BR112014002576B1 - Fragmento fab de anticorpo anti-ngf humano, método para produzir o mesmo e vetor de expressão compreendendo um polinucleotídeo que codifica o dito fragmento fab' - Google Patents

Fragmento fab de anticorpo anti-ngf humano, método para produzir o mesmo e vetor de expressão compreendendo um polinucleotídeo que codifica o dito fragmento fab' Download PDF

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Publication number
BR112014002576B1
BR112014002576B1 BR112014002576-2A BR112014002576A BR112014002576B1 BR 112014002576 B1 BR112014002576 B1 BR 112014002576B1 BR 112014002576 A BR112014002576 A BR 112014002576A BR 112014002576 B1 BR112014002576 B1 BR 112014002576B1
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Brazil
Prior art keywords
fab
fragment
antibody
human
ngf
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BR112014002576-2A
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English (en)
Portuguese (pt)
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BR112014002576A2 (pt
Inventor
Masazumi Kamohara
Hirotsugu Tanaka
Yukari Koya
Jun Takasaki
Atsuo Yonezawa
Eiji Yoshimi
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Astellas Pharma Inc.
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Publication of BR112014002576A2 publication Critical patent/BR112014002576A2/pt
Publication of BR112014002576B1 publication Critical patent/BR112014002576B1/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BR112014002576-2A 2011-08-11 2012-08-10 Fragmento fab de anticorpo anti-ngf humano, método para produzir o mesmo e vetor de expressão compreendendo um polinucleotídeo que codifica o dito fragmento fab' BR112014002576B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011176209 2011-08-11
JP2011-176209 2011-08-11
JP2011-269215 2011-12-08
JP2011269215 2011-12-08
PCT/JP2012/070433 WO2013022083A1 (ja) 2011-08-11 2012-08-10 新規抗ヒトngf抗体

Publications (2)

Publication Number Publication Date
BR112014002576A2 BR112014002576A2 (pt) 2021-01-12
BR112014002576B1 true BR112014002576B1 (pt) 2022-08-23

Family

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BR112014002576-2A BR112014002576B1 (pt) 2011-08-11 2012-08-10 Fragmento fab de anticorpo anti-ngf humano, método para produzir o mesmo e vetor de expressão compreendendo um polinucleotídeo que codifica o dito fragmento fab'

Country Status (30)

