BR112014012288A2 - métodos para diagnosticar e tratar fibrose pulmonar idiopática - Google Patents
métodos para diagnosticar e tratar fibrose pulmonar idiopáticaInfo
- Publication number
- BR112014012288A2 BR112014012288A2 BR112014012288A BR112014012288A BR112014012288A2 BR 112014012288 A2 BR112014012288 A2 BR 112014012288A2 BR 112014012288 A BR112014012288 A BR 112014012288A BR 112014012288 A BR112014012288 A BR 112014012288A BR 112014012288 A2 BR112014012288 A2 BR 112014012288A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- pulmonary fibrosis
- diagnosing
- idiopathic pulmonary
- treating idiopathic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Nuclear Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161562770P | 2011-11-22 | 2011-11-22 | |
| US201261648548P | 2012-05-17 | 2012-05-17 | |
| PCT/US2012/066221 WO2013078283A1 (en) | 2011-11-22 | 2012-11-21 | Methods of diagnosing and treating idiopathic pulmonary fibrosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014012288A2 true BR112014012288A2 (pt) | 2017-05-23 |
Family
ID=47258131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014012288A BR112014012288A2 (pt) | 2011-11-22 | 2012-11-21 | métodos para diagnosticar e tratar fibrose pulmonar idiopática |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20130150426A1 (zh) |
| EP (1) | EP2783016A1 (zh) |
| JP (1) | JP2015504307A (zh) |
| CN (1) | CN103987858A (zh) |
| AU (1) | AU2012340698A1 (zh) |
| BR (1) | BR112014012288A2 (zh) |
| CA (1) | CA2853136A1 (zh) |
| EA (1) | EA201491019A1 (zh) |
| HK (2) | HK1201299A1 (zh) |
| MX (1) | MX2014006130A (zh) |
| WO (1) | WO2013078283A1 (zh) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2986538B1 (fr) | 2012-02-06 | 2016-03-11 | Centre Nat Rech Scient | Utilisation du mir-199a-5p de ses cibles et/ou inhibiteurs pour le diagnostic, le pronostic et le traitement des pathologies fibroproliferatives |
| EP2852669B1 (en) | 2012-05-22 | 2018-07-18 | Ruprecht-Karls-Universität Heidelberg | Therapeutic micro rna targets in chronic pulmonary diseases |
| CN104560991B (zh) * | 2013-10-10 | 2021-02-26 | 复旦大学附属妇产科医院 | 用于防治人乳头瘤病毒感染和宫颈癌的微小rna |
| GB201403489D0 (en) * | 2014-02-27 | 2014-04-16 | Univ London Queen Mary | Biomarkers for endometriosis |
| WO2015171641A1 (en) * | 2014-05-05 | 2015-11-12 | Brigham And Women's Hospital, Inc. | Coordinate control of pathogenic signaling by the mir-130/301 family in pulmonary hypertension and fibroproliferative diseases |
| CN105132525B (zh) * | 2014-05-29 | 2018-11-09 | 中国医学科学院基础医学研究所 | miRNA分子在精神分裂症的诊断和预后中的用途 |
| EP2957634A1 (en) * | 2014-06-20 | 2015-12-23 | Consejo Superior De Investigaciones Científicas | Compounds for prevention and/or treatment of fibrotic diseases |
| CN107108685B (zh) | 2014-09-08 | 2020-10-20 | 米拉根医疗股份有限公司 | miR-29模拟物及其用途 |
| WO2016054094A1 (en) * | 2014-09-30 | 2016-04-07 | Research Institute At Nationwide Children's Hospital | Compositions and methods for treating hepatic fibrosis |
| CN105624271A (zh) * | 2014-10-28 | 2016-06-01 | 广州复能基因有限公司 | 一种与结直肠癌相关的miRNA及其应用 |
| CN104450707B (zh) * | 2014-12-25 | 2017-08-29 | 厦门大学 | 一种血清miRNA生物标志物的应用 |
| CN104694542A (zh) * | 2015-03-19 | 2015-06-10 | 中国人民解放军第四军医大学 | 一种促进组织工程骨血管化的 microRNA 及其应用 |
