MX2015012365A - Uso de fosfoquetolasa y fosfotransacetilasa para la produccion de compuestos derivados de acetil-coenzima a. - Google Patents

Uso de fosfoquetolasa y fosfotransacetilasa para la produccion de compuestos derivados de acetil-coenzima a.

Info

Publication number
MX2015012365A
MX2015012365A MX2015012365A MX2015012365A MX2015012365A MX 2015012365 A MX2015012365 A MX 2015012365A MX 2015012365 A MX2015012365 A MX 2015012365A MX 2015012365 A MX2015012365 A MX 2015012365A MX 2015012365 A MX2015012365 A MX 2015012365A
Authority
MX
Mexico
Prior art keywords
acetyl
derived compounds
production
phosphoketolase
phosphotransacetylase
Prior art date
Application number
MX2015012365A
Other languages
English (en)
Other versions
MX364748B (es
Inventor
Kristy Michelle Hawkins
Adam Leon Meadows
Annie Ening Tsong
Tina Tipawan Mahatdejkul-Meadows
Lauren Barbara Pickens
Anna Tai
Original Assignee
Amyris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amyris Inc filed Critical Amyris Inc
Publication of MX2015012365A publication Critical patent/MX2015012365A/es
Publication of MX364748B publication Critical patent/MX364748B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02009—Phosphoketolase (4.1.2.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/54—Acetic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03021—Glycerol-1-phosphatase (3.1.3.21)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)

Abstract

Se proporcionan aquí composiciones y métodos para mejorar la producción de acetil-CoA y compuestos derivados de acetil-CoA en una célula hospedera. En algunas modalidades, la célula hospedera se modifica genéticamente para comprender un ácido nucleico heterólogo que codifica una fosfoquetolasa (PK); y una disrupción funcional de una enzima endógena que convierte acetil fosfato a acetato. En algunas modalidades, la célula hospedera comprende además una secuencia de nucleótido heteróloga que codifica una fosfotransacetilasa (PTA). En algunas modalidades, la enzima que convierte el acetil fosfato a acetato es una glicerol-1-fosfatasa. En algunas modalidades, la glicerol-1-fosfatasa es GPP1IRHR2. En algunas modalidades, la glicerol-1-fosfatasa es GPP2/HOR2. Las composiciones y métodos descritos aquí proporcionan una ruta eficiente para la producción heteróloga de compuestos derivados de acetil-CoA, incluyendo, pero no limitado a, isoprenoides, policétidos, y ácidos grasos.
MX2015012365A 2013-03-15 2014-03-14 Uso de fosfoquetolasa y fosfotransacetilasa para la produccion de compuestos derivados de acetil-coenzima a. MX364748B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361800356P 2013-03-15 2013-03-15
PCT/US2014/028421 WO2014144135A2 (en) 2013-03-15 2014-03-14 Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds

Publications (2)

Publication Number Publication Date
MX2015012365A true MX2015012365A (es) 2016-04-15
MX364748B MX364748B (es) 2019-05-06

Family

ID=50391556

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012365A MX364748B (es) 2013-03-15 2014-03-14 Uso de fosfoquetolasa y fosfotransacetilasa para la produccion de compuestos derivados de acetil-coenzima a.

Country Status (13)

Country Link
US (1) US9410214B2 (es)
EP (1) EP2971027B1 (es)
JP (2) JP6595449B2 (es)
KR (1) KR102159691B1 (es)
CN (1) CN105189772B (es)
AU (1) AU2014227811C1 (es)
BR (1) BR112015023089A2 (es)
CA (1) CA2903053C (es)
ES (1) ES2721920T3 (es)
MX (1) MX364748B (es)
MY (1) MY171958A (es)
WO (1) WO2014144135A2 (es)
ZA (1) ZA201506406B (es)

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Also Published As

Publication number Publication date
JP2016512047A (ja) 2016-04-25
MX364748B (es) 2019-05-06
ZA201506406B (en) 2017-01-25
KR102159691B1 (ko) 2020-09-24
CA2903053C (en) 2023-01-17
CA2903053A1 (en) 2014-09-18
WO2014144135A2 (en) 2014-09-18
US9410214B2 (en) 2016-08-09
ES2721920T3 (es) 2019-08-06
JP2019213558A (ja) 2019-12-19
MY171958A (en) 2019-11-08
AU2014227811B2 (en) 2018-03-22
JP6595449B2 (ja) 2019-10-23
BR112015023089A2 (pt) 2017-11-21
AU2014227811C1 (en) 2018-09-27
US20140273144A1 (en) 2014-09-18
KR20150132310A (ko) 2015-11-25
AU2014227811A1 (en) 2015-09-24
CN105189772B (zh) 2019-09-13
EP2971027B1 (en) 2019-01-30
WO2014144135A3 (en) 2014-10-23
CN105189772A (zh) 2015-12-23
EP2971027A2 (en) 2016-01-20

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