BR112013028095B1 - Uso de inibidores de csf-1r para o tratamento de tumores cerebrais - Google Patents

Uso de inibidores de csf-1r para o tratamento de tumores cerebrais Download PDF

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Publication number
BR112013028095B1
BR112013028095B1 BR112013028095-6A BR112013028095A BR112013028095B1 BR 112013028095 B1 BR112013028095 B1 BR 112013028095B1 BR 112013028095 A BR112013028095 A BR 112013028095A BR 112013028095 B1 BR112013028095 B1 BR 112013028095B1
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BR
Brazil
Prior art keywords
tumor
csf
blz945
compound
brain
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Application number
BR112013028095-6A
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English (en)
Portuguese (pt)
Other versions
BR112013028095A2 (pt
Inventor
Dylan Daniel
Johanna Joyce
James Sutton
Original Assignee
Sloan-Kettering Institute For Cancer Research
Novartis Ag
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Filing date
Publication date
Application filed by Sloan-Kettering Institute For Cancer Research, Novartis Ag filed Critical Sloan-Kettering Institute For Cancer Research
Publication of BR112013028095A2 publication Critical patent/BR112013028095A2/pt
Publication of BR112013028095B1 publication Critical patent/BR112013028095B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112013028095-6A 2011-05-05 2012-05-04 Uso de inibidores de csf-1r para o tratamento de tumores cerebrais BR112013028095B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161482723P 2011-05-05 2011-05-05
US61/482,723 2011-05-05
US201261624861P 2012-04-16 2012-04-16
US61/624,861 2012-04-16
PCT/US2012/036589 WO2012151523A1 (en) 2011-05-05 2012-05-04 Csf-1r inhibitors for treatment of brain tumors

Publications (2)

Publication Number Publication Date
BR112013028095A2 BR112013028095A2 (pt) 2016-12-27
BR112013028095B1 true BR112013028095B1 (pt) 2020-03-03

Family

ID=46062775

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013028095-6A BR112013028095B1 (pt) 2011-05-05 2012-05-04 Uso de inibidores de csf-1r para o tratamento de tumores cerebrais

Country Status (19)

