PT2704713T - Inibidores de csf-1r para tratamento de tumores cerebrais - Google Patents
Inibidores de csf-1r para tratamento de tumores cerebraisInfo
- Publication number
- PT2704713T PT2704713T PT127207611T PT12720761T PT2704713T PT 2704713 T PT2704713 T PT 2704713T PT 127207611 T PT127207611 T PT 127207611T PT 12720761 T PT12720761 T PT 12720761T PT 2704713 T PT2704713 T PT 2704713T
- Authority
- PT
- Portugal
- Prior art keywords
- csf
- inhibitors
- treatment
- brain tumors
- tumors
- Prior art date
Links
- 208000003174 Brain Neoplasms Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161482723P | 2011-05-05 | 2011-05-05 | |
| US201261624861P | 2012-04-16 | 2012-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2704713T true PT2704713T (pt) | 2017-04-24 |
Family
ID=46062775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127207611T PT2704713T (pt) | 2011-05-05 | 2012-05-04 | Inibidores de csf-1r para tratamento de tumores cerebrais |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20140065141A1 (enExample) |
| EP (1) | EP2704713B1 (enExample) |
| JP (1) | JP6046702B2 (enExample) |
| KR (1) | KR101938431B1 (enExample) |
| CN (1) | CN103501785B (enExample) |
| BR (1) | BR112013028095B1 (enExample) |
| CA (1) | CA2834696C (enExample) |
| CY (1) | CY1119642T1 (enExample) |
| DK (1) | DK2704713T3 (enExample) |
| EA (1) | EA023999B1 (enExample) |
| ES (1) | ES2622527T3 (enExample) |
| HR (1) | HRP20170593T1 (enExample) |
| HU (1) | HUE032754T2 (enExample) |
| LT (1) | LT2704713T (enExample) |
| MX (1) | MX347616B (enExample) |
| PL (1) | PL2704713T3 (enExample) |
| PT (1) | PT2704713T (enExample) |
| SI (1) | SI2704713T1 (enExample) |
| WO (1) | WO2012151523A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014147631A1 (en) * | 2013-03-22 | 2014-09-25 | Natco Pharma Limited | Formulation comprising gefitinib as oral suspension |
| US10722517B2 (en) | 2015-05-08 | 2020-07-28 | Memorial Sloan Kettering Cancer Center | Compositions and methods for treatment of glioma |
| US10316097B2 (en) * | 2015-05-27 | 2019-06-11 | Ucb Biopharma Sprl | Method for the treatment of epilepsy, epileptogenesis, seizures or convulsions by an anti-colony-stimulating factor 1 receptor (CSF-1R) antibody |
| JP6587756B2 (ja) * | 2015-11-04 | 2019-10-09 | デューク ユニバーシティー | 免疫毒素およびチェックポイント阻害剤の併用療法 |
| RU2019114208A (ru) * | 2016-10-14 | 2020-11-16 | Новартис Аг | Кристаллические формы 4-(2-((1r,2r)-2-гидроксициклогексиламино)бензотиазол-6-илокси)-n-метилпиколинамида |
| CA3037116A1 (en) * | 2016-10-14 | 2018-04-19 | Novartis Ag | Methods for treating ocular disease using inhibitors of csf-1r |
| MA46716A (fr) | 2016-11-03 | 2019-09-11 | Juno Therapeutics Inc | Polythérapie de thérapie cellulaire et d'inhibiteur de la microglie |
| AU2018275891B2 (en) | 2017-06-02 | 2025-02-27 | Juno Therapeutics, Inc. | Articles of manufacture and methods related to toxicity associated with cell therapy |
| CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
| JP2020526194A (ja) | 2017-06-29 | 2020-08-31 | ジュノー セラピューティクス インコーポレイテッド | 免疫療法薬と関連する毒性を評価するためのマウスモデル |
| EP3676403A1 (en) | 2017-09-01 | 2020-07-08 | Juno Therapeutics, Inc. | Gene expression and assessment of risk of developing toxicity following cell therapy |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| CA3109702A1 (en) | 2018-08-13 | 2020-02-20 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| CN113710256A (zh) | 2018-11-30 | 2021-11-26 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法的治疗方法 |
| KR20210110811A (ko) | 2018-11-30 | 2021-09-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법에서 ｂ 세포 악성 종양의 투약 및 치료 방법 |
| CN110468210A (zh) * | 2019-09-12 | 2019-11-19 | 暨南大学 | Cdc45作为胶质母细胞瘤标志物及其作为治疗靶点的应用 |
