CA2903053C - Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds - Google Patents
Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds Download PDFInfo
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- CA2903053C CA2903053C CA2903053A CA2903053A CA2903053C CA 2903053 C CA2903053 C CA 2903053C CA 2903053 A CA2903053 A CA 2903053A CA 2903053 A CA2903053 A CA 2903053A CA 2903053 C CA2903053 C CA 2903053C
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- genetically modified
- yeast cell
- acetyl
- enzyme
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- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 title claims abstract description 224
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- -1 but not limited to Chemical class 0.000 claims abstract description 55
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 claims abstract description 54
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- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims description 40
- 230000001965 increasing effect Effects 0.000 claims description 28
- OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 claims description 27
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- C12Y—ENZYMES
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- C—CHEMISTRY; METALLURGY
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
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| Application Number | Priority Date | Filing Date | Title |
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| US201361800356P | 2013-03-15 | 2013-03-15 | |
| US61/800,356 | 2013-03-15 | ||
| PCT/US2014/028421 WO2014144135A2 (en) | 2013-03-15 | 2014-03-14 | Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds |
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| CA2903053A1 CA2903053A1 (en) | 2014-09-18 |
| CA2903053C true CA2903053C (en) | 2023-01-17 |
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Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201401249PA (en) | 2011-10-07 | 2014-05-29 | Danisco Us Inc | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| BR112015011544B1 (pt) | 2012-11-20 | 2022-08-16 | Lallemand Hungary Liquidity Management Llc | Microrganismo recombinante, composição compreendendo o mesmo, método de produção de etanol e co-cultura |
| US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
| US20160376600A1 (en) | 2013-11-25 | 2016-12-29 | Genomatica, Inc. | Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| EP3741865B1 (en) * | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| CN104372017B (zh) * | 2014-11-05 | 2017-06-30 | 中国科学院青岛生物能源与过程研究所 | 一种提高基因工程菌异戊二烯及其衍生物产量的方法及应用 |
| WO2017051930A1 (en) * | 2015-09-25 | 2017-03-30 | Ajinomoto Co., Inc. | Method of producing isoprenoid compound |
| US11166968B2 (en) | 2015-09-29 | 2021-11-09 | Kimberly-Clark Worldwide, Inc. | Synergistic composition for maintenance of healthy balance of microflora |
| GB201519088D0 (en) * | 2015-10-28 | 2015-12-09 | Metabogen Ab | The use of bacteria formulations |
| JP6949838B2 (ja) | 2015-10-29 | 2021-10-13 | フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | 高甘味度甘味料 |
| US10612032B2 (en) | 2016-03-24 | 2020-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inducible production-phase promoters for coordinated heterologous expression in yeast |