| CN105079808B (zh) * | 2015-05-22 | 2018-04-03 | 重庆医科大学 | miR590的用途及其相关药物 |
| JP2018517418A (ja) * | 2015-06-15 | 2018-07-05 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 情動障害の診断および治療の方法 |
| GB201513128D0 (en) * | 2015-07-24 | 2015-09-09 | Sense Biodetection Ltd | Nucleic acid detection method |
| CN105106972A (zh) * | 2015-08-13 | 2015-12-02 | 常州市第一人民医院 | miR-338-5p及靶向作用于miR-338-5p核酸制剂的新用途 |
| CN105169393B (zh) * | 2015-08-31 | 2018-07-03 | 北京泱深生物信息技术有限公司 | miRNA-548a-3p抗急性髓系白血病中的应用 |
| US11180810B2 (en) | 2015-09-29 | 2021-11-23 | Research Institute At Nationwide Children's Hospital | Methods for detecting hepatic fibrosis and responsiveness to therapy |
| JP2017143810A (ja) * | 2016-02-19 | 2017-08-24 | 学校法人慶應義塾 | 抗酸菌症又は抗酸菌感染のバイオマーカー |
| CN106011303B (zh) * | 2016-08-08 | 2019-05-24 | 南京市妇幼保健院 | 一种与儿童肥胖相关的血清或血浆miRNA标志物及其应用 |
| WO2018170622A1 (zh) * | 2017-03-18 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | 一种同步下调微小rna-152和微小rna-185表达的方法 |
| WO2018170652A1 (zh) * | 2017-03-19 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | 多重敲低三种miRNA的Tud RNA及其应用 |
| CN107236799B (zh) * | 2017-06-15 | 2020-06-09 | 昆明医科大学第六附属医院 | 一种肾纤维化miRNA标记物 |
| CN108186564B (zh) * | 2018-01-03 | 2020-06-02 | 上海市肿瘤研究所 | 一种肿瘤微环境响应型基因纳米胶束及其制备方法和应用 |
| CN108611414A (zh) * | 2018-04-26 | 2018-10-02 | 北京工业大学 | 新的靶向肿瘤微环境与肺癌干细胞相互作用的miRNA的检测及应用 |
| CN109486911A (zh) * | 2018-11-28 | 2019-03-19 | 上海纳米技术及应用国家工程研究中心有限公司 | 基于滚环扩增和DNA折纸术检测microRNAs的方法 |
| CN109825575A (zh) * | 2019-04-08 | 2019-05-31 | 首都医科大学附属北京胸科医院 | 辅助诊断结核病的miRNA标志物及其应用 |
| CN110055322A (zh) * | 2019-05-12 | 2019-07-26 | 青岛大学 | 用于急性心肌梗死诊断的循环miRNA标志物及其应用 |
| US20220243204A1 (en) * | 2019-06-14 | 2022-08-04 | Cardior Pharmaceuticals Gmbh | Treatment of heart failure in human subjects |
| WO2021009317A1 (en) | 2019-07-16 | 2021-01-21 | Université de Liège | Extracellular vesicles containing mir-142-3p to treat fibrosing diseases |
| JP7392224B2 (ja) * | 2020-02-19 | 2023-12-06 | 国立医薬品食品衛生研究所長 | びまん性肺胞傷害型薬剤性間質性肺炎のｍｉＲＮＡ診断バイオマーカー |
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| US5430136A (en) | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
| US5359100A (en) | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5310562A (en) | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| US5681697A (en) | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| US5580731A (en) | 1994-08-25 | 1996-12-03 | Chiron Corporation | N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith |
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| US6956044B1 (en) | 2000-02-21 | 2005-10-18 | Margolin Solomon B | Compositions and methods for treatment of epilepsy |
| ATE447970T1 (de) | 2001-02-08 | 2009-11-15 | Ono Pharmaceutical Co | Mittel zur behandlung von harnwegserkrankungen, umfassend mittel zur kontrolle des lpa-rezeptors |
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| JP2005027804A (ja) | 2003-07-10 | 2005-02-03 | Konica Minolta Medical & Graphic Inc | 診察支援システム、データ処理端末及びデータ処理プログラム |
| WO2005012269A1 (ja) | 2003-08-05 | 2005-02-10 | Ajinomoto Co., Inc. | 新規アゾール化合物 |
| CA2545813C (en) | 2003-11-14 | 2011-01-04 | Shanghai Genomics, Inc. | The derivatives of pyridone and use thereof |
| CA2566519C (en) | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micrornas and uses thereof |