| MX2022006715A (es) | 2019-12-06 | 2022-09-23 | Juno Therapeutics Inc | Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b. |
| US20240092774A1 (en) * | 2020-09-21 | 2024-03-21 | Hutchison Medipharma Limited | Heteroaromatic compounds and uses thereof |
| CN115969979B (zh) * | 2022-12-30 | 2025-08-29 | 中国人民解放军陆军军医大学第一附属医院 | C620-0580在制备抗胶质瘤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100721656B1 (ko) | 2005-11-01 | 2007-05-23 | 주식회사 엘지화학 | 유기 전기 소자 |
| UY30282A1 (es) * | 2006-04-14 | 2007-11-30 | Astrazeneca Ab | Compuestos quimicos |
| EP2010528B1 (en) * | 2006-04-19 | 2017-10-04 | Novartis AG | 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling |
| CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
| JP5331679B2 (ja) | 2006-04-20 | 2013-10-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ｃ−ｆｍｓキナーゼの阻害剤 |
| ES2452349T3 (es) * | 2007-05-21 | 2014-04-01 | Novartis Ag | Inhibidores de CSF-1R, composiciones, y métodos de uso |
-
2012
- 2012-05-04 ES ES12720761.1T patent/ES2622527T3/es active Active
- 2012-05-04 CA CA2834696A patent/CA2834696C/en active Active
- 2012-05-04 LT LTEP12720761.1T patent/LT2704713T/lt unknown
- 2012-05-04 JP JP2014509491A patent/JP6046702B2/ja active Active
- 2012-05-04 HU HUE12720761A patent/HUE032754T2/en unknown
- 2012-05-04 KR KR1020137031960A patent/KR101938431B1/ko not_active Expired - Fee Related
- 2012-05-04 PL PL12720761T patent/PL2704713T3/pl unknown
- 2012-05-04 US US14/114,878 patent/US20140065141A1/en not_active Abandoned
- 2012-05-04 CN CN201280021878.2A patent/CN103501785B/zh active Active
- 2012-05-04 WO PCT/US2012/036589 patent/WO2012151523A1/en not_active Ceased
- 2012-05-04 HR HRP20170593TT patent/HRP20170593T1/hr unknown
- 2012-05-04 EP EP12720761.1A patent/EP2704713B1/en active Active
- 2012-05-04 EA EA201391629A patent/EA023999B1/ru not_active IP Right Cessation
- 2012-05-04 PT PT127207611T patent/PT2704713T/pt unknown
- 2012-05-04 SI SI201230916A patent/SI2704713T1/sl unknown
- 2012-05-04 DK DK12720761.1T patent/DK2704713T3/en active
- 2012-05-04 BR BR112013028095-6A patent/BR112013028095B1/pt not_active IP Right Cessation
- 2012-05-04 MX MX2013012939A patent/MX347616B/es active IP Right Grant
-
2015
- 2015-06-29 US US14/754,152 patent/US20150306085A1/en not_active Abandoned
-
2017
- 2017-04-10 CY CY20171100426T patent/CY1119642T1/el unknown
-
2018
- 2018-06-04 US US15/996,945 patent/US10537561B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| LT2704713T (lt) | 2017-04-25 |
| US20140065141A1 (en) | 2014-03-06 |
| HRP20170593T1 (hr) | 2017-07-14 |
| CY1119642T1 (el) | 2018-04-04 |
| KR101938431B1 (ko) | 2019-01-14 |
| AU2012250574B2 (en) | 2016-07-07 |
| CA2834696C (en) | 2019-07-23 |
| SI2704713T1 (sl) | 2017-05-31 |
| AU2012250574A8 (en) | 2016-07-28 |
| EP2704713B1 (en) | 2017-01-18 |
| JP2014513136A (ja) | 2014-05-29 |
| US10537561B2 (en) | 2020-01-21 |
| DK2704713T3 (en) | 2017-04-24 |
| HUE032754T2 (en) | 2017-10-30 |
| EA023999B1 (ru) | 2016-08-31 |
| AU2012250574A1 (en) | 2013-11-28 |
| PL2704713T3 (pl) | 2017-08-31 |
| BR112013028095B1 (pt) | 2020-03-03 |
| CN103501785A (zh) | 2014-01-08 |
| CN103501785B (zh) | 2016-10-26 |
| EA201391629A1 (ru) | 2016-01-29 |
| US20150306085A1 (en) | 2015-10-29 |
| ES2622527T3 (es) | 2017-07-06 |
| MX347616B (es) | 2017-05-04 |
| CA2834696A1 (en) | 2012-11-08 |
| WO2012151523A1 (en) | 2012-11-08 |
| EP2704713A1 (en) | 2014-03-12 |
| KR20140029475A (ko) | 2014-03-10 |
| US20190030013A1 (en) | 2019-01-31 |
| MX2013012939A (es) | 2014-02-27 |
| BR112013028095A2 (pt) | 2016-12-27 |
| JP6046702B2 (ja) | 2016-12-21 |
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