21 2025-06-26 Danstar Ferment Ag Increased production of acetyl-phosphate and products derived therefrom in yeasts
CN119639631B (zh) * 2025-02-12 2025-05-23 云南省农业科学院农业环境资源研究所 一株草根围副伯克霍尔德氏菌及其菌剂与应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0118367B1 (en) 1983-03-08 1989-04-26 Merck & Co. Inc. Recombinant dna cloning vector pve1, deletion and hybrid mutants, and recombinant derivatives thereof, products and processes
US4703009A (en) 1983-03-08 1987-10-27 Merck & Co., Inc. RDNA cloning vector pVE1, deletion and hybrid mutants and recombinant derivatives thereof products and processes
US5272065A (en) 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
IL81892A (en) 1986-03-21 1995-10-31 Lilly Co Eli Recombinant AND molecule containing a sequence encoding O-methyltransfer macrocin
US5672497A (en) 1986-03-21 1997-09-30 Eli Lilly And Company Method for increasing the antibiotic-producing ability of antibiotic-producing microorganisms
US5098837A (en) 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
US5149638A (en) 1988-09-29 1992-09-22 Eli Lilly And Company Tylosin biosynthetic genes tylA, tylB and tylI
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US6060234A (en) 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
WO1993013663A1 (en) 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5824513A (en) 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
JPH09504436A (ja) 1993-11-02 1997-05-06 メルク エンド カンパニー インコーポレーテッド トリオールポリケチドシンターゼをコードするｄｎａ
US5716849A (en) 1994-06-08 1998-02-10 Novartis Finance Corporation Genes for the biosynthesis of soraphen
CA2197160C (en) 1996-02-22 2007-05-01 Stanley Gene Burgett Platenolide synthase gene
CA2197524A1 (en) 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
EP0929681B1 (en) 1996-08-20 2006-09-13 Novartis AG Rifamycin biosynthesis gene cluster
CA2267198C (en) * 1996-11-13 2008-06-17 E.I. Du Pont De Nemours And Company Method for the production of glycerol by recombinant organisms
JP2001511349A (ja) 1997-07-25 2001-08-14 ヘキスト・マリオン・ルセル Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子
US6090601A (en) 1998-01-23 2000-07-18 Kosan Bioscience Sorangium polyketide synthase
US6143526A (en) 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
EP1082439A2 (en) 1998-05-28 2001-03-14 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
NZ508326A (en) 1998-06-18 2003-10-31 Novartis Ag A polyketide synthase and non ribosomal peptide synthase genes, isolated from a myxobacterium, necessary for synthesis of epothiones A and B
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
EP1117801B1 (en) 1998-10-02 2006-11-29 Kosan Biosciences, Inc. Polyketide synthase enzymes and recombinant dna constructs therefor, for the production of compounds related to fk-506 and fk-520
EP1124969A2 (en) 1998-10-29 2001-08-22 Kosan Biosciences, Inc. Recombinant oleandolide polyketide synthase
CN100381566C (zh) 1998-11-20 2008-04-16 科森生物科学公司 产生环氧噻酮及其衍生物的重组方法和材料
US7192751B2 (en) 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US7253001B2 (en) 2002-03-19 2007-08-07 Forskarpatent I Syd Ab Metabolic engineering for improved xylose utilisation of Saccharomyces cerevisiae
WO2009013159A2 (en) 2007-07-23 2009-01-29 Dsm Ip Assets B.V. Acetyl-coa producing enzymes in yeast
EP2358875B1 (en) 2008-11-19 2015-08-12 Amyris, Inc. Compositions and methods for the assembly of polynucleotides
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
CA2768428C (en) 2009-08-04 2021-08-17 Evogene Ltd. Isolated polynucleotides and polypeptides, and methods of using same for increasing abiotic stress tolerance, yield, growth rate, vigor, biomass, oil content, and/or nitrogen use efficiency of plants
JP5056897B2 (ja) 2010-05-14 2012-10-24 トヨタ自動車株式会社 ２−ブタノールの製造方法及び２−ブタノール生産能を有する組換え微生物
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
US9340793B2 (en) * 2011-01-20 2016-05-17 Toyota Jidosha Kabushiki Kaisha Recombinant yeast and substance production method using the same
ES2699747T3 (es) * 2011-04-29 2019-02-12 Danisco Us Inc Microorganismos recombinantes para la producción potenciada de mevalonato, isopreno e isoprenoides
EP2546336A1 (en) * 2011-07-11 2013-01-16 DSM IP Assets B.V. Yeast strains that consume uronic acids and produce fermentation products such as ethanol
ES2628847T3 (es) * 2011-11-09 2017-08-04 Amyris, Inc. Producción de isoprenoides derivados de acetil-coenzima a
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene

Also Published As

Publication number Publication date
MX2015012365A (es) 2016-04-15
US9410214B2 (en) 2016-08-09
BR112015023089A2 (pt) 2017-11-21
JP6595449B2 (ja) 2019-10-23
CA2903053A1 (en) 2014-09-18
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