| CN109689857A (zh) * | 2016-10-28 | 2019-04-26 | 积水化学工业株式会社 | 重组细胞、以及异戊二烯或萜的生产方法 |
| CA3042726A1 (en) * | 2016-11-16 | 2018-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for identifying and expressing gene clusters |
| CA3047268A1 (en) * | 2016-12-16 | 2018-06-21 | Danisco Us Inc. | Bifunctional phosphoketolase-phosphotransacetylase fusion polypeptides |
| EP3574105B1 (en) | 2017-01-25 | 2021-04-21 | Amyris Bio Products Portugal, Unipessoal, LDA | Co-production of a sesquiterpene and a carotenoid |
| RU2748651C2 (ru) | 2017-02-28 | 2021-05-28 | Кимберли-Кларк Ворлдвайд, Инк. | Синергическая композиция для сохранения здорового баланса микрофлоры |
| EP3596199A1 (en) * | 2017-03-13 | 2020-01-22 | DSM IP Assets B.V. | Zinc binuclear cluster transcriptional regulator-deficient strain |
| JP7285786B2 (ja) | 2017-05-03 | 2023-06-02 | フィルメニッヒ インコーポレイテッド | 高強度の甘味料の製造方法 |
| WO2019030007A1 (en) | 2017-08-07 | 2019-02-14 | Total Raffinage Chimie | PROCESS FOR RECOVERING FERMENTATION PRODUCTS |
| US11103808B2 (en) | 2017-08-07 | 2021-08-31 | Amyris, Inc. | Process for recovering isoprenoids produced by microorganisms |
| JP2019041712A (ja) * | 2017-09-05 | 2019-03-22 | 株式会社デンソー | 組み換え体及びスクアレンの製造方法 |
| CA3075528A1 (en) | 2017-09-14 | 2019-03-21 | Lifemine Therapeutics, Inc. | Human therapeutic targets and modulators thereof |
| CA3084263A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| CN111868047A (zh) | 2017-12-21 | 2020-10-30 | 齐默尔根公司 | 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物 |
| WO2019173217A1 (en) * | 2018-03-06 | 2019-09-12 | Danisco Us Inc | Compositions and methods for increasing ethanol production by yeast using gcy1 and dak1 |
| HUE065696T2 (hu) | 2018-03-06 | 2024-06-28 | Danisco Us Inc | Acetát-termelés csökkentése PAB1-et túltermelõ élesztõvel |
| BR112021000313A2 (pt) | 2018-07-12 | 2021-04-06 | Amyris, Inc. | Métodos para controlar taxas de alimentação de fermentação |
| US12286661B2 (en) | 2018-11-07 | 2025-04-29 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| JP2022512931A (ja) | 2018-11-07 | 2022-02-07 | フィルメニッヒ インコーポレイテッド | 高甘味度甘味料の製造方法 |
| CN111378588A (zh) * | 2018-12-29 | 2020-07-07 | 中国科学院青岛生物能源与过程研究所 | 一种转化纤维素水解液合成法尼烯的基因工程菌及其应用 |
| SG11202111965YA (en) * | 2019-05-08 | 2021-11-29 | Auxolytic Ltd | Auxotrophic selection methods |
| WO2021022097A1 (en) * | 2019-08-01 | 2021-02-04 | Danisco Us Inc | Over-expression of adh5p for increased ethanol production by yeast |
| CN110628806B (zh) * | 2019-09-23 | 2021-09-21 | 华南理工大学 | 一种高产β-紫罗兰酮基因工程菌及其构建方法和应用 |
| CN111763662B (zh) * | 2019-11-29 | 2023-12-19 | 上海京新生物医药有限公司 | 酮还原酶及其在替格瑞洛中间体合成中的应用 |
| CN112342163A (zh) * | 2020-11-13 | 2021-02-09 | 华中农业大学 | 一种伯克霍尔德菌及其应用 |
| US11905544B2 (en) | 2020-12-17 | 2024-02-20 | Debut Biotechnology, Inc. | Dehydratase variants with improved specific activity for the production of pyruvate from glycerate |
| WO2022133213A1 (en) * | 2020-12-18 | 2022-06-23 | Debut Biotechnology, Inc. | Cell-free production of geranyl pyrophosphate from glycerol in a cell-free manufacturing system |
| BR112023021282A2 (pt) | 2021-04-13 | 2023-12-26 | Debut Biotechnology Inc | Bioprodução de flavonoides e antocianinas usando hospedeiro de microrganismos |
| CN113430215B (zh) * | 2021-06-03 | 2023-04-18 | 昆明理工大学 | 乙酰CoA合成酶基因RKACS1及其应用 |