Country Link
US (2) US8986952B2 (enExample)
EP (1) EP2743348B1 (enExample)
JP (1) JP5376095B2 (enExample)
KR (1) KR101999867B1 (enExample)
CN (1) CN103748222B (enExample)
AR (1) AR087506A1 (enExample)
AU (1) AU2012293161B2 (enExample)
BR (1) BR112014002576B1 (enExample)
CA (1) CA2841181C (enExample)
CY (1) CY1119914T1 (enExample)
DK (1) DK2743348T3 (enExample)
EA (1) EA024292B1 (enExample)
ES (1) ES2663968T3 (enExample)
HR (1) HRP20180155T1 (enExample)
HU (1) HUE036079T2 (enExample)
IL (1) IL230797A (enExample)
IN (1) IN2014CN00614A (enExample)
LT (1) LT2743348T (enExample)
ME (1) ME02944B (enExample)
MX (1) MX351273B (enExample)
NO (1) NO2743348T3 (enExample)
PH (1) PH12014500001A1 (enExample)
PL (1) PL2743348T3 (enExample)
PT (1) PT2743348T (enExample)
RS (1) RS56876B1 (enExample)
SI (1) SI2743348T1 (enExample)
SM (1) SMT201800166T1 (enExample)
TW (1) TWI554519B (enExample)
WO (1) WO2013022083A1 (enExample)
ZA (1) ZA201400741B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
MX359070B (es) 2010-12-01 2018-09-13 Alderbio Holdings Llc Composiciones anti-ngf y uso de las mismas.
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9127055B2 (en) 2013-02-08 2015-09-08 Astellas Pharma Inc. Method of treating pain with anti-human NGF antibody
JP6135161B2 (ja) * 2013-02-08 2017-05-31 アステラス製薬株式会社 新規抗ヒトngf抗体
MY184164A (en) * 2015-05-22 2021-03-24 Astellas Pharma Inc Novel anti-human ngf antibody fab fragment
TW201738269A (zh) * 2016-03-25 2017-11-01 安斯泰來製藥股份有限公司 含有PEG化抗人類NGF抗體Fab’片段之醫藥組成物
CN109929035B (zh) * 2017-12-15 2022-06-28 安源医药科技(上海)有限公司 抗人ngf抗体及其制备方法和用途
EP3795176A4 (en) 2018-05-15 2022-01-12 Astellas Pharma Inc. Pharmaceutical composition for suppressing atrial fibrillation having as active ingredient anti-human ngf antibody or antigen-binding fragment thereof
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
KR100337069B1 (ko) * 1993-03-11 2002-10-11 사이단호진가가쿠오요비겟세이리요호오겐큐쇼 항-hiv모노클로날항체
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
ATE522229T1 (de) 2001-05-30 2011-09-15 Genentech Inc Anti-ngf-antikörper zur behandlung verschiedener erkrankungen
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
CA2921578C (en) 2002-12-24 2017-02-14 Rinat Neuroscience Corp. Anti-ngf antibodies and methods using same
DK1648509T3 (da) 2003-07-15 2013-01-07 Amgen Inc Humane anti-NGF-neutraliserende antistoffer som selektive NGF-pathway-inhibitorer
ITRM20030601A1 (it) 2003-12-24 2005-06-25 Lay Line Genomics Spa Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
BRPI0606933B8 (pt) 2005-01-24 2021-05-25 Cambridge Antibody Tech Limited membro de ligação específico isolado para fator de crescimento de nervos, molécula de anticorpo isolado, composição e uso de um membro de ligação específico
US8309088B2 (en) 2007-08-10 2012-11-13 Regeneron Pharmaceuticals, Inc. Method of treating osteoarthritis with an antibody to NGF
BRPI0815370B8 (pt) 2007-08-10 2021-05-25 Regeneron Pharma anticorpos humanos de alta afinidade contra o fator de crescimento neural humano e seu uso, molécula de ácido nucleico, vetor de expressão, método para produção de um anticorpo anti-ngf humano e composiçao farmacêutica
ES2498065T3 (es) 2007-10-24 2014-09-24 Astellas Pharma Inc. Compuesto de azolcarboxamida o sal del mismo
AR076650A1 (es) 2009-05-04 2011-06-29 Pangenetics 110 B V Anticuerpos contra el factor de crecimiento nervioso (ngf) con una estabilidad in vivo mejorada

Also Published As

Publication number Publication date
US20140155582A1 (en) 2014-06-05
KR20140047116A (ko) 2014-04-21
WO2013022083A1 (ja) 2013-02-14
IN2014CN00614A (enExample) 2015-04-03
CY1119914T1 (el) 2018-06-27
AR087506A1 (es) 2014-03-26
JPWO2013022083A1 (ja) 2015-03-05
CN103748222B (zh) 2015-07-22
MX351273B (es) 2017-10-06
KR101999867B1 (ko) 2019-07-12
AU2012293161B2 (en) 2017-04-27
NO2743348T3 (enExample) 2018-06-09
EP2743348A1 (en) 2014-06-18
SMT201800166T1 (it) 2018-05-02
IL230797A (en) 2017-06-29
TW201319086A (zh) 2013-05-16
JP5376095B2 (ja) 2013-12-25
DK2743348T3 (en) 2018-02-26
SI2743348T1 (en) 2018-04-30
PL2743348T3 (pl) 2018-04-30
EP2743348B1 (en) 2018-01-10
US20150218265A1 (en) 2015-08-06
US8986952B2 (en) 2015-03-24
HRP20180155T1 (hr) 2018-03-23
ZA201400741B (en) 2014-11-26
AU2012293161A1 (en) 2014-02-06
MX2014001627A (es) 2014-05-28
TWI554519B (zh) 2016-10-21
CA2841181A1 (en) 2013-02-14
HUE036079T2 (hu) 2018-06-28
PT2743348T (pt) 2018-02-23
RS56876B1 (sr) 2018-04-30
EP2743348A4 (en) 2015-04-29
EA201490433A1 (ru) 2014-05-30
PH12014500001A1 (en) 2014-02-10
CN103748222A (zh) 2014-04-23
IL230797A0 (en) 2014-03-31
BR112014002576A2 (pt) 2021-01-12
LT2743348T (lt) 2018-05-10
ES2663968T3 (es) 2018-04-17
EA024292B1 (ru) 2016-09-30
CA2841181C (en) 2022-01-25
ME02944B (me) 2018-04-20

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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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