JP6046702B2 - 脳腫瘍の処置用のｃｓｆ−１ｒ阻害剤 - Google Patents
脳腫瘍の処置用のｃｓｆ−１ｒ阻害剤 Download PDFInfo
- Publication number
- JP6046702B2 JP6046702B2 JP2014509491A JP2014509491A JP6046702B2 JP 6046702 B2 JP6046702 B2 JP 6046702B2 JP 2014509491 A JP2014509491 A JP 2014509491A JP 2014509491 A JP2014509491 A JP 2014509491A JP 6046702 B2 JP6046702 B2 JP 6046702B2
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- csf
- compound
- blz945
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161482723P | 2011-05-05 | 2011-05-05 | |
| US61/482,723 | 2011-05-05 | ||
| US201261624861P | 2012-04-16 | 2012-04-16 | |
| US61/624,861 | 2012-04-16 | ||
| PCT/US2012/036589 WO2012151523A1 (en) | 2011-05-05 | 2012-05-04 | Csf-1r inhibitors for treatment of brain tumors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513136A JP2014513136A (ja) | 2014-05-29 |
| JP2014513136A5 JP2014513136A5 (enExample) | 2015-06-25 |
| JP6046702B2 true JP6046702B2 (ja) | 2016-12-21 |
Family
ID=46062775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509491A Active JP6046702B2 (ja) | 2011-05-05 | 2012-05-04 | 脳腫瘍の処置用のｃｓｆ−１ｒ阻害剤 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20140065141A1 (enExample) |
| EP (1) | EP2704713B1 (enExample) |
| JP (1) | JP6046702B2 (enExample) |
| KR (1) | KR101938431B1 (enExample) |
| CN (1) | CN103501785B (enExample) |
| BR (1) | BR112013028095B1 (enExample) |
| CA (1) | CA2834696C (enExample) |
| CY (1) | CY1119642T1 (enExample) |
| DK (1) | DK2704713T3 (enExample) |
| EA (1) | EA023999B1 (enExample) |
| ES (1) | ES2622527T3 (enExample) |
| HR (1) | HRP20170593T1 (enExample) |
| HU (1) | HUE032754T2 (enExample) |
| LT (1) | LT2704713T (enExample) |
| MX (1) | MX347616B (enExample) |
| PL (1) | PL2704713T3 (enExample) |
| PT (1) | PT2704713T (enExample) |
| SI (1) | SI2704713T1 (enExample) |
| WO (1) | WO2012151523A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014147631A1 (en) * | 2013-03-22 | 2014-09-25 | Natco Pharma Limited | Formulation comprising gefitinib as oral suspension |
| WO2016182988A1 (en) | 2015-05-08 | 2016-11-17 | Memorial Sloan Kettering Cancer Center | Compositions and methods for treatment of glioma |
| CN107660152B (zh) * | 2015-05-27 | 2021-11-05 | Ucb生物制药私人有限公司 | 用于治疗神经系统疾病的方法 |
| EP3973988A1 (en) | 2015-11-04 | 2022-03-30 | Duke University | Combination therapy of immunotoxin and checkpoint inhibitor |
| RU2019114205A (ru) | 2016-10-14 | 2020-11-16 | Новартис Аг | Способы лечения глазного заболевания с применением ингибиторов csf-1r |
| ES2949414T3 (es) * | 2016-10-14 | 2023-09-28 | Novartis Ag | Formas cristalinas de 4-(2-((1R,2R)-2-hidroxiciclohexilamino)benzotiazol-6-iloxi)-N-metilpicolinamida |
| CA3040914A1 (en) | 2016-11-03 | 2018-05-24 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
| CA3065120A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| MX2019014288A (es) | 2017-06-02 | 2020-08-03 | Juno Therapeutics Inc | Articulos de manufactura y metodos relacionados a toxicidad asociada con terapia celular. |
| MX2019015155A (es) | 2017-06-29 | 2020-08-03 | Juno Therapeutics Inc | Modelo de raton para valorar toxicidades asociadas con inmunoterapias. |
| MA50057A (fr) | 2017-09-01 | 2020-07-08 | Juno Therapeutics Inc | Expression génique et évaluation d'un risque de développement d'une toxicité suite à une thérapie cellulaire |
| WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| WO2020036987A1 (en) | 2018-08-13 | 2020-02-20 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| CA3120363A1 (en) | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for dosing and treatment of b cell malignancies in adoptive cell therapy |
| DK3886875T3 (da) | 2018-11-30 | 2024-07-29 | Juno Therapeutics Inc | Behandlingsfremgangsmåder under anvendelse af adoptiv celleterapi |
| CN110468210A (zh) * | 2019-09-12 | 2019-11-19 | 暨南大学 | Cdc45作为胶质母细胞瘤标志物及其作为治疗靶点的应用 |