| CN114480158B (zh) * | 2021-09-15 | 2023-02-03 | 安徽农业大学 | 一种戊糖片球菌及其在棉酚降解中的应用 |
| US20250215388A1 (en) | 2022-06-16 | 2025-07-03 | Amyris, Inc. | HIGH pH METHODS AND COMPOSITIONS FOR CULTURING GENETICALLY MODIFIED HOST CELLS |
| NL2032683B1 (en) * | 2022-07-18 | 2024-01-26 | Sestina Bio Llc | Bioproduction of isoprenoids |
| CN115305226B (zh) * | 2022-09-22 | 2023-06-16 | 郑州轻工业大学 | 一株降解烟碱并产氢的抗辐射不动杆菌zj-22及其应用 |
| CN116926092B (zh) * | 2022-10-28 | 2024-04-26 | 昆明理工大学 | 一种泛酸激酶基因RkPank及其应用 |
| CN116064266B (zh) * | 2022-11-01 | 2024-06-14 | 四川大学 | 盐胁迫抗性增强的重组酿酒酵母菌及其构建方法与应用 |
| EP4649142A1 (en) | 2023-01-10 | 2025-11-19 | Amyris, Inc. | Production of canthaxanthin |
| WO2024235968A1 (en) | 2023-05-15 | 2024-11-21 | Dsm Ip Assets B.V. | Method of reducing emulsion formationduring fermentation process |
| AR133254A1 (es) * | 2023-07-14 | 2025-09-10 | Danstar Ferment Ag | Aumento de la producción de acetil-coenzima a y productos derivados en levaduras |
| WO2025133860A1 (en) * | 2023-12-21 | 2025-06-26 | Danstar Ferment Ag | Increased production of acetyl-phosphate and products derived therefrom in yeasts |
| CN119639631B (zh) * | 2025-02-12 | 2025-05-23 | 云南省农业科学院农业环境资源研究所 | 一株草根围副伯克霍尔德氏菌及其菌剂与应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0118367B1 (en) | 1983-03-08 | 1989-04-26 | Merck & Co. Inc. | Recombinant dna cloning vector pve1, deletion and hybrid mutants, and recombinant derivatives thereof, products and processes |
| US4703009A (en) | 1983-03-08 | 1987-10-27 | Merck & Co., Inc. | RDNA cloning vector pVE1, deletion and hybrid mutants and recombinant derivatives thereof products and processes |
| US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5672497A (en) | 1986-03-21 | 1997-09-30 | Eli Lilly And Company | Method for increasing the antibiotic-producing ability of antibiotic-producing microorganisms |
| IL81892A (en) | 1986-03-21 | 1995-10-31 | Lilly Co Eli | Recombinant AND molecule containing a sequence encoding O-methyltransfer macrocin |
| US5098837A (en) | 1988-06-07 | 1992-03-24 | Eli Lilly And Company | Macrolide biosynthetic genes for use in streptomyces and other organisms |
| US5149638A (en) | 1988-09-29 | 1992-09-22 | Eli Lilly And Company | Tylosin biosynthetic genes tylA, tylB and tylI |
| US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| US6060234A (en) | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
| WO1993013663A1 (en) | 1992-01-17 | 1993-07-22 | Abbott Laboratories | Method of directing biosynthesis of specific polyketides |
| US5824513A (en) | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
| US5849541A (en) | 1993-11-02 | 1998-12-15 | Merck & Co., Inc. | DNA encoding triol polyketide synthase |
| US5716849A (en) | 1994-06-08 | 1998-02-10 | Novartis Finance Corporation | Genes for the biosynthesis of soraphen |
| CA2197524A1 (en) | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
| CA2197160C (en) | 1996-02-22 | 2007-05-01 | Stanley Gene Burgett | Platenolide synthase gene |
| EP0929681B1 (en) | 1996-08-20 | 2006-09-13 | Novartis AG | Rifamycin biosynthesis gene cluster |
| JP4330041B2 (ja) * | 1996-11-13 | 2009-09-09 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 組換え生物体によるグリセロールの製造方法 |
| WO1999005283A2 (fr) | 1997-07-25 | 1999-02-04 | Hoechst Marion Roussel | Genes de biosynthese et de transfert des 6-desoxyhexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation |
| US6090601A (en) | 1998-01-23 | 2000-07-18 | Kosan Bioscience | Sorangium polyketide synthase |
| US6143526A (en) | 1998-03-09 | 2000-11-07 | Baltz; Richard H. | Biosynthetic genes for spinosyn insecticide production |
| EP1082439A2 (en) | 1998-05-28 | 2001-03-14 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
| NZ508326A (en) | 1998-06-18 | 2003-10-31 | Novartis Ag | A polyketide synthase and non ribosomal peptide synthase genes, isolated from a myxobacterium, necessary for synthesis of epothiones A and B |
| US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
| CA2343880C (en) | 1998-10-02 | 2008-08-26 | Kosan Biosciences, Inc. | Polyketide synthase enzymes and recombinant dna constructs therefor |
| AU758421B2 (en) | 1998-10-29 | 2003-03-20 | Kosan Biosciences, Inc. | Recombinant oleandolide polyketide synthase |
| EP1135470A2 (en) | 1998-11-20 | 2001-09-26 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US7253001B2 (en) | 2002-03-19 | 2007-08-07 | Forskarpatent I Syd Ab | Metabolic engineering for improved xylose utilisation of Saccharomyces cerevisiae |
| WO2009013157A1 (en) | 2007-07-23 | 2009-01-29 | Dsm Ip Assets B.V. | Butanol production in a eukaryotic cell |
| MX2011005195A (es) | 2008-11-19 | 2011-09-01 | Amyris Inc | Composiciones y metodos para el ensamblaje de polinucleotidos. |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| CA3121387A1 (en) | 2009-08-04 | 2011-02-10 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same forincreasing abiotic stress tolerance, yield, growth rate, vigor, biomass oil content, and/or nitrogen use efficiency of plants |
| JP5056897B2 (ja) | 2010-05-14 | 2012-10-24 | トヨタ自動車株式会社 | ２−ブタノールの製造方法及び２−ブタノール生産能を有する組換え微生物 |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| CN103328631B (zh) * | 2011-01-20 | 2017-04-26 | 丰田自动车株式会社 | 重组酵母和使用该重组酵母的物质生产方法 |
| US9121038B2 (en) * | 2011-04-29 | 2015-09-01 | The Goodyear Tire & Rubber Company | Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids |
| EP2546336A1 (en) * | 2011-07-11 | 2013-01-16 | DSM IP Assets B.V. | Yeast strains that consume uronic acids and produce fermentation products such as ethanol |
| DK2776571T3 (en) | 2011-11-09 | 2017-06-26 | Amyris Inc | PREPARATION OF ACETYL-COENZYM A-DERIVED ISOPRENOIDS |
| US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
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| ZA201506406B (en) | 2017-01-25 |
| US20140273144A1 (en) | 2014-09-18 |
| AU2014227811C1 (en) | 2018-09-27 |
| MX2015012365A (es) | 2016-04-15 |
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| US9410214B2 (en) | 2016-08-09 |
| CA2903053A1 (en) | 2014-09-18 |
| MX364748B (es) | 2019-05-06 |
| EP2971027B1 (en) | 2019-01-30 |
| CN105189772A (zh) | 2015-12-23 |
| WO2014144135A2 (en) | 2014-09-18 |
| EP2971027A2 (en) | 2016-01-20 |
| JP2019213558A (ja) | 2019-12-19 |
| KR20150132310A (ko) | 2015-11-25 |
| AU2014227811B2 (en) | 2018-03-22 |
| JP2016512047A (ja) | 2016-04-25 |
| CN105189772B (zh) | 2019-09-13 |
| KR102159691B1 (ko) | 2020-09-24 |
| BR112015023089A2 (pt) | 2017-11-21 |
| ES2721920T3 (es) | 2019-08-06 |
| WO2014144135A3 (en) | 2014-10-23 |
| JP6595449B2 (ja) | 2019-10-23 |
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