Country Link
US (3) US20140065141A1 (enExample)
EP (1) EP2704713B1 (enExample)
JP (1) JP6046702B2 (enExample)
KR (1) KR101938431B1 (enExample)
CN (1) CN103501785B (enExample)
BR (1) BR112013028095B1 (enExample)
CA (1) CA2834696C (enExample)
CY (1) CY1119642T1 (enExample)
DK (1) DK2704713T3 (enExample)
EA (1) EA023999B1 (enExample)
ES (1) ES2622527T3 (enExample)
HR (1) HRP20170593T1 (enExample)
HU (1) HUE032754T2 (enExample)
LT (1) LT2704713T (enExample)
MX (1) MX347616B (enExample)
PL (1) PL2704713T3 (enExample)
PT (1) PT2704713T (enExample)
SI (1) SI2704713T1 (enExample)
WO (1) WO2012151523A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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WO2014147631A1 (en) * 2013-03-22 2014-09-25 Natco Pharma Limited Formulation comprising gefitinib as oral suspension
WO2016182988A1 (en) 2015-05-08 2016-11-17 Memorial Sloan Kettering Cancer Center Compositions and methods for treatment of glioma
EP3303390A1 (en) * 2015-05-27 2018-04-11 UCB Biopharma SPRL Method for the treatment of neurological disease
WO2017079520A1 (en) 2015-11-04 2017-05-11 Duke University Combination therapy of immunotoxin and checkpoint inhibitor
BR112019006914A2 (pt) * 2016-10-14 2019-07-02 Novartis Ag formas cristalinas de 4-(2-((1r,2r)-2-hidroxiciclo-hexilamino)benzotiazol-6-ilóxi)-n-metilpicolinamida
AU2017342240A1 (en) * 2016-10-14 2019-04-04 Novartis Ag Methods for treating ocular disease using inhibitors of CSF-1R
CA3040914A1 (en) 2016-11-03 2018-05-24 Juno Therapeutics, Inc. Combination therapy of a cell based therapy and a microglia inhibitor
MX2019014268A (es) 2017-06-02 2020-08-03 Juno Therapeutics Inc Artículos de manufactura y métodos para tratamiento usando terapia celular adoptiva.
MX2019014288A (es) 2017-06-02 2020-08-03 Juno Therapeutics Inc Articulos de manufactura y metodos relacionados a toxicidad asociada con terapia celular.
US20220225597A1 (en) 2017-06-29 2022-07-21 Juno Therapeutics, Inc. Mouse model for assessing toxicities associated with immunotherapies
EP3676403A1 (en) 2017-09-01 2020-07-08 Juno Therapeutics, Inc. Gene expression and assessment of risk of developing toxicity following cell therapy
US11564946B2 (en) 2017-11-01 2023-01-31 Juno Therapeutics, Inc. Methods associated with tumor burden for assessing response to a cell therapy
CA3109702A1 (en) 2018-08-13 2020-02-20 Signablok, Inc. Peptides and compositions for targeted treatment and imaging
JP7695882B2 (ja) 2018-11-30 2025-06-19 ジュノー セラピューティクス インコーポレイテッド 養子細胞療法を用いた処置のための方法
BR112021010120A2 (pt) 2018-11-30 2021-08-31 Juno Therapeutics, Inc. Métodos para dosagem e tratamento de malignidades celulares em terapia celular adotiva
CN110468210A (zh) * 2019-09-12 2019-11-19 暨南大学 Cdc45作为胶质母细胞瘤标志物及其作为治疗靶点的应用
MX2022006715A (es) 2019-12-06 2022-09-23 Juno Therapeutics Inc Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b.
TW202220988A (zh) * 2020-09-21 2022-06-01 大陸商和記黃埔醫藥(上海)有限公司 雜芳環類化合物及其用途
CN115969979B (zh) * 2022-12-30 2025-08-29 中国人民解放军陆军军医大学第一附属医院 C620-0580在制备抗胶质瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100721656B1 (ko) 2005-11-01 2007-05-23 주식회사 엘지화학 유기 전기 소자
RS51483B (sr) * 2006-04-14 2011-04-30 Astrazeneca Ab 4-anilinokvinolin-3-karboksamidi kao inhibitori csf-1r kinaze
CN101432281B (zh) * 2006-04-19 2013-08-28 诺瓦提斯公司 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法
DK2010528T3 (en) * 2006-04-19 2018-01-15 Novartis Ag 6-O-Substituted Benzoxazole and Benzothiazole Compounds and Methods for Inhibiting CSF-1R Signaling
WO2007124322A1 (en) 2006-04-20 2007-11-01 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
AU2008254425A1 (en) * 2007-05-21 2008-11-27 Novartis Ag CSF-1R inhibitors, compositions, and methods of use

Also Published As

Publication number Publication date
PT2704713T (pt) 2017-04-24
MX347616B (es) 2017-05-04
CA2834696A1 (en) 2012-11-08
AU2012250574B2 (en) 2016-07-07
CA2834696C (en) 2019-07-23
KR101938431B1 (ko) 2019-01-14
PL2704713T3 (pl) 2017-08-31
HRP20170593T1 (hr) 2017-07-14
WO2012151523A1 (en) 2012-11-08
EP2704713A1 (en) 2014-03-12
HUE032754T2 (en) 2017-10-30
CY1119642T1 (el) 2018-04-04
US20190030013A1 (en) 2019-01-31
US20140065141A1 (en) 2014-03-06
LT2704713T (lt) 2017-04-25
CN103501785A (zh) 2014-01-08
ES2622527T3 (es) 2017-07-06
AU2012250574A1 (en) 2013-11-28
MX2013012939A (es) 2014-02-27
EP2704713B1 (en) 2017-01-18
US20150306085A1 (en) 2015-10-29
KR20140029475A (ko) 2014-03-10
BR112013028095A2 (pt) 2016-12-27
US10537561B2 (en) 2020-01-21
EA201391629A1 (ru) 2016-01-29
SI2704713T1 (sl) 2017-05-31
CN103501785B (zh) 2016-10-26
JP6046702B2 (ja) 2016-12-21
AU2012250574A8 (en) 2016-07-28
DK2704713T3 (en) 2017-04-24
JP2014513136A (ja) 2014-05-29
EA023999B1 (ru) 2016-08-31

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

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