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| EP2043635A2 (en) * | 2006-06-29 | 2009-04-08 | Astex Therapeutics Limited | Pharmaceutical combinations |
| KR101704953B1 (ko) | 2006-07-05 | 2017-02-08 | 피브로테크 세라퓨틱 피티와이 엘티디 | 치료 화합물 |
| AU2008265595B2 (en) | 2007-06-20 | 2014-12-04 | PureTech LYT 100 Inc. | Substituted N-Aryl pyridinones as fibrotic inhibitors |
| WO2009035598A1 (en) | 2007-09-10 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| JP2011505143A (ja) * | 2007-11-30 | 2011-02-24 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | マイクロｒｎａ発現プロファイリング及び肺癌における末梢血ターゲティング |
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| JP2011512359A (ja) | 2008-02-14 | 2011-04-21 | アミラ ファーマシューティカルズ，インク． | プロスタグランジンｄ２受容体のアンタゴニストとしての環式ジアリールエーテル化合物 |
| EP2096171A1 (en) * | 2008-02-27 | 2009-09-02 | Julius-Maximilians-Universität Würzburg | MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes |
| WO2010039502A2 (en) * | 2008-09-23 | 2010-04-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Micrornas in idiopathic pulmonary fibrosis |
| WO2010054386A2 (en) * | 2008-11-10 | 2010-05-14 | Battelle Memorial Institute | Methods, compositions, and devices utilizing microrna to determine physiological conditions |
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| US20100190731A1 (en) | 2009-01-26 | 2010-07-29 | Jeff Olgin | Methods for treating acute myocardial infarctions and associated disorders |
| JPWO2010137160A1 (ja) * | 2009-05-29 | 2012-11-12 | 株式会社静岡カフェイン工業所 | 肺線維症の予防もしくは治療薬 |
| GB2470833B (en) | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
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| GB2474748B (en) | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| US7816383B1 (en) * | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
-
2012
- 2012-11-21 WO PCT/US2012/066221 patent/WO2013078283A1/en active Application Filing
- 2012-11-21 MX MX2014006130A patent/MX2014006130A/es not_active Application Discontinuation
- 2012-11-21 EP EP12791944.7A patent/EP2783016A1/en not_active Withdrawn
- 2012-11-21 BR BR112014012288A patent/BR112014012288A2/pt not_active IP Right Cessation
- 2012-11-21 CA CA2853136A patent/CA2853136A1/en not_active Abandoned
- 2012-11-21 EA EA201491019A patent/EA201491019A1/ru unknown
- 2012-11-21 AU AU2012340698A patent/AU2012340698A1/en not_active Abandoned
- 2012-11-21 CN CN201280057373.1A patent/CN103987858A/zh active Pending
- 2012-11-21 JP JP2014542588A patent/JP2015504307A/ja active Pending
- 2012-11-21 US US13/683,099 patent/US20130150426A1/en not_active Abandoned
-
2015
- 2015-02-13 HK HK15101658.4A patent/HK1201299A1/zh unknown
- 2015-02-13 HK HK15101592.3A patent/HK1201298A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014006130A (es) | 2015-04-13 |
| JP2015504307A (ja) | 2015-02-12 |
| EA201491019A1 (ru) | 2014-08-29 |
| WO2013078283A1 (en) | 2013-05-30 |
| US20130150426A1 (en) | 2013-06-13 |
| HK1201298A1 (zh) | 2015-08-28 |
| CA2853136A1 (en) | 2013-05-30 |
| CN103987858A (zh) | 2014-08-13 |
| AU2012340698A1 (en) | 2014-04-24 |
| EP2783016A1 (en) | 2014-10-01 |
| HK1201299A1 (zh) | 2015-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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