| BR112022010310A2 (pt) | 2019-12-06 | 2022-08-16 | Juno Therapeutics Inc | Métodos relacionados com a toxicidade e resposta associada com terapia celular para tratamento de malignidades de célula b |
| US20240092774A1 (en) * | 2020-09-21 | 2024-03-21 | Hutchison Medipharma Limited | Heteroaromatic compounds and uses thereof |
| CN115969979B (zh) * | 2022-12-30 | 2025-08-29 | 中国人民解放军陆军军医大学第一附属医院 | C620-0580在制备抗胶质瘤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100721656B1 (ko) | 2005-11-01 | 2007-05-23 | 주식회사 엘지화학 | 유기 전기 소자 |
| AU2007238372A1 (en) * | 2006-04-14 | 2007-10-25 | Astrazeneca Ab | 4-anilinoquinoline-3-carboxamides as CSF-1R kinase inhibitors |
| CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
| SI2010528T1 (en) * | 2006-04-19 | 2018-02-28 | Novartis Ag | 6-O-substituted benzoxazole and benzothiazole compounds and procedures for inhibiting CSF-1R signaling |
| AU2007240443B2 (en) | 2006-04-20 | 2012-11-01 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| WO2008144062A1 (en) * | 2007-05-21 | 2008-11-27 | Novartis Ag | Csf-1r inhibitors, compositions, and methods of use |
-
2012
- 2012-05-04 KR KR1020137031960A patent/KR101938431B1/ko not_active Expired - Fee Related
- 2012-05-04 ES ES12720761.1T patent/ES2622527T3/es active Active
- 2012-05-04 EA EA201391629A patent/EA023999B1/ru not_active IP Right Cessation
- 2012-05-04 SI SI201230916A patent/SI2704713T1/sl unknown
- 2012-05-04 DK DK12720761.1T patent/DK2704713T3/en active
- 2012-05-04 MX MX2013012939A patent/MX347616B/es active IP Right Grant
- 2012-05-04 HU HUE12720761A patent/HUE032754T2/en unknown
- 2012-05-04 PL PL12720761T patent/PL2704713T3/pl unknown
- 2012-05-04 CA CA2834696A patent/CA2834696C/en active Active
- 2012-05-04 HR HRP20170593TT patent/HRP20170593T1/hr unknown
- 2012-05-04 CN CN201280021878.2A patent/CN103501785B/zh active Active
- 2012-05-04 US US14/114,878 patent/US20140065141A1/en not_active Abandoned
- 2012-05-04 WO PCT/US2012/036589 patent/WO2012151523A1/en not_active Ceased
- 2012-05-04 BR BR112013028095-6A patent/BR112013028095B1/pt not_active IP Right Cessation
- 2012-05-04 JP JP2014509491A patent/JP6046702B2/ja active Active
- 2012-05-04 EP EP12720761.1A patent/EP2704713B1/en active Active
- 2012-05-04 LT LTEP12720761.1T patent/LT2704713T/lt unknown
- 2012-05-04 PT PT127207611T patent/PT2704713T/pt unknown
-
2015
- 2015-06-29 US US14/754,152 patent/US20150306085A1/en not_active Abandoned
-
2017
- 2017-04-10 CY CY20171100426T patent/CY1119642T1/el unknown
-
2018
- 2018-06-04 US US15/996,945 patent/US10537561B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20140065141A1 (en) | 2014-03-06 |
| EA023999B1 (ru) | 2016-08-31 |
| CN103501785A (zh) | 2014-01-08 |
| BR112013028095A2 (pt) | 2016-12-27 |
| MX347616B (es) | 2017-05-04 |
| PT2704713T (pt) | 2017-04-24 |
| EP2704713A1 (en) | 2014-03-12 |
| WO2012151523A1 (en) | 2012-11-08 |
| KR101938431B1 (ko) | 2019-01-14 |
| ES2622527T3 (es) | 2017-07-06 |
| US10537561B2 (en) | 2020-01-21 |
| EP2704713B1 (en) | 2017-01-18 |
| CY1119642T1 (el) | 2018-04-04 |
| CA2834696A1 (en) | 2012-11-08 |
| HRP20170593T1 (hr) | 2017-07-14 |
| DK2704713T3 (en) | 2017-04-24 |
| MX2013012939A (es) | 2014-02-27 |
| AU2012250574B2 (en) | 2016-07-07 |
| CA2834696C (en) | 2019-07-23 |
| US20190030013A1 (en) | 2019-01-31 |
| KR20140029475A (ko) | 2014-03-10 |
| EA201391629A1 (ru) | 2016-01-29 |
| PL2704713T3 (pl) | 2017-08-31 |
| LT2704713T (lt) | 2017-04-25 |
| BR112013028095B1 (pt) | 2020-03-03 |
| US20150306085A1 (en) | 2015-10-29 |
| JP2014513136A (ja) | 2014-05-29 |
| SI2704713T1 (sl) | 2017-05-31 |
| CN103501785B (zh) | 2016-10-26 |
| AU2012250574A1 (en) | 2013-11-28 |
| AU2012250574A8 (en) | 2016-07-28 |
| HUE032754T2 (en) | 2017-10-30 |
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