BR112014007687A2 - molécula de ligação a antígeno para promoção de perda de antígenos - Google Patents
molécula de ligação a antígeno para promoção de perda de antígenosInfo
- Publication number
- BR112014007687A2 BR112014007687A2 BR112014007687A BR112014007687A BR112014007687A2 BR 112014007687 A2 BR112014007687 A2 BR 112014007687A2 BR 112014007687 A BR112014007687 A BR 112014007687A BR 112014007687 A BR112014007687 A BR 112014007687A BR 112014007687 A2 BR112014007687 A2 BR 112014007687A2
- Authority
- BR
- Brazil
- Prior art keywords
- antigen
- binding
- binding domain
- molecules
- receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
abstract the present inventors created antigen-binding molecules containing an antigen-binding domain and an fc?-receptor-binding domain, wherein the molecules have human-fcrn-binding activity in an acidic ph range condition, the antigen-binding domain changes the antigen-binding activity of the antigen-binding molecules depending on the ion-concentration condition, and the fc? receptor-binding domain has higher binding activity to the fc? receptor in a neutral ph range condition than an fc region of a native human igg in which the sugar chain bound at position 297 (eu numbering) is a fucose-containing sugar chain. changes from the specification of wo2013/047729 (our ref.: c1-a1110p) to that of wo2013/047752 (our ref.: c1-a1111p). unchanged parts are shown in black. changes in the tables are not shown. this document is provided solely for your reference and convenience. when preparing a translation, please refer to and literally translate the english specification into your language. -------------------------------------------------------------------------- tradução do resumo resumo patente de invenção: "molécula de ligação a antígeno pa-ra promoção de perda de antígenos". a presente invenção refere-se a moléculas de ligação a an-tígeno contendo um domínio de ligação a antígeno e um domínio de ligação a receptor fc?, onde as moléculas têm atividade de ligação a fcrn humano em uma condição de faixa de ph ácido, o domínio de ligação a antígeno muda a atividade de ligação a antígeno das molé-culas de ligação a antígeno dependendo da condição de concentração de íon, e o domínio de ligação a receptor fc? tem atividade de ligação mais alta ao receptor fc? em uma condição de faixa de ph neutro do que uma região fc de uma igg humana nativa onde a cadeia de açúcar ligada na posição 297 (numeração eu) é uma cadeia de açúcar contendo fucose.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011-217498 | 2011-09-30 | ||
| JP2011217498 | 2011-09-30 | ||
| JPPCT/JP2012/054624 | 2012-02-24 | ||
| PCT/JP2012/054624 WO2012115241A1 (ja) | 2011-02-25 | 2012-02-24 | FcγRIIb特異的Fc抗体 |
| JP2012-185866 | 2012-08-24 | ||
| JP2012185866 | 2012-08-24 | ||
| PCT/JP2012/075092 WO2013047752A1 (ja) | 2011-09-30 | 2012-09-28 | 抗原の消失を促進する抗原結合分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112014007687A2 true BR112014007687A2 (pt) | 2017-06-13 |
| BR112014007687A8 BR112014007687A8 (pt) | 2017-09-12 |
| BR112014007687B1 BR112014007687B1 (pt) | 2022-12-06 |
Family
ID=47995777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014007687-1A BR112014007687B1 (pt) | 2011-09-30 | 2012-09-28 | Composiçâo farmacêutica de anticorpos para eliminação de antígenos no plasma |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20140335089A1 (pt) |
| EP (2) | EP3680251A1 (pt) |
| JP (5) | JP6093305B2 (pt) |
| KR (4) | KR20230066646A (pt) |
| CN (4) | CN108144058A (pt) |
| AU (1) | AU2012317418B2 (pt) |
| BR (1) | BR112014007687B1 (pt) |
| CA (2) | CA3186128A1 (pt) |
| HK (2) | HK1198578A1 (pt) |
| MX (1) | MX361713B (pt) |
| RU (1) | RU2014117505A (pt) |
| SG (2) | SG10201610870XA (pt) |
| TW (4) | TWI827333B (pt) |
| WO (1) | WO2013047752A1 (pt) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007114319A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 抗体の血中動態を制御する方法 |
| WO2009041613A1 (ja) | 2007-09-26 | 2009-04-02 | Chugai Seiyaku Kabushiki Kaisha | 抗体定常領域改変体 |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| LT2708559T (lt) | 2008-04-11 | 2018-06-11 | Chugai Seiyaku Kabushiki Kaisha | Antigeną surišanti molekulė, galinti pakartotinai prisijungti prie dviejų ar daugiau antigeno molekulių |
| EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| MX352889B (es) | 2011-02-25 | 2017-12-13 | Chugai Pharmaceutical Co Ltd | Anticuerpo de fc especifico para fcyriib. |
| BR112013032630B1 (pt) | 2011-06-30 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Polipeptídeo heterodimerizado compreendendo região fc de igg |
| TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| US20150050269A1 (en) | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| CA2850322C (en) | 2011-09-30 | 2023-10-10 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule inducing immune response to target antigen |
| MX358220B (es) | 2011-11-30 | 2018-08-10 | Chugai Pharmaceutical Co Ltd | Portador que contiene fármaco en la célula para formar el inmunocomplejo. |
| TWI617577B (zh) * | 2012-02-24 | 2018-03-11 | 中外製藥股份有限公司 | 經ＦｃγＲＩＩＢ促進抗原消失之抗原結合分子 |
| MX2014014678A (es) | 2012-05-30 | 2015-02-10 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno especifico para el tejido objetivo. |
| EP3892638A1 (en) * | 2012-05-30 | 2021-10-13 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for eliminating aggregated antigens |
| JP6628966B2 (ja) | 2012-06-14 | 2020-01-15 | 中外製薬株式会社 | 改変されたＦｃ領域を含む抗原結合分子 |
| AU2013306700B2 (en) | 2012-08-24 | 2019-05-02 | Chugai Seiyaku Kabushiki Kaisha | FcgammaRIIb-specific Fc region variant |
| US11236168B2 (en) | 2012-08-24 | 2022-02-01 | Chugai Seiyaku Kabushiki Kaisha | Mouse FcγammaRII-specific Fc antibody |
| US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| EP3050896B1 (en) | 2013-09-27 | 2021-07-07 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
| MX2016003617A (es) | 2013-09-30 | 2016-07-21 | Chugai Pharmaceutical Co Ltd | Metodo para producir molecula de enlace al antigeno usando fago auxiliar modificado. |
| SG11201700841QA (en) | 2014-12-19 | 2017-03-30 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| PE20181336A1 (es) | 2015-09-18 | 2018-08-21 | Chugai Pharmaceutical Co Ltd | Anticuerpos que se unen a interleucina 8 (il-8) y sus usos |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| MY193497A (en) | 2016-06-17 | 2022-10-17 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies and methods of use |
| JP7464389B2 (ja) | 2016-08-02 | 2024-04-09 | ビステラ， インコーポレイテッド | 操作されたポリペプチドおよびその使用 |
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| US11266728B2 (en) * | 2017-01-03 | 2022-03-08 | National Health Research Institutes | Compositions and methods for enhancement of immune responses |
| US11690919B2 (en) | 2017-01-17 | 2023-07-04 | The Texas A&M University System | Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells |
| JP7337698B2 (ja) | 2017-02-28 | 2023-09-04 | シージェン インコーポレイテッド | コンジュゲート化のためのシステイン突然変異抗体 |
| US11220550B2 (en) * | 2017-05-25 | 2022-01-11 | Bristol-Myers Squibb Company | Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity |
| JP6727438B2 (ja) | 2017-06-12 | 2020-07-22 | 三菱電機株式会社 | 車両用空気調和装置及び車両用空気調和装置の空気調和方法 |
| AU2018291497A1 (en) | 2017-06-30 | 2020-01-16 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains |
| CN111556895B (zh) | 2017-11-14 | 2024-09-13 | 中外制药株式会社 | 抗-c1s抗体及使用方法 |
| MX2020009296A (es) | 2018-03-15 | 2020-11-13 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-virus del dengue que tienen reactividad cruzada con el virus zika y metodos de uso. |
| CA3097741A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
| US11524991B2 (en) | 2018-04-18 | 2022-12-13 | Xencor, Inc. | PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof |
| BR112021002037A2 (pt) | 2018-08-10 | 2021-05-04 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação de antígeno anti-cd137 e uso da mesma |
| MA53862A (fr) | 2018-10-12 | 2022-01-19 | Xencor Inc | Protéines de fusion fc d'il-15/il-15ralpha ciblant pd-1 et utilisations dans des polythérapies faisant intervenir celles-ci |
| AR117091A1 (es) | 2018-11-19 | 2021-07-07 | Bristol Myers Squibb Co | Anticuerpos monoclonales antagonistas contra cd40 y sus usos |
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| US20220213140A1 (en) | 2019-04-10 | 2022-07-07 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying fc region-modified antibody |
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| CA3164818A1 (en) | 2019-12-18 | 2021-06-24 | F. Hoffmann-La Roche Ag | Bispecific anti-ccl2 antibodies |
| IL294226A (en) | 2019-12-27 | 2022-08-01 | Chugai Pharmaceutical Co Ltd | Anti-ctla-4 antibodies and their use |
| TW202144395A (zh) | 2020-02-12 | 2021-12-01 | 日商中外製藥股份有限公司 | 用於癌症之治療的抗cd137抗原結合分子 |
| JPWO2022025220A1 (pt) | 2020-07-31 | 2022-02-03 | ||
| JPWO2022044248A1 (pt) | 2020-08-28 | 2022-03-03 | ||
| AU2022295067A1 (en) | 2021-06-18 | 2023-12-21 | F. Hoffmann-La Roche Ag | Bispecific anti-ccl2 antibodies |
| CA3220353A1 (en) | 2021-06-25 | 2022-12-29 | Chugai Seiyaku Kabushiki Kaisha | Use of anti-ctla-4 antibody |
| CA3221833A1 (en) | 2021-06-25 | 2022-12-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-ctla-4 antibody |
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